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Home > Health Conditions > Neuropathic Pain
Neuropathic Pain/Neuropathy
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Neuropathy
and Diabetic Neuropathy - Life Extension Foundation
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Pain
(Chronic) - Life Extension Foundation
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Switching from pathogenetic treatment with alpha-lipoic acid to gabapentin and
other analgesics in painful diabetic neuropathy: a real-world study in
outpatients - J Diabetes Complications. 2008 Apr 8 - "The daily costs for alpha-lipoic acid were considerably lower than those for
gabapentin or several frequently used drug combinations. The frequency of
outpatient visits was 3.8 times per 3 months during the treatment period with
alpha-lipoic acid, while it increased to 7.9 per 3 months after switching to
gabapentin or the other pain medications. In conclusion, switching from
long-term treatment with alpha-lipoic acid to central analgesic drugs such as
gabapentin in painful diabetic neuropathy was associated with considerably
higher rates of side effects, frequencies of outpatient visits, and daily costs
of treatment. The pathogenic treatment option represents for the practicing
diabetologist an effective, safe, and cost-effective treatment option for the
majority of patients with diabetic polyneuropathy" - See alpha lipoic acid products at iHerb
 .
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Alpha-Linolenic Acid May Lower Risk of Diabetic Peripheral Neuropathy -
Medscape, 1/7/08 - "Alpha-linolenic acid is an
omega-3 fatty acid found in many vegetable oils, including flaxseed,
walnuts, and canola oil ... Relative to adults in the lowest quintile of
alpha-linolenic acid intake (< 0.61 g/day), the multivariate-adjusted odds
of having peripheral neuropathy was 0.54 for subjects in the fourth quintile
(1.35 - 2.10 g/day) of intake and 0.40 for adults in the fifth quintile
(2.11 g/day or higher)" - See
flax seed products at iHerb
 .
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The effect of alpha-lipoic acid on symptoms and skin blood flow in diabetic
neuropathy - Diabet Med. 2007 May 8 - "study suggests that alpha-lipoic
acid, a potent antioxidant, improves symptoms of diabetic neuropathy"
-
Oral
Treatment With {alpha}-Lipoic Acid Improves Symptomatic Diabetic Polyneuropathy:
The SYDNEY 2 trial - Diabetes Care. 2006 Nov;29(11):2365-2370 -
"Oral treatment with ALA for 5 weeks
improved neuropathic symptoms and deficits in patients with DSP. An oral dose of
600 mg once daily appears to provide the optimum risk-to-benefit ratio" -
See
iHerb
or Vitacost
alpha lipoic acid products.
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Copper Deficiency May Be Cause of Mysterious Neuropathy - Doctor's Guide,
5/31/06 - "Unexplained neuropathy may be
the result of a copper deficiency ... Copper deficiency has long been associated
with anemia and neutropenia, but its neurological consequences have only
recently been recognized"
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Treatment for diabetic mononeuropathy with alpha-lipoic acid - Int J
Clin Pract. 2005 Jun;59(6):645-50 -
"alpha-lipoic acid appears to be an effective drug in the treatment for not
only peripheral and autonomic diabetic neuropathy, but also diabetic mononeuropathy of the cranial nerves leading to full recovery of the
patients" - See
iHerb
or Vitacost
alpha lipoic acid products.
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Benfotiamine in the treatment of diabetic polyneuropathy--a three-week
randomized, controlled pilot study (BEDIP study) - Int J Clin Pharmacol
Ther. 2005 Feb;43(2):71-7 - "A
statistically significant (p = 0.0287) improvement in the neuropathy score
was observed in the group given active drug when compared to the
placebo-treated controls"
- Common Nutrient May Ease Diabetic Pain - WebMD, 1/6/05 -
"a 1,000 milligrams three times a day of acetyl-L-carnitine was effective in
relieving pain caused by nerve damage associated with the condition"
- Supplemental Carnitine May Be Helpful in Diabetic Neuropathy - Medscape, 1/3/05 -
"Pain as the most bothersome symptom significantly improved
with ALC"
- Acetyl-L-Carnitine Improves Pain, Nerve Regeneration, and Vibratory Perception in Patients With Chronic Diabetic Neuropathy: An analysis of two randomized
placebo-controlled trials - Diabetes Care. 2005 Jan;28(1):89-94 -
"ALC treatment is efficacious in alleviating symptoms, particularly pain, and improves nerve fiber regeneration and vibration perception in patients with
established diabetic neuropathy"
- Needle Away Neuropathy? - Dr. Weil, 4/12/04
- Antioxidant [alpha]-Lipoic Acid Provides Relief for Diabetic Polyneuropathy - Doctor's Guide, 6/20/03 -
"After 3 weeks,
alpha-lipoic acid had a 24.1% improvement over placebo ... for TSS [Total Symptom Score] and 16.0% for NIS [Neuropathy Impairment Score]" -
See
iHerb
or Vitacost
alpha lipoic acid products.
- Alpha Lipoic Acid Helping the Fight against Diabetes - Physician's Weekly, 5/12/03 -
"the over-the-counter antioxidant supplement
alpha lipoic acid has been effective against the burning, numbness and pain that often is associated with diabetic neuropathy. The antioxidant works mainly as a pain medication and was clinically shown to have few side effects" - See
iHerb
or Vitacost
alpha lipoic acid products.
- Antioxidant Soothes Diabetic Neuropathy - WebMD, 4/11/03 -
"Alpha lipoic acid seems to actually change the metabolism of the nerve
or blood supply to the nerve ... It is a very strong antioxidant and it is assumed that oxidation plays a role in the development of diabetes ... This means the substance -- produced in very small amounts by the body and also found in foods such as potatoes and red meat -- protects against damage by cell-ravaging
"free radicals." This oxidation process is implicated in various diseases, including heart disease, cancer, and neurologic conditions including Parkinson's and Alzheimer's ... alpha lipoic acid improves the function of cell
"transporters" that carry and distribute glucose. "This helps insulin do its role,"" - See
iHerb
or Vitacost
alpha lipoic acid products.
- B-Vitamins Prove Effective In Relieving Chronic Pain - Intelihealth, 4/10/03 -
"B-vitamins, such as thiamin
(B1), pyridoxine (B6), and cyanocobalamin (B12), have been proven to be clinically effective in treating various painful conditions such as lumbago, sciatica, trigeminal
neuralgia, facial paralysis and optic neuritis as acting as an analgesia (pain reliever)"
- Alpha-Lipoic Acid Helpful in Diabetic Neuropathy - Medscape, 3/7/03 -
"Alpha-lipoic acid (ALA) rapidly and significantly reduces sensory
symptoms and pain of diabetic neuropathy" - Note: ALA and acetyl-l-carnitine were supplements discussed in the 2/19/02 issue of the Proceedings of the National Academy of Sciences indicating that it
may slow or reversed aging in mice. See
iHerb
or Vitacost
alpha lipoic acid products.
- Enzymes Can Hasten Pain Relief - Nutrition Science News, 2/01
- The Chemistry of Pain - Nutrition Science News, 2/01
- Persistent Pain - Nutrition Science News, 10/99
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Effectiveness of different benfotiamine dosage regimens in the treatment of
painful diabetic neuropathy - Arzneimittelforschung. 1999
Mar;49(3):220-4 - "An overall
beneficial therapeutic effect on the neuropathy status was observed in all
three groups during the study, and a significant improvement in most of the
parameters studied appeared already at the 3rd week of therapy (p < 0.01).
The greatest change occurred in the group of patients receiving the high
dose of benfotiamine"
- Chronic Joint Pain - Nutrition Science News, 1/99
CME:
General Information:
Other News:
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Protein Found That May Provide Relief From Neuropathic Pain - Science
Daily, 12/5/07
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Pain-free Window Into Painful Neuropathies - Science Daily, 12/5/07
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Renoprotective effect of the addition of losartan to ongoing treatment with
an Angiotensin converting enzyme inhibitor in type-2 diabetic patients with
nephropathy - Hypertens Res. 2007 Oct;30(10):929-35 -
"During the 12-month treatment, addition of losartan
or addition of an ACE-I to the treatment protocol reduced systolic blood
pressure (SBP) by 10% and 12%, diastolic blood pressure (DBP) by 7% and 4%,
and urinary albumin excretion by 38% and 20% of the baseline value,
respectively. However, the effects on both BP and urinary albumin were not
significantly different between the two therapies. In conclusion, addition
of losartan or an ACE-I to an ongoing treatment with an ACE-I, or addition
of an ACE-I to ongoing treatment with a conventional antihypertensive were
equally effective at reducing the urinary albumin excretion and BP, and
provided renal protection in patients with type-2 diabetic nephropathy"
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Thiazolidinediones: A novel class of drugs for the prevention of diabetic
nephropathy? - Kidney Int. 2007 Dec;72(11):1301-1303 -
"Miyazaki et al. report that rosiglitazone, a
thiazolidinedione insulin sensitizer and a potent peroxisome proliferator-activated
receptor gamma agonist, not only effectively improves glycemic control but
also halts progression of albuminuria in type 2 diabetic patients with
early-stage diabetic nephropathy. These findings could offer a new
prevention of diabetic nephropathy in insulin-resistant diabetic patients"
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Common Drugs Cut Diabetes Nerve Damage - WebMD, 6/22/07 -
"protection was 35% for statins and 48% for fibrates
-- statistically the same protection -- and these effects were independent
of blood sugar control, height, age, other things associated with
neuropathy"
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Amitriptyline Commonly Prescribed for Neuropathy Despite Contraindications
- Doctor's Guide, 5/29/06
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Lacosamide May Provide Treatment Option for Painful Distal Diabetic
Neuropathy - Doctor's Guide, 4/7/06
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Local Anesthetics Are Effective For Neuropathic Pain - Science Daily,
10/26/05
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Ruboxistaurin May Improve Diabetic Nephropathy: Presented at ADA -
Doctor's Guide, 6/14/05
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Pregabalin Cuts Pain in Tough-To-Treat Patients With Neuropathic Pain and
Fibromyalgia Syndrome - Doctor's Guide, 4/13/05
- FDA Approves New Pain Reliever - WebMD, 1/3/05
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Pregabalin Appears Benefit Patients With Peripheral Neuropathic Pain - Doctor's Guide, 9/22/04
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Lyrica (Pregabalin) Offers Sustained Relief Of Peripheral Neuropathic Pain - Doctor's Guide, 9/8/04
- Lidocaine Patch Safe and Effective for Diabetic Neuropathic Pain - Medscape, 6/24/04
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Painful Diabetic Neuropathy Often Inadequately Treated - Doctor's Guide, 6/7/04
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Pregabalin Shows Sustained Relief of Diabetic Neuropathic Pain - Doctor's Guide, 6/7/04
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Duloxetine Effective for Diabetic Neuropathic Pain - Clinical Psychiatry News, 6/04
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Duloxetine May Be Effective for Treatment of Pain Associated With Diabetic Neuropathy - Doctor's Guide, 3/5/04
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Neuropathic Pain: Guidelines Simplify Management - Clinical Psychiatry News, 3/04
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Topiramate Used for Successful Treatment of Diabetic Peripheral Neuropathy: a Case Report - Doctor's Guide, 9/17/03
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Duloxetine Relieves Pain Associated With Diabetic Neuropathy - Doctor's Guide, 8/26/03
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Effective Treatments Available for Diagnosed Diabetic Neuropathy - Doctor's Guide, 7/3/03
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Neuropathic Pain: Anticonvulsants and Antidepressants are Effective Adjuvant Analgesics - Physician's Weekly, 5/5/03
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Relieve Range of Neuropathic Pain in Diabetics - Clinical Psychiatry News, 4/03
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Controlled-Release Oxycodone Helps Resolve Sleep Problem in Patients with Diabetic Neuropathy - Doctor's Guide, 2/21/03
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Glucose Tolerance Test Advised For Idiopathic Neuropathy - Doctor's Guide, 1/30/03
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Heavy Proteinuria May Speed Progression Of Diabetic Nephropathy - Doctor's Guide, 1/13/03
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Lidoderm (Lidocaine 5%) Patch Provides Effective Analgesia for Painful Diabetic Neuropathy - Doctor's Guide, 12/13/02
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Range-Of-Motion Exercise Program May Help Prevent Diabetic Neuropathic Ulceration - Doctor's Guide, 10/30/02
- Diabetic Neuropathy, Gastropathy Respond to New Treatments - Medscape, 10/3/02
- Spray [ISDN] Eases Diabetic Foot Pain - WebMD, 10/3/02 -
"Although the exact cause of diabetic neuropathy is unknown, researchers believe the nerve damage
is related to an impaired ability to generate nitric oxide (NO). NO is used by the body to encourage healthy blood flow and oxygen circulation"
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C-Peptide May Improve Sub-clinical Neuropathy in Type I Diabetics - Doctor's Guide, 9/4/02
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Quinapril and Losartan Effectively Treat Diabetic Autonomic Neuropathy, Improve Left Ventricular Function - Doctor's Guide, 9/4/02
- Insulin Resistance Best Predictor of Diabetic Nephropathy - Medscape, 9/3/02
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Zonegran (Zonisamide) May Be Effective Second-line Treatment for Neuropathic Pain - Doctor's Guide, 8/21/02
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Intravenous Adenosine Effective For Control Of Neuropathic Pain - Doctor's Guide, 8/21/02
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Lidocaine 5% Patch May Play Role in Treatment of Painful Diabetic Neuropathy - Doctor's Guide, 8/20/02
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PKS-beta Inhibitor a "Breakthrough" for Diabetic Peripheral Neuropathy - Doctor's Guide, 6/18/02
- IVIG Effective in Diabetic-Related Inflammatory Neuropathy - Medscape, 6/5/02
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Dextromethorphan Effective in Select Patients With Painful Diabetic Neuropathy - Doctor's Guide, 5/22/02
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Lidoderm (Lidocaine Patch 5%) Effective for Neuropathic Pain - Doctor's Guide, 4/17/02
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Combination ACE Inhibitors and Angiotensin II Blockers Decreases Proteinuria in Patients with Diabetic Nephropathy - Doctor's Guide, 4/11/02
- Lamotrigine Controls Pain In Patients With Polyneuropathy - Doctor's Guide, 10/2/01
- Lamictal (Lamotrigine) Relieves Pain of Diabetic Neuropathy - Doctor's Guide, 9/4/01
- Controlled-Release OxyContin (Oxycodone) Provides Analgesia In Painful Diabetic Neuropathy - Doctor's Guide, 6/24/01
- Stubborn Neuropathic Pain Responds to Buproprion - Doctor's Guide, 6/22/01
- Irbesartan Delays Nephropathy In Diabetic Patients - Doctor's Guide, 6/17/01
- Enzyme Therapy Effective, Safe for Fabry Disease - Doctor's Guide, 6/6/01
- Antihypertensive Control Needed To Delay Progression Of Diabetic Neuropathy - Doctor's Guide, 4/6/01 -
"Proper control of blood pressure is the single most important factor in delaying the progression of
diabetic neuropathy ... majority of such patients require more than a single antihypertensive agent to achieve adequate BP control (£ 130/80)"
- Higher Dose Of Duraclon (Clonidine) Now Available For Severe Neuropathic Pain - Doctor's Guide, 3/2/00
- Venlafaxine Has Role In Painful Diabetic Neuropathy - Doctor's Guide, 6/11/00
- Memantine reduces neuropathic pain in diabetics - Doctor's Guide, 5/3/00
- Memantine Significantly Reduces Peripheral Neuropathy Pain In Diabetics - Doctor's Guide, 1/25/00
- Neurontin Significantly Reduces Chronic Neuropathic Pain - Doctor's Guide, 12/23/98
- Severe Shingles Pain Relieved With Anti-Convulsant Drug Gabapentin - Doctor's Guide, 12/2/98
- Gabapentin Effective At Managing Pain Of Diabetic Neuropathy - Doctor's Guide, 12/1/98
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