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Home > Anti-aging Research > Mucuna Pruriens
Mucuna Pruriens
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Heat-Stable Extract From Mucuna Stimulates the Differentiation of Bone Marrow
Cells Into Dendritic Cells and Induces Apoptosis in Cancer Cells - Nutr
Cancer. 2010 Dec 16:1 - "Pine cone extract is known to induce differentiation of
human mononuclear cells into dendritic cells (DCs) and also to induce apoptosis
in human cancer cells. In the present study, we screened edible plants that
contain components with biological activities similar to or more potent than
those of pine cone extract. We found that Mucuna (Mucuna pruviens var. utilis)
contains a DC differentiation/maturation-inducing activity and a component that
induces apoptosis in human cancer cell lines. Mucuna extract specifically
stimulated differentiation of BM cells to immature DCs. Marked production of
IL-6 was observed by sequential treatment with at least 10 μg/mL of Mucuna
extract followed by LPS. The sequential treatment with Mucuna extract followed
by LPS produced a much higher ratio of IL-12 to IL-6 and a lower ratio of TNF-α
to IL-6 than that obtained by sequential treatment with a medicinal mushroom
Phellinus linteus extract and then LPS. The DC differentiation/maturation
activity and the component inducing apoptosis in cancer cells were separable by
column chromatography" - See
Mucuna
pruriens products at iHerb.

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Dendritic cell -
Wikipedia - "Dendritic cells (DCs) are immune cells
that form part of the mammalian immune system. Their main function is to
process antigen material and present it on the surface to other cells of the
immune system, thus functioning as antigen-presenting cells. They act as
messengers between the innate and adaptive immunity"
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