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Home > Anti-aging Research > MGN-3
MGN-3
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Arabinoxylan Rice Bran (MGN-3) Enhances the Effects of Interventional
Therapies for the Treatment of Hepatocellular Carcinoma: A Three-year
Randomized Clinical Trial - Anticancer Res. 2010 Dec;30(12):5145-5151 -
"arabinoxylan rice bran (MGN-3) in conjunction with
an interventional therapy (IT) for the treatment of hepatocellular carcinoma
patients ... Patients in the IT+MGN-3 group showed: (i) lower recurrence of
the disease, 31.6% (12/38), as compared to 46.7% (14/30) for the control;
(ii) higher survival after the second year, 35%, as compared to 6.7% for the
control; (iii) significantly lower alpha-fetoprotein level, a 38% decrease
(p=0.0001), as compared to baseline value, while the control showed no
significant change; and (iv) a significant decrease in tumor volume, in
contrast to the control, which showed no significant change. When the
results were analyzed according to each IT modality, MGN-3+IT sub-groups
displayed a greater response to treatment, in every aspect examined, than
the IT sub-groups alone. However, the patients in the MGN-3+TOCE+PEIT
sub-group demonstrated greater reduction in AFP levels and longer survival
time than the MGN-3+TOCE sub-group"
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Production of tumor necrosis factor-alpha and interferon-gamma from human peripheral blood lymphocytes by MGN-3, a modified arabinoxylan from rice bran, and its synergy with interleukin-2
in vitro - Cancer Detect Prev 2000;24(4):314-24 - "Results showed that MGN-3 is a potent TNF-alpha inducer. The effect was dose-dependent. MGN-3 concentration at 0.1 and 1 mg/ml increased TNF-alpha production by 22.8- and 47. 1-fold, respectively.
MGN-3 also increased production of IFN-gamma but at lower levels as compared to TNF-alpha With respect to key cell surface receptors, MGN-3 increases the expression of CD69, an early activation antigen at 16 hours after treatment. Furthermore, the interleukin-2 receptor CD25 and the adhesion molecule ICAM-1 (CD54)
were upregulated after treatment with MGN-3. Treating highly purified NK cells with MGN-3 also resulted in increased levels of TNF-alpha and IFN-gamma secretion in conjunction with augmentation of NK cell cytotoxic function. Furthermore, addition of MGN-3 to interleukin-2-activated NK cells resulted in a synergistic
induction of TNF-alpha and IFN-gamma secretion"
- Anti-HIV activity in vitro of MGN-3, an activated arabinoxylane from rice bran - Biochem Biophys Res Commun 1998 Feb 4;243(1):25-9
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