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Anti-aging Research > Quercetin
Quercetin
Specific Recommendations:
News & Research:
-
Quercetin
- Vitacost Health Library
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Veggies, Exercise May Cut Cancer Risk - WebMD, 4/15/08 -
"People who ate quercetin-rich foods at least four
times a week, on average, were 51% less likely to have lung cancer than
those who ate none"
-
Onion compound linked to lower blood pressure - Nutra USA, 10/23/07 -
"receive a daily supplement of quercetin (730 mg,
USANA Health Sciences) or placebo for 28 days ... the hypertensives
receiving the quercitin supplement experienced reductions in systolic and
diastolic BP of seven and five mmHg, respectively, compared to placebo"
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Chemical in Curry
May Cut Colon Cancer - WebMD, 8/2/06 -
"Each of the patients then received
480 milligrams of curcumin and 20 milligrams of quercetin three times a day
for six months ... The results showed that treatment with the curry and
onion compounds reduced the average number of polyps by 60%, and decreased
their size by 50%" - See
iHerb
or
Vitacost
curcumin products and
iHerb
or
Vitacost
quercetin products.
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Apples May Ward Off Alzheimer's Disease
- WebMD, 11/18/04 -
"The results suggest that quercetin "contributes significantly" to the
protection of brain cells from free radicals in conditions like
Alzheimer's disease"
- Mediterranean diet 'extends life' - bbc.co.uk.
8/24/03 - "The[y] found that
quercetin, which is abundant in olive oil, has a similar effect"
- Drinking Tea May Help Prevent Heart Attacks -
Doctor's Guide, 5/9/02 - "Drinking
more tea and increasing
flavonoid intake may help primary prevention of
ischaemic heart disease ...
The intake of the dietary flavonoids quercetin,
kaempferol
and myricetin
was significantly associated inversely with fatal myocardial infarction only
in upper tertiles
of intake"
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Quercetin Relieves Prostate Pain - Nutrition Science News, 7/01
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Quercetin Is Promising for Chronic Prostatitis - Nutrition Science News,
4/01 - "an encouraging 59 percent of
the subjects improved"
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Canceling Cancer: New Cancer Prevention Strategies on the Horizon -
WebMD, 3/26/01 - "Xing has shown
that quercetin blocks androgen receptors when applied to cancer cells in the
laboratory ... We are very excited by our finding that the new approach
quercetin [can be used] in the fight against prostate cancer"
- Eating apples improves lung function - Doctor's
Guide, 1/26/00 - "Apples are high in
the antioxidant flavoid quercetin. This antioxidant is also found in onions,
tea and red wine and it may be important in protecting the lungs from the
harmful effects of atmospheric pollution and cigarette smoke"
- New
Study Offers Hope for Chronic Prostatitis Treatment
- Medscape, 1/00 -
"More than 80% of chronic prostatitis patients who took a proprietary
formulation of quercetin, a natural dietary supplement, significantly
reduced pain and improved their quality of life, according to a new study
published in the December issue of Urology"
Abstracts:
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Serum
C-reactive protein concentrations are inversely associated with
dietary flavonoid intake in u.s. Adults - J Nutr. 2008
Apr;138(4):753-60 - "Among the flavonoid
compounds investigated, quercetin, kaempferol, malvidin, peonidin,
daidzein, and genistein had inverse associations with serum CRP
concentration"
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Quercetin
inhibits vascular superoxide production induced by endothelin-1:
Role of NADPH oxidase, uncoupled eNOS and PKC - Atherosclerosis.
2008 Mar 16 - "Chronic administration of the
most abundant dietary flavonoid quercetin exerts antihypertensive
effects and improves endothelial function ... endothelin-1 (ET-1,
10nM). ET-1 increased the contractile response induced by
phenylephrine and reduced the relaxant responses to acetylcholine in
phenylephrine contracted intact aorta, and these effects were
prevented by co-incubation with quercetin, isorhamnetin or
chelerythrine (protein kinase C (PKC) inhibitor). This endothelial
dysfunction was also improved by superoxide dismutase (SOD),
apocynin (NADPH oxidase inhibitor) and sepiapterin (tetrahydrobiopterin
synthesis substrate). Furthermore, ET-1 increased intracellular
O(2)(-) production in all layers of the vessel, protein expression
of NADPH oxidase subunit p47(phox) without affecting p22(phox)
expression and lucigenin-enhanced chemiluminescence signal
stimulated by calcium ionophore A23187. All these changes were
prevented by both quercetin and isorhamnetin. Moreover, apocynin,
endothelium denudation and N(G)-nitro-l-arginine methylester
(l-NAME, nitric oxide synthase inhibitor) suppressed the
ET-1-induced increase in A23187-stimulated O(2)(-) generation.
Moreover, quercetin but not isorhamnetin, inhibited the increased
PKC activity induced by ET-1"
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The flavonoid
luteolin inhibits niacin-induced flush - Br J Pharmacol. 2008
Jan 28 - "Sustained release niacin
effectively lowers serum cholesterol, LDL and triglycerides, while
raising HDL. However, 75% of patients experience cutaneous warmth
and itching known as flush, leading to discontinuation.
Acetylsalicylic acid (aspirin) reduces this flush only by about 30%
... Quercetin and luteolin (4.3 mg per rat; 1000 mg per human),
administered i.p. 45 min prior to niacin, inhibited the niacin
effect by 96 and 88%, respectively. Aspirin (1.22 mg per rat; 325 mg
per human) inhibited the niacin effect by only 30%. Niacin almost
doubled plasma PGD(2) and 5-HT, but aspirin reduced only PGD(2) by
86%. In contrast, luteolin inhibited both plasma PGD(2) and 5-HT
levels by 100 and 67%, respectively"
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Quercetin selectively inhibits bioreduction and enhances apoptosis
in melanoma cells that overexpress tyrosinase - Nutr Cancer.
2007;59(2):258-68 - "quercetin can
selectively sensitize Tyr+ expressing melanoma cells to apoptosis
and may serve as an adjuvant to chemotherapy by enhancing cell death
and interfering with GST-mediated drug resistance"
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Quercetin reduces blood pressure in hypertensive subjects - J
Nutr. 2007 Nov;137(11):2405-11 - "730 mg
quercetin/d for 28 d vs. placebo ... reductions in (P < 0.01)
systolic (-7 +/- 2 mm Hg), diastolic (-5 +/- 2 mm Hg), and mean
arterial pressures (-5 +/- 2 mm Hg) were observed in stage 1
hypertensive patients after quercetin treatment"
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Comparative effects of quercetin and its predominant human
metabolites on adhesion molecule expression in activated human
vascular endothelial cells - Atherosclerosis. 2007 Sep 17 -
"both quercetin and its metabolites, at
physiological concentrations, can inhibit the expression of key
molecules involved in monocyte recruitment during the early stages
of atherosclerosis"
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