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Home > Anti-aging Research > Mistletoe

Iscador and Mistletoe

News & Research:

Mistletoe in Supportive Care for Colorectal and Pancreatic Cancers - Doctor's Guide, 7/12/07 - "Use of a fermented mistletoe extract (MEx; Iscador®) in long-term supportive care in hospitals and private practices demonstrated significant survival benefit and improvements in quality of life for patients with surgically treated primary, nonmetastatic colorectal carcinoma and for patients with all-stages pancreatic carcinoma, when combined with adjuvant chemotherapy and/or radiotherapy or passive aftercare in two multicentre, controlled, retrospective, epidemiological, observational, cohort studies"
Mistletoe for Cancer? Maybe Not - WebMD, 12/21/06
New Drugs Show Promise in Hepatitis C Fight - WebMD, 5/18/04 - "Mistletoe, Green Tomatoes, Novel Antiviral Drug May Work When Standard Treatments Don't"
Mistletoe Extract May be Effective for Hepatitis C Patients Intolerant or Unresponsive to Interferon and Ribavirin - Doctor's Guide, 5/18/04
Studies Question Benefit of Mistletoe for Cancer - Healthwell Exchange Daily News, 12/18/03
Study disputes value of mistletoe for cancer - CNN, 5/14/01 - "Skin cancer metastasized to the brain in 19 percent of the patients who took mistletoe, but in only 7 percent of the patients who didn't take it"
Under the Mistletoe: Suzanne Somers' Breast Cancer Treatment, Tried-and-True Therapies Offer Much Better Odds - WebMD, 4/4/01
Somers' self-treatment worries cancer experts - USA Today, 4/3/01
Somers' cancer treatment worries some experts - CNN, 3/30/01 - ""You do not look at one product like Iscador and expect to reverse cancer," Burton Goldberg of Alternative Medicine magazine. "It is not a magic bullet. Alternative physicians have to look at the multiple causes of cancer, and they use multiple therapies in reversing the system."
Herbal Aids for Cancer - Nutrition Science News, 3/00
Anthroposophically Extended Medicine: A First View - Ralph W. Moss, Ph.D, 1997 - "I also met with Dr. Heiligtag, director of the hospital, and with Dr. Michael Werner, director of the Hiscia institute across the street from the Klinik. It is here that the world famous Iscador is prepared from mistletoe (Viscum alba)"

Abstracts:

Case reports of sarcoma patients with optimized lectin-oriented mistletoe extract therapy - J Altern Complement Med. 2011 Oct;17(10):973-9 - "Mistletoe (Viscum album L) extracts (ME) are widespread as immunomodulatory therapeutic agents in alternative tumor treatment. Assessing the often-controversial clinical results is rather difficult since the effects of ME on the immune system cannot be equally reproduced. Mistletoe lectins (ML) are the only mistletoe ingredients also found in vivo that are capable of having a positive effect on the immune balance of patients with tumors. Other components have only been tested in vitro, and the removal of mistletoe lectins ML from the extract can put an end to the immunological efficacy of ME. Preclinical investigations in the tumor models (using nude mice xenotransplanted with human leiomyosarcoma and interleukin-12-deficient C57BL6 mice) show that without immunological reactions, ME induce less antitumor efficacy. ML, functioning as ligands for pattern recognition receptors of the natural immune system, are docked to ganglioside molecules (CD75) of monocytes and granulocytes, thereby stimulating the natural antitumor mechanisms. Objectives: The aim of this article is to present and discuss several favorable clinical responses of patients who had sarcoma and who were treated with immunologically effective ME preparations. Course of therapy and results: In accordance with the bell-shaped dose-response relationship of ML, the patients with sarcoma were treated with ME preparations, standardized for the active sugar-binding lectin contents. Thus, an optimal dose of 0.75-1.0 ng/kg ML was given twice a week subcutaneously. In this report, the clinical progress of 6 patients with sarcoma showed remissions of tumor symptoms. Conclusions: It seems that this disease is beneficially influenced by optimized lectin-oriented ME therapy since patients with sarcoma may react especially well to the improved balance of natural immunological mechanisms" - Note: Six out of how many???? It's an important part that was left out. You can probably find a way to get Mistletoe via this website: http://www.iscador.com/index.aspx
In vitro investigation into the potential of a mistletoe extract to alleviate adverse effects of cyclophosphamide - Altern Ther Health Med. 2010 May-Jun;16(3):40-8 - "Mistletoe extract strongly stimulated healthy PBMC but not malignant Jurkat cells. In addition, mistletoe extract seemed to partially protect healthy PBMC-but not malignant Jurkat cells-from the cytostatic effect of 4-hpc. The results motivate further preclinical and clinical investigations of mistletoe extracts as an adjuvant medication in cancer therapy to alleviate side effects of conventional therapy"
Molecular mechanisms of mistletoe plant extract-induced apoptosis in acute lymphoblastic leukemia in vivo and in vitro - Cancer Lett. 2008 Feb 29 - "Aqueous mistletoe extracts (MT) ... Both MTs significantly improved survival (up to 55.4 days) at all tested concentrations in contrast to controls (34.6 days) without side effects"