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Anti-aging Research > SHBG
Sex Hormone Binding Globulin (SHBG)
Alternative News:
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Association of vitamin D status with serum androgen levels in men - Clin
Endocrinol (Oxf). 2009 Dec 29 - "Men with sufficient
25(OH)D levels (>/=30 mug/l) had significantly higher levels of testosterone
and FAI and significantly lower levels of SHBG when compared to 25(OH)D
insufficient (20-29.9 mug/l) and 25(OH)D deficient (<20 mug/l) men (p<0.05
for all). In linear regression analyses adjusted for possible confounders,
we found significant associations of 25(OH)D levels with testosterone, FAI,
and SHBG levels (p<0.05 for all). 25(OH)D, testosterone, and FAI levels
followed a similar seasonal pattern with a nadir in March (12.2 mug/l, 15.9
nmol/l, and 40.8, respectively) and peak levels in August (23.4 mug/l, 18.7
nmol/l, and 49.7, respectively) (p<0.05 for all). Conclusion: Androgen
levels and 25(OH)D levels are associated in men and reveal a concordant
seasonal variation" - See
vitamin D products at iHerb
 .
News & Research:
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High Serum
Testosterone Is Associated With Reduced Risk of Cardiovascular Events in Elderly
Men The MrOS (Osteoporotic Fractures in Men) Study in Sweden - J Am Coll
Cardiol. 2011 Oct 11;58(16):1674-81 - "During a median
5-year follow-up, 485 CV events occurred. Both total testosterone and SHBG
levels were inversely associated with the risk of CV events (trend over
quartiles: p = 0.009 and p = 0.012, respectively). Men in the highest quartile
of testosterone (≥550 ng/dl) had a lower risk of CV events compared with men in
the 3 lower quartiles (hazard ratio: 0.70, 95% confidence interval: 0.56 to
0.88). This association remained after adjustment for traditional CV risk
factors and was not materially changed in analyses excluding men with known CV
disease at baseline (hazard ratio: 0.71, 95% confidence interval: 0.53 to 0.95).
In models that included both testosterone and SHBG, testosterone but not SHBG
predicted CV risk"
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Sex
Hormone-Binding Globulin, But Not Testosterone, Is Associated Prospectively and
Independently With Incident Metabolic Syndrome in Men: The Framingham Heart
Study - Diabetes Care. 2011 Sep 16 - "Cross-sectionally,
testosterone and SHBG were more strongly associated with metabolic syndrome than
free testosterone in the training sample. SHBG, but not testosterone or free
testosterone, was significantly associated with metabolic syndrome after
adjusting for age, smoking, BMI, and insulin sensitivity (homeostasis model
assessment of insulin resistance [HOMA-IR]). These findings were confirmed in a
validation sample. Longitudinally, SHBG at examination 7, but not testosterone
or free testosterone, was associated with incident metabolic syndrome at
examination 8 after adjusting for age, smoking, BMI, and HOMA-IR. Multivariable
analyses suggested that age, BMI, and insulin sensitivity independently affect
SHBG and testosterone levels and the risk of metabolic syndrome and its
components"
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Serum sex
hormone-binding globulin levels are independently associated with nonalcoholic
fatty liver disease in patients with type 2 diabetes - Diabetes Res Clin
Pract. 2011 Aug 19
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SHBG, Sex
Hormones, and Inflammatory Markers in Older Women - J Clin Endocrinol Metab.
2011 Jan 14 - "In premenopausal and older women, high
testosterone and estradiol (E2) and low SHBG levels are associated with insulin
resistance and diabetes, conditions characterized by low-grade inflammation ...
SHBG was negatively associated with CRP (P = 0.007), IL-6 (P = 0.008), and
sIL-6r (P = 0.02). In addition, testosterone was positively associated with CRP
(P = 0.006), IL-6 (P = 0.001), and TNF-α (P = 0.0002). The negative relationship
between testosterone and sIL-6r in an age-adjusted model (P = 0.02) was no
longer significant in a fully adjusted model (P = 0.12). E2 was positively
associated with CRP (P = 0.002) but not with IL-6 in fully adjusted models. In a
final model including E2, testosterone, and SHBG, and all the confounders
previously considered, SHBG (0.23 ± 0.08; P = 0.006) and E2 (0.21 ± 0.08; P =
0.007), but not testosterone (P = 0.21), were still significantly associated
with CRP. Conclusion: In late postmenopausal women not on hormone replacement
therapy, SHBG and E2 are, respectively, negative and positive, independent and
significant correlates of a proinflammatory state"
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Why
coffee protects against diabetes - Science Daily, 1/12/11 -
"A protein called sex hormone-binding globulin (SHBG)
regulates the biological activity of the body's sex hormones, testosterone and
estrogen, which have long been thought to play a role in the development of type
2 diabetes. And coffee consumption, it turns out, increases plasma levels of
SHBG"
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Sex Hormones
and the Risk of Incident Prostate Cancer - Urology. 2010 May 6 -
"Serum testosterone, estradiol, estrone, and sex
hormone-binding globulin were assayed at baseline ... the mean age was 73 years.
Higher serum estrone was strongly related to an increased risk of prostate
cancer: compared with men in the lower quartile, the risk of prostate cancer
among those in the highest 3 quartiles (>24.9 pg/dL) was nearly 4-fold higher
(adjusted heart rate = 3.93, CI: 1.61-9.57). Other sex hormones were not
associated with the risk of prostate cancer" - The following results
for estrone are for women. I didn't find any results for men but
see the
"For Aromatization (in males):" section on my letrozole page.
-
Letrozole
suppresses plasma estradiol and estrone sulphate more completely
than anastrozole in postmenopausal women with breast cancer - J
Clin Oncol. 2008 Apr 1;26(10):1671-6 -
"Letrozole reduces plasma E2 and E1S levels to a significantly
greater extent than anastrozole" - See
Femara (letrozole)at OffshoreRX
 .
- Influence of
letrozole and anastrozole on total body aromatization and plasma estrogen
levels in postmenopausal breast cancer patients evaluated in a randomized,
cross-over study - J Clin Oncol. 2002 Feb 1;20(3):751-7 -
"estrone (E(1)), estradiol (E(2)), and estrone
sulfate (E(1)S) ... Treatment with anastrozole suppressed plasma levels of
E(1), E(2), and E(1)S by a mean of 81.0%, 84.9%, and 93.5%, respectively,
whereas treatment with letrozole caused a corresponding decrease of 84.3%,
87.8% and 98.0%, respectively. The suppression of E(1) and E(1)S was found
to be significantly better during treatment with letrozole compared with
anastrozole"
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Association of Testosterone and Sex Hormone-Binding Globulin with Metabolic
Syndrome and Insulin Resistance in Men - Diabetes Care. 2010 Apr 5 -
"men in the first quartile (lowest) (PR, 2.16; 95%
CI, 1.53-3.06) and second quartile of total testosterone (PR, 2.51; 95% CI,
1.86-3.37) were more likely to have metabolic syndrome than men in the
fourth quartile ... Similarly, men in the first quartile of SHBG (PR, 2.17;
95% CI, 1.32-3.56) were more likely to have metabolic syndrome than men in
the fourth quartile ... Low concentrations of total testosterone and SHBG
were strongly associated with increased likelihood of having metabolic
syndrome, independent of traditional cardiovascular risk factors and insulin
resistance"
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Low
testosterone levels and SHBG levels and high estradiol levels are
independent predictors of type 2 diabetes in men - Eur J Endocrinol.
2010 Jan 8 - "There was a significantly lowered
multi-adjusted risk for later diabetes with higher normal total testosterone
levels, both linearly per SD increase (HR 0.71, CI 0.54-0.92) and in the
higher quartiles of total testosterone compared to the lowest (HR 0.53, CI
0.33-0.84). A reduced multi-adjusted risk for incident diabetes was also
found for men with higher SHBG levels, both linearly per SD increase (HR
0.55, CI 0.39-0.79) and when comparing the third (HR 0.38, CI 0.18-0.81) and
the fourth quartile (HR 0.37, 0.17-0.82) to the lowest. The associations
with total testosterone and SHBG were no longer significant after inclusion
of waist circumference to the multivariate models. Estradiol was positively
associated with incident diabetes after multivariate adjustments including
waist circumference, when comparing the second (HR 0.49, CI 0.26-0.93) and
the third (HR 0.51, CI 0.27-0.96) quartile to the highest Conclusion. Men
with higher estradiol levels had an increased risk of later diabetes
independent of obesity, while men with lower total testosterone and SHBG had
an increased risk of diabetes that appeared dependent of obesity"
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Association of sex hormones and C-reactive protein levels in men - Clin
Endocrinol (Oxf). 2009 Sep 21 - "A robust, inverse
dose-response correlation between testosterone and SHBG levels with CRP
levels provides further evidence of a potential role of androgens in
inflammatory processes"
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New Sign of Diabetes Risk - WebMD, 9/16/09 -
"People with the lowest SHBG levels have a tenfold higher risk of type 2
diabetes than those with the highest SHBG levels"
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Sex
Hormones Associated With Broken Bones In Older Men - Science Daily,
8/3/09 - "Low levels of estradiol or high levels of
sex hormone binding globulin (SHBG) are associated with an increased risk of
osteoporotic fracture in older men"
-
FDA Revises Opinion of SHBG - Health Supplement Retailer, 8/4/03
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