Recent Longevity News for the seven days ending 11/17/10.  You should consult your doctor if you are taking any medications.

Oral Aloe Vera for Treatment of Diabetes Mellitus and Dyslipidemia (printer-friendly) - Medscape, 11/16/10 - "Five out of the seven studies that evaluated diabetes endpoints in humans showed significant reductions in fasting blood glucose after treatment with oral aloe vera in patients with diabetes or prediabetes;[21,22,24,25,28] the remaining two studies reported a trend toward decreased blood or plasma glucose concentrations in the aloe-treated groups.[26,27] Significant reductions in HbA1c—up to 22.6% of baseline—were seen in all three studies that evaluated this measure.[22,27,28] One of these studies reported improvements in fructosamine levels,[27] suggesting an improvement in average blood glucose levels over time" - See aloe vera products at iHerb.

Secondhand smoke exposure increases risk of hearing loss - Science Daily, 11/15/10 - "Former smokers were significantly more likely to have impaired hearing. The prevalence of low to mid frequency hearing loss among this group was 14%. And almost half (over 46%) had high frequency hearing loss (more than 25 decibels) ... Although the risk was not as strong among those who had never smoked, almost one in 10 (8.6%) had low to mid frequency hearing loss and one in four (26.6%) had high frequency hearing loss"

US scientists significantly more likely to publish fake research - Science Daily, 11/15/10 - "US scientists are significantly more likely to publish fake research than scientists from elsewhere, finds a trawl of officially withdrawn (retracted) studies ... A total of 788 papers had been retracted during this period. Around three quarters of these papers had been withdrawn because of a serious error (545); the rest of the retractions were attributed to fraud (data fabrication or falsification)"

Regular exercise reduces large number of health risks including dementia and some cancers, study finds - Science Daily, 11/15/10 - "Regular exercise can reduce around two dozen physical and mental health conditions and slow down how quickly the body ages ... Health conditions covered by the review include: cancer, heart disease, dementia, stroke, type 2 diabetes, depression, obesity and high blood pressure"

Natural compound shows promise against Huntington's disease - Science Daily, 11/15/10 - "Fisetin, a naturally occurring compound found in strawberries and other fruits and vegetables, slows the onset of motor problems and delays death in three models of Huntington's disease ... tested fisetin's effects in a mouse model of HD. HD mice develop motor defects early on and have much shorter life spans than normal control animals. When Maher and her team fed them fisetin, the onset of the motor defects was delayed, and their life span was extended by about 30 percent"

Trust hormone associated with happiness: Human study suggests new role for oxytocin - Science Daily, 11/15/10 - "women who show large increases in oxytocin when they are trusted also report being more satisfied with life and less depressed" - See See Oxytocin 6x5iu tablets at International Antiaging Systems.

HPV Vaccine: Not Just for Women? - US News and World Report, 11/10/10 - "the federal Advisory Committee on Immunization Practices is deliberating whether to issue a public recommendation that boys and men be vaccinated with Gardasil, the only HPV vaccine approved for that group, just as it's recommended for women" - Note: The author talks about several cancers but leaves out head and neck which I believe is the main reason for boys to get vaccinate with Gardasil.  I was given a 25% chance of survival six years ago from cancer of the tonsil that spread to the lymph nodes.  They believe it was caused by HPV.  Somehow I made it through that with just a 6 inch scar on my neck that's hardly noticeable but I went through a lot of agony with that operation, lost about 15 pounds from not being able to eat for a long time after the operation plus about 15 months with the doctors convinced it would return because I refused radiation and chemo plus it was a late stage III before the operation.  I still need to be very careful with eating meat because the muscle tissue they took from my tonsil area makes it difficult to swallow.  I mostly eat turkey meat balls for the protein portion of meals.  That may have been prevented by Gardasil.

Why chocolate protects against heart disease - Science Daily, 11/10/10 - "ate 75 grams of unsweetened chocolate with a cocoa content of 72 percent. To analyze what happened with the ACE enzyme, blood samples were taken in advance and then a half hour, one hour, and three hours afterward ... In the sample taken three hours afterward, there was a significant inhibition of ACE activity. The average was 18 percent lower activity than before the dose of cocoa, fully comparable to the effect of drugs that inhibit ACE and are used as a first-choice treatment for high blood pressure" - Note:  I find that ACE inhibitor theory hard to believe. The results of up to 57% reduction in heart disease was found with amounts of chocolate much less than that and it would seem that amount would have very little effect on blood pressure. Plus two recent studies showed blood pressures of 135/85 and 146/81 so lower is not necessarily better.

Fructose-rich beverages associated with increased risk of gout in women - Science Daily, 11/10/10 - "Compared with consumption of less than 1 serving per month, women who consumed one serving per day had a 74 percent increased risk of gout; and those with 2 or more servings per day had a 2.4 times higher risk ... Orange juice intake was also associated with risk of gout. Compared with women who consumed less than a glass (6 oz.) of orange juice per month, women who consumed 1 serving per day had a 41 percent higher risk of gout, and there was a 2.4 times higher risk with 2 or more servings per day"

Probiotics shorten diarrhea episodes, review suggests - Science Daily, 11/9/10 - "Giving probiotics in conjunction with rehydration fluids reduced the duration of diarrhea by around a day and reduced the risk of diarrhea lasting four or more days by 59%"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations - Br J Nutr. 2010 Nov 15:1-12 - "α-Lipoic acid (ALA) has been termed the 'ideal' antioxidant, a readily absorbed and bioavailable compound capable of scavenging a number of free radicals, and it has been used for treating diseases in which oxidative stress plays a major role ... We showed that ALA exhibited anti-inflammatory effects on both acute and chronic inflammations, and a strongly anti-oxidative potency on linoleic acid oxidation. Moreover, the administration of CAR induced oedema in the paws. ALA significantly inhibited the ability of CAR to induce: (1) the degree of acute inflammation, (2) the rise in MPx activity, (3) the increases of GST and iNOS activities and the amount of LPO and (4) the decreases of GPx, GR and SOD activities and the amount of GSH. In conclusion, these results suggest that the anti-inflammatory properties of ALA, which has a strong anti-oxidative potency, could be related to its positive effects on the antioxidant system in a variety of tissues in rats" - See alpha lipoic acid at Amazon.com.

Orange juice decreases low-density lipoprotein cholesterol in hypercholesterolemic subjects and improves lipid transfer to high-density lipoprotein in normal and hypercholesterolemic subjects - Nutr Res. 2010 Oct;30(10):689-94 - "normolipidemic (NC) and hypercholesterolemic (HCH) subjects ... consumed 750 mL/day OJ concentrate (1:6 OJ/water) for 60 days ... Orange juice consumption decreased low-density lipoprotein cholesterol (160 +/- 17 to 141 +/- 26 mg/dL, P < .01) in the HCH group but not in the NC group. HDL-cholesterol and triglycerides remained unchanged in both groups. Free-cholesterol transfer to HDL increased (HCH: 4.4 +/- 2 to 5.6 +/- 1%, NC: 3.2 +/- 2 to 6.2 +/- 1%, P< .05) whereas triglyceride (HCH 4.9 +/- 1 to 3.1 +/- 1%, NC 4.4 +/- 1 to 3.4 +/- 1%, P< .05) and phospholipid (HCH 21.6 +/- 2 to 18.6 +/- 3%, NC 20.2 +/- 2 to 18.4 +/- 2%, P < .05) transfers decreased in both groups. Cholesteryl-ester transfer decreased only in HCH (3.6 +/- 1 to 3.1 +/- 1%, P < .05), but not in NC" - Note:  750 ml is .79 quarts.  Seem like it might be a problem with weight gain.

Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers - Am J Clin Nutr. 2010 Nov 10 - "Throughout the three 4-wk periods, volunteers consumed daily 500 mL orange juice, 500 mL control drink plus hesperidin (CDH), or 500 mL control drink plus placebo (CDP) ... Diastolic blood pressure (DBP) was significantly lower after 4 wk consumption of orange juice or CDH than after consumption of CDP (P = 0.02), whereas microvascular endothelium-related reactivity was not significantly affected when measured after an overnight fast. However, both orange juice and CDH ingestion significantly improved postprandial microvascular endothelial reactivity compared with CDP (P < 0.05) when measured at the peak of plasma hesperetin concentration" - See hesperidin at Amazon.com and Natural Balance, Great Legs, 60 Capsules at iHerb.  Note:  This link went dead but I've been taking hesperidin for years for the HDL benefit::

• High Levels of HDL Cholesterol Can Save Your Life - ABC News, 11/3/00 - "So how much HDL is enough? Current guidelines say 35 milligrams per deciliter of blood (mg/dl) is normal, but most cardiologists would prefer you to have an HDL count that’s twice that. “The higher the better,” says Gaziano. “Once you get over 60 mg/dl, it’s a strong positive factor in avoiding heart disease.” ... this will increase your HDL by 21 percent (or 10 to 20 points) within 4 weeks. “We’re not sure, but this effect may be due to a flavonoid in orange juice called hesperidin"

Protective effects of dehydroepiandrosterone on atherosclerosis in ovariectomized rabbits via alleviating inflammatory injury in endothelial cells - Atherosclerosis. 2010 Aug 3 - "The risk for atherosclerosis is increased in postmenopausal women. Dehydroepiandrosterone (DHEA) is postulated to have anti-atherogenic properties ... DHEA administration alleviates efficiently the early pathologic damage of atherosclerosis, increases the serum NO level, and up-regulates the endothelial cell estrogen receptor (ER) expression of ovariectomized rabbits. DHEA in vitro significantly promotes NO synthesis, suppresses MDA and MCP-1 secretion of endothelial cells, and decreases ICAM-1, VCAM-1 and E-selectin expression in HUVECs; neither selective ERα antagonist (methyl-piperidino-pyrazole, MPP) nor ERβ antagonist (R,R-tetrahydrochrysene, R,RTHC) can abolish these effects. Furthermore, DHEA reduces CCR2, LFA-1 and VLA-4 expression in U937 cells, which in turn inhibits the adherence of monocytes to the injured endothelial cells. DHEA significantly decreased the LPS-induced NF-κB transcription" - See DHEA at Amazon.com.

Effects of telmisartan added to Angiotensin-converting enzyme inhibitors on mortality and morbidity in hemodialysis patients with chronic heart failure a double-blind, placebo-controlled trial - J Am Coll Cardiol. 2010 Nov 16;56(21):1701-8 - "In hemodialysis patients, CHF is responsible for a high mortality rate ... At 3 years, telmisartan significantly reduced all-cause mortality (35.1% vs. 54.4%; p < 0.001), cardiovascular death (30.3% vs. 43.7%; p < 0.001), and hospital admission for CHF (33.9% vs. 55.1%; p < 0.0001). With Cox proportional hazards analysis, telmisartan was an independent determinant of all-cause mortality (hazard ratio [HR]: 0.51; 95% confidence interval [CI]: 0.32 to 0.82; p < 0.01), cardiovascular mortality (HR: 0.42; 95% CI: 0.38 to 0.61; p < 0.0001), and hospital stay for deterioration of heart failure (HR: 0.38; 95% CI: 0.19 to 0.51; p < 0.0001). Adverse effects, mainly hypotension, occurred in 16.3% of the telmisartan group versus 10.7% in the placebo group" - Note:  It makes me wonder if similar effects on mortality might be seen in people without kidney disease.  See my telmisartan as a first line treatment page.

Skin carotenoid levels in adult patients with psoriasis - J Eur Acad Dermatol Venereol. 2010 Nov - "Patients with psoriasis appear to have lower skin carotenoid counts than patients without psoriasis"

Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities - Proc Natl Acad Sci U S A. 2010 Nov 8 - "Bisphenol A (BPA) is a highly prevalent constituent of plastics that has been associated with diabetes, cardiovascular disease, and an increased risk of miscarriages in humans ... BPA exposure results in impaired chromosome synapsis and disruption of meiotic double-strand break repair (DSBR) progression. BPA carries an anti-estrogenic activity in the germline and results in germline-specific down-regulation of DSBR genes, thereby impairing maintenance of genomic integrity during meiosis. C. elegans therefore constitutes a model of remarkable relevance to mammals with which to assess how our chemical landscape affects germ cells and meiosis"

What Is the Optimal Blood Pressure in Patients After Acute Coronary Syndromes?: Relationship of Blood Pressure and Cardiovascular Events in the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction (PROVE IT-TIMI) 22 Trial - Circulation. 2010 Nov 8 - "The relationship between BP (systolic or diastolic) followed a J- or U-shaped curve association with primary, secondary, and individual outcomes, with increased events rates at both low and high BP values, both unadjusted and after adjustment for baseline variables, baseline C-reactive protein, and on-treatment average levels of low-density lipoprotein cholesterol. A nonlinear Cox proportional hazards model showed a nadir of 136/85 mm Hg (range 130 to 140 mm Hg systolic and 80 to 90 mm Hg diastolic) at which the incidence of primary outcome was lowest. The curve was relatively flat for systolic pressures of 110 to 130 mm Hg and diastolic pressures of 70 to 90 mm Hg. Conclusions- After acute coronary syndrome, a J- or U-shaped curve association existed between BP and the risk of future cardiovascular events, with lowest event rates in the BP range of approximately 130 to 140 mm Hg systolic and 80 to 90 mm Hg diastolic and a relatively flat curve for systolic pressures of 110 to 130 mm Hg and diastolic pressures of 70 to 90 mm Hg, which suggests that too low of a pressure (especially <110/70 mm Hg) may be dangerous" - Note:  This says 135/85 for lowest mortality.  Below study says 146/81.

• J-curve revisited: an analysis of blood pressure and cardiovascular events in the Treating to New Targets (TNT) trial - Eur Heart J. 2010 Sep 16 - "The relationship between SBP or DBP and primary outcome followed a J-curve with increased event rates above and below the reference BP range, both unadjusted and adjusted (for baseline covariates, treatment effect, and LDL levels). A time-dependent, non-linear, multivariate Cox proportional hazard model identified a nadir of 146.3/81.4 mmHg where the event rate was lowest. A similar non-linear relationship with a higher risk of events at lower pressures was found for most of the secondary outcomes of all-cause mortality, cardiovascular mortality, non-fatal MI, or angina. However, for the outcome of stroke, lower was better for SBP. Conclusion In patients with CAD, a low BP (<110-120/<60-70 mmHg) portends an increased risk of future cardiovascular events (except stroke)"

Neat Tech Stuff / "How To's":

• Watt Stopper - Legrand WN-100-120-W - 0-1500 Watts - Occupancy Sensor Wall Switch w/ Night Light - White - It says "Occupancy Sensor" but it's also got "Automatic On".  I searched for a long time to find one that works with compact fluorescent.
• Novatel Wireless MiFi 2372 Unlocked 3G Mobile Wi-Fi Hotspot GSM For North America (AT&T & T-Mobile)
• Novatel Wireless MiFi 2200 3G Mobile WiFi Hotspot Modem (Verizon Wireless)

Health Focus (Cancer Cures?):

Related Topics:

• bladder cancer / brain cancer / breast cancer / cervical cancer / colon cancer / Endometrial Cancer / head and neck cancer / kidney cancer / Hodgkin's disease / leukemia / liver cancer / lung cancer / lymphoma / ovarian cancer / pancreatic cancer / prostate cancer / stomach cancer / testicular cancer

Popular Supplements:

• IP-6 / coenzyme Q10 / green tea / Calcium D-Glucarate / Iscador® (mistletoe) / mixed carotenoids / quercetin / grape seed / maitake / MGN3 / IC-3 / DIM / cruciferous vegetables / isoflavones / curcumin / omega-3 / ginseng / garlic / flaxseed / GLA / pau d'arco / CLA / selenium / astragalus / aspirin / boron / red yeast rice / melatonin / glysine / Celebrex or Vioxx

Alternative News:

• Influence of diet enriched with Conjugated Linoleic Acids on their distribution in tissues of rats with DMBA induced tumors - Lipids Health Dis. 2010 Nov 2;9(1):126 - "Animals were divided into four groups depending on the diet supplementation (oil or Bio-C.L.A. (Pharma Nord Denmark) given intragastrically) and presence or absence of carcinogenic agent (7,12-dimethylbenz[a]antharcene) ... Diet enriched with CLA decreased the cancer morbidity (67% in Bio-C.L.A. compared to 88% in oil) and delayed the cancer induction" - See conjugated linoleic acid at Amazon.com.
• Flavonoids, proanthocyanidins, and cancer risk: a network of case-control studies from Italy - Nutr Cancer. 2010 Oct;62(7):871-7 - "Total flavonoids, flavanones, and flavonols were inversely related to oral and laryngeal cancers (ORs, respectively 0.56 and 0.60 for total flavonoids; 0.51 and 0.60 for flavanones; and 0.62 and 0.32 for flavonols). Flavanols were also inversely related to laryngeal cancer (OR = 0.64), whereas flavanones were inversely related to esophageal cancer (OR = 0.38). A reduced risk of colorectal cancer was found for high intake of anthocyanidins (OR = 0.67), flavonols (OR = 0.64), flavones (OR = 0.78), and isoflavones (OR = 0.76). Inverse relations with breast cancer were found for flavones (OR = 0.81) and flavonols (OR = 0.80). Flavonols (OR = 0.63) and isoflavones (OR = 0.51) were inversely associated to ovarian cancer, whereas flavonols (OR = 0.69) and flavones (OR = 0.68) were inversely associated to renal cancer. No association between flavonoids and prostate cancer emerged. We found inverse associations between proanthocyanidins and colorectal cancer. These associations appeared stronger for proanthocyanidins with a higher degree of polymerization (OR = 0.69 for ≥ 10 mers)" - See bioflavonoids at Amazon.com.
• Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer improves long-term survival - Am J Clin Nutr. 2010 Sep 29 - "Plasma arginine concentrations are lower in patients with cancer, which indicates that arginine metabolism may be disturbed in these patients. Arginine supplementation has been associated with positive effects on antitumor mechanisms and has been shown to reduce tumor growth and to prolong survival. Furthermore, the prognosis of patients with head and neck cancer remains disappointing. Insufficient intake frequently leads to malnutrition, which contributes to high morbidity and mortality rates ... The group receiving arginine-enriched nutrition had a significantly better overall survival (P = 0.019) and better disease-specific survival (P = 0.022). Furthermore, the arginine-supplemented group had a significantly better locoregional recurrence-free survival (P = 0.027). No significant difference in the occurrence of distant metastases or occurrence of a second primary tumor was observed between the groups" - See L-arginine products at Amazon.com.
• Sulphoraphane inhibited the expressions of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 through MyD88-dependent toll-like receptor-4 pathway in cultured endothelial cells - Nutr Metab Cardiovasc Dis. 2010 Sep 27 - "Chronic inflammation plays pivotal roles in both cancer and cardiovascular diseases. A large body of evidence suggests that high intake of cruciferous vegetables is closely related with low risk of these disorders ... Taken all together, adhesion molecules are confirmed to be the novel targets of sulphoraphane in preventing inflammatory insult to endothelial cells. Sulphoraphane suppressed TLR-4 followed by MyD88 and downstream factors such as p38 MAPK and JNK, ultimately blocking NF-кB translocation and the subsequent expression of adhesion molecules. These data suggested a novel inflammatory pathway mediated by sulphoraphane" - See sulforaphane at Amazon.com.
• Curcuminoids Suppress the Growth and Induce Apoptosis through Caspase-3-Dependent Pathways in Glioblastoma Multiforme (GBM) 8401 Cells - J Agric Food Chem. 2010 Sep 7 - "The results observed with proliferation inhibition (y = 94.694e(-0.025x), R(2) = 0.9901, and n = 6) and apoptosis (y = 0.9789e(-0.0102x), R(2) = 0.99854, and n = 3) depend upon the amount of curcuminoid treatment in the cancer cells" - See curcumin products at Amazon.com.
• Metformin Might Prevent Colorectal, Lung Cancers - Medscape, 9/3/10 - "The chance observation that diabetes patients taking metformin have a 40% reduced risk for cancer triggered intense research interest in this old off-patent drug ... After about 10% of the mouse lifespan — about 12 weeks — with the highest dose in the drinking water, we found a 33% reduction in tumor multiplicity and a 34% reduction in tumor size in the mice. In mice that did not get metformin, 100% got tobacco carcinogen-induced lung tumors ... metformin might prevent tumors by reducing levels of insulin and IGF-1" - See my Insulin and Aging page.  There are a lot of studies pointing toward insulin being a major cause of aging and caner.  See metformin at The Antiaging Store.
• {gamma}-Tocotrienol but not {gamma}-tocopherol blocks STAT3 cell signaling pathway through induction of protein tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents - J Biol Chem. 2010 Aug 18 - "We found that gamma-T3 but not gamma-tocopherol, the most common saturated form of Vitamin E, inhibited constitutive activation of STAT3 in a dose- and time-dependent manner and this inhibition was not cell type specific. gamma-T3 also inhibited STAT3 DNA binding ... This vitamin also sensitized the tumor cells to the apoptotic effects of thalidomide and bortezomib. Overall, our results suggest that gamma-T3 is a novel blocker of STAT3 activation pathway in both in vitro and in vivo and thus may have potential in prevention and treatment of cancers" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
• N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death - Cancer Lett. 2010 Jul 26 - "NAC/Cu(II) significantly alters growth and induces apoptosis in human cancer lines, yet NAC/Zn(II) and NAC/Fe(III) do not. We further confirmed that this cytotoxicity of NAC/Cu(II) is attributed to reactive oxygen species (ROS). These findings indicate that the combination of Cu(II) and thiols generates cytotoxic ROS that induce apoptosis in cancer cells. They also indicate a fourth class of anti-neoplastic metal-binding compounds, the "ROS generators"" - See n-acetyl cysteine at Amazon.com.
• Cutting fat and calories can lower cancer risk in dogs and people - Science Daily, 7/22/10 - "As many as 1 out of 3 cancer deaths in both humans and dogs could be prevented by reducing Omega-6 fatty acids and cutting calories ... Omega-6, such as corn oil, vegetable oil and grain-fed red meat. Too much Omega-6 fatty acid can lead to inflammation, which creates an environment conducive to cancer in dogs and people ... obesity in both dogs and humans limits the production of adiponectin, a hormone that has been shown to inhibit cancer cell growth. He recommended reducing calories, particularly those from sugar, which has the additional danger of not only causing obesity, but also feeding cancer cells and encouraging their growth ... the ideal blend of fiber for dog food is about 75 to 80 percent insoluble and 20 to 25 percent soluble. In addition, adding quality prebiotics to pet foods can enhance their gut health"
• Short Telomeres Tied to Cancer Risk - Medscape, 7/9/10 - "short telomere length was associated with a 60% increased risk for subsequent cancer"
• HDL Cholesterol and Cancer - Medscape, 6/15/10 - "even after adjustment for multiple variables, there was a 36% lower risk of cancer for every 10-mg/dL increase in HDL cholesterol" - See niacin at Amazon.com.
• Researchers fishing for cancer cure discover active DHA derivatives - Science Daily, 3/1/10 - "Results showed that DHA killed the cancer cells, but that the toxic derivatives produced by DHA were even more effective at killing the cancer cells. This suggests that DHA could become a new agent for treating neuroblastoma and possibly many other cancers" - See Jarrow Max DHA at Amazon.com.
• Improved Survival in Patients with End-stage Cancer Treated with Coenzyme Q(10) and Other Antioxidants: a Pilot Study - J Int Med Res. 2009;37(6):1961-1971 - "This pilot study evaluated the survival of patients with end-stage cancer who received supplements of coenzyme Q(10) and a mixture of other antioxidants (e.g. vitamin C, selenium, folic acid and beta-carotene) ... Median predicted survival was 12 months (range 3 - 29 months), whereas median actual survival was 17 months (1 - 120 months), which is > 40% longer than the median predicted survival. Mean actual survival was 28.8 months versus 11.9 months for mean predicted survival. Ten patients (24%) survived for less time than predicted, whereas 31 (76%) survived for longer. Treatments were very well tolerated with few adverse effects" - See ubiquinol products at Amazon.com.
• The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells - Nutr Cancer. 2010;62(1):116-21 - "We first confirmed and extended the results of others showing that the inhibitory action of CLA on proliferation is dependent on the cell type as well as the structure of the isomer, the 10,12 isomer being a more potent inhibitor than the 9,11 isomer in the concentration range 25-100 microM. By Western analysis, we showed that 10,12 CLA downregulated FAS expression in all of the cell lines in a concentration-dependent manner, but the 9,11 isomer had no effect. Both isomers inhibited FAS enzyme activity, but 10,12 CLA was again more potent than the 9,11 isomer. Our results suggest that downregulation of FAS by 10,12 CLA, but not by the 9,11 isomer, as well as inhibition of FAS enzyme activity by both isomers, may contribute to growth inhibition of cancer cells but only at relatively high concentrations" - Note:  I wish they would state brand names instead of leaving the reader with trying to figure which brand correlates with which isomers.  See conjugated linoleic acid at Amazon.com.
• Vitamin D Supplementation and Cancer Prevention - Medscape, 12/8/09 - "The relative risk for the development of cancer at the study's end was 0.402 for the calcium plus vitamin D group (P = .013) and 0.532 for the calcium-only group (P = .063) ... This translated to a predicted 35% reduced risk of cancer for every 25-nmol/L (10-ng/mL) increase in serum 25-hydroxyvitamin D. The authors concluded that improving vitamin D nutritional status substantially reduced all-cancer risk in postmenopausal women and that baseline and treatment-induced serum 25-hydroxyvitamin D concentrations were strong predictors of cancer risk" - See vitamin D at Amazon.com.
• Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation - J Agric Food Chem. 2009 Nov 20 - "Similar to those effects associated with caloric restriction (CR), resveratrol has multiple beneficial activities, such as increased life span and delay in the onset of diseases associated with aging ... Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells ... Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells. Once activated, AMPK inhibited 4E-BP1 signaling and mRNA translation via mammalian target of rapamycin (mTOR). Moreover, we also found that AMPK activity mediated by resveratrol in cancer cells was due to inducing the expression of Sirtuin type 1 (SIRT1) via elevation in the cellular NAD(+)/NADH in ER-positive cells. To our knowledge, we demonstrate here for the first time that resveratrol induces the expression of SIRT1 protein in human cancer cells. These observations raise the possibility that SIRT1 functions as a novel upstream regulator for AMPK signaling and may additionally modulate tumor cell proliferation. Targeting SIRT1/AMPK signaling by resveratrol may have potential therapeutic implications for cancer and age-related diseases" - See resveratrol products at Amazon.com.
• Indoleamine 2,3-Dioxygenase, an Immunomodulatory Protein, Is Suppressed by (-)-Epigallocatechin-3-gallate via Blocking of gamma-Interferon-Induced JAK-PKC-delta-STAT1 Signaling in Human Oral Cancer Cells - J Agric Food Chem. 2009 Nov 24 - "In this study, (-)-epigallocatechin-3-gallate (EGCG), the major constituent of green tea, is found to significantly inhibit the expression of IDO in human oral cancer cell lines ... This study indicates that EGCG is a potential drug for immune and target therapy to enhance cancer therapy by increasing antitumor immunity" - See green tea extract at Amazon.com.
• HDL Cholesterol Inversely Associated With Cancer Risk - Doctor's Guide, 11/16/09 - "The investigators found a significant inverse relationship between baseline HDL-C levels and the rate of incident cancer, reporting that every 10 mg/dL increase in HDL-C was associated with a 24% (95% CI: 1%-41%) relative reduction in the cancer rate ... They also found a significant inverse relationship between baseline LDL-C and the rate of incident cancer, with every 10-mg/dL reduction in LDL-C associated with a 14% (95% CI: 9%-18%) relative increase in the cancer rate ... There was a significant direct relationship between both age and BMI and rate of incident cancer, with every 5-year increase in age associated with a 28% (95% CI: 16%-42%) relative increase in cancer (P < .001) and every 1-kg/m2 increase in BMI associated with an 18% (95% CI: 6%-31%) relative increase in the cancer rate"
• Link Between Alcohol And Cancer Explained: Alcohol Activates Cellular Changes That Make Tumor Cells Spread - Science Daily, 10/26/09
• Diabetes Drug Fights Breast Cancer - WebMD, 9/14/09 - "And in mice carrying human breast cancers, metformin made standard chemotherapy vastly more effective. Mice treated with the combination remain cancer-free for four months, unlike mice treated with either drug alone ... A lot of data shows lower cancer risk -- not just breast cancer -- in people taking metformin for diabetes ... This drug at low doses can be considered a very good candidate for cancer prevention before a person has any cancer at all" - Note:  I've been taking metformin for years for anti-aging.  See my Insulin and Aging page.  See metformin at IAS.
• Natural Compounds, Chemotherapeutic Drugs May Become Partners In Cancer Therapy - Science Daily, 9/7/09 - "New research shows that chlorophyllin -- a water-soluble derivative of chlorophyll, the green pigment found in most plants -- may be 10 times more potent at killing colon cancer cells than hydroxyurea, a chemotherapeutic drug commonly used in cancer treatment" - See chlorophyllin at Amazon.com.
• Red-wine Polyphenol Called Resveratrol Demonstrates Significant Health Benefits - Science Daily, 6/11/09 - "The breadth of benefits is remarkable – cancer prevention, protection of the heart and brain from damage, reducing age-related diseases such as inflammation, reversing diabetes and obesity, and many more ... Resveratrol exhibits therapeutic potential for cancer chemoprevention as well as cardioprotection ... The simplest explanation is that resveratrol turns on the cell's own survival pathways, preventing damage to individual cells ... Further mechanisms help, including removing very reactive oxidants in the body and improving blood supply to cells ... Low doses of resveratrol improve cell survival as a mechanism of cardio- and neuro-protection, while high doses increase cell death" - See resveratrol products at Amazon.com.
• New Model Of Cancer Development: Low Vitamin D Levels May Have Role - Science Daily, 5/22/09 - "previous theories linking vitamin D to certain cancers have been tested and confirmed in more than 200 epidemiological studies, and understanding of its physiological basis stems from more than 2,500 laboratory studies ... Vitamin D may halt the first stage of the cancer process by re-establishing intercellular junctions in malignancies having an intact vitamin D receptor ... Vitamin D levels can be increased by modest supplementation with vitamin D3 in the range of 2000 IU/day" - See vitamin D at Amazon.com.
• Naturally Occurring Compounds Selectively Deplete Mutant P53 In Tumor Cells - Science Daily, 4/20/09 - "This study demonstrates for the first time that phenethyl isothiocyante (PEITC), a naturally-occurring compound, can selectively deplete mutant p53. The authors also made an intriguing observation that the depletion of mutant p53 in human cancer cells is accompanied by restoration of the wild type p53. PEITC is a member of the isothiocyanate family compounds found in cruciferous vegetables, such as watercress, broccoli and cabbage. PEITC has been shown to have cancer preventive activity"
• Omega-3 Kills Cancer Cells - Science Daily, 4/1/09 - "Docosahexanoic acid (DHA), an omega-3 fatty acid found in fish oils, has been shown to reduce the size of tumours and enhance the positive effects of the chemotherapy drug cisplatin, while limiting its harmful side effects ... at the molecular level, DHA acts by reducing leukocytosis (white blood cell accumulation), systemic inflammation, and oxidative stress – all processes that have been linked with tumour growth" - See Jarrow Max DHA at Amazon.com.
• Health Benefits, Consequences Of Folic Acid Dependent On Circumstances - Science Daily, 4/1/09 - "Under most circumstances, adequate intake of folate appears to assume the role of a protective agent against cancer, most notably colorectal cancer. However, in select circumstances in which an individual who harbors a pre-cancerous or cancerous tumor consumes too much folic acid, the additional amounts of folate may instead facilitate the promotion of cancer"
• Tocotrienol build-up in tumours ‘critical’ for anti-cancer benefits: Study - Nutra USA, 3/31/09 - "the effects of gamma- and delta-tocotrienol on mouse cancer cells ... the diet supplemented with 0.1 per cent gamma-tocotrienol or 0.1 per cent delta-tocotrienol for four weeks ... In conclusion, our results suggested that accumulation is critical for the anti-tumour activity of tocotrienols" - [Abstract] - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.  Note:  If gamma-tocotrienol is critical for preventing cancer and alpha vitamin E (the form found nearly always in supplements) reduces the gamma, it seems like alpha vitamin E would increase cancer risks. See:
  • The response of gamma vitamin E to varying dosages of alpha vitamin E plus vitamin C - Metabolism. 2009 Apr;58(4):469-78 - "at every dose of alpha vitamin E, gamma vitamin E concentration was significantly suppressed"
  • Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation - J Lipid Res. 1991 Aug;32(8):1325-32 - "gamma-Tocopherol significantly decreased in plasma and LDL during vitamin E (alpha-tocopherol) supplementation"
• Specific accumulation of gamma- and delta-tocotrienols in tumor and their antitumor effect in vivo - J Nutr Biochem. 2008 Sep 26 - "In C3H/HeN mice implanted with MH134, it was found that gamma-T3 and delta-T3 feeding significantly delayed tumor growth ... Intriguingly, we found that T3 was detected in tumor, but not in normal tissues. These results, to our knowledge, are the first demonstration of specific accumulation of gamma-T3 and delta-T3 in tumors and suggest that T3 accumulation is critical for the antitumor activities of T3" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
• Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression - Lipids Health Dis. 2009 Mar 17;8(1):8 - "Gamma-linolenic acid is a known inhibitor of tumour cell proliferation and migration in both in vitro and in vivo conditions ... Combination therapy using drugs with other, complementary targets and GLA could lead to gains in treatment efficacy in this notoriously difficult to treat tumour" - See borage oil at Amazon.com.
• Support For Adjunctive Vitamin C Treatment In Cancer - Science Daily, 3/5/09 - "Challem points out two main problems with the study: the oxidized form of vitamin C (dehydroascorbic acid) and not actual vitamin C (ascorbic acid) was used; and in the mouse experiments, the animals were given toxic doses of dehydroascorbic acid, a compound that is not used as a dietary supplement in humans ... This study and the subsequent headlines [it generated] were a grievous disservice to physicians and patients with cancer ... considerable positive research…has shown striking benefits from high-dose vitamin C (ascorbic acid) in cancer cells and animals—and in actual human beings"
• 1 in 3 Common Cancers May Be Preventable - WebMD, 2/26/09 - "eating a nutritious diet, being physically active, and keeping body fat under control may prevent: ... 38% of breast cancers ... 45% of colorectal cancers ... 36% of lung cancers ... 39% of pancreatic cancers ... 47% of stomach cancers ... 69% of esophageal cancers ... 63% of cancers of the mouth, pharynx, or larynx ... 70% of endometrial cancers ... 24% of kidney cancers ... 21% of gallbladder cancers ... 15% of liver cancers ... 11% of prostate cancers"
• Excessive Dietary Fat Caused 300 Percent Increase in Metastasizing Tumor Cells In Animal Models - Science Daily, 2/25/09 - "Researchers at Purdue University have precisely measured the impact of a high-fat diet on the spread of cancer, finding that excessive dietary fat caused a 300 percent increase in metastasizing tumor cells in laboratory animals"
• Blueberries May Shrink Tumors in Babies - WebMD, 1/21/09 - "Mice with blood vessel tumors that were fed the blueberry extract lived twice as long as mice that did not get the substance and had tumors 60% smaller than mice that did not receive blueberry extract treatment ... Oral administration of blueberry extract represents a potential therapeutic strategy for treating endothelial cell tumors in children" - See blueberry extracts at Amazon.com.
• Broccoli Compound Targets Key Enzyme In Late-stage Cancer - Science Daily, 12/14/08 - "The new findings are the first to explain how indole-3-carbinol (I3C) stops cell growth, and thus provides the basis for designing improved versions of the chemical that would be more effective as a drug and could work against a broader range of breast as well as prostate tumors ... I3C inhibits the enzyme elastase, which at high levels in breast cancer cells heralds a poor prognosis: decreased response to chemotherapy, reduced response to endocrine treatment and reduced survival rates" - See indole 3 carbinol at Amazon.com.
  Physical Activity, Sleep May Cut Cancer Risk - WebMD, 11/17/08 - "Among the most physically active women younger than 65 -- women who reported getting about an hour a day of moderate physical activity -- cancer was 47% rarer for those who got at least seven hours of nightly sleep. Those findings held regardless of other cancer risk factors"
• Pectin Power: Why Fruits And Vegetables May Protect Against Cancer's Spread - Science Daily, 10/13/08 - "They have shown that a fragment released from pectin, found in all fruits and vegetables, binds to and is believed to inhibit galectin 3 (Gal3), a protein that plays a role in all stages of cancer progression" - See pectin supplements at Amazon.com.
• Unpopular veggies vital for cancer protection: Study - Nutra USA, 10/7/08 - "Significant inhibition of all the cancer cell lines tested – stomach, lung, breast, kidney, skin, pancreas, prostate, and brain – was observed for all the extracts from cruciferous vegetables, such as broccoli, kale, Brussels sprouts, and curly cabbage, and vegetables of the genus Allium, such as garlic ... These chemopreventive effects are likely related to the formation of organosulfur compounds following mechanical disruption of these vegetables, namely isothiocyanates from cruciferous and a series of allyl sulfur molecules from Allium vegetables"
• Coffee consumption and the risk of cancer: An overview - Cancer Lett. 2008 Sep 30 - "Habitual coffee drinking has been associated with a reduced risk of mortality and chronic diseases, including cancer. The favourable influence of coffee is supported by several plausible mechanisms due to the presence of a variety of biological compounds such as caffeine, diterpenes, caffeic acid, polyphenols as well as volatile aroma and heterocyclic substances. Current evidence suggests that coffee consumption is associated with a reduced risk of liver, kidney, and to a lesser extent, premenopausal breast and colorectal cancers, while it is unrelated to prostate, pancreas and ovary cancers. Coffee drinking may still help reduce death due to liver cancer"
• Black Raspberries Slow Cancer By Altering Hundreds Of Genes - Science Daily, 8/27/08 - "examined the effect of freeze-dried black raspberries on genes altered by a chemical carcinogen in an animal model of esophageal cancer ... The carcinogen affected the activity of some 2,200 genes in the animals’ esophagus in only one week, but 460 of those genes were restored to normal activity in animals that consumed freeze-dried black raspberry powder as part of their diet during the exposure"
• Mushroom extract demonstrates immunity benefits - Nutra USA, 8/25/08 - "measured the production of two cytokines – Interferon (IFN-y) and Tumor Necrosis Factor (TNF-a) – for 30 and 60 days ... These cytokines are produced by white blood cells and used by the body to prevent the growth of abnormal and cancerous cells ... the production of IFN-y and TNF-a increased within four weeks of taking the recommended of AHCC and continued to boost the immune system for at least four weeks after AHCC consumption stopped" - See AHCC at Amazon.com.
• Dietary Supplement Use in Cancer Care: Help or Harm (.pdf) - Hematol Oncol Clin North Am. 2008 Aug 1;22(4):581-617 - "Immune Modulation ..."
• Vitamin C Injections Slow Tumor Growth In Mice - Science Daily, 8/4/08 - "high concentrations of ascorbate had anticancer effects in 75 percent of cancer cell lines tested, while sparing normal cells. In their paper, the researchers also showed that these high ascorbate concentrations could be achieved in people" - Note:  I was taking about 8 grams of vitamin C per day when I had neck cancer.  Maybe that's what saved me.
• Magnolia Compound Hits Elusive Target In Cancer Cells - Science Daily, 7/11/08 - "A natural compound from magnolia cones blocks a pathway for cancer growth that was previously considered "undruggable," ... has been studying the compound honokiol ... We found that it is particularly potent against tumors with activated Ras" - See honokiol at Amazon.com.
• Chinese Red Yeast Rice Is Good For Your Heart, Study Suggests - Science Daily, 6/9/08 - "a partially purified extract of Chinese red yeast rice, Xuezhikang (XZK), reduced the risk of repeat heart attacks by 45%, revascularization (bypass surgery/angioplasty), cardiovascular mortality and total mortality by one-third and cancer mortality by two-thirds" - See red yeast rice at Amazon.com.
• Exercise Cuts Cancer Death In Men - Science Daily, 5/29/08 - "Men who walked or cycled for at least 30 minutes a day had an increased survival from cancer with 33 per cent, than the men who exercised less or did nothing at all ... a more extensive programme of walking and cycling for between 60 and 90 minutes and a day, led to a l6 per cent lower incidence of cancer. But these activities only led to a five per cent reduction in cancer rates among the men who walked or cycled for 30 minutes day, a finding which could be due to chance"
• To Block The Carcinogens, Add A Touch Of Rosemary When Grilling Meats - Science Daily, 5/21/08 - "Rosemary, a member of the mint family and a popular seasoning on its own, also has benefits as a cancer prevention agent. Apply it to hamburgers and it can break up the potentially cancer-causing compounds that can form when the meat is cooked ... Rosemary’s antioxidant content makes this method possible thanks to the presence of phenolic compounds. Those compounds – rosmarinic acid, carnosol and carnosic acid – block the HCAs before they can form during heating"
• Dietary flavonoid intake and risk of cancer in postmenopausal women: The Iowa Women's Health Study - Int J Cancer. 2008 May 19 - "After multivariable adjustment, lung cancer incidence was inversely associated with intakes of flavanones (HR = 0.68; 95% CI: 0.53-0.86, all results highest vs. lowest quintile) and proanthocyanidins (HR = 0.75; 95% CI: 0.57-0.97). Among current and past smokers, those with intakes in the highest quintile for flavanones (HR = 0.66; 95% CI: 0.50-0.86), and proanthocyanidins (HR = 0.66; 95% CI; 0.49-0.89) had significantly lower lung cancer incidence than those in the lowest quintile. Similar associations were not seen in never smokers. Isoflavone intake was inversely associated with overall cancer incidence (HR = 0.93, 95% CI: 0.86-1.00). This study provides further support for a beneficial effect of flavonoid intake on lung cancer risk, especially among current and past smokers" - See bioflavonoids at Amazon.com.
• Vitamin D and cancer: maintaining levels key to protection? - Nutra USA, 5/12/08 - "After adjusting for various potential confounding factors, the researchers report that people with the highest level of 25(OH)D (76.3 nanomoles per litre) were 55 per cent less likely to die form fatal cancer than those with the lowest levels (18.1 nmol/L)" - [Abstract] - See vitamin D at Amazon.com.
• Low Serum Levels of 25-Hydroxyvitamin D Predict Fatal Cancer in Patients Referred to Coronary Angiography - Cancer Epidemiol Biomarkers Prev. 2008 May 7 - "After adjustment for possible confounders, the Cox proportional hazard ratio (95% confidence interval) of the fourth 25(OH)D quartile was 0.45 (0.22-0.93) when compared with the first quartile and the hazard ratio per increase of 25 nmol/L in serum 25(OH)D concentrations was 0.66 (0.49-0.89)" - See vitamin D at Amazon.com.
• Curcumin and cancer: An "old-age" disease with an "age-old" solution - Cancer Lett. 2008 May 5 - "The activity of curcumin reported against leukemia and lymphoma, gastrointestinal cancers, genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, melanoma, neurological cancers, and sarcoma reflects its ability to affect multiple targets. Thus an "old-age" disease such as cancer requires an "age-old" treatment" - See curcumin products at Amazon.com.
• Low Serum Levels of 25-Hydroxyvitamin D Predict Fatal Cancer in Patients Referred to Coronary Angiography - Cancer Epidemiol Biomarkers Prev. 2008 May 7 - "our data suggest that low levels of 25(OH)D are associated with increased risk of fatal cancer in patients referred to coronary angiography and that the maintenance of a sufficient vitamin D status might therefore be a promising approach for the prevention and/or treatment of cancer" - See vitamin D at Amazon.com.
• Multi-targeted prevention and therapy of cancer by proanthocyanidins - Cancer Lett. 2008 May 3 - "A wide variety of botanicals, mostly dietary flavonoids or polyphenolic substances, have been reported to possess substantial anti-carcinogenic and antimutagenic activities because of their antioxidant and anti-inflammatory properties. Proanthocyanidins are considered as one of them, and are abundantly available in various parts of the plants, such as fruits, berries, bark and seeds. Their modes of action were evaluated through a number of in vitro and in vivo studies which showed their potential role as anti-carcinogenic agent. We summarize and highlight the latest developments on anti-carcinogenic activities of proanthocyanidins from different sources, specifically from grape seeds, and their molecular targets, such as NF-kappaB, mitogen-activated protein kinases, PI3K/Akt, caspases, cytokines, angiogenesis and cell cycle regulatory proteins and other check points, etc. Although the bioavailability and metabolism data on proanthocyanidins is still largely unavailable, certain reports indicate that at least monomers and smaller oligomeric procyanidins are absorbed in the gut. The modulation of various molecular targets by proanthocyanidins in vitro and in vivo tumor models suggests their importance, contribution and mechanism of action to the prevention of cancers of different organs" - See grape seed extract at Amazon.com and Pycnogenol at Amazon.com.  Some say the grape seed extract if the same as Pycnogenol without the patent markup.
• Veggies, Exercise May Cut Cancer Risk - WebMD, 4/15/08 - "Overall, women who engaged in recreational exercise 30 to 150 minutes per week were 50% less likely to have breast cancer than women who exercised less than a half hour per week ... People who ate quercetin-rich foods at least four times a week, on average, were 51% less likely to have lung cancer than those who ate none"
• Extracts From Reishi Mushroom And Green Tea Shows Synergistic Effect To Slow Sarcoma - Science Daily, 4/8/08 - "Both the reishi mushroom (Ganoderma lucidum; Lingzhi) and green tea have long held a place in traditional medicine in China and other Asian countries, for the general promotion of health and long life and for the treatment of specific diseases. More recent scientific studies have confirmed that both enhance the body¹s immune functions and hold the potential for treatment and prevention of many types of cancer" - See reishi at Amazon.com and green tea extract at Amazon.com.
• Dehydroascorbic acid as an anti-cancer agent - Cancer Lett. 2008 Mar 28 - "dehydroascorbic acid has the remarkable ability to eliminate the aggressive mouse tumours, L1210, P388, Krebs sarcoma, and Ehrlich carcinoma"
  • Dehydroascorbic acid - Wikipedia - "Dehydroascorbic acid (DHA) is an oxidized form of ascorbic acid"
• Mounting Evidence Shows Red Wine Antioxidant Kills Cancer - Science Daily, 3/25/08 - "Rochester researchers showed for the first time that a natural antioxidant found in grape skins and red wine can help destroy pancreatic cancer cells by reaching to the cell's core energy source, or mitochondria, and crippling its function ... The new study also showed that when the pancreatic cancer cells were doubly assaulted -- pre-treated with the antioxidant, resveratrol, and irradiated -- the combination induced a type of cell death called apoptosis, an important goal of cancer therapy" - [WebMD] - See resveratrol products at Amazon.com.
• Indole-3-carbinol as a chemopreventive and anti-cancer agent - Cancer Lett. 2008 Feb 29 - "Indole-3-carbinol and its metabolite 3,3'-diindoylmethane (DIM) target multiple aspects of cancer cell-cycle regulation and survival including Akt-NFkappaB signaling, caspase activation, cyclin-dependent kinase activities, estrogen metabolism, estrogen receptor signaling, endoplasmic reticulum stress, and BRCA gene expression. This broad spectrum of anti-tumor activities in conjunction with low toxicity underscores the translational value of indole-3-carbinol and its metabolites in cancer prevention/therapy. Furthermore, novel anti-tumor agents with overlapping underlying mechanisms have emerged via structural optimization of indole-3-carbinol and DIM, which may provide considerable therapeutic advantages over the parental compounds with respect to chemical stability and anti-tumor potency. Together, these agents might foster new strategies for cancer prevention and therapy" - See indole 3 carbinol at Amazon.com and diindolylmethane at Amazon.com.
• beta-Sitosterol induces G(2)/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways - Cancer Lett. 2008 Feb 29 - "beta-Sitosterol (SITO) is a potentially valuable candidate for cancer chemotherapy ... results suggest that SITO induces endoreduplication by promoting spindle microtubule dynamics through the Bcl-2 and PI3K/Akt signaling pathways" - See beta sitosterol at Amazon.com.
• Serum Selenium Levels and All-Cause, Cancer, and Cardiovascular Mortality Among US Adults - Arch Intern Med. 2008 Feb 25;168(4):404-10 - "we found a nonlinear association between serum selenium levels and all-cause and cancer mortality. Increasing serum selenium levels were associated with decreased mortality up to 130 ng/mL. Our study, however, raises the concern that higher serum selenium levels may be associated with increased mortality"
• A Ray Of Sunshine In The Fight Against Cancer: Vitamin D May Help - Science Daily, 2/13/08 - "It sounds too good to be true … a little inexpensive pill that could block the development of some cancers, strengthen bones, prevent multiple sclerosis and alleviate winter depression ... But it’s not science fiction. The “new aspirin” could be Vitamin D ... during the winter, Canadians take at least 1,000 units a day of Vitamin D" - See vitamin D at Amazon.com.
• DCA or dichloroacetate for Cancer - Dr. Weil, 1/17/08
• Sunlight: Good for Bad for Cancer Risk? - WebMD, 1/7/08 - "In populations with similar skin types, the incidence of all kinds of skin cancer increases from north to south, they found ... The incidence of internal cancers -- colon, lung, breast, and prostate -- also increased from north to south. But Setlow's team found that those who lived in southern latitudes -- and who made more vitamin D from sun exposure -- were much less likely to die from those cancers than were the northern latitude residents" - See vitamin D at Amazon.com.
• Is There an Anticancer Diet? - WebMD, 12/6/07 - "Raw cruciferous vegetables such as broccoli, broccoli sprouts, cabbage, and cauliflower seem to reduce bladder cancer risk by about 40%"
• Chemoprevention, Naturally: Findings On Plant-derived Cancer Medicines - Science Daily, 12/6/07 - "rats fed a diet containing Polyphenon E, a standardized green tea polyphenol preparation, are less than half as likely to develop colon cancer ... After 34 weeks, rats that received Polyphenon E developed 55 percent fewer tumors compared to the control rats that did not receive Polyphenon E. Moreover, the tumors were 45 percent smaller in rats treated with green tea extract" - See green tea extract at Amazon.com.
• Diet And Cancer Prevention: New Evidence For The Protective Effects Of Fruits And Veggies - Science Daily, 12/6/07
• Night Shift Work May Cause Cancer - WebMD, 11/30/07 - "They note that shift work may raise cancer risk by suppressing production of melatonin, a chemical involved in the circadian rhythm" - See melatonin at Amazon.com.
• Molecular basis of the potential of vitamin D to prevent cancer - Curr Med Res Opin. 2007 Nov 21 - "Research strongly supports the view that efforts to improve vitamin D status would have significant protective effects against the development of cancer. The clinical research community is currently revising recommendations for optimal serum levels and for sensible levels of sun exposure, to levels greater than previously thought. Currently, most experts in the field believe that intakes of between 1000 and 4000 IU will lead to a more healthy level of serum 25(OH)D, in the range of 75 nmol/L that will offer significant protect effects against cancers of the breast, colon, prostate, ovary, lungs, and pancreas. The first randomized trial has shown significant protection against breast cancer, and other clinical trials will follow and ultimately lead to improved public health policies and significantly fewer cancers" - See vitamin D at Amazon.com.
• Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products - Nutr Cancer. 2007;57(1):78-87 - "Zyflamend inhibited receptor activator of NF-kappa B ligand-induced osteoclastogenesis, suppressed tumor necrosis factor (TNF)-induced invasion, and potentiated the cytotoxicity induced by TNF and chemotherapeutic agents, all of which are known to require NF-kappa B activation. Zyflamend suppressed NF-kappa B activation induced by both TNF and cigarette smoke condensate. The expression of NF-kappa B-regulated gene products involved in antiapoptosis (inhibitor-of-apoptosis protein 1/2, Bcl-2, Bcl-xL, FADD-like interleukin-1betaconverting enzyme/caspase-8 inhibitory protein, TNF receptor-associated factor-1, and survivin) and angiogenesis (vascular endothelial growth factor, cyclooxygenase-2, intercellular adhesion molecule, and matrix metalloproteinase-9) was also down-regulated by Zyflamend. This correlated with potentiation of cell death induced by TNF and chemotherapeutic agents. Overall, our results indicate that Zyflamend suppresses osteoclastogenesis, inhibits invasion, and potentiates cytotoxicity through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products" - See Zyflamend at Amazon.com.
• Antioxidants Could Provide All-purpose Radiation Protection - Science Daily, 11/5/07 - "Inositol and inositol hexaphosphate (IP6) protected both human skin cells and a skin cancer-prone mouse from exposure to ultraviolet B (UVB) radiation, the damaging radiation found in sunlight ... Twenty-three percent of treated mice developed tumors, compared to 51 percent of untreated, or control mice, which developed tumors. Moreover, the mice in the treated group that did develop cancer had only half as many tumors as the control mice" - See IP-6 products at Amazon.com.  Note:  IP-6 was one of the supplements I took when they told me I only had a small chance of survival from neck cancer.  Click here for the full story.  I still take it.
• Extra Weight = Extra Cancer Risk - WebMD, 10/31/07
• Chemical In Red Wine, Fruits And Vegetables May Stop Cancer, Heart Disease, Depending On The Dose - Science Daily, 10/30/07 - "very high doses of antioxidant polyphenols shut down and prevent cancerous tumors by cutting off the formation of new blood vessels needed for tumor growth ... the same polyphenols play a beneficial role for those with diseased hearts and circulatory systems by facilitating blood vessel growth ... the amount of polyphenols necessary to obtain an anti-cancer effect is the equivalent of drinking about a bottle of red wine each day" - See grape seed extract at Amazon.com.
• Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: Their inhibition by resveratrol - Cancer Lett. 2007 Oct 3 - "Lysophosphatidic acid (LPA) is a bioactive phospholipid that is involved in various cellular events, including tumor invasion and metastasis ... Collectively, these results show that LPA under hypoxic condition enhances cell migration through the sequential induction of HIF-1alpha and VEGF, and that this enhancement is efficiently blocked by resveratrol" - See resveratrol products at Amazon.com.
• How Vitamin C Stops Cancer - Science Daily, 9/10/07 - "Both of these cancers produce high levels of free radicals that can be suppressed by feeding the mice supplements of antioxidants, either vitamin C or N-acetylcysteine (NAC) ... Some rapidly growing tumors consume enough energy to easily suck out the available oxygen in their vicinity, making HIF-1 absolutely critical for their continued survival. But HIF-1 can only operate if it has a supply of free radicals. Antioxidants remove these free radicals and stop HIF-1, and the tumor, in its tracks" - See vitamin C products at Amazon.com.
• Compound In Broccoli Could Boost Immune System, Says Study - Science Daily, 8/20/07 - "This study shows that there is a whole new universe of cancer regulation related to DIM ... There are virtually no other agents known that can both directly shut down the growth of cancer cells and enhance the function of the immune system at the same time" - See diindolylmethane at Amazon.com.
• Coenzyme Q10 Summary - U. of Texas Alternative Medicine - See iHerb or Vitacost. coenzyme Q10 products.
• Green Tea Boosts Production Of Detox Enzymes, Rendering Cancerous Chemicals Harmless - Science Daily, 8/10/07 - "In a study of 42 people, the concentrate -- composed of chemicals known as green tea catechins in amounts equal to that found in 8-16 cups of green tea -- boosted production of the enzymes, which belong to the glutathione S-transferase (GST) family, by as much as 80 percent in some participants ... GST enzymes are believed to be crucial to the body's defense against cancer-causing chemicals and other toxins, according to the study's lead investigator, H.-H. Sherry Chow, Ph.D., a research associate professor at the University of Arizona. They modify the cancer-causing molecules that would otherwise damage cellular DNA, thus rendering them inert" - See green tea extract at Amazon.com.  My favorite is green tea extract at Amazon.com.
• Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial - Am J Clin Nutr. 2007 Jun;85(6):1586-91 - "Improving calcium and vitamin D nutritional status substantially reduces all-cancer risk in postmenopausal women"
• Cancer Benefit From Vitamin D? - WebMD, 6/8/07 - "Women in the four-year study took 1,500 milligrams of calcium supplementation either alone or with 1,100 International Units (IU) of vitamin D each day ... women who took both supplements wound up with nearly 60% less risk of cancers at the end of the study compared with women who took placebo" - vitamin D at Amazon.com.
• Ginseng May Relieve Cancer Fatigue - WebMD, 6/4/07
• Can Aspirin Help Keep Cancer At Bay? - Science Daily, 4/16/07 - "those who said they regularly used aspirin had a 16 percent reduced risk of developing cancer more than a decade later, as well as a 13 percent reduced risk of dying from cancer over this same time period, compared to women who did not use aspirin. But there was no statistically significant impact on cancer incidence or mortality among women who used non-aspirin NSAIDs"
• Broccoli, soy anti-cancer benefits suggested - Nutra USA, 4/16/07 - "this attraction between CXCR4 and CXCL12 draws cancer cells to the organs they spread to ... exposure with either DIM or genistein cut movement by 80 per cent"
• DCA: Cancer Breakthrough or Urban Legend? - ABC News, 2/5/07 - "In one group of rats where DCA was given after the injected tumors had been allowed to grow, the tumors immediately (in the authors' words) decreased in size"
• Cheap, safe drug kills most cancers -  New Scientist, 1/23/07
• A Curry A Day Keeps The Doctor Away? - Science Daily, 1/11/07 - "the chemical compound capsaicin -- which is responsible for the burning sensation when we eat chillies -- can kill cells by directly targeting their energy source ... It could mean that patients could control or prevent the onset of cancer by eating a diet rich in capsaicin" - See curcumin products at Amazon.com.
• Body Composition May Be Key Player In Controlling Cancer Risks - Science Daily, 1/3/07 - "This study suggests that body composition, being lean as opposed to being obese, has a greater protective effect against cancer"
• More evidence for tea’s anticancer potential - Nutra USA, 12/21/06
• Research shows benefits of cranberries -MSNBC, 11/20/06 - "Cranberries may prevent tumors from growing rapidly or starting in the first place ..." - See cranberry supplements at Amazon.com.
• Onion and garlic use and human cancer - Am J Clin Nutr. 2006 Nov;84(5):1027-32 - "The multivariate ORs for the highest category of onion and garlic intake were, respectively, 0.16 and 0.61 for cancer of the oral cavity and pharynx, 0.12 and 0.43 for esophageal cancer, 0.44 and 0.74 for colorectal cancer, 0.17 and 0.56 for laryngeal cancer, 0.75 and 0.90 for breast cancer, 0.27 and 0.78 for ovarian cancer, 0.29 and 0.81 for prostate cancer, and 0.62 and 0.69 for renal cell cancer" - See iHerb or Vitacost garlic products.
• Aspirin May Be Newest Cancer Drug - WebMD, 10/2/06 - "In test-tube studies, the researchers find that aspirin does what some of the most cutting-edge new anticancer drugs do. It seems to keep newborn cancers from growing the blood vessels they need to become full-blown tumors -- a process called angiogenesis ... anticancer effect may not be due to blocking Cox enzymes at all" - See aspirin at Amazon.com.
• Do 'Real' Exercise to Prevent Cancer - WebMD, 9/28/06
• Antioxidants and Cancer Treatment? - Dr. Weil, 9/14/06
• Sun Exposure Cuts Cancer Risk at 16 Sites, Study Says - Medscape, 8/15/06 - "solar ultraviolet B irradiance is associated with reduced risk at 16 sites of cancer through production of vitamin D. These cancers include 6 sites of gastrointestinal cancers, 3 cancers of female sites, 3 urogenital cancers, 2 types of lymphomas, and 2 upper aerodigestive tract cancers"
• Vitamin D Targets Thrombosis in Cancer Patients - Doctor's Guide, 6/15/06
• Encouraging Results For Folic Acid As A Cancer Prevention Drug - Science Daily, 6/12/06 - "31 of 43 patients with the precancerous laryngeal lesion called leucoplakia demonstrated 50 percent or greater reduction in the lesion size after six months of taking folate supplements. In 12 of 31 responders, there was no evidence of the original lesion ... Folate deficiency is the most common vitamin deficiency in the United States"
• Broccoli, Cauliflower And Genetic Cancer - Science Daily, 5/18/06 - "cruciferous vegetables ... are abundant in sulforaphane (SFN) ... those mice fed with an SFN-supplemented diet developed significantly fewer and smaller tumors"
• Product Review of Supplements for Cancer Prevention (Green Tea, Lycopene, and Selenium) - ConsumerLab.com, 4/20/06
• Vitamin D May Prevent Cancer Risk - Medscape, 4/10/06 - "For each 25-nmol/L increase in predicted level of 25(OH)D, the risk for cancer decreased by 17%. Higher 25(OH)D levels were associated with a significantly decreased risk for colorectal cancer (RR, 0.63), pancreatic cancer (RR, 0.49), esophageal cancer (RR, 0.37), oral and pharyngeal cancer (RR, 0.30), and leukemia (RR, 0.44). There were no significant relationships between other types of cancer and 25(OH)D levels" - See Vitacost or vitamin D at Amazon.com.
• Vitamin D May Protect Against Cancer - WebMD, 4/4/06 - "At least half of American adults suffer from vitamin D deficiencies that place them at increased risk of cancer ... taking at least 1,000 international units (IU) of vitamin D daily can slash the risk of breast, colon, and other cancers" - See Vitacost or vitamin D at Amazon.com.
• Vitamin D and Cancer: A Goldilocks Paradox? - Medscape, 3/30/06 - "In laboratory models, vitamin D reduces cell proliferation and increases cell differentiation, improves cell adhesion, and inhibits cancer progression and metastasis"
• Vitamin D - Cancer Prevention and Other New Uses - Life Extension Magazine, 3/06 - "Once considered little more than a compound that promotes healthy bones, vitamin D is now recognized as an important weapon in the fight against cancer ... While the Institute of Medicine suggests 400-600 IU of vitamin D daily, the American Medical Women’s Association (AMWA) advises that all men and women over the age of 50 should consume 800-1000 IU of vitamin D each day"
• Ginkgo Biloba Extract: More Than Just For Memory? - Science Daily, 2/24/06 - "treating mice with an extract of leaves of Ginkgo biloba both before and after implanting human breast or brain (glioma) tumors decreased expression of a cell receptor associated with invasive cancer. This decreased expression slowed the growth of the breast tumors by 80 percent as long as the extract was used, compared to untreated mice" - See ginkgo biloba at Amazon.com.
• Grapefruit flavonoid could repair DNA, may protect against cancer - Nutra USA, 2/15/06 - "Naringenin, a flavonoid found in grapefruit and oranges, helped to repair damaged DNA in cancer cells"
• Broccoli chemical's cancer check - BBC News, 2/7/06 - "A chemical in vegetables such as broccoli, cauliflower and cabbage can boost DNA repair in cells and may stop them becoming cancerous ... Vegetables such as broccoli were found to contain a compound called I3C" - See indole-3-carbinol at Amazon.com.
• How to get vitamin D? - USA Today, 1/29/06 - "Adults who consume 1,000 international units (IU) of vitamin D daily might lower their risks of colon, breast and ovarian cancers by up to 50% ... Essentially no one in the United States is getting that"
• Vitamin D Needed To Cut Cancer Risk, Researchers Say - Science Daily, 12/28/05 - "Taking 1,000 international units (IU) of vitamin D3 daily appears to lower an individual's risk of developing certain cancers – including colon, breast, and ovarian cancer – by up to 50 percent" - See Vitacost or vitamin D at Amazon.com.
• The Nude Mouse Tale: Omega-3 Fats Save The Life Of A Terminal Cancer Patient - Science Daily, 11/14/05 - "In 2000 he was told by his doctor he had only a few months to live ... But five years later, he is still alive, and has even gained a little weight ... It was a nutritional intervention, drastically increasing the patient’s intake of omega-3 fatty acids" - See Mega Twin EPA at Vitacost or iHerb.
• A Shopping Cart of Cancer Fighters - Intelihealth, 10/31/05 - "Broccoli sprouts, cabbage, ginkgo biloba and garlic appear to have a role in preventing a variety of cancers"
• Spice Ingredient May Cut Breast Cancer Spread - WebMD, 10/17/05
• Coenzyme Q10 New Applications for Cancer Therapy - Life Extension Magazine, 10/05
• Broccoli May Fight Lung Cancer - WebMD, 9/15/05
• Compounds Found In Cruciferous Vegetables Block Lung Cancer Progression - Science Daily, 9/15/05 - "A family of compounds found in cruciferous vegetables, such as broccoli, cauliflower, and watercress, blocked lung cancer progression in both animal studies and in tests with human lung cancer cells"
• Study: Vitamin C May Fight Cancer - WebMD, 9/12/05 - "Vitamin C appeared to boost production of hydrogen peroxide, which killed cancer cells and left healthy cells unharmed ... The levels of vitamin C were so high that they could only be achieved through IV infusions"
• Curry Spice May Curb Breast Cancer's Spread - WebMD, 6/9/05 - "Less than a quarter of the mice in the curcumin-plus-Taxol group had cancer that spread to the lungs. So did half of the curcumin group. In comparison, cancer spread to the lungs in three-fourths of the Taxol group and almost all (95%) mice that got no treatment" - See iHerb or Vitacost curcumin/turmeric products.
• Scientists: Sunshine May Prevent Cancer - CBS 2 Chicago, 5/21/05 - "vitamin D increasingly seems important for preventing and even treating many types of cancer ... In the last three months alone, four separate studies found it helped protect against lymphoma and cancers of the prostate, lung and, ironically, the skin. The strongest evidence is for colon cancer"
• Statin Drugs Linked to Reduced Cancer Risk - WebMD, 5/16/05 - "During a six-year period, women who used statins reduced their risk of breast cancer by more than half (51%) compared with nonusers ... Statin users were 48% less likely to develop lung cancer than nonusers ... statin use reduces the rate of prostate cancer by 54%" - See Zocor at International Anti-aging Systems.
• Chinese Herb's [danggui longhui wan] Component May Fight Cancer - WebMD, 4/18/05
• Chocolate compound stops cancer cell cycle in lab - Nutra USA, 4/18/05 - "the breast cancer cells stopped dividing when treated with pentamer and that all four proteins were inactivated ... the novel aspect here is that a pattern of several regulatory proteins are jointly deactivated, probably greatly enhancing the inhibitory effect compared to targeting any one of the proteins singly"
• Grapes May Stop Cancer Cells - WebMD, 3/31/05 - "We are getting direct evidence that these components in grapes work synergistically in fighting cancer"
• Flavonoids work together to inhibit cancer cells - Nutra USA, 3/30/05 - "Components in grapes, including some newly identified ones, work together to dramatically inhibit an enzyme crucial to the proliferation of cancer cells"
• Cancer-Enabling Enzyme Can Be Blocked Naturally: Danish Research Confirms Cancer Breakthrough Approach by Matthias Rath, M.D - Life Extension Foundation, 3/21/05 - "Vitamin C, the amino acids L-lysine and L-proline, and a green tea extract known as Epigallocatechin Gallate (EGCG) work together to synergistically block the spread of cancer cells through connective tissue"
• Avoid mixing supplements, cancer treatment - MSNBC, 3/11/05
• Herbs That Pack An Anticancer Punch - Life Extension Foundation, 3/8/05
• Green Tea Extract Shows Potential As An Anti-cancer Agent - Science Daily, 2/23/05 - "green tea extract interrupts a process that is crucial in allowing bladder cancer to become invasive and spread to other areas of the body" - See iHerb or Vitacost green tea extracts.
• Green Tea's Record Against Cancer Grows - WebMD, 2/15/05 - "In effect, the green tea extract may keep the cancer cells confined and localized, where they are easier to treat and the prognosis is better ... you should drink four cups a day. Green tea supplements are also available, and at least one study has shown that you may actually get more powerful antioxidants from supplements than from drinking tea" - See iHerb or Vitacost green tea extracts.
• Dog's tale of survival opens door in cancer research - USA Today, 7/24/02 - "The treatment is a cocktail of so-called anti-angiogenic drugs, which have been widely researched for more than a decade and work by starving tumors of their blood supply. Researchers say the three-drug combination, which Haber mixed into Navy's regular dog food, targets the cancer from many angles ... When researchers heard that Navy was cancer-free after receiving a cocktail of drugs already approved by the Food and Drug Administration — Celebrex, tamoxifen (sold as Nolvadex) and doxycycline — the treatment became known as the Navy Protocol ... Navy's treatment, though experimental, cost $2,000"
• Carrots may help ward off cancer - BBC News, 2/9/05 - "After 18 weeks, rats who ate carrots along with their ordinary feed, and those given feed and falcarinol supplement were one third less likely to develop full-scale tumours than rats who were given just ordinary feed"
• Popular Arthritis Drug [Celebrex] KO's Lung Cancer - WebMD, 5/21/02 - "In a small study of 16 patients with early cancer than had not spread beyond the lungs, patients who took Celebrex along with chemotherapy benefited from the treatment, and the cancer virtually disappeared in five patients ... In eight other patients, tumors shrank, and four more patients had stable disease ... The expected complete clinical response rate -- meaning that tumors are no longer visible by X-ray -- with the chemotherapy alone "is just 1%, so these results were very encouraging."" - See my COX-2 inhibitor page for natural COX-2 inhibitors.
• Vitamin E in Food May Fight Cancer - WebMD, 12/15/04 - "Most supplements provide a different form of the vitamin, alpha-tocopherol ... Gamma-tocopherol aced its lab tests. It inhibited the spread of prostate and lung cancer cells without hurting the healthy cells ... Mixing several forms of vitamin E -- including gamma-tocopherol -- was even better at blocking cancer's spread"  - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
• Citrus Shows Promise For Certain Childhood Cancer - Science Daily, 12/1/04 - "Orange juice and other citrus contain potent natural compounds – limonoids – which showed dramatic results in killing certain cancer cells"
• An Apple a Day for Cancer Prevention - WebMD, 10/18/04 - "exposed cancer cells to various antioxidants found in apples ... one type of antioxidant, called procyanidins, triggered a series of cell signals that resulted in cancer cell death ... Rats getting "apple water" for six weeks had half the number of precancerous lesions in their colons compared with rats eating the regular diet ... compared the cancer patients' diets with a group of people without cancer ... Those who ate both green leafy and cruciferous vegetables got "particularly strong" cancer prevention protection"
• Plant food combo offers higher cancer protection - Nutra USA, 7/19/04 - "rats fed a combination of tomatoes and broccoli had markedly less prostate tumour growth than rats who ate diets containing either food alone"
• Healthy Lifestyle Can Lower Cancer Risk - WebMD, 7/7/04 - "The nine guidelines to better ensure a cancer-free life are:"
• Modulation of carcinogen metabolism and DNA interaction by calcium glucarate in mouse skin - Toxicol Sci. 2004 May;79(1):47-55. Epub 2004 Feb 19 - "Cag exerted its antitumor effect possibly by inhibiting the carcinogen-DNA binding, which appears to be due to reduced DNA synthesis and AHH activity"
• Women: Walk Away From Cancer - WebMD, 3/29/04
• Green Tea's Cancer-Fighting Target Found - WebMD, 3/15/04 - "the antioxidant, known as EGCG, binds to a protein found on tumor cells and dramatically slows their growth ... the antioxidant required to produce these anticancer effects was equivalent to those found in the body after drinking only two to three cups of green tea"  - See iHerb or Vitacost green tea extracts.
• Intentional Weight Loss of 20 Pounds or More Linked to Decreased Cancer Risk - Doctor's Guide, 12/1/03 - "Compared with women who never had any weight loss episodes of 20 or more pounds, women who had ever experienced intentional weight loss of 20 or more pounds, but not unintentional weight loss, had an 11% reduced risk for any type of cnacer"
• Some Herbs May Fight Cancer - WebMD, 10/28/03
• Diet & Exercise: It's for Cancer, too - WebMD, 10/27/03
• Natural Products for Cancer Patients - Separating Hope from Hype - Dr. Murray's Natural Facts, 10/8/03
• Cancer Fighter: Vitamin B-6 - Physician's Weekly, 8/11/03 - "Washington State University researchers suggest that consuming more vitamin B-6 can ward off cancer. The vitamin Converts folate to a form the body can use to produce thymine, a component of DNA"
• Vitamin cocktail cuts cancer deaths - BBC News, 8/4/03
• Pizza Prevents Cancer? It's Part of the Mediterranean Diet - WebMD, 7/21/03 - "Gallus and colleagues sifted through diet surveys completed by 5,500 Italians ... regular pizza eaters had 34% less risk of oral cavity and pharyngeal cancer, 59% less risk of esophageal cancer, and 25% less risk of colon cancer ... Italian pizza is less than 50% crust, 20% tomato sauce, 20% mozzarella cheese, and 4% olive oil ... There's less refined carbohydrates, plus cooked tomatoes, which are a rich source of lycopene, a natural chemical that has been shown in numerous studies to protect against cancer ... We think that there's a specific compound in cooked tomatoes that is protective"
• Detoxifying cancer causing agents to prevent cancer - Integr Cancer Ther. 2003 Jun;2(2):139-44 - "There is now growing evidence for the possible control of different stages of the cancer induction by inhibiting beta-glucuronidase with D-glucaric acid derivatives, especially with its salts (D-glucarates) ... the consumption of fruits and vegetables naturally rich in D-glucaric acid or self-medication with D-glucaric acid derivatives such as calcium D-glucarate offers a promising cancer prevention approach"
• Alpha-Tocopheryl Succinate Seen as Auxiliary Cancer Treatment - AltMedicine.com, 5/22/03 - "alpha-tocopheryl succinate has inhibited and killed both human and rodent cancer cells in test tubes (in vitro) and later in the living body of rodents (in vivo)—without causing normal cells to proliferate. So far, tests in living human bodies have not been conducted"
• Fruits: Cancer-Fighting Foods - WebMD, 2/19/03 - "Compared with those who ate the least fruit as children, those who ate the most were about 40% less likely to get cancer 60 years later ... a variety of nutritional factors might explain fruit's protective effects, such as their high antioxidant, fiber, and vitamin Content. But when they looked at the cancer-fighting impact of vitamins C, E, and beta carotene separately, no single nutrient emerged as the winner"
• 70 Percent Of Cancer Is Preventable - thesandiegochannel.com, 2/4/03 - "We have good evidence that breast cancer, prostate cancer, and colon cancer are related to increased dietary fat and too many calories ... As far as something to add to your lifestyle -- physical activity. This can cut your risk of colon and other cancers by as much as a half"
• In Praise of Spirulina - CancerDecisions.com, 12/12/02 - "In a 2002 Japanese study, 12 adult males were administered an oral hot water extract of spirulina, and the number and activity of their natural killer (NK) cells was measured before and after treatment. (NK cells destroy tumor cells by binding to them and delivering lethal chemicals that kill on contact.) At the study's end, there was a significant increase in the production and cancer-killing ability of these subjects' NK cells ... Spirulina also shows potential for decreasing the adverse effects of both chemotherapy and radiation" - See iHerb or Vitacost spirulina products.
• Nutrients Are Key to Preventing Cancer - Intelihealth, 12/3/02 - "Cancer doesn't just arise overnight. A few tiny cells gone wrong slowly grow over decades. Whether the result is a life-threatening tumor depends on genes and environment including food ... Up to 35 percent of cancers are related to dietary habits ... people who eat lots of fruits and vegetables generally are skinnier. Obesity increases risks of cancers of the uterus, gallbladder and possibly colon and prostate, while a large weight gain after reaching adulthood is linked to breast cancer ... Not everybody gets equal benefit from nutrient-rich diets, a discrepancy that probably points to genetic variability. For example, scientists studying lung cancer rates in part of China found people with the lowest cancer risks also were genetically deficient in an enzyme that metabolizes certain nutrients in cruciferous vegetables"
• Ability To Cope With Stress May Play A Role In Cancer Progression - Intelihealth, 11/2/02 - "Studies have shown that people who adopt active coping strategies have better immune function and lower cortisol levels, and just the opposite for people who use passive coping strategies"
• Cancer-Fighting Foods, Supplements Against Cancer - Dr. Janson Newsletter, 12/02
• Soy, Cow's Milk May Fight Breast Cancer - WebMD, 9/27/02 - "A combination of soy and cow's milk could have some beneficial, anti-cancer nutrients ... She explains that conjugated linoleic acid, or CLA, is the key to the cow's role in cancer prevention. CLA is a minor fatty acid found in milk and milk products and beef ... He says he thinks the most potent cancer-fighting component of soy is a compound called genistein ... He demonstrated that by feeding rats a diet containing genistein before exposing them to a cancer-causing drug. The number of breast tumors was reduced by 50%" - See iHerb and Vitacost CLA products.
• Eating Healthy Lowers Cancer Risk - WebMD, 9/20/02
• Avoiding Weight Gain Has A Major Role In Cancer Prevention - Doctor's Guide, 9/13/02 - "Obesity is linked to colon, breast (in postmenopausal women), endometrium, kidney, and oesophagus ... associations with cancer risk could be explained by alterations in the metabolism of endogenous hormones, including sex steroids, insulin, and insulin-like growth factors. These can lead to distortion of the normal balance between cell proliferation, differentiation, and apoptosis"
• Experts outline convincing evidence on diet and cancer - USA Today, 9/13/02 - "Poor diet is thought to account for about 30% of cancer"
• Aspirin Lowers Pancreatic Cancer Risk - WebMD, 8/6/02 - "A new study shows regular use of aspirin might lower your risk of one of the deadliest forms of cancer ... women who used aspirin cut their risk of developing pancreatic cancer nearly in half ... the more aspirin use a woman reported, the less likely she was to develop pancreatic cancer ... Other NSAIDs did not have the same effect"
• Sunlight, A Cancer Protector In The Guise Of A Villain? - Intelihealth, 8/6/02 - "Their theory was that vitamin D, which the skin produces when exposed to sunshine, somehow prevents the growth of malignant cells ... researchers are looking into vitamin D as a possible remedy. Clinical trials in people are now under way, testing whether the vitamin or similar compounds can treat tumors or bolster chemotherapy"
• Novel Method of Enhancing Anti-Fat Effects of CLA - Life Extension Magazine, 8/02 - "CLA is not just for fat-loss. Studies show it may help protect against many diseases including atherosclerosis and cancer ... CLA is also able to inhibit the growth of prostate cancer. CLA, as the article went on to say, can be considered a powerful prostate cancer preventative, as well as a partial treatment" - See iHerb and Vitacost CLA products.
• Green Tea Cancer Benefits Detailed - USA Today, 7/9/02 - "polyphenols in green tea help eliminate free radicals ... Hsu discovered the polyphenols actually separate healthy cells containing the P-57 protein from cancer cells, which lack the protein. While the healthy cells are sent to safety, the polyphenols attack the cancer cells ... The polyphenols go after the cancer cells' mitochondria, the main energy source in cells. The destruction of the mitochondria weakens the cancer cells, and eventually leads to their death" - See iHerb or Vitacost green tea extracts.
• A Report on Curcumin's Anti-cancer Effects - Life Extension Magazine, 7/02 - "Imagine a natural substance so smart it can tell the difference between a cancer cell and a normal cell; so powerful it can stop chemicals in their tracks; and so strong it can enable DNA to walk away from lethal doses of radiation virtually unscathed. Curcumin has powers against cancer so beneficial that drug companies are rushing to make drug versions. Curcumin is all this and more" - See curcumin at Amazon.com or Vitacost.
• Cimetidine (Tagamet) For Cancer Treatment - Life Extension Foundation, 7/02
• Vitamin K Therapy Slows Spread of Liver Cancer - Doctor's Guide, 5/29/02 - "Results show that 59 percent of patients treated with vitamin K-II were alive at two years compared to 29 percent of those who were not given vitamin K-II (p=0.14). Invasion of the cancer into the portal vein occurred in 2 percent of the vitamin K-II treated group at one year and in 13 percent at two years, compared to 21 and 55 percent of controls, respectively" - Vitamin K3 (menadione sodium bisulfite) is put in animal foods and animal vitamins. Places that sell it in bulk are http://www.dyets.com/ordering.htm ($156/kilogram).  A company at 360-387-0129 called me and said they sell it also.  Also see liver cancer.
• Black Raspberries Fight Cancer - WebMD, 5/3/02 - "Earlier studies have shown that blueberries and strawberries also have cancer-preventing properties. But black raspberries seem to work even better. Berries are chock full of antioxidants, chemicals that help block tumors from forming. Antioxidants sop up cancer-causing molecules called free radicals -- damaging substances produced from your body's everyday functions"
• Japanese Ministry Looks At Cancer "Remedies" - Intelihealth, 4/12/02
• Common Foods Help Prevent Cancer - WebMD, 4/10/02 - "found that regular green tea drinking cut cancer risk in half ... men who ate more than two servings of tomato sauce per week had a 23% lower risk of prostate cancer than men who ate less than one serving a week"
• Exposure To Sunlight Lowers Risks Of Four Cancers - Doctor's Guide, 4/4/02 - "exposure to sunlight contributes to non-melanoma skin cancer. "By contrast, several ecological studies suggest that sunlight may protect against female breast, ovarian, prostate, and colon cancer, all diseases that contribute to a substantially higher proportion of cancer mortality in the western industrialized world." ... Some studies have suggested an association between circulating vitamin D in blood, which is largely derived from sunlight, or dietary vitamin D and colorectal, prostate and female breast cancers"
• Sunshine May Keep Certain Cancers at Bay - WebMD, 4/4/02
• The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1 - Br J Cancer 2002 Mar 4;86(5):774-8 - "This observation provides a novel explanation for the cancer preventative properties of resveratrol. It demonstrates that a natural dietary cancer preventative agent can be converted to a compound with known anticancer activity by an enzyme that is found in human tumours"
• Sun May Protect Against Some Cancers - WebMD, 3/14/02 - "new findings from an independent researcher suggest that getting too little sun may increase the risk of dying from a host of other cancers ... Sunlight exposure increases the body's production of vitamin D. People who get lower amounts of sunlight exposure therefore manufacture lower amounts of vitamin D. Grant says vitamin D may have a protective effect and taking vitamin D supplements might offer adequate protection to people who get little natural sunlight"
• 'Gift Of The Magi' Bears Anti-Cancer Agents [myrrh plant (Commiphora myrrha)], Researchers Suggest - Intelihealth, 12/4/01
• New research shows how broccoli beats cancer - Life Extension Magazine, 11/01 - "Sulforaphane is most highly concentrated in broccoli, as well as in other cruciferous vegetables, such as Brussels sprouts, cabbage and cauliflower ... animal studies to date have shown that sulforaphane can dramatically reduce the number of malignant tumors, reproduction, growth rate and size, as well as delay cancer onset"
• Does Green Tea Aid in Cancer Prevention? - Life Extension Magazine, 10/01
• Unlocking the power of curcumin - Life Extension Magazine, 9/01 - "research is discovering that curcumin is a powerful carcinogenic inhibitor, slowing cancerous cell proliferation by inducing apoptosis, a pre-programmed set of processes within a cell that results in its death"
• Report: An Innovative Approach to Cancer Therapy - Life Extension Foundation, 8/01 - "For cancer patients the main anti-cancer supplements are pancreatic enzymes"
• Cancer: What You Should Do If You Have It - Life Extension Magazine, 12/99
• Study: Power Lines May Aid Cancer Cells - Intelihealth, 10/29/01 - "electromagnetic fields disrupted the functioning of the hormone melatonin in individual cells ... Scientists have accepted since 1987 that the substance suppresses the multiplication of cancer cells ... They exposed two batches of the [breast cancer] cell to two different levels of electromagnetic field ... In both cases, the ability of melatonin to suppress the growth of the cancer cells was found to have declined. In some cells with smaller concentrations of melatonin, the suppressive effect was entirely absent"
• Diet, Cancer, and Confusion - WebMD, 10/24/01
• Cancer Patients Need Regular Advice About What To Eat - Intelihealth, 10/24/01
• The Co-Q10 - Cancer Connection - Nutrition Science News, 7/01
• Preventing Skin Cancer: There's a Doctor in Your Kitchen, Household Items Like Aspirin and Green Tea Can Ward Off Cancer - WebMD, 4/30/01 - "Vitamin A ... Diet ... Green Tea ... Soybeans ... NSAIDS"
• Red Wine, Coffee, and Almonds May Lower Prostate Cancer Risk, Protective Effect Linked to Dietary Boron - WebMD, 4/5/01 - "men who consumed the greatest amount of boron were 64% less likely to develop prostate cancer, when compared with men who consumed the least amount of boron"
• Somers' cancer treatment worries some experts - CNN, 3/30/01 - see my Iscador page
• Regular Physical Activity Reduces Cancer Risk - Doctor's Guide, 2/13/01
• Colon Cancer Prevented, Promoted by Diet - Nutrition Science News, 2/01
• Honey May Prevent Recurring Tumors - Intelihealth, 12/15/00
• Coffee May Offer Bladder Cancer Protection To Smokers - Doctor's Guide, 12/13/00
• Vitamin B12: Surprising New Findings - Life Extension Magazine, 12/00 - "High levels of homocysteine are consistently linked with DNA damage ... the accepted standard for vitamin B12 sufficiency (i.e., plasma concentration <150 pmol/L) may not be adequate to minimize chromosome damage rates"
• Ulcer Therapy, Vitamins May Team Up to Prevent Stomach Cancer, Drugs Halted, Healed Abnormalities With Cancer Potential - WebMD, 12/8/00 - "people who took the three-drug combination alone or in combination with vitamin C and/or beta carotene were three to five times more likely than people who received no treatment to have a reduction in the size of precancerous stomach abnormalities."
• Flaxseed Lignans Show - Nutrition Science News, 10/00 - "The plant lignans found in flax, namely matairesinol and secoisolariciresinol, must be converted by gut bacteria to mammalian lignans, namely enterolactone and enterodiol. These mammalian lignans have been shown to have chemoprotective effects in cell and animal studies ... Epidemiological studies show breast cancer patients have low urinary excretion of enterolcatone and enterodiol, suggesting that consumption of lignans may exert cancer-preventive or protective effects"
• Breathe Easier With Fruits and Veggies, Study Finds They May Lower Lung Cancer Risk - WebMD, 10/9/00
• Astragalus Asserts Immunity - Nutrition Science News, 10/00 - "breast cancer patients given a combination of astragalus and ligustrum as an adjunct to irradiation treatments showed a statistically significant decrease in deaths from one in two to one in 10 ... In another study of patients with advanced non-small-cell lung cancer, the effectiveness of conventional chemotherapy (chemotherapeutic regimen not reported) was compared to the effectiveness of chemotherapy in conjunction with the same astragalus-ligustrum preparation. Those with squamous carcinoma of the lung showed a significant increase in mean survival time from 204 to 465 days"
• Studies Suggest Eating Garlic Does Protect Against Cancers - WebMD, 10/4/00 - "studies suggest that there may be a 30 to 50% reduction in colorectal cancer in people who eat a lot of garlic"
• Diet Tips To Stave Off Cancer - Intelihealth, 9/5/00 - "Make sure two-thirds of your plate is filled with fruits, vegetables, grains and beans and only one-third is devoted to meat, poultry or fish"
• Chemicals in apples slow cancer growth in lab tests, scientists report - CNN, 8/30/00 - "The stronger the concentration of apple extract, the slower the rate of reproduction among the cancer cells ... The anti-cancer effect, a spokesman said, was strongest in extracts made from unpeeled apples"
• One More Reason To Eat Your Broccoli, Chemical Compounds Found to Prevent Lung Cancer - WebMD, 8/25/00 - "The protection comes from chemicals known as isothiocyanates that are found in these vegetables ... men with no detectable levels of isothiocyanates had a 36% greater chance of developing lung cancer than those who did have the chemical in their bodies ... isothiocyanates inactivate certain cancer-causing chemicals in tobacco smoke. The compounds may also work as antioxidants to help prevent natural damage to cells in the body"
• Researchers Find Phytochemicals In Apples May Fight Off Cancer - Intelihealth, 8/22/00
• NCI Looks to Nutraceuticals - Nutrition Science News, 8/00
• Prostate Cancer and Cruciferous Vegetables - Life Extension Magazine, 7/00
• Follow These Tips to Reduce Your Cancer Risk - WebMD, 7/27/00
• Lower Vitamin C Means Higher Cancer Risk for Men - WebMD, 7/18/00
• Study Examines Red Wine Antioxidant - Intelihealth, 6/30/00
• CLA and Cancer - Life Extension Magazine, 4/00 - "feeding CLA to female rats while they were young and still developing conferred life-long protection against breast cancer"
• Cancer's Sweet Tooth - Nutrition Science News, 4/00
• Flavonoids may help fight cancer, study finds - CNN, 3/30/00
• Researchers Find Cancer-Fighting Chemical In Hazelnuts - Intelihealth, 3/29/00
• Vitamin D Is For Cancer Defense - Nutrition Science News, 3/00
• Herbal Aids for Cancer - Nutrition Science News, 3/00
• Unusual dietary treatment may fight pancreatic cancer - CNN, 11/29/99
• Cancer Prevention Diet - Nutrition Science News, 8/99
• Using natural therapies for the prevention of breast and other forms of cancer - Life Extension Magazine, 6/99
• Chinese Herb Boosts Action of New Lung-cancer Drug - Intelihealth, 4/27/99
• CO-Q10 and Cancer - Nutrition Science News, 4/99
• Vitamins Show Promise In Improving Cancer Treatment - Intelihealth, 2/24/99
• Great Expectations: Hot Herbs in '99 - Nutrition Science News, 1/99 (See the section on IP-6)
• Anti-HIV activity in vitro of MGN-3, an activated arabinoxylane from rice bran - Biochem Biophys Res Commun. 1998 Feb 4;243(1):25-9
• Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals - Am J Clin Nutr. 1997 Dec;66(6 Suppl):1523S-1529S - "Conjugated linoleic acid is unique in the sense that concentrations < or = 1% are sufficient for producing significant cancer protection and that this effect seems to be independent of the other fatty acids." - see my CLA page
• Soy Intake May Reduce Risk of Uterine Cancer -- New Cancer Research Study - Doctor's Guide, 8/29/97
• Natural Sugar-Phosphate Compound Shows Promise In Cancer - Doctor's Guide, 3/30/98  - "What if a common, naturally occurring substance could shrink tumors, stop their growth, even make cancer cells normal again? A University of Maryland School of Medicine researcher is finding that it can." - see my IP-6 page
• Selenium Is Found to Reduce Cancer Mortality by 50 Percent - Life Extension Magazine, 6/97
• Researchers Credit Processed Tomato Products With Reduced Cancer Risk - Doctor's Guide, 3/3/97
• Study: Grapes inhibit cancer growth - CNN, 1/10/97
• Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases - Biochem Biophys Res Commun 1995 Jul 6;212(1):172-7 - "The numerous metastases in the liver of a 44-year-old patient "disappeared," and no signs of metastases were found elsewhere. A 49-year-old patient, on a dosage of 390 mg of vitamin Q10, revealed no signs of tumor in the pleural cavity after six months, and her condition was excellent. A 75-year-old patient with carcinoma in one breast, after lumpectomy and 390 mg of CoQ10, showed no cancer in the tumor bed or metastases"

Other News:

• Physical symptoms prevalent no matter what stage of cancer including remission - Science Daily, 10/11/10
• Stress accelerates breast cancer progression in mice, researchers find - Science Daily, 9/15/10 - "stress is biologically reprogramming the immune cells that are trying to fight the cancer, transforming them instead from soldiers protecting the body against disease into aiders and abettors. The study found a 30-fold increase in cancer spread throughout the bodies of stressed mice compared to those that were not stressed ... Beta blockers, used in this study to shut down the stress pathways in the mice, are currently being examined in several large breast cancer databases for their role in potential prevention of recurrence and cancer spread ... using beta blockers in stressed mice prevented the same cancer progression seen in the stressed mice that did not receive medication"
• Probability of surviving nine types of cancer analyzed - Science Daily, 7/15/10
• Experts explore emerging evidence linking diabetes and cancer - Science Daily, 6/16/10 - "Possible mechanisms for a direct link between diabetes and cancer include hyperinsulinemia, hyperglycemia, and inflammation"
• New cancer vaccine starves tumours of blood - Science Daily, 5/24/10
• The impact of alcohol consumption on the risk of cancer among men: A 20-year follow-up study from Finland - Eur J Cancer. 2010 May 3 - "About 6.7% of the cancer cases in this cohort were due to alcohol consumption"
• Excessive alcohol consumption may lead to increased cancer risk - Science Daily, 4/21/10 - "Researchers have detected a link between alcohol consumption, cancer and aging that starts at the cellular level with telomere shortening ... Telomeres are found at the region of DNA sequences at the end of a chromosome, and are important for the genetic stability of cells. As people age, telomere length shortens progressively ... Since telomere shortening is thought to increase cancer risk, the researchers speculated that those with shorter telomeres due to heavy alcohol consumption would have an increased risk of cancer ... telomere length was dramatically shortened in those who consumed heavy amounts of alcohol; telomere length was nearly half as long as telomere length in the non-abusers (0.41 vs. 0.79 relative units)"
• Insulin used to treat diabetes may be linked to increased cancer risk, review suggests - Science Daily, 3/2/10 - "Research suggests that metformin, which is used to treat some patients with diabetes, may provide a protective effect, while insulin and/or certain insulin analogues may promote tumour growth ... Diabetic patients were 30 per cent more likely to develop colorectal cancer ... Women with diabetes had a 20 per cent greater risk of developing breast cancer ... People with diabetes had an 82 per cent higher risk of developing pancreatic cancer" -  Note:  See my Insulin and Aging page.  I think it's like what came first the chicken or the egg.  I don't believe they know whether it's the insulin or the high blood sugar.  This seems to support that it's the high insulin.
• Increased Cancer Risk Seen With Higher Blood Glucose Levels - Medscape, 1/28/10 - "in men, each 1 mmol/L (18 mg/dL) increment in blood glucose level was associated with a 5% increase in incident cancer risk and a 15% increase in fatal cancer risk ... In women, each 1 mmol/L increase in blood glucose level was associated with an 11% increase in incident cancer risk and a 21% increase in fatal cancer risk ... For men, there were glucose-related increases in the risks of incident and fatal cancer of the liver, gallbladder, and respiratory tract; incident thyroid cancer and multiple myeloma; and fatal rectal and colon cancer .... For women, there were glucose-related increases in the risks of incident and fatal pancreatic and stomach cancer; incident urinary bladder cancer and endometrial cancer; and fatal cervical and uterine corpus cancer. In women, there was also an inverse association of blood glucose with incident thyroid cancer risk ... For men and women combined, higher glucose increased the risk of death from oropharyngeal and esophageal cancers"
• Metformin associated with lower cancer mortality in type 2 diabetes (ZODIAC-16) - Diabetes Care. 2009 Nov 16 - "Median follow-up time was 9.6 years, average age at baseline was 68 years, and average HbA1c was 7.5%. Five hundred seventy patients died, of which 122 from malignancies. SMR for cancer mortality was 1.47 (95%CI 1.22-1.76). In patients taking metformin compared to patients not taking metformin at baseline, the adjusted hazard ratio (HR) for cancer mortality was 0.43 (95%CI 0.23-0.80), and the HR with every increase of 1 gram of metformin was 0.58 (95%CI 0.36-0.93) ... In general, patients with type 2 diabetes are at increased risk for cancer mortality. In our group, metformin use was associated with lower cancer mortality when compared to non-metformin use. Although the design cannot be conclusive about causality, our results suggest a protective effect of metformin on cancer mortality"
• Low Cholesterol May Be Marker of Undiagnosed Cancer - Medscape, 11/5/09 - "This finding supports the idea that the low serum cholesterol levels that we detected as a possible risk factor may actually have been the result of undiagnosed cancers," he added. "In addition, we observed a greater decline in total serum cholesterol from baseline to 3 years, specifically among the cases that were diagnosed in the early half of the observation, as opposed to the latter portion ... higher HDL cholesterol levels were associated with a decreased risk for cancer (>55.3 vs <36.2 mg/dL; RR for the highest vs the lowest quintile, 0.89; 95% CI, 0.83 - 0.97; P = .01). This inverse association of HDL cholesterol was evident for cancers of the lung, prostate, liver, and hematopoietic system"
• Cholesterol-lowering Medicines May Be Effective Against Cancer - Science Daily, 11/2/09 - "Our results support the idea that statins can be used in more ways than just to lower cholesterol," says Pilon. "Not least that they can prevent the growth of cancer cells caused by lipid-modified proteins, but also that they can be effective in the treatment of diabetes and neurological disorders such as Parkinson's."
• Diabetes Drug Shows Promise In Fighting Lethal Cancer Complication - Science Daily, 9/24/09 - "in an animal study, a diabetes drug that promotes insulin sensitivity slowed the progression of muscle wasting and fat loss, the main consequences of a syndrome called cachexia ... Research suggests that cachexia is responsible for between one-fifth and one-third of all cancer deaths ... These data provide evidence that in mice with colon cancer tumors, insulin resistance may be involved in the development of cachexia rather than occur as a result of cachexia ... Within eight days, the mice with cancer receiving the rosiglitazone showed more sensitivity to insulin than did the mice with tumors that received no medication. The insulin sensitivity of the medicated mice matched that of mice without tumors ... In addition to stopping fat and muscle loss, the rosiglitazone also dramatically reduced two biological markers present when proteins break down, particularly in muscles, and a third marker that indicates cells are eating their own amino acids in an attempt to survive" - Note:  I don't know why they did this study with rosiglitazone.  That's the one that may be connected to heart disease.  Pioglitazone is the same class of drug and is not connected to heart disease.  I take it for anti-aging also.  See my Insulin and Aging page.
• Depression Increases Cancer Patients' Risk Of Dying - Science Daily, 9/15/09
• New users of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes - Diabetes Care. 2009 Jun 29 - "Activation of AMPK can suppress tumour formation and inhibit cell growth, in addition to lowering blood glucose levels. We tested the hypothesis that metformin reduces the risk of cancer in people with type 2 diabetes ... Cancer was diagnosed among 7.3% of 4,085 metformin users compared with 11.6% of 4,085 comparators, with median times to cancer of 3.5 years and 2.6 years respectively (p < 0.001). The unadjusted hazard ratio for cancer was 0.46 (0.40-0.53). After adjusting for sex, age, BMI, HbA1c, deprivation, smoking and other drug use, there was still a significantly reduced risk of cancer associated with metformin: 0.63 (0.53-0.75)" - See metformin at The Antiaging Store.
• Common Diabetes Drug May 'Revolutionize' Cancer Therapies: Unexpected T-cell Breakthrough - Science Daily, 6/4/09 - "We used metformin, which is known to operate on fatty-acid metabolism, to enhance this process, and have shown experimentally in mice that metformin increases T-cell memory as well as the ensuing protective immunity of an experimental anti-cancer vaccine"
• 'Cancer hope' from diabetes drug - BBC News, 6/3/09 - "Tests on mice found metformin, used for Type 2 diabetes, helps the body's T-cells work more effectively"
• Personalized Medicine Helps Cancer Patients Survive - Science Daily, 4/19/09
• Procedure Improves Health Of Cancer Patients - Science Daily, 4/1/09
• New Anti-cancer Drug: 200 Times More Active In Killing Tumor Cells - Science Daily, 3/25/09 - "In humans, compounds like BPH-715 and zoledronate have an added benefit in fighting cancer: They spur the proliferation of immune cells called gamma delta T-cells, which aid in killing tumor cells ... The new drugs are about 200 times more effective than the drugs used in recent clinical trials at killing tumor cells and in activating gamma delta T-cells to kill tumor cells ... They also prevent tumor progression in mice much better than do existing bisphosphonate molecules" - Note:  I sounds like hope with terminal cancer, something I was looking for when they inaccurately told me I had terminal neck cancer.
• 'Miracle Dog' Beats Aggressive Cancer - WebMD, 3/23/09 - "the drug is made of a cancer-killing substance called nitric oxide, which is attached to vitamin B12. Substances called receptors on a cell's surface attract the vitamin and help it enter the cell. Cancer cells grow abnormally fast with extra B12 receptors. NO-Cbl spots these receptors, sneaks into cancer cells, and releases the nitric oxide, which kills the cancer cells from within"
• Million Women Study Shows Even Moderate Alcohol Consumption Associated With Increased Cancer Risk - Science Daily, 2/24/09 - "Low to moderate alcohol consumption among women is associated with a statistically significant increase in cancer risk and may account for nearly 13 percent of the cancers of the breast, liver, rectum, and upper aero-digestive tract combined"
• ACE Inhibitors May Protect Diabetics From Cancer, Peptic Ulcer - Medscape, 12/19/08 - "There was a significant association between ACE inhibitor use and the risk for cancer, with an adjusted odds ratio of 0.59 ... The rate of cancer among users of ACE inhibitors was 10% vs 15% for nonusers ... There was also a significant association between ACE inhibitor use and peptic ulcer disease, with an odds ratio of 0.68 ... The rate of peptic ulcer disease among ACE inhibitor users was 12% vs 16% among nonusers"
• Key Mechanism Behind Cancer Spread Is Explained - Science Daily, 10/30/08
• Severe Stress More Common Among Long-term Cancer Survivors - Science Daily, 9/23/08
• Palms Can Foretell Cancer - WebMD, 9/23/08 - "The symptoms: curling or thickening of the palm with swelling of the fingers, making the hand look wooden. It's called PFPAS -- palmar fasciitis and polyarthritis syndrome"
• Untapped Potential Of Antidepressants For Cancer - Science Daily, 9/11/08 - "Antidepressants work by affecting levels of chemicals known as prostaglandins. These are ephemeral, infinitesimal signallers self-regulating every cell in the body, including those serving mood and immunity ... Prostaglandins are responsible, paradoxically, for both cell function and dysfunction. Excessive prostaglandin synthesis depresses immune function and may induce cancer ... An ideal anticancer agent would inhibit prostaglandins in such a manner as to shut down the pathogenesis of cancer. The article indicates that antidepressants have such properties"
• How Cancer Cells Come Unstuck And Spread - Science Daily, 8/21/08
• Modafinil Reduces Severe Cancer Fatigue - Clinical Psychiatry News, 8/08 - "Among those with severe fatigue at baseline, patients on modafinil had significantly greater reductions in fatigue, compared with those on placebo" - See modafinil at International Anti-aging Systems.
• Overcoming Resistance To A Cancer Drug - Science Daily, 6/24/08
• New Cancer Treatment Targets Both Tumor Cells And Blood Vessels - Science Daily, 6/18/08
• Treatment Can Make Cancer Stronger - WebMD, 6/10/08 - "About half of patients are cured -- that is, all of their tumor cells die ... The other half of the time, some tumor cells survive treatment. These cancer cells are more aggressive than they were before treatment"
• Narcolepsy Drug Fights Cancer Fatigue - WebMD, 6/4/08 - "The narcolepsy drug Provigil may help to relieve the debilitating fatigue often experienced by cancer patients undergoing chemotherapy ... patients taking the drug who had the most severe fatigue at the beginning of the study demonstrated significant improvement, compared with those in the placebo group" - See Provigil (modafinil) at OffshoreRx1.com.
• Link Between Inflammation, Cancer Confirmed - Science Daily, 6/2/08 - "Chronic inflammation of the intestine or stomach can damage DNA, increasing the risk of cancer ... Researchers have long known that inflammation produces cytokines (immune response chemicals that encourage cell proliferation and suppress cell death), which can lead to cancer"
• The Good And Bad Side Of Anti-cancer Compounds - Science Daily, 4/10/08
• ROSIGLITAZONE AND RISK OF CANCER. A META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS - Diabetes Care. 2008 Mar 28 - "The incidence of malignancies was significantly lower in rosiglitazone-treated patients than in control groups (0.23[0.19-0.26] vs. 0.44[0.34-0.58] cases/100 patient*years" - Note:  I was taking rosiglitazone when I had my neck cancer.  Maybe that's one of the things that saved me.  I've since switched to pioglitazone (as an anti-aging measure to prevent AGEs, I don't have diabetes).
• Strengthening The Tumor-fighting Ability Of T Cells - Science Daily, 3/24/08
• The Association Between Statins and Cancer Incidence in a Veterans Population - J Natl Cancer Inst. 2008 Jan 8 - "After multivariable adjustment, a statistically significantly decreased risk of all cancers was also associated with increasing statin use"
• Statin Drugs May Cut Cancer Risk - WebMD, 1/8/08 - "The veterans were followed for five years, on average. During that time, 9% of those taking statins were diagnosed with cancer, compared with 13% of those not taking statins, VA records show"
• Eating More Red And Processed Meats Linked To Greater Risk For Bowel And Lung Cancer, Findings Suggest - Medscape, 12/10/07 - "people who eat a lot of red and processed meats have greater risk of developing colorectal and lung cancer than people who eat small quantities. They also indicate that a high red meat intake is associated with an increased risk of esophageal and liver cancer and that 1 in 10 colorectal and 1 in 10 lung cancers could be avoided if people reduced their red and processed meat intake to the lowest quintile"
• Treatment For Spreading Cancer: Llymphatic Vessel And Lymph Node Function Are Restored With Growth Factor Treatment - Science Daily, 12/3/07
• Novel Mechanism For Spread Of Sarcoma Tumors Discovered - Science Daily, 11/28/07
• Freezing the Pain of Cancerous Tumors - WebMD, 11/27/07
• Mechanism Of Action Of EGFR Inhibitors in Cancer Chemotherapy - Science Daily, 10/30/07
• Combination Targets For Cancer: Some Drugs Work Well Together, Studies Suggest - Science Daily, 10/29/07
• Cancer Treatment: Support Crucial - WebMD, 10/23/07
• First Clinical Trial Of Apatone For Cancer Treatment Promising - Science Daily, 10/5/07
• Decrease in Cancer Risk for Pill Users - WebMD, 9/11/07 - "researchers found a 12% decreased risk of any cancer in oral contraceptive users compared with women who never used birth control pills"
• Diabetes Drug Kills Some Cancer Cells - Science Daily, 8/14/07 - "Four weeks later, the p53-deficient tumors in mice treated with metformin were half the size of the p53 deficient tumors in control mice"
• Stress May Help Cancer Cells Stay Alive - Doctor's Guide, 4/10/07 - "the stress hormone epinephrine causes changes in prostate and breast cancer cells that may make them resistant to cell death"
• Untried cancer drug [DCA] bought on web - BBC News, 3/29/07
• Chemotherapy Drug Packs A One-two Punch - Science Daily, 2/20/07
• Gum Disease Ups Pancreatic Cancer Risk - WebMD, 1/16/07 - "subjects who reported gum disease were 64% more likely to have pancreatic cancer ... Michaud and colleagues suggest that long-standing gum infections trigger a body-wide immune response: inflammation. Inflamed tissues give off chemical signals that promote tumor growth"
• Personalized Cancer Vaccine Improves Disease Free Survival - Doctor's Guide, 10/20/06 - "administration of the BiovaxID™ anti-cancer vaccine formulation resulted in long-lasting remission in NHL patients"
• FDA OKs New Cancer Pain Drug - WebMD, 9/27/06
• Cephalon Receives FDA Approval of Fentora(TM) (fentanyl buccal tablet) for the Management of Breakthrough Pain in Patients with Cancer - Doctor's Guide, 9/26/06
• Blood Pressure Drugs Counter Cancer? - WebMD, 5/23/06 - "After crunching the numbers, the risk reduction in veterans taking ACE inhibitors was 53% for colon cancer, 52% for pancreatic cancer, and 46% for esophageal cancer"
• Equivalent Of 2-4 Drinks Daily Fuels Blood Vessel Growth, Encourages Cancer Tumors In Mice - Science Daily, 4/4/06 - "the tumors of the mice that ingested alcohol ... were nearly twice as heavy compared to the mice that did not have alcohol ..."
• A new cancer vaccine and cutting-edge medicines that target tumors may help finally win the war on cancer - US News, 4/3/06
• The New Cancer Fighter (And Other Hot Drugs On The Way) - Time, 3/20/06
• Think Twice Before Exercising When Getting That PET Scan - Science Daily, 3/9/06
• Even Mild Muscle Activity Impacts Positron Emission Tomography Results - Doctor's Guide, 3/8/06
• Late-stage cancer patients flock to Mexico - MSNBC, 2/3/06
• Fever of Unknown Origin: A Marker for Occult Cancer? - Doctor's Guide, 9/28/05
• Chronic Diseases Common Among Adult Survivors of Childhood Cancer - Doctor's Guide, 5/18/05

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