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Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.

Home > Anti-aging Research > Protein

Protein

Related Topics:

General Information:

  • Protein -  Harvard School of Public Health
  • Calcium & Milk: Nutrition Source - Harvard School of Public Health - "Avoid too much protein. Getting too much protein can leach calcium from your bones. As your body digests protein, it releases acids into the bloodstream, which the body neutralizes by drawing calcium from the bones. Animal protein seems to cause more of this calcium leaching than vegetable protein does"
  • Carbohydrates: Nutrition Source - Harvard School of Public Health - "Protein intake should be kept at moderate amounts (about 8 grams per day for every 20 pounds of body weight) and should be mainly vegetable protein"
  • Dietary Protein Intake Differences Based on Activity Levels - Medscape, 3/6/01 - "Research clearly indicates that protein needs for athletes are greater than the recommended 0.8 grams per kilogram of body weight recommended for sedentary people ... Research supports a range in protein needs from 1.2 to 1.4 grams of protein per kilogram body weight for endurance athletes such as marathoners ... Excess protein intake is associated with dehydration, and may be related to excessive urinary calcium losses ... an impairment of kidney function has been associated with excessive protein intake" - 1 kilogram = 2.2 pounds, 154 pounds is 70 kilograms.  So for an obese 154 pound marathoner, 1.4 x 70 = 98 grams of protein maximum.  For a sedentary 154 pound person, .8 x 70 = 56 grams.

News & Research:

  • Magnesium: The Multi-Purpose Mineral - Think Muscle Newsletter - "It is important to note that increasing dietary protein intake may increase magnesium requirements because high protein intake may decrease magnesium retention"
  • Watching Your Protein May Be Key to Weight Control - WebMD, 10/12/11 - "men and women fed a 10% protein diet ate 12% more calories over four days than they did on a 15% protein diet ... When protein in the diet goes too low, ''We keep eating in an attempt to attain our target level of protein," ... As the protein declined to 10%, the men and women tended to eat more carbohydrates and fat-containing food, boosting the risk for weight gain. But Gosby found that increasing the protein from 15% to 25% didn't seem to make any difference in total calories eaten ... Aiming at 15%-25% of total energy intake as protein seems about right for a moderately active person" - [Science Daily]
  • High-Protein Diet Raises Type 2 Diabetes Risk - Medscape, 9/13/11 - "The study consisted of 27,140 individuals 45 to 74 years of age who participated in the Malmö Diet and Cancer study ... the researchers found a 37% increased risk for type 2 diabetes associated with high protein intake (hazard ratio [HR], 1.37; 95% confidence interval [CI], 1.17 to 1.61; P for trend < .001]. High intake of processed meat was also associated with an elevated risk for diabetes (HR, 1.17; 95% CI, 1.00 to 1.36; P for trend = .005) ... The intake of breads and cereals rich in fiber was associated with a lower risk of developing diabetes (HR, 0.95; 95% CI, 0.92 to 0.98; P for trend = .005)"
  • Eating protein throughout the day preserves muscle and physical function in dieting postmenopausal women, study suggests - Science Daily, 8/10/11 - "higher protein intake during weight loss can offset negative effects on muscle mass by maintaining more muscle relative to the amount of weight lost. Women who ate more protein lost 3.9 percent more weight and had a relative gain of 5.8 percent more thigh muscle volume than woman who did not ... 31 healthy, postmenopausal obese women were divided into two groups. Each group followed a 1,400-calorie weight-loss diet based on USDA's My Pyramid, but one group received a powdered whey protein supplement in the morning and again in the afternoon or evening; the other received a placebo that contained carbohydrates ... We hypothesize that more vigorous exercise -- in particular, resistance training -- would preserve even more muscle" - See whey products at iHerb or try the yogurt recipe at the top of my yogurt page.
  • Low-carbohydrate, high-protein diets may reduce both tumor growth rates and cancer risk - Science Daily, 6/14/11 - "The first diet, a typical Western diet, contained about 55 percent carbohydrate, 23 percent protein and 22 percent fat. The second, which is somewhat like a South Beach diet but higher in protein, contained 15 percent carbohydrate, 58 percent protein and 26 percent fat. They found that the tumor cells grew consistently slower on the second diet ... As well, mice genetically predisposed to breast cancer were put on these two diets and almost half of them on the Western diet developed breast cancer within their first year of life while none on the low-carbohydrate, high-protein diet did. Interestingly, only one on the Western diet reached a normal life span (approximately 2 years), with 70 percent of them dying from cancer while only 30 percent of those on the low-carbohydrate diet developed cancer and more than half these mice reached or exceeded their normal life span ... tumor cells, unlike normal cells, need significantly more glucose to grow and thrive. Restricting carbohydrate intake can significantly limit blood glucose and insulin, a hormone that has been shown in many independent studies to promote tumor growth in both humans and mice"
  • Protein drinks after exercise help maintain aging muscles - Science Daily, 5/26/11 - "protein drinks after aerobic activity increases the training effect after six weeks, when compared to carbohydrate drinks. Additionally, this study suggests that this effect can be seen using as little as 20 grams of protein"
  • High-Protein Diet Limits Bone Resorption - Doctor's Guide, 10/19/10 - "The clinical takeaway message is that if you are a postmenopausal woman and dieting, if you can take 24% of your total calories as protein, and have adequate calcium and vitamin D, you can prevent the bone loss that is typically associated with weight loss"
  • Animal-Based Low-Carbohydrate Diet Linked to Higher All-Cause Mortality - Medscape, 9/7/10 - "In a pooled analysis comparing the lowest vs the highest deciles, overall low-carbohydrate score was associated with a slight increase in overall mortality rates (hazard ratio [HR], 1.12; 95% confidence interval [CI], 1.01 - 1.24; P for trend = .136). Higher animal-based low-carbohydrate score was associated with higher all-cause mortality rates (pooled HR, 1.23; 95% CI, 1.11 - 1.37; P for trend = .051), cardiovascular deaths (HR, 1.14; 95% CI, 1.01 - 1.29; P for trend = .029), and cancer-related deaths (corresponding HR, 1.28; 95% CI, 1.02 - 1.60; P for trend = .089) ... In contrast, higher vegetable-based low-carbohydrate score was linked to reduced all-cause mortality rates (HR, 0.80; 95% CI, 0.75 - 0.85; P for trend ≤ .001) and cardiovascular deaths (HR, 0.77; 95% CI, 0.68 - 0.87; P for trend < .001)"
  • High-protein diets may cause bone loss in older women, study - Nutra USA, 7/8/10 - "Study 1 ... on average, all women lost around 19 pounds, but those who ate the higher-protein, meat-containing diet also lost bone mineral density by about 1.4 percent ... Study 2 ... All women lost weight, but the groups that consumed the higher-protein meat-containing diets again also lost bone mineral density by up to 1.4 percent compared to the control group ... In the first study, all the participants con&shy;sumed calcium supplements to achieve calcium intakes of 2,000mg per day. In the second study, about half of the participants con&shy;sumed calcium supplements ... However, in neither case were the supplements found to impact the loss of bone density"
  • Eat less, live longer? - New Scientist, 6/3/10 - "One piece of evidence for this idea comes from studies in fruit flies and rodents. If these animals are fed special diets with less amino acids - the building blocks of proteins - they can eat as many calories as they want and still live longer ... The protein theory is bad news for people on low-carbohydrate weight-loss plans like the Atkins diet. "I'd be wary of diets that put a heavy emphasis on protein," says Piper. "It's hard to see how that could be healthy." Fontana goes one step further, saying that high-protein diets could risk accelerated ageing and cancer ... There may be another reason for vegans to celebrate. Studies on flies and rodents suggest that cutting intake of one particular amino acid, called methionine, lengthens life to a similar degree as calorie restriction. Proteins in meat and other animal products have high levels of methionine, so a vegan diet would score well by that measure, too"
  • Dietary protein may reduce hip fractures in the elderly - Science Daily, 5/5/10 - "individuals who were in the lowest 25 percent of dietary protein intake had approximately 50 percent more hip fractures than those who consumed greater amounts of dietary protein (all within normal intakes). Those who suffered hip fractures consumed less than the 46 grams of dietary protein per day recommended for adults"
  • Protein supplements are misused by athletes - Science Daily, 1/19/10
  • 'Anti-Atkins' Low Protein Diet Extends Lifespan In Flies - Science Daily, 10/1/09 - Science Daily, 10/1/09 - "Flies fed an "anti-Atkins" low protein diet live longer because their mitochondria function better"
  • High-Carb, High-Fat Diets Better for Cognitive Performance - Medscape, 9/1/09 - "Diets high in carbohydrates or fat can lead to significantly better cognitive-performance and inflight-testing scores in pilots than diets high in protein"
  • Low-carb Diets Linked To Atherosclerosis And Impaired Blood Vessel Growth - Science Daily, 8/25/09 - "Even as low-carbohydrate/high-protein diets have proven successful at helping individuals rapidly lose weight, little is known about the diets' long-term effects on vascular health ... mice placed on a 12-week low carbohydrate/high-protein diet showed a significant increase in atherosclerosis, a buildup of plaque in the heart's arteries and a leading cause of heart attack and stroke ... our research suggests that, at least in animals, these diets could be having adverse cardiovascular effects that are not reflected in simple serum markers"
  • Recipe for Diabetes: Too Much Protein, Fat - WebMD, 4/7/09 - "A high-fat diet may lead to insulin resistance, a major step on the path to type 2 diabetes. But cutting back on fat may not help those who continue to eat too much protein"
  • Eating Red, Processed Meat Associated With Increased Risk of Death From All Causes - Doctor's Guide, 3/23/09 - "When comparing the one-fifth of participants who ate the most white meat to the one-fifth who ate the least white meat, those with high white meat intake had a slightly lower risk for total death, death from cancer and death from causes other than heart disease or cancer ... For overall mortality, 11% of deaths in men and 16% of deaths in women could be prevented if people decreased their red meat consumption to the level of intake in the first quintile ... The impact on cardiovascular disease mortality was an 11% decrease in men and a 21% decrease in women if the red meat consumption was decreased to the amount consumed by individuals in the first quintile. For women eating processed meat at the first quintile level, the decrease in cardiovascular disease mortality was approximately 20%" - [Science Daily]
  • Calcium And Vitamin D May Not Be The Only Protection Against Bone Loss - Science Daily, 12/3/08 - "Diets that are high in protein and cereal grains produce an excess of acid in the body which may increase calcium excretion and weaken bones ... When fruits and vegetables are metabolized they add bicarbonate, an alkaline compound, to the body ... bicarbonate had a favorable effect on bone resorption and calcium excretion ... 171 men and women aged 50 and older were randomized to receive placebo or doses of either: potassium bicarbonate, sodium bicarbonate, or potassium chloride for three months. Researchers found that subjects taking bicarbonate had significant reductions in calcium excretion, signaling a decrease in bone resorption"
  • Optimal protein intake in the elderly - Clin Nutr. 2008 Sep 24 - "It appears that an intake of 1.5gprotein/kg/day, or about 15-20% of total caloric intake, is a reasonable target for elderly individuals wishing to optimize protein intake in terms of health and function"
  • High protein breakfast could aid weight loss - Nutra USA, 9/3/08
  • Scientists find 'proof' for high protein diets - Nutra USA, 9/7/06
  • Protein + Exercise May Promote Weight Loss - WebMD, 8/29/05 - "obese women who exercised regularly and ate a reduced-calorie diet high in protein lost more fat and less muscle than those who ate a similar diet high in carbohydrates. Both diets contained the same number of total calories and percentage of calories from fat"
  • The Protein Solution - washingtonpost.com, 7/19/05
  • Diet Study: Protein May Help Tame Appetite - WebMD, 7/13/05
  • Low-Carb Diets: More Protein May Not Help - WebMD, 4/15/05
  • High protein promotes bone health - Nutra USA, 4/5/04
  • Improved Glucose Response with High-protein Diet in Individuals with Type 2 Diabetes - Doctor's Guide, 10/16/03 - "either a control diet designed according to the recommendations of the American Diabetes Association (protein:carbohydrate:fat, 15:55:30) or a high-protein diet (30:40:30) for a period of 5 weeks ... fasting glucose concentration was consistently lower after the high-protein diet, with no significant change in body weight. The mean 24-hour integrated glucose area responses (with fasting glucose concentration as baseline) were 34.1 ± 7.2 mmol x h/L and 21.0 ± 4.2 mmol x h/L after the control and high-protein diets, respectively, revealing a 40% decrease with the high-protein diet"
  • High-Protein Diet Helpful in Type 2 Diabetes - Medscape, 10/6/03 - "The ratio of protein to carbohydrate to fat was 30:40:30 in the high-protein diet and 15:55:30 in the control diet ... there was a 40% decrease in the mean 24-hour integrated glucose area response after the high-protein diet. Patients on the high-protein diet also fared better in terms of decrease in glycated hemoglobin ... longer-term studies are necessary to determine the total magnitude of response, possible adverse effects, and the long-term acceptability of the diet"
  • High Protein Diets More Effective At Maintaining Weight Loss - Doctor's Guide, 6/4/03 - "Despite no differences in attitudes to eating, a protein intake of 18% as energy versus 15% as energy resulted in improved weight maintenance, as well as improved fat distribution based on body waist circumference, and improved substrate oxidation and satiety"
  • Scientific Evidence Lacking on High-Protein, Low-Carbohydrate Diets - WebMD, 4/8/03
  • Whey Better Protein? - Dr. Weil, 3/19/03
  • High-Protein Diets Can Hurt Kidneys - WebMD, 3/17/03
  • Interaction of Dietary Calcium and Protein in Bone Health in Humans - J. Nutr. 133:852S-854S, 3/03 - "Protein has both positive and negative effects on calcium balance, and the net effect of dietary protein on bone mass and fracture risk may be dependent on the dietary calcium intake. In addition to providing substrate for bone matrix, dietary protein stimulates the production of insulin-like growth factor-1 (IGF-1), a factor that promotes osteoblast-mediated bone formation. Protein also increases urinary calcium losses, by several proposed mechanisms. Increasing calcium intake may offset the negative impact of dietary protein on urinary calcium losses, allowing the favorable effect of protein on the IGF-1 axis to dominate"
  • Protein Diet May Prompt Weight Loss - WebMD, 2/7/03 - "The study was funded by beef producers and Kraft Foods, which makes dairy products, as well as the USDA and Illinois Council on Food and Agricultural Research ... "However, what concerns me is that in this study, they provided all the food for four weeks so they could make sure the participants that were getting more protein got very lean meat. They also received intensive counseling for the next six weeks ... and they still didn't have as good cholesterol reductions as those eating what is a typical diet," she tells WebMD. "If you tell someone to eat seven servings of beef a week, I doubt they will be as careful in choosing the leanest cuts of beef, and as a result, they may consume even more saturated fat and dietary cholesterol. What's more, if I was counseling someone to eat more protein to get leucine, I would stress baked or broiled fish, nonfat dairy products, and legumes.""
  • Vegetarians: Pondering Protein? - Dr. Weil, 12/11/02
  • Low-Carbohydrate, High-Protein Diets: Are They Safe? - New Hope Natural Media, 12/5/02 - "Low-carbohydrate, high-protein diets are known to suppress the appetite and to curb feelings of hunger, which is why many people lose weight on these types of diets. However, consuming these diets can result in the depletion of minerals such as potassium and magnesium, which are needed to maintain a normal heart rhythm. This mineral-losing effect may be compounded when the daily calorie intake is restricted"
  • American Heart Association Statement on High-Protein, Low-Carbohydrate Diet Study Presented at Scientific Sessions - AHA, 11/19/02
  • Experts ping-pong on protein advice - MSNBC, 10/22/02 - "Now protein can range from 10 percent to 35 percent of daily intake. At the annual meeting of the American Dietetic Association this week, nutritionists basically admitted that they really don’t know how much protein Americans need ... Studies have shown that you need to get at least 76 grams of protein, so that means you have to go to the upper ranges of the protein recommendations for a 1,200 calorie diet"
  • High Protein Diet Helps Control Blood Glucose in Untreated Type 2 Diabetics - Doctor's Guide, 9/5/02
  • Low-Carbohydrate, High-Protein Diets Increase Risk Of Kidney Stones And May Raise Bone Loss Risk - Doctor's Guide, 8/1/02 - "acid excretion - a marker for the acid load in the blood - increased as much as 90 percent while subjects were on diets that severely restricted carbohydrates. Levels of urinary citrate, which inhibits kidney stones, fell by almost 25 percent in the group during the six-week study ... People may lose weight on this diet, but this study shows that this is not a healthy way to lose weight ... there was an increased risk of developing kidney stones and a possible increase in the risk of bone loss"
  • High-Protein Diets Cause Dehydration - WebMD, 4/22/02
  • Increased Protein And Reduced Fat Has No Significant Effect On Weight Loss Among Type 2 Diabetics - Doctor's Guide, 4/11/02
  • Aging Bone Mineral Density Better With High Protein Diet Plus Extra Calcium, Vitamin D - Doctor's Guide, 4/1/02
  • High-Protein Diet Could Repair Bone Loss - WebMD, 3/25/02 - "The supplement group -- particularly those who ate a diet high in protein -- had significantly better bone mass density -- an accurate measure of bone loss. Those who took the placebo, however, had less calcium absorbed into their bloodstream when they consumed more protein"
  • High-Protein Beats High-Carbohydrate for Weight Loss in Low-Fat Diets - Doctor's Guide, 2/26/02 - "Measurements taken after a 10 hour fast and at 2.5-hour post breakfast, lunch and dinner showed that postprandial thermogenesis averaged about twofold higher on the high-protein against the high-carbohydrate diet ... Nitrogen balance on the high protein diet was found to be significantly greater than the high-carbohydrate diet"
  • Mother's Diet During Pregnancy May Influence Child's Blood Pressure Later In Life - Intelihealth, 1/17/02 - "Pregnant women who consume a diet rich in animal protein and low in carbohydrates may be more likely to have children with elevated blood pressure later in life"
  • Health Experts Advise Against High-Protein Diets - WebMD, 10/8/01
  • Prone to Kidney Stones? Watch What You Eat - WebMD, 7/20/01 - "On average, the men with a history of kidney stones developed higher levels of oxalate in their urine while on the high protein diet compared with the medium protein diet"
  • Many Parents Are Confused About What to Feed Growing Athletes - WebMD, 7/6/01 - "The survey of parents of 6- to 12-year-old athletes, conducted by the American Dietetic Association's sports group, SCAN (Sports, Cardiovascular and Wellness Nutritionists) found that 60% said athletic kids need lots of protein to increase muscle size. However, such kids actually need a diet rich in breads, cereals, pasta, and other carbohydrates because carbs are the body's main energy source for exercise and the major fuel for the brain ... "Despite the popular myth, extra protein doesn't mean bigger muscles because muscle size is dependent on calories, physical maturity, genetics, and training," she tells WebMD. The athletic kid's diet ratio should be 50-55% carbohydrate, 10-15% protein and 30% fat"
  • Pregnant Women Need a Balanced Diet That's 'Just Right' - WebMD, 6/1/01 - "Women given supplements containing large amounts of protein actually had babies that were smaller on average than women who did not take the supplements. That led the government, which sets the Recommended Daily Allowance (RDA), to lower its recommended level of daily protein for pregnant women from 74 grams per day to 60 grams"
  • WebMD Goes One-on-One With the 'Revolutionary' Robert C. Atkins, MD - WebMD, 3/23/01
  • Heart Association to warn against low-carb diets - CNN, 3/20/01
  • The Protein Connection - Nutrition Science News, 1/01
  • Protein That Helps May Also Harm in High Amounts - WebMD, 10/2/00
  • Protein Popularity: The Evidence Behind the Hype - WebMD, 4/25/00
  • Too much animal protein causes osteoporosis - drmirkin.com, 1/11/00
  • Atkins' Diet: Can We Have Our Turkey and Eat it Too? - CNN, 11/26/99
  • Group Calls Low-Carb Diet Unhealthy - Intelihealth, 10/18/99
  • Survey: Many opt for high-protein, low-carb diets - CNN, 3/5/99
  • Low-Protein Diet Postpones Dialysis In Chronic Kidney Failure Patients - Doctor's Guide, 2/16/99
  • The Low Down on High Protein Diets - Healthcalc, 10/13/98

Abstracts:

  • A diet with 35 % of energy from protein leads to kidney damage in female Sprague-Dawley rats - Br J Nutr. 2011 May 3:1-8 - "High-protein (HP) diets for weight loss remain popular despite questions surrounding overall safety. In a recent study using the pig model, we showed that long-term intakes from whole proteins at 35 % energy (en %) cause moderate renal histological damage. To examine whether this observation may be species specific or more generalisable, the effect of this diet in rats was examined ... Rats consuming the HP diet had 17 % higher kidney weights (P < 0·0001), three times higher proteinuria (P < 0·0001) and 27 % higher creatinine clearance (P = 0·0012) compared with those consuming the NP diet. Consistent with this, HP-fed rats had larger glomeruli (P < 0·0001) and more glomerulosclerosis (P = 0·0003) compared with NP-fed rats. The HP diet also resulted in altered levels of free monocyte chemoattractant protein-1 (P < 0·0001). The histological changes are consistent with those observed in the pig model. In contrast to the pig model, the elevated proteinuria and creatinine clearance observed in the rat model are also usually observed with HP consumption in human subjects. These results indicate that the rat is a useful model for HP effects on the kidney and, along with previous results using the pig model, suggest that long-term intake of high levels of protein may be detrimental to renal health"
  • A protein-rich beverage consumed as a breakfast meal leads to weaker appetitive and dietary responses v. a protein-rich solid breakfast meal in adolescents - Br J Nutr. 2011 Feb 15:1-5 - "A total of fifteen adolescents (eight girls and seven boys; age 14 (sem 1) years, BMI percentile 79 (sem 4) %) randomly completed two testing days that included protein-rich (PR) breakfast meals (38 % of energy as protein, 48 (sem 2) g/meal) provided as a solid (S) or beverage (B). Breakfast was 24 % of estimated daily energy needs (2146 (sem 96) kJ/meal). Perceived appetite and satiety responses were collected over 5 h followed by an ad libitum lunch buffet. The PR-S meal led to greater reductions in 4 h postprandial appetite ( - 6221 (sem 1171) mm × 240 min) v. the PR-B meal ( - 3570 (sem 957) mm × 240 min; P < 0·05). When examining the data according to hourly responses, the PR-S meal led to greater reductions in appetite during postprandial hours 2, 3 and 4 v. the PR-B meal (all comparisons, P < 0·05). No differences in postprandial hourly or total (4 h) fullness were observed following the PR-S v. PR-B meals. The PR-S meal led to approximately 480 kJ less energy consumed at the ad libitum lunch buffet (1418 (sem 222) kJ) v. the PR-B meal (1900 (sem 326) kJ; P < 0·05). These data indicate that, although the food form of the PR breakfast meals had little, if any, effect on satiety, the appetitive responses were diminished and the subsequent food intake was greater when protein was consumed as a beverage v. a solid meal"
  • Dietary protein and risk of ischemic heart disease in middle-aged men - Am J Clin Nutr. 2010 Sep 29 - "The RR of IHD was 1.08 (95% CI: 0.95, 1.23; P for trend = 0.30) comparing the top with the bottom quintile of percentage of energy from total protein. RRs for animal and vegetable protein were 1.11 (95% CI: 0.97, 1.28; P for trend = 0.18) and 0.93 (95% CI: 0.78, 1.12; P for trend = 0.49), respectively. When the population was restricted to "healthy" men (those free of hypertension, hypercholesterolemia, and diabetes at baseline), the RR of IHD was 1.21 (95% CI: 1.01, 1.44; P for trend = 0.02) for total protein, 1.25 (95% CI: 1.04, 1.51; P for trend = 0.02) for animal protein, and 0.93 (95% CI: 0.72, 1.19; P for trend = 0.65) for vegetable protein ... We observed no association between dietary protein and risk of total IHD in this group of men aged 40-75 y. However, higher intake of animal protein may be associated with an increased risk of IHD in "healthy" men"
  • Acid diet (high-meat protein) effects on calcium metabolism and bone health - Curr Opin Clin Nutr Metab Care. 2010 Aug 16 - "Increased potential renal acid load resulting from a high protein (intake above the current Recommended Dietary Allowance of 0.8 g protein/kg body weight) intake has been closely associated with increased urinary calcium excretion. However, recent findings do not support the assumption that bone is lost to provide the extra calcium found in urine. Neither whole body calcium balance is, nor are bone status indicators, negatively affected by the increased acid load. Contrary to the supposed detrimental effect of protein, the majority of epidemiological studies have shown that long-term high-protein intake increases bone mineral density and reduces bone fracture incidence. The beneficial effects of protein such as increasing intestinal calcium absorption and circulating IGF-I whereas lowering serum parathyroid hormone sufficiently offset any negative effects of the acid load of protein on bone health"
  • Major Dietary Protein Sources and Risk of Coronary Heart Disease in Women - Circulation. 2010 Aug 16 - "26 years of follow-up ... higher intakes of red meat, red meat excluding processed meat, and high-fat dairy were significantly associated with elevated risk of CHD. Higher intakes of poultry, fish, and nuts were significantly associated with lower risk. In a model controlling statistically for energy intake, 1 serving per day of nuts was associated with a 30% (95% confidence interval, 17% to 42%) lower risk of CHD compared with 1 serving per day of red meat. Similarly, compared with 1 serving per day of red meat, a lower risk was associated with 1 serving per day of low-fat dairy (13%; 95% confidence interval, 6% to 19%), poultry (19%; 95% confidence interval, 3% to 33%), and fish (24%; 95% confidence interval, 6% to 39%). Conclusions-These data suggest that high red meat intake increases risk of CHD and that CHD risk may be reduced importantly by shifting sources of protein in the US diet"
  • Long-Term High Intake of Whole Proteins Results in Renal Damage in Pigs - J Nutr. 2010 Jul 28 - "These findings suggest that long-term intakes of protein at the upper limit of the AMDR from whole protein sources may compromise renal health"
  • Intake of plant foods and associated nutrients in prostate cancer risk - Nutr Cancer. 2009;61(2):216-24 - "Plant foods and associated nutrients may impact prostate cancer (PC) risk and survival ... Reduced PC risk was associated with the highest tertile of cryptoxanthin (OR = 0.51; 95% CI = 0.35-0.75), fiber (OR = 0.56; 95% CI = 0.35-0.89), vitamin C (OR = 0.60; 95% CI = 0.41-0.88), and fruits and/or fruit juices (OR = 0.46; 95% CI = 0.31-0.68), with significant linear trends. Increased risk of PC was associated with the highest tertile of protein (OR = 1.99; 95% CI = 1.05-3.79) and daily servings of grains (OR = 1.99; 95% CI = 1.23-3.22) with significant linear trends"
  • Inadequate dietary protein increases hunger and desire to eat in younger and older men - J Nutr. 2007 Jun;137(6):1478-82 - "younger and older men who consume inadequate protein experience appetite changes that may promote increased food intake"
  • Effect of high protein vs high carbohydrate intake on insulin sensitivity, body weight, hemoglobin A1c, and blood pressure in patients with type 2 diabetes mellitus - J Am Diet Assoc. 2005 Apr;105(4):573-80 - "Both the high-carbohydrate and high-protein groups lost weight (-2.2+/-0.9 kg, -2.5+/-1.6 kg, respectively, P <.05) and the difference between the groups was not significant ( P =.9). In the high-carbohydrate group, hemoglobin A1c decreased (from 8.2% to 6.9%, P <.03), fasting plasma glucose decreased (from 8.8 to 7.2 mmol/L, P <.02), and insulin sensitivity increased (from 12.8 to 17.2 mumol/kg/min, P <.03). No significant changes in these parameters occurred in the high-protein group, instead systolic and diastolic blood pressures decreased (-10.5+/-2.3 mm Hg, P =.003 and -18+/-9.0 mm Hg, P <.05, respectively)"
  • The impact of dietary protein on calcium absorption and kinetic measures of bone turnover in women - J Clin Endocrinol Metab. 2004 Nov 16 - "The high protein diet caused a significant reduction in the fraction of urinary calcium of bone origin and a nonsignificant trend toward a reduction in the rate of bone resorption. There were no protein induced effects on net bone balance. These data directly demonstrate that, at least in the short-term, high protein diets are not detrimental to bone"
  • High-protein, low-fat diets are effective for weight loss and favorably alter biomarkers in healthy adults - J Nutr. 2004 Mar;134(3):586-91 - "low-fat, energy-restricted diets of varying protein content (15 or 30% energy) promoted healthful weight loss, but diet satisfaction was greater in those consuming the high-protein diet"
  • Dietary protein intake and urinary excretion of calcium: a cross-sectional study in a healthy Japanese population - Am J Clin Nutr 1998 Mar;67(3):438-444 - "Our findings suggest that excess protein, especially that rich in sulfur-containing amino acids, in habitual diets may augment calcium excretion in the urine, at least in the elderly."

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