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Home > Anti-aging Research > Phosphatidylserine (PS)
Phosphatidylserine (PS)
Specific Recommendations:
News & Research:
-
Novel Strategy to Restore Brain Cell Function
- Life Extension Magazine, 5/06 -
"Alzheimer’s patients taking 300 mg of phosphatidylserine daily performed
significantly better on standardized memory tests at the end of the 12-week
trial period than did the study participants who received placebo.
Importantly, those patients who were the least afflicted by dementia
demonstrated the greatest benefit from phosphatidylserine therapy. These
results suggest that beginning supplementation very early on, or perhaps
even before the appearance of symptoms, can help prevent age-related loss of
memory and other cognitive impairments"
-
Cortisol, Stress, and Health
- Life Extension Magazine, 12/05 -
"Supplements to reduce high cortisol levels
secondary to stress ... Vitamin C: 1000-3000
mg/day ... Fish oil (omega-3 fatty
acids):1-4 gm/day ... Phosphatidylserine: 300-800 mg/day ...
Rhodiola rosea: 100-200 mg/day,
standardized extract ... Ginseng: 100-300
mg/day, standardized extract ... Ginkgo biloba:
100-200 mg/day, standardized extract ... DHEA:
25-50 mg/day (any hormone supplementation should be monitored by your
physician)"
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Cortisol
- Keeping a Dangerous Hormone in Check - Life Extension Magazine, 7/04 - "Phosphatidylserine, DHEA, and ginkgo biloba all have been shown to reduce the amount of cortisol produced
during stressful events, and these stress fighters can help retard the negative consequences of this hormone"
- Stress and Cortisol Levels - Vitamin Research News, 2/04 - "I want to reduce cortisol levels in my body ... Phosphatidylserine, 300 mg per day, is a good choice"
- FDA Allows Health Claim
 - Vitacost
News, 3/27/03 - "On February 24, 2003, the Food and Drug Administration (FDA) allowed two health claims for a nutrient called phosphatidylserine (PS). The first claim is that PS may reduce the risk
of cognitive dysfunction in the elderly with a second claim being that PS may reduce the risk of dementia in the elderly"
- Phospholipids: Versatile Nutraceutical Ingredients For Functional Foods - Functional Foods & Nutraceuticals, 12/02 - "Ryser concluded that PS yielded clinically significant benefit to
25 of the 27 children. PS improved attention, concentration, learning, behaviour and academic performance, seemingly extending their level of benefit once they had "plateaued"
on fish oil and other nutritional supplements. Those prescribed methylphenidate (Ritalin) or other pharmaceuticals also seemed to derive additional benefit from PS which also benefited the depression and anxiety commonly seen in these children"
- Using Complementary Treatments - PsychiatricTimes.com, 11/15/02 - "Phosphatidylserine is active at cell
membranes, including synaptic membrane zones. Partial improvement of learning and recall capacity was noted in subjects with age-related cognitive decline"
- Stress, Cortisol and Health - Supplement Watch Newsletter, 10/02 - "several lines of evidence have converged to solidify the concept that
stress makes us fat (because of cortisol), thins our bones (because of cortisol), shrinks our brains (because of cortisol), suppresses our immune system (because of cortisol), saps our energy levels (because of cortisol), and kills our sex drive (because of cortisol) ... Take a daily
multivitamin/multi-mineral supplement - because calcium, magnesium, vitamin C and B-complex vitamins are needed for a proper stress response ... Chief among the supplements with documented
cortisol-controlling effects are Phosphatidylserine, Beta-sitosterol, Magnolia bark, Theanine, Epimedium, Ashwagandha and
Passionflower"
-
Phosphatidylserine
(PS) The Essential Brain Nutrient - Life Extension Magazine, 9/02 - "Among its list of functions, phosphatidylserine stimulates the release of dopamine (a mood regulator that also control physical sensations, and movement), increases the
production of acetylcholine (necessary for learning and memory), enhances brain glucose metabolism (the fuel used for brain activity), reduces cortisol levels (a stress hormone), and boosts the activity of nerve growth factor (NGF),
which oversees the health of cholinergic neurons"
- A Supplement to Prevent Alzheimer’s - Dr. Weil, 8/20/02 - "In theory, PS works by strengthening cell membranes
thus protecting them and their contents from damage, particularly from the stress hormone cortisol"
- Choline Precursors Lower Stroke Death and Disability Rates, Meta-analysis Indicates - Doctor's Guide, 2/11/02 - "Choline precursors are a group
of molecules that get converted to phospholipids in the brain. Phospholipids perform many functions, including serving as crucial nerve cell membrane components and acting as neurotransmitters. Choline precursors include drugs like lecithin and citicoline ... Death and disability rate was 54.6 (611/1119) percent for
patients treated with choline precursors compared to 66.4 (561/844) percent for those on placebo ... choline precursors might improve ischemic brain damage in two ways, by neuroprotection or by enhancement of neurorepair processes"
- Phosphatidylserine Boosts Brain Function - Nutrition Science News, 3/01 - "Recent animal studies have now compared PS taken from different sources (egg, soy and cow brain),
and have found injectable soy PS to be on par with cow brain PS"
- The Latest from the American College of Sports Medicine - Nutrition Science News, 9/00 - "It is generally accepted that the enzyme creatine kinase is an indicator of
cell membrane damage and necrosis of the muscle fibers," says John Seifert, a principal investigator at St. Cloud. "Our work shows that PS supplementation results in significantly lower amounts of creatine kinase (CK) levels 24 hours after exercise. This implies that PS can help minimize muscle fiber damage caused
by muscular stress."
-
Enhancing
Cognitive Function - Life Extension Magazine, 5/00 - "It has been shown that PS can increase the number of neurotransmitter receptors back to youthful levels."
- Phosphatidylserine - Dr. Shahelian
Abstracts:
-
The effect
of phosphatidylserine-containing omega-3 fatty acids on memory abilities in
subjects with subjective memory complaints: a pilot study - Clin Interv
Aging. 2010 Nov 2;5:313-6 - "PS-omega-3 supplementation resulted in 42% increase
in the ability to recall words in the delayed condition" - See
phosphatidyl Serine products at iHerb and
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb.
-
Phosphatidylserine Containing omega-3 Fatty Acids May Improve Memory Abilities
in Non-Demented Elderly with Memory Complaints: A Double-Blind
Placebo-Controlled Trial - Dement Geriatr Cogn Disord. 2010 Jun
3;29(5):467-474 - "The results indicate that PS-DHA may improve cognitive
performance in non-demented elderly with memory complaints. Post-hoc analysis of
subgroups suggests that participants with higher baseline cognitive status were
most likely to respond to PS-DHA" - See
Jarrow Max DHA at iHerband
phosphatidylserine products at iHerb.
-
Effects of phosphatidylserine supplementation on exercising humans -
Sports Med. 2006;36(8):657-69 - "S-PtdSer
800 mg/day reduced the cortisol response to overtraining during weight
training while improving feeling of well-being and decreasing perceived
muscle soreness"
-
Effects of soy lecithin phosphatidic acid and
phosphatidylserine complex (PAS) on the endocrine and psychological
responses to mental stress - Stress. 2004
Jun;7(2):119-26 -
"These data provide initial evidence for a selective stress
dampening effect of PAS on the pituitary-adrenal axis, suggesting the
potential of PAS in the treatment of stress related disorders"
-
The influence of phosphatidylserine supplementation on mood and heart rate
when faced with an acute stressor - Nutr Neurosci. 2001;4(3):169-78 -
"In young adults, with neuroticism
scores above rather than below the median, the taking of 300mg PS each day
for a month was associated with feeling less stressed and having a better
mood"
-
Blunting by chronic phosphatidylserine administration of the stress-induced
activation of the hypothalamo-pituitary-adrenal axis in healthy men -
Eur J Clin Pharmacol. 1992;42(4):385-8 -
"chronic oral administration of
phosphatidylserine may counteract stress-induced activation of the
hypothalamo-pituitary-adrenal axis in man"
-
Effects of phosphatidylserine on the neuroendocrine response to physical
stress in humans - Neuroendocrinology. 1990 Sep;52(3):243-8 -
"Pretreatment with both 50 and 75 mg
BC-PS significantly blunted the ACTH and cortisol responses to physical
stress"
800 mg active phosphatidylserine has been show to
reduce cortisol by 30%. That's pretty significant. I feel that if there were a prescription drug that did that, it would be a first line treatment for
Cushing's. I'm sure the medical establishment will argue that there needs to be more studies. I agree, but who is going to pay for the studies on something that is not patentable and doctors can't get the big bucks to write a prescription for. Maybe the AMA will fund the study out of the kindness or
their heart. Yea, right!
Most PS sold is actually only 20% PS. Leci-PS® by
Cargil Bbioactives has 20%, 40% and 90% PS. I've got no
affiliation with them but feel that they have the best product. To get 800 mg active, it's eight 500 mg capsules of the usual 20% PS products. With Leci-PS 20 (which is 20% PS), it's about a 2.38 teaspoons. It is expensive stuff. Probably your best bet for phosphatidylserine is
iHerb.
Cushing's syndrome is caused by prolonged exposure of the body's tissues to high levels of the hormone cortisol. I've talked to doctors who implied that it was black and white, i.e. you have Cushing's or you don't. My personal opinion, and I'm not a doctor, is that there is
a linear gray area in between.
Other possible phosphatidylserine suppliers:
Related Searches:
Related Sites:
Recommended Reading:
- The Memory Cure by Phd Crppl. Thomas Iii, Thomas H. Crook, Brenda D. Adderly
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