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Pterostilbene
Pterostilbene
Specific Recommendations:
News & Research:
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Pterostilbene ‘more potent than resveratrol’ for colon health: Study - Nutra
USA, 3/21/11 - "the chemopreventive effect of
pterostilbene was more potent than resveratrol and was associated with a
decreased inflammation as well as modulation of the antioxidant signaling
pathways in the colons of mice" - [Abstract]
Abstracts:
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Inhibitory
effects of resveratrol and pterostilbene on human colon cancer cells: a side by
side comparison - J Agric Food Chem. 2011 Sep 20 - "Cell viability tests
indicated that IC50s of pterostilbene were 2~5-fold lower than those of
resveratrol in all three cancer cells. Pterostilbene was also more potent in
inhibiting colony formation of all three cancer cells. Annexin V/Propidium
Iodide (PI) co-staining assay and western blotting analysis showed pterostilbene
had stronger apoptosis-inducing effects, which was evidenced by the higher
percentage of annexin V positive cells and higher levels of cleaved caspae-3 and
Poly (ADP-ribose) polymerase (PARP) proteins in cancer cells treated with
pterostilbene than resveratrol. High performance liquid chromatography (HPLC)
analysis demonstrated that intracellular levels of pterostilbene were 2~4-fold
higher than those of resveratrol after treatments with individual compounds at
the same concentration. Overall, our results demonstrated that pterostilbene had
more potent inhibitory effects on colon cancer cells than resveratrol, which may
be associated with the superior bioavailability of pterostilbene to resveratrol"
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Pterostilbene ‘more potent than resveratrol’ for colon health: Study - J
Agric Food Chem. 2011 Mar 23;59(6):2725-33 - "Inflammatory bowel diseases have
been a risk factor of colorectal cancer (CRC). The reactive oxygen species (ROS)
generated by inflammatory cells create oxidative stress and contribute to neoplastic transformation, proliferation, and even metastasis. Previously,
resveratrol (RS) and pterostilbene (PS) had been reported to prevent
chemical-induced colon carcinogenesis by anti-inflammatory and pro-apoptotic
properties ... Administrations of PS can be more effective than RS in reducing
AOM-induced formation of aberrant crypt foci (ACF), lymphoid nodules (LNs), and
tumors. We also find that PS is functioning more effectively than RS to reduce
nuclear factor-κB (NF-κB) activation by inhibiting the phosphorylation of
protein kinase C-β2 (PKC-β2) and decreasing downstream target gene expression,
including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and
aldose reductase (AR) in mouse colon stimulated by AOM. Moreover, administration
of RS and PS for 6 weeks significantly enhanced expression of antioxidant
enzymes, such as heme oxygenase-1 (HO-1) and glutathione reductase (GR), via
activation of NF-E2-related factor 2 (Nrf2) signaling. When the above findings
are taken together, they suggest that both stilbenes block cellular inflammation
and oxidative stress through induction of HO-1 and GR, thereby preventing
AOM-induced colon carcinogenesis. In comparison, PS was a more potent
chemopreventive agent than RS for the prevention of colon cancer. This is also
the first study to demonstrate that PS is a Nrf2 inducer and AR inhibitor in the
AOM-treated colon carcinogenesis model"
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