Recent Longevity News for the seven days ending 11/23/11.  You should consult your doctor if you are taking any medications.

Your daily cup of coffee may be aging your skin - MSNBC, 11/22/11 - Four minute video on skin health.

FDA Approves Gel Dermal Filler for Facial Wrinkles - Medscape, 11/21/11 - "The product combines a cohesive polydensified matrix technology with a hyaluronic acid base that attracts water to the injected area to fill and plump the wrinkle in natural way ... Potential treatment areas include nasolabial folds, worry lines, crow's feet, lips/chin/cheek augmentation, marionette lines, smile lines, perioral lines, and wrinkles at the décolletage ... According to information on the company Web site, patients are able to see the lines and wrinkles on their face softening and becoming less noticeable immediately after treatment. Results improve during the first week or so and continue for about 6 to 12 months before additional treatments are needed"

Joint Supplements for Aromatase Inhibitor Adverse Effects - Medscape, 11/18/11 - "Aromatase inhibitors are widely used in the treatment of breast cancer but are associated with significant musculoskeletal adverse effects, including joint pain and stiffness ... We know that these symptoms are unresponsive to conventional pain medication and often lead to low adherence to aromatase inhibitor therapy ... The cohort consisted of postmenopausal breast cancer patents with stage I to III disease who had been on aromatase therapy for at least 3 months, who reported a pain rating of 4 or higher on a 10-point visual analog scale, and whose pain worsened after initiating treatment with aromatase inhibitors if they had preexisting osteoarthritis ... Participants took 1500 mg/day of glucosamine and 1200 mg/day of chondroitin, and were evaluated every 6 weeks at the clinic ... There was a drop in pain and stiffness in the hips and knees at 12 and 24 weeks, as well as improvement in function. "This affected about 50% of the women," she explained. "We saw a very similar pattern looking at the hands and the wrist. We saw similar results with the Brief Pain/Stiffness Inventory — with about 35% to 50% of women."" - See glucosamine products at Amazon.com and chondroitin sulfate at Amazon.com.

Probiotics appear to mitigate pancreatitis: Surprising hypothetical mechanism warrants further investigation - Science Daily, 11/16/11 - "The major finding: in the small intestine, higher than normal numbers of the newly discovered bacterium, "commensal rat ileum bacterium" (CRIB) were correlated with reduced severity of acute pancreatitis in animals that had been fed probiotic. These animals had less infection of remote organs, less infection of dying and dead pancreatic tissues, and less severe immune response during acute pancreatitis, as demonstrated by lower plasma levels of proinflammatory cytokines" - See probiotics at Amazon.com.

Probiotic protects intestine from radiation injury - Science Daily, 11/16/11 - "the therapy can kill both cancer cells and healthy ones, leading to severe bouts of diarrhea if the lining of the intestine gets damaged ... For many patients, this means radiation therapy must be discontinued, or the radiation dose reduced, while the intestine heals ... Probiotics may provide a way to protect the lining of the small intestine from some of that damage ... the probiotic bacteria Lactobacillus rhamnosus GG (LGG), among other Lactobacillus probiotic strains, protected the lining of the small intestine in mice receiving radiation ... the probiotic was effective only if given to mice before radiation exposure ... The bacteria we use is similar to what's found in yogurt or in commercially available probiotics ... So theoretically, there shouldn't be risk associated with this preventative treatment strategy any more than there would be in a patient with abdominal cancer eating yogurt" - See probiotics at Amazon.com.

Milk thistle extract stops lung cancer in mice, study shows - Science Daily, 11/15/11 - "Compared to these multi-million dollar drugs, naturally-occurring silibinin blocked not only the expression of COX2 and iNOS, but also the migration of existing lung cancer cells" - See silymarin at Amazon.com.

Low vitamin D levels may be associated with recurrent inflammatory spinal cord disease - Science Daily, 11/14/11 - "The study found that vitamin D levels were significantly lower in patients who developed recurrent spinal cord disease. "Our findings suggest that there may be an association between lower total 25-hydroxyvitamin D levels in patients with recurrent TM/NMO/NMO spectrum disorders as compared with their counterparts with monophasic disease," ... This is consistent with other recurrent autoimmune conditions and points to a common link between low vitamin D levels and immunologic dysregulation" - See vitamin D at Amazon.com.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Effects of coenzyme Q10 on vascular endothelial function in humans: A meta-analysis of randomized controlled trials - Atherosclerosis. 2011 Oct 25 - "Coenzyme Q10 supplementation is associated with significant improvement in endothelial function. The current study supports a role for CoQ10 supplementation in patients with endothelial dysfunction" - See ubiquinol products at Amazon.com.

The association of antihypertensive medication use with risk of cognitive decline and dementia: a meta-analysis of longitudinal studies - Int J Clin Pract. 2011 Dec;65(12):1295-305 - "The association of antihypertensive medication use with cognitive decline (including mild cognitive impairment) or dementia (including Alzheimer's disease (AD), vascular dementia (VD) and any dementia) has still been an area of controversy ... The quantitative meta-analysis showed that there was no significant difference in incidence of AD (RR: 0.90, 95% confidence interval (CI): 0.79-1.03), cognitive decline (RR: 0.97; 95% CI: 0.92-1.03) and cognitive impairment (RR: 0.97; 95% CI: 0.92-1.03). The quantitative meta-analysis showed that the subjects with antihypertensive medication use were lower incidence of VD (RR: 0.67, 95% CI: 0.52-0.87) and any dementia (RR: 0.87; 95% CI: 0.77-0.96) than those without"

LCAT, HDL Cholesterol and Ischemic Cardiovascular Disease: A Mendelian Randomization Study of HDL Cholesterol in 54,500 Individuals - J Clin Endocrinol Metab. 2011 Nov 16 - "Low plasma HDL cholesterol levels robustly associated with increased risk of MI but genetically decreased HDL cholesterol did not. This may suggest that low HDL cholesterol levels per se do not cause MI"

Urinary Bisphenol A (BPA) Concentration Associates with Obesity and Insulin Resistance - J Clin Endocrinol Metab. 2011 Nov 16 - "Bisphenol A (BPA) is one of the world's highest-volume chemicals in use today. Previous studies have suggested BPA disturbs body weight regulation and promotes obesity and insulin resistance. But epidemiological data in humans were limited ... The participants in the highest quartile of BPA had the highest prevalence of generalized obesity [odds ratio (OR) = 1.50; 95% confidence interval (CI) = 1.15-1.97], abdominal obesity (OR = 1.28; 95% CI = 1.03-1.60), and insulin resistance (OR = 1.37; 95% CI = 1.06-1.77). In participants with BMI under 24 kg/m(2), compared with the lowest quartile, the highest quartile of BPA increased the prevalence of insulin resistance by 94% (OR = 1.94; 95% CI = 1.20-3.14), but this association was not observed in those with BMI of 24 kg/m(2) or higher"

Association between serum cholesterol and noncardiovascular mortality in older age - J Am Geriatr Soc. 2011 Oct;59(10):1779-85 - "Participants were evaluated for total cholesterol and subfractions and followed for mortality for a median of 13.9 years ... Age- and sex-adjusted analyses showed that each 1-mmol/L increase in total cholesterol was associated with an approximately 12% lower risk of noncardiovascular mortality (hazard ratio (HR) = 0.88, 95% confidence interval (CI) = 0.84-0.92, P < .001). Age group-specific analyses demonstrated that this association reached significance after the age of 65 and increased in magnitude across each subsequent decade. This was driven largely by non-high-density lipoprotein cholesterol (non-HDL-C) (HR = 0.89, 95% CI 0.85-0.93, P < .001) and was partly attributable to cancer mortality. Conversely, HDL-C was not significantly associated with noncardiovascular mortality (HR = 0.92, 95% CI 0.79-1.07, P = .26)"

Frequency of dairy consumption and functional disability in older persons - J Nutr Health Aging. 2011;15(9):795-800 - "of milk and milk products consumption were obtained using a food frequency questionnaire and functional disability was assessed using the instrumental activities of daily living (IADL) and ADL scales ... In men, dietary intake of dairy products was associated with a significantly reduced risk of IADL disability after controlling for known functional disability risk factors and other dietary factors (p for trend, 0.038). Compared with men who consumed dairy products < 1 time/week, those who consumed ≥ 1 time/day had a reduced risk of IADL disability (odds ratio [OR], 0.35; 95% confidence interval [CI], 0.13-0.91). Meanwhile, milk and milk products consumption was not significantly associated with ADL disability. In women, dairy products consumption was not significantly associated with physical disability"

Plasma 25-Hydroxyvitamin D and Risk of Pancreatic Cancer - Cancer Epidemiol Biomarkers Prev. 2011 Nov 15 - "Mean plasma 25(OH)D was lower in cases versus controls (61.3 vs. 64.5 nmol/L, P=0.005). In logistic regression models, plasma 25(OH)D was inversely associated with odds of pancreatic cancer. Participants in quintiles two through five had multivariable-adjusted odds ratios (OR [95% confidence intervals]) of 0.79 (0.56-1.10), 0.75 (0.53-1.06), 0.68 (0.48-0.97), and 0.67 (0.46-0.97); P-trend=0.03), respectively, compared to the bottom quintile. Compared to those with insufficient levels (25[OH]D<50 nmol/L), ORs were 0.75 (0.58-0.98) for subjects with relative insufficiency (25[OH]D 50-<75 nmol/L) and 0.71 (0.52-0.97) for those with sufficient levels (25[OH]D≥75 nmol/L). No increased risk was noted in subjects with 25(OH)D ≥100 nmol/L, as suggested in a prior study. In subgroup analyses, ORs for the top versus bottom quartile of 25(OH)D were 0.72 (0.48-1.08) for women, 0.73 (0.40-1.31) for men, and 0.73 (0.51-1.03) for Whites ... Low circulating 25(OH)D may predispose individuals to the development of pancreatic cancer" - See vitamin D at Amazon.com.

Effect of folic acid intervention on ALT concentration in hypertensives without known hepatic disease: a randomized, double-blind, controlled trial - Eur J Clin Nutr. 2011 Nov 16 - "A total of 480 participants with mild or moderate essential hypertension and without known hepatic disease were randomly assigned to three treatment groups: (1) enalapril only (10 mg, control group); (2) enalapril-FA tablet (10 mg enalapril combined with 0.4 mg of FA, low FA group); and (3) enalapril-FA tablet (10 mg enalapril combined with 0.8 mg of FA, high FA group), once daily for 8 weeks ... This report included 455 participants in the final analysis according to the principle of intention to treat. We found a significant reduction in ALT level in the high FA group (median (25th percentile, 75th percentile), -0.6 (-6.9, 2.0)IU/l, P=0.0008). Compared with the control group, the high FA group showed a significantly greater ALT-lowering response in men (median ALT ratio (ALT at week 8 to ALT at baseline; 25th percentile, 75th percentile): 0.93 (0.67, 1.06) vs 1.00 (0.91, 1.21), P=0.032), and in participants with elevated ALT (ALT>40 IU/l) at baseline. There was no difference in ALT lowering between the control and the low FA group" - See folic acid products at Amazon.com.

Neat Tech Stuff / "How To's":

• Video For Everybody Generator - Generates html5 code for adding video to web pages.
• HP's WiFi Touch Mouse X7000 has a Facebook button, doesn't like lefties - Engadget, 11/15/11
  • HP X7000 Touch Mouse with Wi-Fi

Health Focus (Triglycerides):

Related Topics:

• cholesterol concerns / HDL cholesterol / statins / homocysteine / inflammation / heart disease / strokes / red yeast rice / policosanol / guggul / pantethine / artichoke / inositol hexanicotinate / triglycerides / green tea / hesperidin / hypertension / trans fatty acids

Popular Supplements:

• omega-3 fish oil / pantethine / guggul / niacin / green tea / chromium / garlic / fructo-oligosaccharides (FOS) / inositol hexanicotinate / Sytrinol

Alternative News:

• Estimating health and economic benefits from using prescription omega-3 Fatty acids in patients with severe hypertriglyceridemia - Am J Cardiol. 2011 Sep 1;108(5):691-7 - "In patients with severe (≥500 mg/dl) hypertriglyceridemia (SHTG), clinical trials have demonstrated that prescription ω-3 fatty acids (P-OM3s) 4 g/day can decrease triglyceride levels by 45% ... Simulation results for the control arm indicated that subjects with SHTG are at about 2 times higher risk for myocardial infarction than those with normal triglyceride levels. Using estimates from previous epidemiologic studies and meta-analyses with OM3s, the model predicted 29% to 36% decreases in various measurements of adverse cardiac events for the intervention arm. The model also predicted a decrease in ischemic stroke of 24% (95% confidence interval 15 to 33)" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials - Am J Clin Nutr. 2011 Jun 29 - "We performed a comprehensive literature search to identify relevant trials of green tea beverages and extracts on lipid profiles in adults ... The analysis of eligible studies showed that the administration of green tea beverages or extracts resulted in significant reductions in serum TC and LDL-cholesterol concentrations, but no effect on HDL cholesterol was observed" - See green tea extract at Amazon.com.
• Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Patients With Very High Triglyceride Levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] Trial) - Am J Cardiol. 2011 Jun 15 - "AMR101 is an omega-3 fatty acid agent containing ≥96% eicosapentaenoic acid ethyl ester and no docosahexaenoic acid ... AMR101 4 g/day reduced the placebo-corrected TG levels by 33.1%" - See Mega Twin EPA at Amazon.com.
• Dietary, lifestyle changes can significantly reduce triglycerides - 4/18/11 - "Changes such as substituting healthy, unsaturated dietary fats for saturated ones, engaging in physical activity and losing excess weight can decrease triglycerides by 20 percent to 50 percent ... analyzed more than 500 international studies from the past 30 years to formulate the scientific statement ... Recommended dietary changes for those outside the normal range of triglycerides include limiting: ... added sugar to less than 5 percent to 10 percent of calories consumed -- about 100 calories per day for women and 150 calories per day for men ... fructose from both processed foods and naturally occurring foods -less than 50 to 100 grams per day ... saturated fat to less than 7 percent of total calories ... trans fat to- less than 1 percent of total calories ... alcohol, especially if triglyceride levels are higher greater than 500 mg/dL ... nearly one-third (31 percent) of adults have elevated triglyceride levels (more than 150 mg/dL)"
• Pomegranate Juice Protects Macrophages from Triglyceride Accumulation: Inhibitory Effect on DGAT1 Activity and on Triglyceride Biosynthesis - Ann Nutr Metab. 2011 Jan 6;58(1):1-9 - "pomegranate juice (PJ) ... PJ (0-50 μM) significantly and dose-dependently decreased the triglyceride content and triglyceride biosynthesis rate in J774A.1 macrophages or in C57BL/6 MPM by about 30%. Similarly, punicalagin, the major PJ polyphenol, inhibited the MPM triglyceride biosynthesis rate by 40%. The triglyceride hydrolytic rate, however, was not significantly affected by PJ or punicalagin. The activity of diacylglycerol acyltransferase 1 (DGAT1; the rate-limiting enzyme in triglyceride biosynthesis) was significantly inhibited, by 54%, in C57BL/6 MPM that were treated with 50 μM PJ or punicalagin, with no significant effect on DGAT1 mRNA or protein expression. Both PJ and punicalagin increased (1.7-fold) MPM PON2 mRNA expression, and PON2 was previously shown to inhibit DGAT1 activity. However, the addition of PJ or punicalagin (50 μM) to microsomes from PON2-deficient MPM still resulted in a significant reduction (50-58%) in DGAT1 activity" - See pomegranate at Amazon.com.
• Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia - Am J Clin Nutr. 2010 Dec 15 - "effects of 0.85 and 3.4 g EPA+DHA/d ... The higher dose of EPA+DHA lowered triglycerides by 27% compared with placebo (173 +/- 17.5 compared with 237 +/- 17.5 mg/dL; P = 0.002), whereas no effect of the lower dose was observed on lipids. No effects on cholesterol (total, LDL, and HDL), endothelial function [as assessed by flow-mediated dilation, peripheral arterial tonometry/EndoPAT (Itamar Medical Ltd, Caesarea, Israel), or Doppler measures of hyperemia], inflammatory markers (interleukin-1β, interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein), or the expression of inflammatory cytokine genes in isolated lymphocytes were observed" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Prospective randomized comparison between omega-3 fatty acid supplements plus simvastatin versus simvastatin alone in Korean patients with mixed dyslipidemia: lipoprotein profiles and heart rate variability - Eur J Clin Nutr. 2010 Sep 29 - "After 6 weeks of drug treatment, triglyceride levels decreased by 41.0% in the combination treatment group and 13.9% in the simvastatin monotherapy group (from 309.2+/-95 mg per 100 ml to 177.7+/-66 versus 294.6+/-78 mg per 100 ml to 238.3+/-84 mg per 100 ml, respectively" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study - Menopause. 2010 Aug 31 - "Myo-inositol plus diet improved systolic and diastolic blood pressure, HOMA index, cholesterol, and triglyceride serum levels with highly significant differences, compared with the groups treated only with diet and placebo. In the group treated with myo-inositol, a decrease in diastolic blood pressure (-11%), HOMA index (-75%), and serum triglycerides (-20%) and an improvement in high-density lipoprotein cholesterol (22%) were shown ... CONCLUSIONS: Supplementation with myo-inositol may be considered a reliable option in the treatment of metabolic syndrome in postmenopausal women" - Note:  See raysahelian.com/inositol.html  and http://en.wikipedia.org/wiki/Inositol which claim myo-inositol and inositol are the same.  See myo inositol at Amazon.com.
• Astaxanthin’s heart benefits get human data support - Nutra USA, 8/9/10 - "Daily supplements of the carotenoid astaxanthin may improve HDL ‘good’ cholesterol levels in people with mildly abnormal blood lipid levels ... participants receiving the two highest doses experienced significant reductions in their triglyceride levels, of 25 and 24 percent, respectively, compared to baseline. Furthermore, people receiving 6 or 12 mg per day experienced significant increases in their HDL-cholesterol levels of 10 and 15 percent, respectively ... Additionally, adiponectin levels increased in the two highest dose groups, with increases over 20 percent in the 12 mg per day group, and between 15 and 20 percent in the 18 percent group" - See Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.comor astaxanthin products at iHerb.
• Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia - Atherosclerosis. 2010 Apr;209(2):520-3 - "Multiple comparison tests showed that 12 and 18 mg/day doses significantly reduced triglyceride, and 6 and 12 mg doses significantly increased HDL-cholesterol. Serum adiponectin was increased by astaxanthin (12 and 18 mg/day), and changes of adiponectin correlated positively with HDL-cholesterol changes independent of age and BMI" - See Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.comor astaxanthin at Amazon.com.
• Effects of a 1-year dietary intervention with n-3 polyunsaturated fatty acid-enriched olive oil on non-alcoholic fatty liver disease patients: a preliminary study - Int J Food Sci Nutr. 2010 May 13 - "Consumption of olive oil enriched with n-3 PUFA demonstrated a significant improvement of liver echo-texture and of the Doppler Perfusion Index after 12 months (after: 0.19 +/- 0.02 vs. pre: 0.15 +/- 0.03; P < 0.05), whereas no significant changes were seen at the end of follow-up in controls. Moreover, patients who consumed the olive oil enriched with n-3 PUFA showed a significant amelioration of liver enzymes, and of triglycerides (post: 132.8 +/- 63.7 vs. pre: 164.5 +/- 85.5 mg/dl; P = 0.04) in a general linear model adjusted for age and gender. Interestingly, patients reported to have a significant increase of adiponectin levels (post: 1,487.9 +/- 96.7 vs. pre: 1,143 +/- 24.8 mug/ml; P = 0.04)"
• Successful Treatment of Severe Hypertriglyceridemia with a Formula Diet Rich in Omega-3 Fatty Acids and Medium-Chain Triglycerides - Ann Nutr Metab. 2010 Feb 12;56(3):170-175 - "Patients with highly increased plasma triglyceride levels are at risk of developing serious complications such as pancreatitis, coronary heart disease and stroke. Therefore it is important to rapidly decrease plasma triglyceride levels. A sufficient control of triglyceride levels with drugs like fibrates, statins or nicotinic acid can usually only be attained after a couple of weeks. Plasma exchange appears to be a fast but expensive method to reduce triglyceride levels. In this study we describe the use of a new omega-3 fatty acid and medium-chain triglyceride-rich formula diet as a therapeutic concept to reduce plasma triglyceride levels fast and effectively ... Thirty-two patients with severe hypertriglyceridemia were treated with the especially composed formula diet for a period of 7 days. Results: Within this period of time, plasma triglycerides decreased from 1,601 (402-4,555) to 554 (142-2,382) mg/dl (p < 0.05). Total cholesterol levels were reduced from 417 (211-841) to 287 (165-457) mg/dl (p < 0.001). Fasting glucose and uric acid levels also slightly decreased (-8%; -12%). The formula diet as a 1-week treatment was well tolerated and accepted by the patients" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Dietary supplementation of n-3 PUFA reduces weight gain and improves postprandial lipaemia and the associated inflammatory response in the obese JCR:LA-cp rat - Diabetes Obes Metab. 2009 Nov 16 - "n-3 PUFA treatment resulted in a significant improvement (i.e. decrease) in the postprandial response for triglyceride (45%) (p < 0.05), apoB48 (45%) (p < 0.03) and LBP (33%) (p < 0.05) compared to controls (measured as area under the clearance curve). In contrast, we observed a significant elevation in postprandial haptoglobin (165%) (p < 0.001) in obese rats supplemented with 10% n-3 PUFA. Treatment with 5% n-3 PUFA in the JCR:LA-cp obese animals resulted in a complementary decrease in total body weight gain (6%) (p < 0.001) and an increase (i.e. improvement) in adiponectin (33%) (p < 0.05) compared to controls, without a concomitant reduction in food intake" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• The effects of [omega]3 fatty acids and coenzyme Q10 on blood pressure and heart rate in chronic kidney disease: a randomized controlled trial - J Hypertens. 2009 Sep;27(9):1863-72 - "patients were randomized to either omega3FA (4 g), CoQ (200 mg), both supplements or control (4 g), daily for 8 weeks ... omega3FA, but not CoQ, reduced 24-h ambulatory heart rate (P<0.0001) and blood pressure ... omega3FA reduced triglycerides 24%" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity - Acta Cardiol. 2009 Jun;64(3):321-7 - "were given 1 gram of fish oil as a single capsule, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid daily for 6 months. Control subjects did not receive any supplementation over the same period. RESULTS: The study was completed by 47 subjects in the intervention group and 42 subjects in the control group. Treatment with omega 3 supplements was associated with a significant fall in body weight (P < 0.05), systolic blood pressures (P < 0.05), serum low density lipoprotein cholesterol (P < 0.05), and total cholesterol (P < 0.05), triglycerides (P < 0.05), high-sensitivity C-reactive protein (hs-CRP) (P < 0.01), and Hsp27 antibody titres (P < 0.05). No significant changes were observed in the control group. CONCLUSION: It appears that omega 3 improves the cardiovascular risk profile of subjects with metabolic syndrome, having effects on weight, systolic blood pressure, lipid profile and markers of inflammation and autoimmunity" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Quercetin inhibits fatty acid and triacylglycerol synthesis in rat-liver cells - Eur J Clin Invest. 2009 Jun 8 - "In hepatocytes from normal rats, the quercetin-induced decrease in both de novo fatty acid and TAG synthesis, with a consequent reduction in VLDL-TAG formation, may represent a potential mechanism contributing to the reported hypotriacylglycerolemic effect of quercetin" - See quercetin at Amazon.com.
• Triglycerides Too High? - Dr. Weil, 2/19/09
• New Approach Discovered To Lowering Triglycerides - Science Daily, 3/30/09 - "In the lab animals, supplements of lipoic acid lowered triglyceride levels up to 60 percent ... supplements of lipoic acid appeared to affect triglyceride levels through two pathways. After eating, lipoic acid supplementation increased the rate of disappearance of triglycerides in the bloodstream. And supplements also reduced the genetic expression of enzymes in the liver that synthesize triglycerides ... Lipoic acid supplements have in various studies been shown to be an appetite suppressant ... The amount of lipoic acid supplementation used in these laboratory experiments would equate to about two grams per day for a 150-pound person" - See alpha lipoic acid at Amazon.com.
• Late Bedtimes Linked to Heart Disease - WebMD, 3/30/09 - "The fewer hours a man slept each night, the higher his BMI, blood pressure, and triglyceride levels"
• Trans-10, cis-12-conjugated linoleic acid reduces the hepatic triacylglycerol content and the leptin mRNA level in adipose tissue in obese Zucker fa/fa rats - Br J Nutr. 2009 Mar 19:1-13 - "Conjugated linoleic acid (CLA) isomers have been reported to reduce body weight and beneficially affect glucose metabolism in animals, but the results are inconsistent and seem to depend on animal model and type of CLA isomer. In the present study, feeding male Zucker fa/fa rats diets supplemented with 1 % trans-10, cis-12-CLA for 10 d reduced the liver TAG content without improving the overall adiposity, and enhanced hepatic mitochondrial and peroxisomal beta-oxidation ... The present results suggest that dietary supplementation with trans-10, cis-12-CLA may increase the catabolism of lipids in liver and adipose tissue. Moreover, we provide new data suggesting that trans-10, cis-12-CLA modulates the expression of resistin and adiponectin inversely in adipose tissue. Hence, the present results suggest that trans-10, cis-12-CLA may have some beneficial effects on lipid metabolism and adiposity but possibly reduces insulin sensitivity" - See conjugated linoleic acid at Amazon.com.
• Resveratrol inhibits fatty acid and triacylglycerol synthesis in rat hepatocytes - Eur J Clin Invest. 2009 Mar;39(3):211-8 - "Results here reported show that in isolated hepatocytes from normal rats a resveratrol-induced short-term inhibition of fatty acid and triacylglycerol synthesis occurs. This finding may represent a potential mechanism contributing to the reported hypolipidemic effect of resveratrol" - See resveratrol products at Amazon.com.
• Dietary Green Tea Extract Lowers Plasma and Hepatic Triglyceride and Decreases the Expression of Sterol Regulatory Element-Binding Protein-1c mRNA and Its Responsive Genes in Fructose-Fed Ovariectomized Rats - J Nutr. 2009 Feb 4 - "Fructose elevated plasma TG and cholesterol compared with the S group. GT at 0.5 and 1.0% markedly lowered plasma and liver TG. Fructose increased the expression of SREBP-1c, fatty acid synthase, and stearoyl-CoA desaturase 1 mRNAs in the liver, whereas GT decreased the expression of these lipogenic genes. Similarly, fructose increased the abundance of hepatic 3-hydroxy-3-methyl-glutaryl-CoA reductase mRNA, whereas GT significantly decreased its expression ... the lipid-lowering effect of GT is mediated partly by its inhibition of hepatic lipogenesis involving SREBP-1c and its responsive genes without affecting lipoprotein assembly" - See green tea extract at Amazon.com.
• Fish Oil, Red Yeast Rice Cut Cholesterol - WebMD, 7/23/08 - "We followed them for a three-month period ... The LDL declined 42% in the supplement group and 39% in the Zocor group ... The supplement group also lost an average of 10 pounds in 12 weeks, but there was no significant weight loss in the medication group. Triglyceride levels, while on average normal in both groups at the start, decreased by 29% in the supplement group but just 9.3% in the medication group -- a significant difference" - See red yeast rice at Amazon.com and Mega Twin EPA at Amazon.com.
• Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia - Expert Opin Pharmacother. 2008 May;9(7):1237-48 - "Prescription omega-3 fatty acid concentrates (P-OM3) are indicated for use in people with very high triglycerides ... P-OM3 are effective in reducing triglycerides by approximately 30% in this population" - See Mega Twin EPA at Amazon.com.
• Omega-3 fatty acid containing diets decrease plasma triglyceride concentrations in mice by reducing endogenous triglyceride synthesis and enhancing the blood clearance of triglyceride-rich particles - Clin Nutr. 2008 Mar 22 - "Levels of hepatic TG and apoB synthesis were 30-50% and 42% lower in mice fed with the fish oil diet compared to the other three diets. In addition, compared to soy oil diet, fish oil feeding significantly increased blood clearance of chylomicron-like lipid emulsions by 21-26%" - See Mega Twin EPA at Amazon.com.
• Omega-3 Fatty Acids May Be Useful for Cardioprotection - Medscape, 3/18/08 - "To date, the strongest evidence showing a CV benefit from omega-3 fatty acid intake derives from 3 large controlled trials in which a total of 32,000 participants were randomized to a control group or to receive omega-3 fatty acid supplements containing DHA and EPA. In these trials, the supplemented group had a 19% to 45% reduction in CV events vs the control group ... Patients with hypertriglyceridemia should consume 3 to 4 g/day of DHA and EPA, which can lower triglyceride levels by 20% to 50%" - See Mega Twin EPA at iHerb.
• Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications - Expert Rev Cardiovasc Ther. 2008 Mar;6(3):391-409 - "Hypertriglyceridemia is a risk factor for atherosclerotic coronary heart disease. Very high triglyceride (TG) levels (>/=500 mg/dl [5.65 mmol/l]) increase the risk of pancreatitis. One therapeutic option to lower TG levels is omega-3 fatty acids, which are derived from the oil of fish and other seafood. The American Heart Association has acknowledged that fish oils may decrease dysrhythmias, decrease sudden death, decrease the rate of atherosclerosis and slightly lower blood pressure, and has recommended fish consumption or fish oil supplementation as a therapeutic strategy to reduce cardiovascular disease. A prescription omega-3-acid ethyl esters (P-OM3) preparation has been available in many European nations for at least a decade, and was approved by the US FDA in 2004 to reduce very high TG levels (>/=500 mg/dl [5.65 mmol/l]). Mechanistically, most evidence suggests that omega-3 fatty acids reduce the synthesis and secretion of very-low-density lipoprotein (VLDL) particles, and increase TG removal from VLDL and chylomicron particles through the upregulation of enzymes, such as lipoprotein lipase. Omega-3 fatty acids differ mechanistically from other lipid-altering drugs, which helps to explain why therapies such as P-OM3 have complementary mechanisms of action and, thus, complementary lipid benefits when administered with statins" - See Mega Twin EPA at Amazon.com.
• Omega3 Fatty acids for cardioprotection - Mayo Clin Proc. 2008 Mar;83(3):324-32 - "The most compelling evidence for the cardiovascular benefit provided by omega-3 fatty acids comes from 3 large controlled trials of 32,000 participants randomized to receive omega-3 fatty acid supplements containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) or to act as controls. These trials showed reductions in cardiovascular events of 19% to 45%. These findings suggest that intake of omega-3 fatty acids, whether from dietary sources or fish oil supplements, should be increased, especially in those with or at risk for coronary artery disease. Patients should consume both DHA and EPA. The target DHA and EPA consumption levels are about 1 g/d for those with known coronary artery disease and at least 500 mg/d for those without disease. Patients with hypertriglyceridemia benefit from treatment with 3 to 4 g/d of DHA and EPA, a dosage that lowers triglyceride levels by 20% to 50%. Although 2 meals of oily fish per week can provide 400 to 500 mg/d of DHA and EPA, secondary prevention patients and those with hypertriglyceridemia must use fish oil supplements if they are to reach 1 g/d and 3 to 4 g/d of DHA and EPA, respectively" - See Mega Twin EPA at iHerb and Jarrow Max DHA at Amazon.com.  I take both because the percentage of omega-3 (EPA and DHA) is very low in other supplements.  I don't know what the rest of that oil is but your not saving anything by getting supplements with a low percentage.  Just do the math plus if the rest of the oil is an omega-6 you're not helping the omega-6/omega-3 ratio.
• Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters - Biochem Biophys Res Commun. 2007 Dec 28 - "The concentrations of serum total cholesterol and triglyceride were significantly lower in the resveratrol-fed group than in the control group. The resveratrol contained diet significantly decreased Apo B, Lp(a), and cholesterol-ester-transport protein (CETP) concentrations, but increased Apo A-I levels and the Apo A-I/Apo B ratio. The contents of cholesterol and triglyceride in hepatic tissue were significantly lower in the resveratrol group than in the control group. Real-time PCR analysis revealed that HMGR mRNA expression was significantly lower in the resveratrol group than in the control group" - See resveratrol products at Amazon.com.
• Combination Niacin-Laropiprant Plus Simvastatin Reduces Cholesterol by Almost 50% - Doctor's Guide, 11/6/07 - "When patients with dyslipidemia added simvastatin to their experimental combination of extended-release niacin and laropiprant -- a novel anti-flushing agent -- they reported reductions in low density lipoprotein cholesterol (LDL-C) of as much as 48% from baseline ... high density liopoprotein cholesterol (HDL-C) was increased by 28% and triglycerides decreased by 33%"
• Role of prescription omega-3 Fatty acids in the treatment of hypertriglyceridemia - Pharmacotherapy. 2007 May;27(5):715-28 - "In patients with triglyceride levels above 500 mg/dl, approximately 4 g/day of EPA and DHA reduces triglyceride levels 45% and very low-density lipoprotein cholesterol levels by more than 50%" - See Mega Twin EPA at Amazon.com or Vitacost or Jarrow Max DHA at Amazon.com.
• Effect of omega-3 Fatty Acid supplementation on the arachidonic Acid:eicosapentaenoic Acid ratio - Pharmacotherapy. 2007 May;27(5):633-8 - "Triglyceride levels were not reduced in patients with CAD but were significantly decreased in healthy subjects (by 20% decrease with omega-3 fatty acids 1.5 g/day and by 32% decrease with 3 g/day)"
• Effect of combination lipid-modifying therapy on the triglyceride lowering effect of fish oil - Am J Med Sci. 2007 Mar;333(3):168-72 - "Fish oil effectively reduces plasma triglyceride levels when administered with concomitant lipid medications"
• DHA alone can lower triglycerides, says study - Nutra USA, 2/7/07 - "Subjects were randomized to either 1000mg of DHA or 1252 mg of DHA + EPA for eight weeks ... triglycerides were lowered an average of 21.8 per cent in the DHA group and 18.3 per cent in the DHA + EPA group" - See Jarrow Max DHA at Amazon.com.
• The triglyceride-lowering effects of a modest dose of docosahexaenoic acid alone versus in combination with low dose eicosapentaenoic acid in patients with coronary artery disease and elevated triglycerides - J Am Coll Nutr. 2006 Dec;25(6):480-5 - "randomized to either 1000 mg of DHA or 1252 mg of DHA + EPA for eight weeks ... Triglycerides decreased by an average of 21.8% in the DHA group (p < 0.001) and 18.3% in the DHA + EPA group (p < 0.001). The difference between groups was not significant. A greater proportion of subjects in the DHA group achieved triglyceride goal (less than 150 mg/dL) compared to the DHA + EPA group (24.6% versus 10.2%, p < 0.05)" - See Jarrow Max DHA at Amazon.com or Mega Twin EPA at Amazon.com.
• Hypertriglyceridemia - Medscape, 6/1/06 - "Omega-3 fatty acids (4 g per day) will reduce triglyceride levels by 30% ... ER niacin has been shown to lower the triglyceride level by ~25% and raise the HDL level by almost 30%"
• In search of those omega-3 fatty acids -  San Diego Union-Tribune, 3/7/06 - "Fish oils from supplements or dietary sources can reduce triglycerides by 20 percent to 50 percent ... Studies have used triglyceride-lowering doses of 1 to 4 grams (1,000 mg to 4,000 mg) daily"
• Omega-3 Fatty Acids in the Management of Hypertriglyceridemia: New Findings and Formulations - Continuing Medical Education (CME):Princeton Media Associates, exp. 10/29/06 - "To lower TG levels, the dose of omega-3 therapy is ~4 g of EPA + DHA per day" - See Mega Twin EPA at Amazon.com or Vitacost.
• Fish Oil Supplements Improve Lipid Risk Factors in Obese Children - Medscape, 11/14/05 - "given 3 g of a daily fish oil supplement ... After 12 weeks, the researchers found that triglyceride levels in the control group did not significantly differ from baseline. In contrast, triglyceride levels in children treated with fish oil significantly decreased. However, differences in other lipid measures were not statistically significant" - See Mega Twin EPA at iHerb or Vitacost.
• Omega-3 Fatty Acids: Recommendations for Therapeutics and Prevention - Medscape, 10/19/05 - "Supplementation of 4 g EPA/DHA per day for 6 weeks resulted in a 20% TG decline in mildly hyperlipidemic middle-aged men"  - See Mega Twin EPA at iHerb or Vitacost.
• Plasma Triglyceride and the Risk for Vascular Disease - Medscape, 9/19/05 - "omega-3 fatty acid therapy, particularly when administered in moderate doses[42] on a scale matching natural fish consumption, significantly reduces plasma triglyceride"
• Women and Omega-3 Fatty Acids - Obstet Gynecol Surv. 2004 Oct;59(10):722-730 - "because elevated triglyceride levels are associated with cardiovascular disease, especially in women; and because omega-3 FA have powerful effects on triglycerides, women in particular gain from an increased intake of these fatty acids. This is especially important in women receiving hormone therapy, which can increase triglyceride levels." - See Mega Twin EPA at iHerb or Vitacost.
• Increased n-6 polyunsaturated fatty acids do not attenuate the effects of long-chain n-3 polyunsaturated fatty acids on insulin sensitivity or triacylglycerol reduction in Indian Asians - Am J Clin Nutr. 2004 Jun;79(6):983-991 - "were supplemented with 4.0 g fish oil/d (2.5 g eicosapentaenoic acid + docosahexaenoic acid) ... After the 6-wk period of fish oil supplementation, fasting and postprandial plasma triacylglycerol concentrations decreased significantly" - See Mega Twin EPA at iHerb or Vitacost.
• Soy protein reduces triglyceride levels and triglyceride fatty acid fractional synthesis rate in hypercholesterolemic subjects - Atherosclerosis. 2004 Apr;173(2):269-75 - "Soy protein reduced TG by 12.4% ( [Formula: see text] ) ... compared to animal protein"
• Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study - Am J of Clin Nutr, Vol. 78, No. 6, 1098-1102, 12/03 - "We used generalized linear models to estimate adjusted mean triacylglycerol concentrations according to categories of total dietary linolenic acid (alpha- and gamma-linolenic acid) intake ... Consumption of total linolenic acid is inversely related to plasma triacylglycerol concentrations in both white men and white women. This suggests a pathway by which dietary linolenic acid might reduce cardiovascular disease risk" - The way I understand it, by linolenic acid they are talking about alpha (omega-3) and gamma (GLA, an omega-6). - Ben
• Eating Fish Lowers Heart Disease Risk in Women With Diabetes - WebMD, 3/31/03 - "It is believed that omega-3 fatty acids abundant in the fat of many fish reduces the risk of heart disease by lowering triglyceride levels, improving blood vessel function, and reducing blood-clot formation"
• Lipid Benefits With Monounsaturated-Fatty-Acids Diet In Healthy People - Doctor's Guide, 3/14/03 - "A moderate supplementation of long-chain n-3 fatty acids in healthy individuals reduces both fasting and post-prandial triacylglycerol concentrations but increases LDL cholesterol, irrespective of the type of diet"
• Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes - Am J Clin Nutr 2003 Mar;77(3):605-11 - "Olive oil induced lower triacylglycerol concentrations and higher HDL-cholesterol concentrations than did butter, without eliciting significant changes in glucose, insulin, or fatty acids" - Olive oil is 76% omega-9.
• I take Lopid (gemfibrozil) to lower my blood triglyceride and cholesterol levels, but I am concerned about the side effects. Is there anything natural that I can take instead? - Dr. Murray - "Pantethine has been shown to significantly reduce serum triglyceride (-32%), total cholesterol (-19%), and LDL-cholesterol (-21%) levels while increasing HDL-cholesterol (+23%) levels in several clinical trials"
• Randomized controlled trial of the effect of n–3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity1 - Am. J. of Clin. Nutr., 2/03 - "randomly assigned to receive either fish oil capsules (4 g/d, consisting of 45% eicosapentaenoic acid and 39% docosahexaenoic acid as ethyl esters) or matching placebo ... Fish oil supplementation significantly (P < 0.05) lowered plasma concentrations of triacylglycerols (-18%) and VLDL apo B (-20%) and the hepatic secretion of VLDL apo B (-29%) compared with placebo" - Doing the math, 45% of 4 grams equals 1,800 mg of EPA,  39% of 4 grams equals 1,560 mg of DHA.  Three Mega Twin EPA at iHerb or Vitacost plus three Jarrow Max DHA at Amazon.com (the two strongest formulas I know) would be 2,100 mg EPA and 1,570 mg DHA.
• Chromium For Insulin Function - Functional Foods & Nutraceuticals, 1/03 - "28 patients received 200mcg/day chromium picolinate for two months. Although there was no change seen in HDL or LDL cholesterol, triglyceride levels dropped 17.4 per cent"
• Ispaghula Husk [psyllium] Nearly As Effective As Simvastatin For Hyperlipidemia - Doctor's Guide, 12/24/02 - "One group received 3.5 grams of ispaghula husk twice a day and the second group received 20 milligrams of simvastatin each day ... total cholesterol decreased by 15.8 percent and low-density lipoprotein (LDL) cholesterol decreased by 22.97 percent among patients taking ispaghula husk ... Triglycerides decreased by 20.89 percent and high-density lipoprotein (HDL) cholesterol increased by 10.69 percent in these patients ... Among patients taking simvastatin, total cholesterol decreased by 24.15 percent, LDL cholesterol decreased by 36.08 percent, triglycerides decreased by 20.47 percent and HDL cholesterol increased by 11.4 percent" - I've got that. See psyllium husk at Amazon.com.  3.5 grams is about one wafer (3.4 grams psyllium/wafer).  Plus 24 wafers runs about $4.49 versus about $116 for 30 of the 20 mg simvastatin.
• Atkins diet good for cholesterol - USA Today, 11/18/02 - "After six months, the people on the Atkins diet had lost an average of 31 pounds, compared with 20 pounds on the AHA diet, and more people stuck with the Atkins regimen ... Total cholesterol fell slightly in both groups. However, those on the Atkins diet had an 11% increase in HDL, the good cholesterol, and a 49% drop in triglycerides. On the AHA diet, HDL was unchanged, and triglycerides dropped 22%. High triglycerides may raise the risk of heart disease" - That may be true but what about a diet devoid of anti-oxidants making you old before your time.  Plus, how much of that extra 11 pounds was water loss? - Ben
• Silybin-Beta-Cyclodextrin Reduces Glucose, Triglyceride Levels In Diabetes With Liver Disease - Doctor's Guide, 11/12/02 - "Fasting blood glucose levels decreased by 14.7 percent from baseline in patients receiving silybin-beta-cyclodextrin ... Plasma triglycerides concentrations dropped from a mean 186 to 111 mg/dl at six months in those that received silybin-beta-cyclodextrin" - See iHerb and Vitacost silymarin products.
• Fish Oil May Augment Atorvastatin As Treatment For Dyslipidemia In Obese, Insulin-Resistant Men - Doctor's Guide, 8/7/02 - "fish oils significantly decreased plasma levels of triglycerides and very low density lipoprotein-apoB, decreased the very low density lipoprotein-apoB secretion rate" - See Mega Twin EPA at iHerb or Vitacost.
• Omega-3 Fatty Acids May Prevent Heart Disease By Improving Arterial Elasticity - Intelihealth, 7/25/02 - "Both omega-3 fatty acid supplement groups experienced significant declines in plasma total triacylglycerol concentrations"
• Omega 3: Implications in human health and disease - PowerPak (39 page CME course for Registered Dietitians), exp. 8/1/03 - "A substantial body of evidence supports the use of fish oil in the treatment of hypertriglyceridemia.130 In normolipidemic subjects, daily dosages of 2-25 g of omega 3 fatty acids produced decreases in triglyceride concentrations of 20-60%. In patients with hypertriglyceridemia, decreases of up to 81% have been reported" - See Mega Twin EPA at iHerb or Vitacost.
• Rice Bran Lowers Diabetic Blood Sugar - WebMD, 4/10/02 - "Rice bran was able to lower blood glucose by up to 30% in a small group of patients with type 1 or 2 diabetes ... also found that patients with elevated cholesterol who consumed 20 grams per day of stabilized rice bran lowered their total serum cholesterol and triglyceride levels between 5% and 15%"
• question regarding your new cholesterol-lowering supplement, Policosanol - Life Extension Magazine, 11/01 - "Studies show that niacin (B3) in doses of 1.5 grams to 3 grams lower triglycerides levels and raise HDL concentrations. Those who tolerated higher doses of niacin (nicotinic acid) showed even more improvement in lipid levels. Some people taking just 1000 mg of flush-free niacin see an elevation in beneficial HDL. Green tea also has been shown to elevate levels of HDL while lowering serum triglyceride levels. In the Journal of Molecular Cell Biochemistry, curcumin has been demonstrated, in vivo, to decrease triglycerides and increase HDL. In a study published in 1989 by the Journal of Associated Physicians-India, 125 patients receiving gugulipid showed a drop of 16.8% in triglycerides, and a 60% increase in HDL cholesterol within three to four weeks. Make sure you are taking at least six Mega EPA fish oil capsules daily, as low dose fish oil may not adequately suppress triglycerides. Finally, there are some lifestyle changes you may wish to consider. If you are overweight, weight loss would be recommended, as it would help to lower triglycerides and raise HDL. Also, try reducing carbohydrates, which can raise triglycerides"
• Product Review: Omega-3 Fatty Acids (EPA and DHA) from Fish/Marine Oils - ConsumerLabs.com, 11/20/01 - "It's been discovered that EPA and DHA may help prevent heart disease and atherosclerosis by lowering triglyceride levels, raising HDL ("good") cholesterol and, possibly "thinning" the blood ... By decreasing inflammation, EPA and DHA can also reduce the pain of rheumatoid arthritis ... Fish oils may also be useful in treating a host of conditions including bipolar (manic-depressive) disorder, Raynaud's phenomenon (abnormal sensitivity of hands and feet to cold), lupus, IgA nephropathy, kidney stones, chronic fatigue syndrome, Crohn's disease, cystic fibrosis, and ulcerative colitis ... EPA specifically may be helpful for schizophrenia, while DHA may be more helpful in reducing high blood pressure ... DHA may be helpful in the treatment of disorders such as attention deficit disorders, dyslexia, and cognitive impairment and dementia ... experts now believe that the American diet contains too little omega-3 fatty acids and too much omega-6 fatty acids"
• A Fish Story - Nutrition Science News, 4/01 - "daily consumption of very low daily doses of EPA/DHA (120 mg/180 mg, about one standard fish oil capsule) in an enriched milk led to a 19 percent decrease in blood triglycerides and a 19 percent increase in HDL cholesterol after six weeks ... It is unclear whether EPA is superior to DHA, although EPA has proven more potent in relaxing cow coronary arteries and producing the vasodilator gas, nitric oxide, in vitro"
• Fish Oil - The Natural Pharmacist - "Subsequent investigation found that the omega-3 fatty acids found in fish oil can lower blood triglyceride levels, "thin" the blood, and also decrease inflammation in various parts of the body."
• Niacin Reduces Triglycerides, Increases Good Cholesterol In Diabetics - Doctor's Guide, 3/20/01 - "There had been concern that niacin use in diabetic patients might increase blood sugar levels ... but we didn't see that in our study ... Patients were randomised to receive placebo, 1,000 mg of niacin or 1,500 mg of prescription niacin ... Patients taking the active agent increased high-density lipoprotein (HDL) cholesterol by 20 to 24 percent compared with a 4 percent increase among the placebo patients. At the same time, triglycerides were reduced 15 to 29 percent in the patients on niacin compared with a 5 percent reduction among patients taking placebo"
• Evaluation of the Antihyperlipidemic Properties of Dietary Supplements - Medscape, 4/1/01 - "[omega]-3 Fatty Acids ... Triglyceride concentrations decreased by 25% in subjects with normal triglyceride concentrations (< 177 mg/dl) and by 34% in those with elevated concentrations"
• Evaluation of the Antihyperlipidemic Properties of Dietary Supplements - Medscape, 4/1/01 - "After 24 weeks of gugulipid treatment, total cholesterol levels decreased by 25.2 mg/dl, compared with a 7.6 mg/dl increase in the placebo group (p<0.01). The LDL was 16.9 mg/dl lower and 4.0 mg/dl higher, respectively ... In addition, a significant reduction in triglycerides was seen in the gugulipid-treated arm compared with placebo (-18 vs +5.5 mg/dl"
• Using Creatine For More Than Muscles - Nutrition Science News, 10/99 - "A variety of published and unpublished research shows creatine may decrease tumor growth, increase body mass, decrease blood glucose, reduce triglycerides and cholesterol, extend exercise endurance in congestive heart failure patients, and even alter metabolism in people with neurodegenerative diseases such as Alzheimer's and Lou Gehrig's diseases"
• Green Tea Lowers Cholesterol - Nutrition Science News, 10/99
• Chromium Steels the Body Against Diabetes - Nutrition Science News, 2/99 - "The chromium treatment significantly lowered triglycerides"

Other News:

• Disrupted circadian rhythm may cause triglycerides to rise - Science Daily, 8/3/10
• Study: Too Much Sugar Increases Heart Risks - Time Magazine, 4/21/10 - "Compared with people consuming less than 5% of their daily calories in added sugar, those in the highest consumption group — who got 25% or more of their daily calories in added sugar — were twice as likely to have low levels of HDL cholesterol, the beneficial lipid that mops up artery-clogging LDL cholesterol. According to government health guidelines, HDL levels below 50 mg/dL for women and 40 mg/dL for men are considered low; 43% of the highest sugar consumers recorded low HDL, while only 22% of the lowest sugar consumers did ... People eating the most added sugar also recorded the highest triglyceride levels ... Low HDL and high triglyceride levels are two of the primary risk factors for heart disease"
• A high normal TSH is associated with the metabolic syndrome - Clin Endocrinol (Oxf). 2009 Sep 10 - "Subjects with a TSH in the upper normal range (2.5 to 4.5 mU/l, n = 119) had a significantly higher BMI (30.47 +/- 0.57 vs. 28.74 +/- 0.18 kg/m(2), p = 0.001) and higher fasting triglycerides (1.583 +/- 0.082 vs. 1.422 +/- 0.024 mmol/l, p = 0.023), and their likeliness for fulfilling the criteria of the MS was 1.7-fold increased"
• Fat In The Liver -- Not The Belly -- May Be A Better Marker For Disease Risk - Science Daily, 8/25/09 - "Having too much liver fat is known as nonalcoholic fatty liver disease ... when fat collects in the liver, people experience serious metabolic problems such as insulin resistance, which affects the body's ability to metabolize sugar. They also have increases in production of fat particles in the liver that are secreted into the bloodstream and increase the level of triglycerides"
• Triglycerides Implicated in Diabetic Neuropathy - Doctor's Guide, 5/22/09
• High Triglyceride Levels Common, Often Untreated Among Americans - Science Daily, 3/23/09
• Fructose-sweetened Drinks Increase Nonfasting Triglycerides In Obese Adults - Science Daily, 2/12/09 - "Obese people who drink fructose-sweetened beverages with their meals have an increased rise of triglycerides following the meal ... Increased triglycerides after a meal are known predictors of cardiovascular disease"
• Cortisol And Fatty Liver: Researchers Find Cause Of Severe Metabolic Disorders - Science Daily, 9/11/08 - "The researchers in Herzig's team specifically switched off the cortisol receptor in the livers of mice, thus blocking the hormone's effect. As a result, the triglyceride level in the livers of the experimental animals dropped considerably"
• Marijuana Users Have Increased apoC3, Triglycerides - Medscape, 5/19/08 - "Heavy, chronic use of marijuana causes increased levels of apolipoprotein C3 (apoC3), which in turn results in a major increase in triglyceride levels"
• Metformin May Delay Onset of Diabetes in At-Risk Subjects - Medscape, 3/24/08 - "Metformin treatment, compared with placebo or no treatment, reduced body mass index by 5.3%, fasting glucose by 4.5%, fasting insulin by 14.4%, and calculated insulin resistance by 22.6% ... Metformin treatment also reduced triglycerides and LDL cholesterol by 5.3% and 5.6%, respectively, and increased HDL cholesterol by 5.0% ... The incidence of new-onset diabetes was reduced by 40% (odds ratio, 0.6), with an absolute risk reduction of 6%, during a mean trial duration of 1.8 years" - I don't have diabetes yet still take 1,000 mg of metformin per day.  I still feel high blood sugar and advanced glycation end products are major causes of aging.  See metformin at OffshoreRx1.com.
• Low serum testosterone in men is inversely associated with non-fasting serum triglycerides: The Tromsø study - Nutr Metab Cardiovasc Dis. 2007 Jun 7 - "a linear increase in serum TG levels was found in men with total testosterone levels below the 50th percentile during the day (p for trend=0.004). In contrast, serum triglycerides did not change during the day in men with testosterone levels above the 50th percentile. In regression analyses, total testosterone and SHBG were inversely and independently associated with TG (p<0.001 and p<0.001 respectively), and positively and independently associated with HDL"
• The prevalence of newly diagnosed hyperlipidaemia in men with erectile dysfunction - BJU Int. 2007 Jun 6 - "This study shows the high prevalence of undiagnosed hypercholesterolaemia and hypertriglyceridaemia in men presenting with ED"
• Telmisartan improves lipid metabolism and adiponectin production but does not affect glycemic control in hypertensive patients with type 2 diabetes - Adv Ther. 2007 Jan-Feb;24(1):146-53 - "Triglyceride levels were significantly decreased, however, and adiponectin levels were significantly increased"
• Mixed Results for Cardiovascular Drug - WebMD, 11/14/05
• Big Waist + High Blood Fats = Heart Danger - WebMD, 4/18/05 - "heart deaths concentrate in women with just two factors -- high levels of triglycerides and a 34 2/3-inch waist or larger"
• Winning The Battle Of The Bulge: We're A Scrimmage Closer To Victory - Science Daily, 4/29/04 - "High triglycerides are blocking the leptin from getting into the brain. If leptin can't get into the brain, it can't tell you to stop eating ... If you lower triglycerides, you should theoretically help the body's own leptin to work better so people can get skinnier"
• Four Part Treatment Regimen Recommended for Severe Hypertriglyceridaemia - Doctor's Guide, 10/3/03
• Non-Fasting Triglyceride Levels May Be Useful in Coronary Heart Disease Risk Stratification - Doctor's Guide, 5/27/03
• Nonfasting Triglyceride Levels Predict Cardiovascular Risk - Doctor's Guide, 5/23/03
• Relation of Triglyceride Levels, Fasting and Nonfasting, to Fatal and Nonfatal Coronary Heart Disease - Archives of Internal Medicine, 5/12/03 - "nonfasting TG levels may be more useful than fasting ones for risk stratification"
• Unhealthy Trans Fats Not Labeled on Foods - WebMD, 2/10/03 - "[Trans fats] are there and they are not labeled ... Saturated fats are the only fats given special treatment on a product's label. Yet trans fats are just as bad. They may even be worse ... Trans fat increases 'bad' LDL cholesterol -- in some studies more than saturated fat ... It also has a tendency to reduce 'good' HDL cholesterol, which saturated fat doesn't do ... Trans fat also increases blood levels of two other bad actors. One is the kind of fat called triglycerides. The other is a particle called lipoprotein(a), which promotes clogged arteries ... Any amount of trans fat is bad"
• Ezetimibe Plus Simvastatin Safely Improves Lipid Profile - Doctor's Guide, 1/17/03 - "Ezetimibe and simvastatin given together reduced low-density lipoprotein cholesterol by 44 to 57%, reduced triglycerides by 20 to 28% and raised high-density lipoprotein cholesterol by 8 to 11%, depending on the simvastatin dose" - Ezetimibe is a cholesterol absorption inhibitor, simvastatin is a statin.
• Big gut, other factors can kill you - USA Today, 12/3/02 - "People with this syndrome have at least three of the following risk factors: high blood sugar; a waist circumference of greater than 40 inches for men or 35 inches for women; lower-than-average HDL cholesterol (the so-called good cholesterol); high triglycerides and high blood pressure ... men who had the syndrome at the study's start had a two to three times greater chance of dying of a heart attack or a stroke during the study than men who did not have this collection of risk factors ... People getting a checkup should ask their family doctor to look for metabolic syndrome"
• New Study Indicates Pioglitazone HCl/Metformin Combination Therapy Enhances Glycemic Control in Patients With Type 2 Diabetes - Doctor's Guide, 11/7/02 - "Diabetes patients taking the insulin sensitizer pioglitazone HCl in combination with metformin experienced significantly greater improvement in triglyceride levels than patients taking rosiglitazone maleate and metformin"
• High Triglycerides Common In Cystic Fibrosis Patients - Doctor's Guide, 6/11/02
• High Triglycerides, Higher Stroke Risk - Intelihealth, 12/19/01 - "Participants with high triglycerides had a 27 percent higher risk of ischemic strokes and transient ischemic attacks, or TIAs, than participants with normal triglyceride levels. People with high levels of high-density lipoprotein (HDL), so-called good cholesterol, were less likely to have strokes than those with lower HDL ... the results provide another reason for people with coronary heart disease to control triglycerides and not just cholesterol ... This also confirms that the high-density cholesterol, HDL, is very important"
• Triglycerides May Be Stroke Indicator - Intelihealth, 12/11/01 - "heart patients who have high levels of these fatty particles in their blood run a higher risk of a stroke, even if their cholesterol is low ... this study is the first to identify triglycerides as an independent risk factor for stroke ... The lesson from our study is, in addition to managing well the bad cholesterol, one should not ignore the triglycerides ... Those with high levels of triglycerides, or over 200 milligrams per deciliter, had a nearly 30 percent higher risk of stroke. The heart association says the normal level for triglycerides is less than 150"
• Atorvastatin May Lower LDL And Triglycerides In Type 2 Diabetics - Doctor's Guide, 6/24/01
• Low-Fat, High-Carbohydrate Diets Not Necessarily Cause Hypertriglyceridemia - Doctor's Guide, 5/31/01
• Niaspan (Niacin Extended Release Tablets) Safe And Effective For Diabetics - Doctor's Guide, 11/14/00 - "Results from the trial indicated that Niaspan therapy increased HDL up to 24 percent and decreased triglycerides as much as 30 percent"
• Do Triglyceride Tests Really Help Predict Heart Disease? - WebMD, 7/10/00
• Study: Heart risks rise with high triglycerides even if cholesterol normal - CNN, 6/20/00
• High Blood Triglycerides Linked To High Risk Of Heart Disease Mortality - Doctor's Guide, 6/19/00
• FDA Approves New Lescol Indication To Reduce Triglycerides And Apo B - Doctor's Guide, 3/9/99
• Very Low Fat Diets May Not Provide Additional Benefit - Doctor's Guide, 8/31/98 - "Very low fat diets, at least in the short term, tend to increase triglycerides and decrease good cholesterol, or HDL, levels without yielding additional decreases in LDL levels"
• TriCor, Micronized Fenofibrate, Now Available In U.S. For High Triglycerides - Doctor's Guide, 6/2/98
• Triglyceride Levels May Be Independent Risk Factor For Heart Attack - Doctor's Guide, 3/24/98
• FDA Approves Zocor To Lower Both Cholesterol and Triglycerides - Doctor's Guide, 11/6/97
• Triglyceride Blood Levels Predict Heart Attack - Doctor's Guide, 10/30/97