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Anti-aging Research > Telomerase
Telomere
I'm surprised that the below abstract regarding
vitamin D being associated with longer leukocyte telomere length didn't
hit the news. Telomere length is believed to be and important
factor in anti-aging. The way I understand it, when they cloned
Dolly (Sheep)
she was six years old when she was born because she had the telomere
length of her mother when she was born. Some theorize that was the
reason she had the diseases of old age such at arthritis at a young age
and died young. I understand that on Dolly's offspring, the
telomere length was reset to normal.
News and Research:
- Telomere - Wikipedia,
the free encyclopedia - "it has been hypothesized
that there is a trade-off between cancerous tumor suppression and tissue
repair capacity, in that lengthening telomeres might slow aging and in
exchange increase vulnerability to cancer (Weinstein and Ciszek, 2002)"
- Dolly (sheep) -
Wikipedia, the free encyclopedia - "A Finn Dorset
such as Dolly would have had a life expectancy of around 12 - 15 years, but
Dolly only lived to 6 years of age. Some believe the reason for this is
because Dolly was actually born genetically 6 years old, the same age as her
donor at the time that her genetic data was taken from her"
- Can We Cure Aging? - International Anti-Aging
Systems
-
Stress Promotes Cell Aging - About.com - "The telomeres of the women
suffering from severe stress (those caring for a chronically ill child) had
undergone shortening equivalent to about 10 years of additional aging when
compared with those of less-stressed women"
-
Clean living 'slows cell ageing' - BBC News, 9/15/08 -
"Among 24 men asked to adopt healthy lifestyle
changes for a US study in The Lancet Oncology, levels of telomerase
increased by 29% on average ... Telomerase repairs and lengthens telomeres,
which cap and protect the ends of chromosomes housing DNA ... These
consisted of a diet high in fruit and vegetables, supplements of vitamins
and fish oils, an exercise regimen and classes in stress management,
relaxation techniques and breathing exercises"
-
Sedentary Lifestyles Associated With Accelerated Aging Process - Science
Daily, 1/28/08 - "Telomere length decreased with age,
with an average loss of 21 nucleotides (structural units) per year. Men and
women who were less physically active in their leisure time had shorter
leukocyte telomeres than those who were more active. ... "The mean difference in
leukocyte telomere length between the most active [who performed an average of
199 minutes of physical activity per week] and least active [16 minutes of
physical activity per week] subjects was 200 nucleotides, which means that the
most active subjects had telomeres the same length as sedentary individuals up
to 10 years younger, on average."" - I'm must be in fat city on
this one. I must have averaged 60 minutes per day since I've been 18
which comes to 420 minutes per week. Maybe that's the main reason
people claim I look young. Plus I've always taken vitamin D which helps with
telomere length also. - Ben
-
Live longer with vitamin D, study says - Nutra USA, 11/9/07
-
Vitamin D 'may help slow ageing' - BBC News, 11/8/07 -
"those with higher vitamin D levels showed fewer
ageing-related changes in their DNA ...women with higher levels of vitamin D
were more likely to have longer telomeres in these cells, and vice versa"
- See
Vitamin D products at iHerb
 .
-
Decreased Vitamin D Levels Linked to Shorter Telomeres - Doctor's Guide,
6/5/07 - "Investigators found the
difference in TRFL between the highest and lowest tertiles of vitamin D was
92.6 base pairs (P =.006). That result was equivalent to 4.2 years of
telomeric aging"
-
Biological Aging
Predicts Heart Attack - WebMD, 1/11/07 -
"People who age fast -- as measured
by DNA shortening -- have a higher heart disease risk. Statin drugs may help
... Pravachol -- one of the "statin" family of cholesterol-lowering drugs --
dramatically lowered the heart disease risk of people with shorter
telomeres. But the drug seemed to have little effect on heart disease risk
in people with the longest telomeres"
-
Does Telomere Shortening Predict Dementia? A Critical Review - Doctor's
Guide, 4/24/06 - "Telomere lengths
in both the dementia and non-dementia patients showed no significant decline
with age"
-
Tiny
Roundworm's Telomeres Help Scientists To Tease Apart Different Types Of
Aging - Science Daily, 8/8/05 -
"telomeres alone do not dictate aging and lifespan ... For successful aging
you have to control both, aging in your dividing cells, which hinges on
telomere maintenance, but also aging in your non-dividing cells. We thought
that telomeres might play a role in the later but that's clearly not the
case ... What is probably playing a role in the other half of aging is the
insulin signaling pathway, proper mitochondrial function and dietary
restriction"
-
Obesity, Smoking Linked to Faster Aging - WebMD, 6/13/05 -
"Telomeres are the tips of the
chromosomes, which contain DNA. They gradually shorten over a lifetime ...
The difference in telomere length between being lean and being obese
corresponds to 8.8 years of aging ... Obesity and smoking are important risk
factors for many age-related diseases. Both are states of heightened
oxidative stress … and inflammation"
-
Extra Weight May Age You Faster - WebMD, 5/25/05 -
"inflammation burns out white blood
cells faster, and the effort of replacing them wears down the telomeres"
- Chronic Stress Makes Cells Age Faster - WebMD,
11/29/04 - "In
translating telomere length into years of aging, researchers determined the
cells from the highly stressed mothers had aged
from nine to 17 additional years compared with the cells from the low-stress
mothers"
- Shortened Chromosomes Linked To Early Stages Of Cancer Development
- Science Daily, 5/28/04
- Life Span Lives in Length of Chromosomes - WebMD,
1/31/03
- Chromosome Shrinkage May Promote Disease -
Intelihealth, 1/31/03
- Chromosome Ends In Elderly Could Show Mortality Risks
- Doctor's Guide, 1/31/03
-
Telomere Control & Cellular Aging - Life Extension Magazine, 9/02
- Shorter Lifespan Found In Study Of Cloned Mice -
Intelihealth, 2/11/02
-
Cell-life Extender Linked to Cancer - Nutrition Science News, 9/00
-
"Youth" Cells May Promote Cancer - Intelihealth, 6/14/00
-
Cloned Cows Cells Stay Young - Intelihealth, 4/28/00
-
Science takes cellular approach to explore aging process - CNN, 1/4/00
-
The Technology of Immortality - Life Enhancement Magazine, 7/99
-
Cloned sheep Dolly has 'old' DNA - CNN, 5/27/99
-
'Turning on' Telomerase To Stop Cell Aging: The Quest for Immortality -
Life Extension Magazine, 2/98
Abstracts:
-
Resveratrol reduces endothelial progenitor cells senescence through
augmentation of telomerase activity by Akt-dependent mechanisms - Br J
Pharmacol. 2008 Jun 30 - "Resveratrol significantly
increased telomerase activity and Akt phosphorylation ... Resveratrol
delayed the onset of EPC senescence and this effect was accompanied by
activation of telomerase through the PI3K-Akt signalling pathway. The
inhibition of EPCs senescence by resveratrol might protect EPCs against
dysfunction induced by pathological factors in vivo and improve EPC
functional activities in a way that may be important for cell therapy"
- See
Jarrow Resveratrol 100 at iHerb.
-
Telomere length and obesity - Acta Paediatr. 2008 Apr 21 -
"No difference was found between the TRF lengths of
obese and normal children. Obese adults had shorter TRF lengths than adults who
were not obese (mean TRF length difference, -884.5; 95% confidence intervals
-1727 to -41.8; t= 2.183; df = 17; p < 0.041)"
-
Telomere length in white blood cells, buccal cells and brain tissue and its
variation with ageing and Alzheimer's disease - Mech Ageing Dev. 2008 Jan 31
- "We observed a significantly lower telomere length in
white blood cells (P<0.0001) and buccal cells (P<0.01) in Alzheimer's patients
relative to healthy age-matched controls (31.4% and 32.3%, respectively)"
-
Telomere length may be associated with hypertension - J Hum Hypertens. 2007
Nov 29
-
Higher serum vitamin D concentrations are associated with longer leukocyte
telomere length in women - Am J Clin Nutr. 2007 Nov;86(5):1420-1425 -
"Leukocyte telomere length (LTL) ... higher vitamin D
concentrations, which are easily modifiable through nutritional supplementation,
are associated with longer LTL, which underscores the potentially beneficial
effects of this hormone on aging and age-related diseases" - See
vitamin D products at iHerb.
-
Obesity, cigarette smoking, and telomere length in women - Lancet. 2005 Aug
20-26;366(9486):662-4 - "telomere length
decreased steadily with age at a mean rate of 27 bp per year. Telomeres of obese
women were 240 bp shorter than those of lean women (p=0.026). A dose-dependent
relation with smoking was recorded (p=0.017), and each pack-year smoked was
equivalent to an additional 5 bp of telomere length lost (18%) compared with the
rate in the overall cohort"
-
Oxidative stress shortens telomeres - Trends Biochem Sci. 2002
Jul;27(7):339-44 - "oxidative stress
accelerates telomere loss, whereas antioxidants decelerate it"
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