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Anti-aging Research > Protein
Protein
Related Topics:
General Information:
- Protein - Harvard School of Public Health
-
Calcium & Milk: Nutrition Source - Harvard School of Public Health -
"Avoid too much protein. Getting too much protein can leach calcium from
your bones. As your body digests protein, it releases acids into the
bloodstream, which the body neutralizes by drawing calcium from the bones.
Animal protein seems to cause more of this calcium leaching than vegetable
protein does"
- Carbohydrates: Nutrition Source - Harvard School
of Public Health - "Protein intake
should be kept at moderate amounts (about 8 grams per day for every 20
pounds of body weight) and should be mainly vegetable protein"
- Dietary Protein Intake Differences Based on Activity Levels
- Medscape, 3/6/01 - "Research
clearly indicates that protein needs for athletes are greater than the
recommended 0.8 grams per kilogram of body weight recommended for sedentary
people ... Research supports a range in protein needs from 1.2 to 1.4 grams
of protein per kilogram body weight for endurance athletes such as
marathoners ... Excess protein intake is associated with dehydration, and
may be related to excessive urinary calcium losses ... an impairment of
kidney function has been associated with excessive protein intake" -
1 kilogram = 2.2 pounds, 154 pounds is 70 kilograms. So for an obese
154 pound marathoner, 1.4 x 70 = 98 grams of protein maximum. For a
sedentary 154 pound person, .8 x 70 = 56 grams.
News & Research:
- Magnesium: The Multi-Purpose Mineral - Think
Muscle Newsletter -
"It is important to note that increasing dietary protein intake may increase
magnesium requirements because high protein intake may decrease magnesium
retention"
-
Watching Your Protein May Be Key to Weight Control - WebMD, 10/12/11 -
"men and women fed a 10% protein diet ate 12% more
calories over four days than they did on a 15% protein diet ... When protein
in the diet goes too low, ''We keep eating in an attempt to attain our
target level of protein," ... As the protein declined to 10%, the men and
women tended to eat more carbohydrates and fat-containing food, boosting the
risk for weight gain. But Gosby found that increasing the protein from 15%
to 25% didn't seem to make any difference in total calories eaten ... Aiming
at 15%-25% of total energy intake as protein seems about right for a
moderately active person" - [Science Daily]
-
High-Protein Diet Raises Type 2 Diabetes Risk - Medscape, 9/13/11 -
"The study consisted of 27,140 individuals 45 to 74
years of age who participated in the Malmö Diet and Cancer study ... the
researchers found a 37% increased risk for type 2 diabetes associated with
high protein intake (hazard ratio [HR], 1.37; 95% confidence interval [CI],
1.17 to 1.61; P for trend < .001]. High intake of processed meat was also
associated with an elevated risk for diabetes (HR, 1.17; 95% CI, 1.00 to
1.36; P for trend = .005) ... The intake of breads and cereals rich in fiber
was associated with a lower risk of developing diabetes (HR, 0.95; 95% CI,
0.92 to 0.98; P for trend = .005)"
-
Eating
protein throughout the day preserves muscle and physical function in dieting
postmenopausal women, study suggests - Science Daily, 8/10/11 -
"higher
protein intake during weight loss can offset negative effects on muscle mass by
maintaining more muscle relative to the amount of weight lost. Women who ate
more protein lost 3.9 percent more weight and had a relative gain of 5.8 percent
more thigh muscle volume than woman who did not ... 31 healthy, postmenopausal
obese women were divided into two groups. Each group followed a 1,400-calorie
weight-loss diet based on USDA's My Pyramid, but one group received a powdered
whey protein supplement in the morning and again in the afternoon or evening;
the other received a placebo that contained carbohydrates ... We hypothesize
that more vigorous exercise -- in particular, resistance training -- would
preserve even more muscle" - See
whey products at iHerb
or try the yogurt recipe at the top of my yogurt page.
-
Low-carbohydrate, high-protein diets may reduce both tumor growth rates and
cancer risk - Science Daily, 6/14/11 - "The
first diet, a typical Western diet, contained about 55 percent carbohydrate,
23 percent protein and 22 percent fat. The second, which is somewhat like a
South Beach diet but higher in protein, contained 15 percent carbohydrate,
58 percent protein and 26 percent fat. They found that the tumor cells grew
consistently slower on the second diet ... As well, mice genetically
predisposed to breast cancer were put on these two diets and almost half of
them on the Western diet developed breast cancer within their first year of
life while none on the low-carbohydrate, high-protein diet did.
Interestingly, only one on the Western diet reached a normal life span
(approximately 2 years), with 70 percent of them dying from cancer while
only 30 percent of those on the low-carbohydrate diet developed cancer and
more than half these mice reached or exceeded their normal life span ...
tumor cells, unlike normal cells, need significantly more glucose to grow
and thrive. Restricting carbohydrate intake can significantly limit blood
glucose and insulin, a hormone that has been shown in many independent
studies to promote tumor growth in both humans and mice"
-
Protein drinks after exercise help maintain aging muscles - Science
Daily, 5/26/11 - "protein drinks after aerobic
activity increases the training effect after six weeks, when compared to
carbohydrate drinks. Additionally, this study suggests that this effect can
be seen using as little as 20 grams of protein"
-
High-Protein Diet Limits Bone Resorption - Doctor's Guide, 10/19/10 -
"The clinical takeaway message is that if you are a
postmenopausal woman and dieting, if you can take 24% of your total calories
as protein, and have adequate calcium and vitamin D, you can prevent the
bone loss that is typically associated with weight loss"
-
Animal-Based Low-Carbohydrate Diet Linked to Higher All-Cause Mortality
- Medscape, 9/7/10 - "In a pooled analysis comparing
the lowest vs the highest deciles, overall low-carbohydrate score was
associated with a slight increase in overall mortality rates (hazard ratio
[HR], 1.12; 95% confidence interval [CI], 1.01 - 1.24; P for trend = .136).
Higher animal-based low-carbohydrate score was associated with higher
all-cause mortality rates (pooled HR, 1.23; 95% CI, 1.11 - 1.37; P for trend
= .051), cardiovascular deaths (HR, 1.14; 95% CI, 1.01 - 1.29; P for trend =
.029), and cancer-related deaths (corresponding HR, 1.28; 95% CI, 1.02 -
1.60; P for trend = .089) ... In contrast, higher vegetable-based
low-carbohydrate score was linked to reduced all-cause mortality rates (HR,
0.80; 95% CI, 0.75 - 0.85; P for trend ≤ .001) and cardiovascular deaths
(HR, 0.77; 95% CI, 0.68 - 0.87; P for trend < .001)"
-
High-protein diets may cause bone loss in older women, study - Nutra
USA, 7/8/10 - "Study 1 ... on average, all women
lost around 19 pounds, but those who ate the higher-protein, meat-containing
diet also lost bone mineral density by about 1.4 percent ... Study 2 ... All
women lost weight, but the groups that consumed the higher-protein
meat-containing diets again also lost bone mineral density by up to 1.4
percent compared to the control group ... In the first study, all the
participants con­sumed calcium supplements to achieve calcium intakes of
2,000mg per day. In the second study, about half of the participants
con­sumed calcium supplements ... However, in neither case were the
supplements found to impact the loss of bone density"
-
Eat less, live longer? - New Scientist, 6/3/10 -
"One piece of evidence for this idea comes from studies in fruit flies and
rodents. If these animals are fed special diets with less amino acids - the
building blocks of proteins - they can eat as many calories as they want and
still live longer ... The protein theory is bad news for people on
low-carbohydrate weight-loss plans like the Atkins diet. "I'd be wary of
diets that put a heavy emphasis on protein," says Piper. "It's hard to see
how that could be healthy." Fontana goes one step further, saying that
high-protein diets could risk accelerated ageing and cancer ... There may be
another reason for vegans to celebrate. Studies on flies and rodents suggest
that cutting intake of one particular amino acid, called methionine,
lengthens life to a similar degree as calorie restriction. Proteins in meat
and other animal products have high levels of methionine, so a vegan diet
would score well by that measure, too"
-
Dietary protein may reduce hip fractures in the elderly - Science Daily,
5/5/10 - "individuals who were in the lowest 25
percent of dietary protein intake had approximately 50 percent more hip
fractures than those who consumed greater amounts of dietary protein (all
within normal intakes). Those who suffered hip fractures consumed less than
the 46 grams of dietary protein per day recommended for adults"
-
Protein supplements are misused by athletes - Science Daily, 1/19/10
-
'Anti-Atkins' Low Protein Diet Extends Lifespan In Flies - Science
Daily, 10/1/09 - Science Daily, 10/1/09 - "Flies fed
an "anti-Atkins" low protein diet live longer because their mitochondria
function better"
-
High-Carb, High-Fat Diets Better for Cognitive Performance - Medscape,
9/1/09 - "Diets high in carbohydrates or fat can
lead to significantly better cognitive-performance and inflight-testing
scores in pilots than diets high in protein"
-
Low-carb
Diets Linked To Atherosclerosis And Impaired Blood Vessel Growth -
Science Daily, 8/25/09 - "Even as
low-carbohydrate/high-protein diets have proven successful at helping
individuals rapidly lose weight, little is known about the diets' long-term
effects on vascular health ... mice placed on a 12-week low
carbohydrate/high-protein diet showed a significant increase in
atherosclerosis, a buildup of plaque in the heart's arteries and a leading
cause of heart attack and stroke ... our research suggests that, at least in
animals, these diets could be having adverse cardiovascular effects that are
not reflected in simple serum markers"
-
Recipe for Diabetes: Too Much Protein, Fat - WebMD, 4/7/09 -
"A high-fat diet may lead to insulin resistance, a
major step on the path to type 2 diabetes. But cutting back on fat may not
help those who continue to eat too much protein"
-
Eating Red, Processed Meat Associated With Increased Risk of Death From All
Causes - Doctor's Guide, 3/23/09 - "When
comparing the one-fifth of participants who ate the most white meat to the
one-fifth who ate the least white meat, those with high white meat intake
had a slightly lower risk for total death, death from cancer and death from
causes other than heart disease or cancer ... For overall mortality, 11% of
deaths in men and 16% of deaths in women could be prevented if people
decreased their red meat consumption to the level of intake in the first
quintile ... The impact on cardiovascular disease mortality was an 11%
decrease in men and a 21% decrease in women if the red meat consumption was
decreased to the amount consumed by individuals in the first quintile. For
women eating processed meat at the first quintile level, the decrease in
cardiovascular disease mortality was approximately 20%" - [Science
Daily]
-
Calcium And Vitamin D May Not Be The Only Protection Against Bone Loss -
Science Daily, 12/3/08 - "Diets that are high in
protein and cereal grains produce an excess of acid in the body which may
increase calcium excretion and weaken bones ... When fruits and vegetables
are metabolized they add bicarbonate, an alkaline compound, to the body ...
bicarbonate had a favorable effect on bone resorption and calcium excretion
... 171 men and women aged 50 and older were randomized to receive placebo
or doses of either: potassium bicarbonate, sodium bicarbonate, or potassium
chloride for three months. Researchers found that subjects taking
bicarbonate had significant reductions in calcium excretion, signaling a
decrease in bone resorption"
-
Optimal protein intake in the elderly - Clin Nutr. 2008 Sep 24 -
"It appears that an intake of 1.5gprotein/kg/day, or
about 15-20% of total caloric intake, is a reasonable target for elderly
individuals wishing to optimize protein intake in terms of health and
function"
-
High protein breakfast could aid weight loss - Nutra USA, 9/3/08
-
Scientists find 'proof' for high protein diets - Nutra USA, 9/7/06
-
Protein + Exercise May Promote Weight Loss - WebMD, 8/29/05 -
"obese women who exercised regularly
and ate a reduced-calorie diet high in protein lost more fat and less muscle
than those who ate a similar diet high in carbohydrates. Both diets
contained the same number of total calories and percentage of calories from
fat"
-
The Protein Solution - washingtonpost.com, 7/19/05
-
Diet Study: Protein May Help Tame Appetite - WebMD, 7/13/05
-
Low-Carb Diets: More Protein May Not Help - WebMD, 4/15/05
- High protein promotes bone health - Nutra USA,
4/5/04
- Improved Glucose Response with High-protein Diet in Individuals with Type 2
Diabetes - Doctor's Guide, 10/16/03 -
"either a control diet designed according to the recommendations of the
American Diabetes Association (protein:carbohydrate:fat, 15:55:30) or a
high-protein diet (30:40:30) for a period of 5 weeks ... fasting glucose
concentration was consistently lower after the high-protein diet, with no
significant change in body weight. The mean 24-hour integrated glucose area
responses (with fasting glucose concentration as baseline) were 34.1 ± 7.2
mmol x h/L and 21.0 ± 4.2 mmol x h/L after the control and high-protein
diets, respectively, revealing a 40% decrease with the high-protein diet"
- High-Protein Diet Helpful in Type 2 Diabetes -
Medscape, 10/6/03 - "The ratio of
protein to carbohydrate to fat was 30:40:30 in the high-protein diet and
15:55:30 in the control diet ... there was a 40% decrease in the mean
24-hour integrated glucose area response after the high-protein diet.
Patients on the high-protein diet also fared better in terms of decrease in glycated
hemoglobin ... longer-term studies are necessary to determine the total
magnitude of response, possible adverse effects, and the long-term
acceptability of the diet"
- High Protein Diets More Effective At Maintaining Weight Loss
- Doctor's Guide, 6/4/03 - "Despite
no differences in attitudes to eating, a protein intake of 18% as energy
versus 15% as energy resulted in improved weight maintenance, as well as
improved fat distribution based on body waist circumference, and improved
substrate oxidation and satiety"
- Scientific Evidence Lacking on High-Protein, Low-Carbohydrate Diets
- WebMD, 4/8/03
- Whey Better
Protein? - Dr. Weil, 3/19/03
- High-Protein Diets Can Hurt Kidneys - WebMD,
3/17/03
-
Interaction of Dietary Calcium and Protein in Bone Health in Humans - J.
Nutr. 133:852S-854S, 3/03 - "Protein
has both positive and negative effects on calcium
balance, and the net effect of dietary protein on bone mass and
fracture risk may be dependent on the dietary calcium intake. In
addition to providing substrate for bone matrix, dietary protein stimulates
the production of insulin-like growth factor-1 (IGF-1), a factor that
promotes osteoblast-mediated
bone formation. Protein also increases urinary calcium losses, by several
proposed mechanisms. Increasing calcium intake may offset the negative
impact of dietary protein on urinary calcium losses, allowing the favorable
effect of protein on the IGF-1 axis to dominate"
- Protein Diet May Prompt Weight Loss - WebMD,
2/7/03 - "The study was funded by
beef producers and Kraft Foods, which makes dairy products, as well as the
USDA and Illinois Council on Food and Agricultural Research ... "However,
what concerns me is that in this study, they provided all the food for four
weeks so they could make sure the participants that were getting more
protein got very lean meat. They also received intensive counseling for the
next six weeks ... and they still didn't have as good cholesterol reductions
as those eating what is a typical diet," she tells WebMD. "If you tell
someone to eat seven servings of beef a week, I doubt they will be as
careful in choosing the leanest cuts of beef, and as a result, they may
consume even more saturated fat and dietary cholesterol. What's more, if I
was counseling someone to eat more protein to get
leucine,
I would stress baked or broiled fish, nonfat dairy products, and legumes.""
- Vegetarians:
Pondering Protein? - Dr. Weil, 12/11/02
- Low-Carbohydrate, High-Protein Diets: Are They Safe?
- New Hope Natural Media, 12/5/02 -
"Low-carbohydrate, high-protein diets are known to suppress the appetite and
to curb feelings of hunger, which is why many people lose weight on these
types of diets. However, consuming these diets can result in the depletion
of minerals such as potassium and magnesium, which are needed to maintain a
normal heart rhythm. This mineral-losing effect may be compounded when the
daily calorie intake is restricted"
- American Heart Association Statement on High-Protein, Low-Carbohydrate Diet
Study Presented at Scientific Sessions - AHA,
11/19/02
- Experts
ping-pong on protein advice - MSNBC, 10/22/02 -
"Now protein can range from 10 percent to 35 percent of daily intake. At the
annual meeting of the American Dietetic Association this week, nutritionists
basically admitted that they really don’t know how much protein Americans
need ... Studies have shown that you need to get at least 76 grams of
protein, so that means you have to go to the upper ranges of the protein
recommendations for a 1,200 calorie diet"
- High Protein Diet Helps Control Blood Glucose in Untreated Type 2 Diabetics
- Doctor's Guide, 9/5/02
- Low-Carbohydrate, High-Protein Diets Increase Risk Of Kidney Stones And May
Raise Bone Loss Risk - Doctor's Guide, 8/1/02 - "acid excretion - a marker for the acid load in the blood -
increased as much as 90 percent while subjects were on
diets that severely restricted
carbohydrates. Levels of urinary citrate, which inhibits
kidney stones, fell by almost 25 percent in the group during the
six-week study ... People may lose weight on this diet, but this study shows
that this is not a healthy way to lose weight ... there was an increased
risk of developing kidney stones and a possible increase in the risk of
bone loss"
- High-Protein Diets Cause Dehydration - WebMD,
4/22/02
- Increased Protein And Reduced Fat Has No Significant Effect On Weight Loss
Among Type 2 Diabetics - Doctor's Guide, 4/11/02
- Aging Bone Mineral Density Better With High Protein Diet Plus Extra Calcium,
Vitamin D - Doctor's Guide, 4/1/02
- High-Protein Diet Could Repair Bone Loss - WebMD,
3/25/02 - "The supplement group --
particularly those who ate a diet high in protein -- had significantly
better bone mass density -- an accurate measure of
bone loss. Those who took the placebo, however, had less
calcium absorbed into their bloodstream when they consumed more protein"
- High-Protein Beats High-Carbohydrate for Weight Loss in Low-Fat Diets
- Doctor's Guide, 2/26/02 -
"Measurements taken after a 10 hour
fast and at 2.5-hour post breakfast, lunch and dinner showed that
postprandial thermogenesis
averaged about twofold higher on the high-protein against the
high-carbohydrate diet ... Nitrogen balance on the high protein diet was
found to be significantly greater than the high-carbohydrate diet"
- Mother's Diet During Pregnancy May Influence Child's Blood Pressure Later In
Life - Intelihealth, 1/17/02 -
"Pregnant women who consume a diet rich in animal protein and low in
carbohydrates may be more likely to have children with elevated blood
pressure later in life"
- Health Experts Advise Against High-Protein Diets -
WebMD, 10/8/01
- Prone to Kidney Stones? Watch What You Eat -
WebMD, 7/20/01 - "On average, the
men with a history of kidney stones developed higher levels of oxalate in
their urine while on the high protein diet compared with the medium protein
diet"
- Many Parents Are Confused About What to Feed Growing Athletes
- WebMD, 7/6/01 - "The survey of
parents of 6- to 12-year-old athletes, conducted by the American Dietetic
Association's sports group, SCAN (Sports, Cardiovascular and Wellness
Nutritionists) found that 60% said athletic kids need lots of protein to
increase muscle size. However, such kids actually need a diet rich in
breads, cereals, pasta, and other carbohydrates because carbs are the body's
main energy source for exercise and the major fuel for the brain ... "Despite
the popular myth, extra protein doesn't mean bigger muscles because muscle
size is dependent on calories, physical maturity, genetics, and training,"
she tells WebMD. The athletic kid's diet ratio should be 50-55%
carbohydrate, 10-15% protein and 30% fat"
-
Pregnant Women Need a Balanced Diet That's 'Just Right' - WebMD, 6/1/01
- "Women given supplements
containing large amounts of protein actually had babies that were smaller on
average than women who did not take the supplements. That led the
government, which sets the Recommended Daily Allowance (RDA), to lower its
recommended level of daily protein for pregnant women from 74 grams per day
to 60 grams"
-
WebMD Goes One-on-One With the 'Revolutionary' Robert C. Atkins, MD -
WebMD, 3/23/01
-
Heart Association to warn against low-carb diets - CNN, 3/20/01
-
The Protein Connection - Nutrition Science News, 1/01
-
Protein That Helps May Also Harm in High Amounts - WebMD, 10/2/00
-
Protein Popularity: The Evidence Behind the Hype - WebMD, 4/25/00
- Too much
animal protein causes osteoporosis - drmirkin.com, 1/11/00
-
Atkins' Diet: Can We Have Our Turkey and Eat it Too? - CNN, 11/26/99
-
Group Calls Low-Carb Diet Unhealthy - Intelihealth, 10/18/99
-
Survey: Many opt for high-protein, low-carb diets - CNN, 3/5/99
- Low-Protein
Diet Postpones Dialysis In Chronic Kidney Failure Patients - Doctor's
Guide, 2/16/99
- The Low
Down on High Protein Diets - Healthcalc, 10/13/98
Abstracts:
-
A diet
with 35 % of energy from protein leads to kidney damage in female Sprague-Dawley
rats - Br J Nutr. 2011 May 3:1-8 - "High-protein
(HP) diets for weight loss remain popular despite questions surrounding
overall safety. In a recent study using the pig model, we showed that
long-term intakes from whole proteins at 35 % energy (en %) cause moderate
renal histological damage. To examine whether this observation may be
species specific or more generalisable, the effect of this diet in rats was
examined ... Rats consuming the HP diet had 17 % higher kidney weights (P <
0·0001), three times higher proteinuria (P < 0·0001) and 27 % higher
creatinine clearance (P = 0·0012) compared with those consuming the NP diet.
Consistent with this, HP-fed rats had larger glomeruli (P < 0·0001) and more
glomerulosclerosis (P = 0·0003) compared with NP-fed rats. The HP diet also
resulted in altered levels of free monocyte chemoattractant protein-1 (P <
0·0001). The histological changes are consistent with those observed in the
pig model. In contrast to the pig model, the elevated proteinuria and
creatinine clearance observed in the rat model are also usually observed
with HP consumption in human subjects. These results indicate that the rat
is a useful model for HP effects on the kidney and, along with previous
results using the pig model, suggest that long-term intake of high levels of
protein may be detrimental to renal health"
-
A
protein-rich beverage consumed as a breakfast meal leads to weaker
appetitive and dietary responses v. a protein-rich solid breakfast meal in
adolescents - Br J Nutr. 2011 Feb 15:1-5 - "A
total of fifteen adolescents (eight girls and seven boys; age 14 (sem 1)
years, BMI percentile 79 (sem 4) %) randomly completed two testing days that
included protein-rich (PR) breakfast meals (38 % of energy as protein, 48 (sem
2) g/meal) provided as a solid (S) or beverage (B). Breakfast was 24 % of
estimated daily energy needs (2146 (sem 96) kJ/meal). Perceived appetite and
satiety responses were collected over 5 h followed by an ad libitum lunch
buffet. The PR-S meal led to greater reductions in 4 h postprandial appetite
( - 6221 (sem 1171) mm × 240 min) v. the PR-B meal ( - 3570 (sem 957) mm ×
240 min; P < 0·05). When examining the data according to hourly responses,
the PR-S meal led to greater reductions in appetite during postprandial
hours 2, 3 and 4 v. the PR-B meal (all comparisons, P < 0·05). No
differences in postprandial hourly or total (4 h) fullness were observed
following the PR-S v. PR-B meals. The PR-S meal led to approximately 480 kJ
less energy consumed at the ad libitum lunch buffet (1418 (sem 222) kJ) v.
the PR-B meal (1900 (sem 326) kJ; P < 0·05). These data indicate that,
although the food form of the PR breakfast meals had little, if any, effect
on satiety, the appetitive responses were diminished and the subsequent food
intake was greater when protein was consumed as a beverage v. a solid meal"
-
Dietary
protein and risk of ischemic heart disease in middle-aged men - Am J
Clin Nutr. 2010 Sep 29 - "The RR of IHD was 1.08
(95% CI: 0.95, 1.23; P for trend = 0.30) comparing the top with the bottom
quintile of percentage of energy from total protein. RRs for animal and
vegetable protein were 1.11 (95% CI: 0.97, 1.28; P for trend = 0.18) and
0.93 (95% CI: 0.78, 1.12; P for trend = 0.49), respectively. When the
population was restricted to "healthy" men (those free of hypertension,
hypercholesterolemia, and diabetes at baseline), the RR of IHD was 1.21 (95%
CI: 1.01, 1.44; P for trend = 0.02) for total protein, 1.25 (95% CI: 1.04,
1.51; P for trend = 0.02) for animal protein, and 0.93 (95% CI: 0.72, 1.19;
P for trend = 0.65) for vegetable protein ... We observed no association
between dietary protein and risk of total IHD in this group of men aged
40-75 y. However, higher intake of animal protein may be associated with an
increased risk of IHD in "healthy" men"
-
Acid
diet (high-meat protein) effects on calcium metabolism and bone health -
Curr Opin Clin Nutr Metab Care. 2010 Aug 16 -
"Increased potential renal acid load resulting from a high protein (intake
above the current Recommended Dietary Allowance of 0.8 g protein/kg body
weight) intake has been closely associated with increased urinary calcium
excretion. However, recent findings do not support the assumption that bone
is lost to provide the extra calcium found in urine. Neither whole body
calcium balance is, nor are bone status indicators, negatively affected by
the increased acid load. Contrary to the supposed detrimental effect of
protein, the majority of epidemiological studies have shown that long-term
high-protein intake increases bone mineral density and reduces bone fracture
incidence. The beneficial effects of protein such as increasing intestinal
calcium absorption and circulating IGF-I whereas lowering serum parathyroid
hormone sufficiently offset any negative effects of the acid load of protein
on bone health"
-
Major
Dietary Protein Sources and Risk of Coronary Heart Disease in Women -
Circulation. 2010 Aug 16 - "26 years of follow-up
... higher intakes of red meat, red meat excluding processed meat, and
high-fat dairy were significantly associated with elevated risk of CHD.
Higher intakes of poultry, fish, and nuts were significantly associated with
lower risk. In a model controlling statistically for energy intake, 1
serving per day of nuts was associated with a 30% (95% confidence interval,
17% to 42%) lower risk of CHD compared with 1 serving per day of red meat.
Similarly, compared with 1 serving per day of red meat, a lower risk was
associated with 1 serving per day of low-fat dairy (13%; 95% confidence
interval, 6% to 19%), poultry (19%; 95% confidence interval, 3% to 33%), and
fish (24%; 95% confidence interval, 6% to 39%). Conclusions-These data
suggest that high red meat intake increases risk of CHD and that CHD risk
may be reduced importantly by shifting sources of protein in the US diet"
-
Long-Term High Intake of Whole Proteins Results in Renal Damage in Pigs
- J Nutr. 2010 Jul 28 - "These findings suggest that
long-term intakes of protein at the upper limit of the AMDR from whole
protein sources may compromise renal health"
-
Intake
of plant foods and associated nutrients in prostate cancer risk - Nutr
Cancer. 2009;61(2):216-24 - "Plant foods and
associated nutrients may impact prostate cancer (PC) risk and survival ...
Reduced PC risk was associated with the highest tertile of cryptoxanthin (OR
= 0.51; 95% CI = 0.35-0.75), fiber (OR = 0.56; 95% CI = 0.35-0.89), vitamin
C (OR = 0.60; 95% CI = 0.41-0.88), and fruits and/or fruit juices (OR =
0.46; 95% CI = 0.31-0.68), with significant linear trends. Increased risk of
PC was associated with the highest tertile of protein (OR = 1.99; 95% CI =
1.05-3.79) and daily servings of grains (OR = 1.99; 95% CI = 1.23-3.22) with
significant linear trends"
-
Inadequate dietary protein increases hunger and desire to eat in younger and
older men - J Nutr. 2007 Jun;137(6):1478-82 - "younger and older men who consume
inadequate protein experience appetite changes that may promote increased
food intake"
-
Effect of high protein vs high carbohydrate intake on insulin
sensitivity, body weight, hemoglobin A1c, and blood pressure in patients
with type 2 diabetes mellitus - J Am Diet Assoc.
2005 Apr;105(4):573-80 - "Both the high-carbohydrate and high-protein groups lost
weight (-2.2+/-0.9 kg, -2.5+/-1.6 kg, respectively, P <.05) and the
difference between the groups was not significant ( P =.9). In the
high-carbohydrate group, hemoglobin A1c decreased (from 8.2% to 6.9%, P
<.03), fasting plasma glucose decreased (from 8.8 to 7.2 mmol/L, P <.02),
and insulin sensitivity increased (from 12.8 to 17.2 mumol/kg/min, P <.03).
No significant changes in these parameters occurred in the high-protein
group, instead systolic and diastolic blood pressures decreased (-10.5+/-2.3
mm Hg, P =.003 and -18+/-9.0 mm Hg, P <.05, respectively)"
-
The impact of dietary protein on calcium absorption and
kinetic measures of bone turnover in women - J
Clin Endocrinol Metab. 2004 Nov 16 - "The high protein diet caused a
significant reduction in the fraction of urinary calcium of bone origin and
a nonsignificant
trend toward a reduction in the rate of bone resorption.
There were no protein induced effects on net bone balance. These data
directly demonstrate that, at least in the short-term, high protein diets
are not detrimental to bone"
- High-protein, low-fat diets are effective for weight loss and favorably
alter biomarkers in healthy adults - J Nutr. 2004
Mar;134(3):586-91 - "low-fat,
energy-restricted diets of varying protein content (15 or 30% energy)
promoted healthful weight loss, but diet satisfaction was greater in those
consuming the high-protein diet"
-
Dietary protein intake and urinary excretion of calcium: a cross-sectional
study in a healthy Japanese population - Am J Clin Nutr 1998
Mar;67(3):438-444 - "Our findings suggest
that excess protein, especially that rich in sulfur-containing amino acids,
in habitual diets may augment calcium excretion in the urine, at least in
the elderly."
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