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Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.
Home > Anti-aging Research > Vitamin K
Vitamin K
Specific Recommendations:
General Information:
- Vitamin K1 (Phylloquinone)
- Vitacost Health Library
- Vitamin K - The Natural Pharmacist
News & Research:
-
Vitamin K2 linked to lower prostate cancer risk - Nutra USA, 4/9/08 -
"While no reduction in the risk of prostate cancer
was observed for vitamin K1 (phylloquinone), an increased intake of all
menaquinones (vitamin K2) was associated with a 35 per cent reduction in
risk"
-
Study gives vitamin K anti-inflammation boost - Nutra USA, 12/3/07 -
"Limited in vitro data support the inverse
association between vitamin K and interleukin-6, and this may influence the
association between vitamin K and other cytokines, such as osteoprotegerin"
- [Abstract]
-
Vitamin K shows potential in the fight against wrinkles - Nutra USA,
10/19/07 - [Abstract]
- "Recent studies have linked vitamin K to the
elasticity of skin in patients suffering from pseudoxanthoma elasticum
(PXE), an inherited condition resulting in severe wrinkling of the skin on
the face and body"
-
Vitamin K linked to fewer varicose veins, better vascular health - Nutra
USA, 8/23/07 - "they suggested that adequate dietary
intake of vitamin K may be a necessary prerequisite in preventing the
development of varicose veins" - [Abstract]
-
Is vitamin K deficiency more common than thought? - Nutra USA, 7/18/07
-
Vitamin K may reverse arterial calcification - Nutra USA, 4/3/07 -
"using 10-week old male Wistar Kyoto
rats ... high-vitamin K intake (both K1 and K2) not only blocked the
progress of further calcium accumulation but also lead to a greater than 37
per cent reduction of previously accumulated arterial calcium precipitates
within six weeks"
-
Many
Seniors Are Still Not Meeting The Recommended Intake Of Vitamin K -
Science Daily, 2/12/07 - "Although
older adults seem to consume more vitamin K than younger adults, many
seniors are still not meeting the recommended intake of vitamin K ...
Research has shown poor vitamin K intake may be associated with conditions
such as bone fractures, bone loss, hardening of the arteries, and
osteoarthritis"
-
Vitamin K2 higher bioavailability than K1, say scientists - Nutra USA,
12/18/06
-
Vitamin K may reverse artery hardening, suggests study - Nutra USA,
12/11/06 - "A high-dose vitamin K
supplement reduced calcium precipitates associated with hardening of the
arteries by 37 per cent in rats"
-
Study Suggests Vitamin K Deficiency as an Osteoporosis Risk Factor -
Doctor's Guide, 9/22/06 - "one of
the early effects of declining estrogen is the impairment of vitamin K
function in bone even before any bone loss that could be attributed to
menopause can be measured ... Our study suggests that the generally accepted
level of vitamin K in healthy women is inadequate to maintain bone health
just at the onset of menopause"
-
Vitamin K1-rich diet linked to better heart health - Nutra USA, 8/29/06
-
Strong support for vitamin K’s bone health benefits - Nutra USA, 6/27/06
- "Supplementation of vitamin K
(MK-4) resulted in reductions in hip fractures of 77 per cent, vertebral
fracture of 60 per cent, and all non-vertebral fractures of 81 per cent"
-
More support for vitamin K’s protection from osteoarthritis - Nutra USA,
4/12/06 - "Higher intake of vitamin
K, found naturally in cabbage, spinach, cauliflower, and other green leafy
vegetables, could reduce the risk of osteoarthritic knee problems by 40 per
cent"
-
Vitamin K's Delicate Balancing Act
- Life Extension Magazine, 4/06 -
"Scientists have discovered that vitamin K regulates several biochemical
processes that require exquisite balance to function normally, including blood
coagulation, bone mineralization, and vascular health"
-
Vitamin K in the Treatment and Prevention of Osteoporosis - Am J Health-Syst
Pharm. 2005;62(15):1574-1581/Medscape, 8/5/05 -
"The results of two dose-response
studies have indicated that (1) the amount of vitamin K needed for optimal
γ-carboxylation of osteocalcin is significantly higher than what is provided
by diet alone and (2) there is a need to increase current dosage
recommendations to optimize bone mineralization"
- Natto vitamin K2 superior to vitamin K? - Nutra USA, 3/24/04
-
Vitamin
K - Life Extension Magazine, 3/04
- Vitamin K Builds Strong Bones - New Hope Natural Media, 3/28/03 -
"Without adequate vitamin K, osteocalcin
cannot be produced, and bone formation becomes impaired ... when women with osteoporosis take supplemental vitamin K, the urinary excretion of calcium falls by about 50%, suggesting that less calcium is being leached from the bones ... Some research, however, suggests that the
optimal level of intake may be higher, as much as 400 mcg per day. A typical western diet contains 80 to 150 mcg per day"
- Vitamin K(1) Absorption Unreliable in Infants with Conjugated Hyperbilirubinaemia - Doctor's Guide, 3/5/03
- Watch Out for Vitamin K? - Dr. Weil, 11/27/02
- Low Bone Mineral Density and Quantitative Ultrasound in Men Associated with Low Vitamin K Status - Doctor's Guide, 9/23/02 -
"Low vitamin K
status is associated with low quantitative ultrasound (QUS) and low bone mineral density (BMD) of the femoral neck and trochanter
... What we did was measure the amount of vitamin K in circulation and use the more sensitive measures of vitamin K status which was % undercarboxylated osteocalcin
... We corrected for triglycerides because vitamin K is transported in the blood by triglyceride-rich lipoproteins ... What we found was that the higher the amounts of vitamin K in the plasma, the higher the BMD" - So does that mean that if your triglycerides are in check you
may need extra vitamin K? - Ben
- Topical Vitamin K Effectively Treats Bruising Following Laser Therapy - Doctor's Guide, 8/26/02
- Vitamin K Therapy Slows Spread of Liver Cancer - Doctor's Guide, 5/29/02 -
"Results show that 59 percent of patients treated with vitamin K-II were alive at two years compared to 29 percent of those who were
not given vitamin K-II (p=0.14). Invasion of the cancer into the portal vein occurred in 2 percent of the vitamin K-II treated group at one year and in 13 percent at two years, compared to 21 and 55 percent of controls, respectively" - Also see liver
cancer. Vitamin K3 (menadione sodium bisulfite) is put in animal foods and animal vitamins.
- Hydrogenated Oils Affect Amount of Vitamin K Available to Bone - Doctor's Guide, 11/30/01 -
"Hydrogenation of plant oils decreases the amount of
vitamin K available to bone in consumers using food products containing the oils ... available data indicate that more than half of younger US adults do not meet the current guidelines governing adequate intake of the nutrient" - Another reason to stay away from the brands of peanut butter that are
hydrogenated. - Ben
- Vitamin K Deficiency Linked to Low Bone Mineral Density in Women - Doctor's Guide, 10/15/01
- Vitamin K Cuts Hip Fractures - Nutrition Science News, 9/01
- Low-Dose Vitamin K Treats Excessive Anticoagulation - Doctor's Guide, 7/9/01
- US Anticoagulation Clinics Underuse Vitamin K - Doctor's Guide, 7/9/01
- Low Dose Vitamin K Helps Warfarin Patients - Doctor's Guide, 11/2/00
- Bone Up on Osteoporosis - Nutrition Science News, 11/00
- Lack of Vitamin K Linked to Hip Fractures - Doctor's Guide, 5/9/00
-
Vitamin
K - Life Extension Magazine, 2/00
- Research Points to Better Blood Clotting Control - Doctor's Guide, 4/13/98
- Combining Acetaminophen With Anticoagulant Increases Risk Of Bleeding - Doctor's Guide, 3/3/98
- Is Vitamin K Linked To Childhood Cancer? - Doctor's Guide, 1/16/98
Abstracts:
-
An
Attempt to Evaluate the Effect of Vitamin K(3) Using as an Enhancer of
Anticancer Agents - Biol Pharm Bull. 2008;31(6):1270-1273 -
"These findings suggest that VK(3) induces G(2)/M
arrest by inhibition of cyclin B/cdk1 complex formation, and is thus useful
as an enhancer of G(2) phase-dependent drugs in hepatic cancer chemotherapy"
-
A
12 week, open label, phase I/IIa study using apatone for the treatment of
prostate cancer patients who have failed standard therapy - Int J Med
Sci. 2008 Mar 24;5(2):62-7 - "oral Apatone (Vitamin
C and Vitamin K3) administration in the treatment of prostate cancer ...
5,000 mg of VC and 50 mg of VK3 each day ... At the conclusion of the 12
week treatment period, PSAV decreased and PSADT increased in 13 of 17
patients (p < or = 0.05). There were no dose-limiting adverse effects. Of
the 15 patients who continued on Apatone after 12 weeks, only 1 death
occurred after 14 months of treatment"
-
Vitamin K(2) suppresses malignancy of HuH7 hepatoma cells via inhibition of
connexin 43 - Cancer Lett. 2008 Jan 29 - "The
anti-cancer potential of vitamin K(2) (VK(2)) in hepatoma has gained
considerable attention"
-
Vitamin K and Vitamin D Status: Associations with Inflammatory Markers in
the Framingham Offspring Study - Am J Epidemiol. 2007 Nov 15 -
"Vitamin K status, measured by plasma phylloquinone
concentration and phylloquinone intake, was inversely associated with
circulating inflammatory markers as a group and with several individual
inflammatory biomarkers" - See
vitamin K products at iHerb
 .
-
Vitamin K(2) supplementation improves hip bone geometry and bone strength
indices in postmenopausal women - Osteoporos Int. 2007 Feb 8 -
"Vitamin K(2) helps maintaining bone
strength at the site of the femoral neck in postmenopausal women by
improving BMC and FNW, whereas it has little effect on DXA-BMD"
-
Vitamin K and the Prevention of Fractures: Systematic Review and
Meta-analysis of Randomized Controlled Trials - Arch Intern Med. 2006
Jun 26;166(12):1256-61 - "This
systematic review suggests that supplementation with phytonadione and
menaquinone-4 reduces bone loss. In the case of the latter, there is a
strong effect on incident fractures among Japanese patients"
-
Two-year randomized controlled trial of vitamin K1 (phylloquinone) and
vitamin D3 plus calcium on the bone health of older women - J Bone Miner
Res. 2007 Apr;22(4):509-19 - "women
who took combined vitamin K and vitamin D plus calcium showed a significant
and sustained increase in both BMD and BMC at the site of the ultradistal
radius"
-
Vitamin K treatment for postmenopausal osteoporosis in Indonesia - J
Obstet Gynaecol Res. 2006 Apr;32(2):230-4 - "After 48 weeks of treatment, the
mean percentage change of lumbar BMD in the vitamin K(2) group was
significantly higher (P < 0.05) than that of the control group"
-
Vitamin K, bone turnover, and bone mass in girls - Am J Clin Nutr. 2004 Oct;80(4):1075-80 -
"Better vitamin K status was associated with decreased bone turnover in healthy girls consuming a typical US diet"
- Bone health. New role for vitamin K? - Can Fam Physician. 2004 Jul;50:993-7 -
"Evidence suggests that
dietary phylloquinone intake of <100 microg daily might not be optimal for bone health. Low intake of vitamin K could contribute
to osteoporosis and subsequent fracture ... Family physicians need to be aware of the importance of encouraging adequate vitamin K intake, particularly among institutionalized elderly people, to prevent increased bone resorption"
-
Role of Vitamin K2 in the Development of Hepatocellular Carcinoma in Women With Viral Cirrhosis of the Liver - JAMA. 2004 Jul 21;292(3):358-61 -
"Hepatocellular carcinoma was detected in 2 of the 21 women given vitamin K2 and 9 of the 19 women in the control group ... the risk ratio for the development of hepatocellular carcinoma in patients given vitamin K2 was 0.13" - See
vitamin K2
 at iHerb.
- Vitamin K intake and bone mineral density in women and men - Am. J. of Clin. Nutr., 2/03 -
"Low dietary
vitamin K intake was associated with low BMD in women ... In contrast, there was no association between dietary vitamin K intake and BMD in men"
- Vitamin K supplementation in cystic fibrosis - Arch Dis Child. 2003 Nov;88(11):974-5 -
"a increased vitamin K intake may have significant health benefits for children with CF"
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