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Anti-aging Research > Melatonin
News & Research:
iPads, tablets, smartphones disrupt good sleep, study finds - The Washington
Post, 12/22/14 - "During a two-week inpatient experiment
involving a dozen adults, some participants were asked to read on an iPad for
four hours each night before bedtime, for five consecutive nights. Others read
printed books in dim light. After a week, the groups switched ... participants
using iPads displayed reduced levels of melatonin, a hormone that typically
increases in the evening and helps induce sleepiness. They took longer to fall
asleep, and spent less time in restorative REM, or rapid-eye movement, sleep ...
the iPad readers reported being sleepier and less alert the following morning,
even after eight hours of sleep. They also displayed delayed circadian rhythms
... although the study used only iPads, the effect isn't unique to that device.
Other products produce similar blue-light emissions, including tablets,
e-readers, smartphones, laptops and LED monitors" - See
melatonin at Amazon.com.
New Study Shows Melatonin Makes Old Bones Stronger - Dr. Michael Murray,
6/3/14 - "One of the underlying causes of low melatonin
levels as a person ages may be low vitamin B12 levels. Vitamin B12 is a
necessary cofactor in the manufacture of melatonin ... Methylcobalamin is the
body’s active form of vitamin B12. Methylcobalamin has been shown to help some
people suffering from what is referred to as sleep-wake disorder ... In people
with sleep wake disorders, taking methylcobalamin (3 mg daily first thing in the
morning) has often led to improved sleep quality, increased daytime alertness
and concentration, and improved mood. Much of the benefit appears to be a result
of methylcobalamin influencing melatonin secretion" - See
vitamin B12 at Amazon.com.
Melatonin makes old bones stronger, research shows - Science Daily, 5/26/14
- "gave twenty 22-month-old male rats (the equivalent of
60 year-old humans) melatonin supplements diluted in water for 10 weeks (the
equivalent of six years in human years) ... there was a significant increase in
both bone volume and density among the rats that had received melatonin
Melatonin Agonist Cuts
Delirium Risk - Medscape, 2/19/14 - "ramelteon was
associated with a lower risk for delirium ― 3% vs 32% ― compared with placebo
... One previous randomized controlled trial suggested that melatonin, a pineal
gland hormone that regulates the sleep-wake rhythm, is associated with a lower
risk for delirium. In addition, case series have suggested that ramelteon, which
was approved in 2005 by the FDA for the treatment of insomnia, may help prevent
delirium in elderly patients" - Note: Why use the over-the-counter
melatonin when you can make a drug that increases melatonin and charge a hundred
times as much? I'm just being factitious.
Melatonin shows potential to slow tumor growth in certain breast cancers -
Science Daily, 1/28/14 - "These early stage research
results with the melatonin drug in a triple-negative breast cancer animal models
achieved in our lab has not been seen anywhere else ... The mice were randomly
assigned to either the melatonin or control groups. The melatonin group received
treatment each night for 21 days ... Those treated showed significantly smaller
tumors after 21 days while the mean tumor volume increased significantly in the
control group. And, there was less vascular growth in the tumors of the treated
Melatonin may lower prostate cancer risk - Science Daily, 1/20/14 -
"conducted a case-cohort study of 928 Icelandic men from
the AGES-Reykjavik cohort between 2002 and 2009. They collected first morning
void urine samples at recruitment, and asked the participants to answer a
questionnaire about sleep patterns ... men whose 6-sulfatoxymelatonin levels
were higher than the median value had a 75 percent decreased risk for advanced
prostate cancer. A 31 percent decreased risk for prostate cancer overall was
observed as well, but this finding was not statistically significant"
Melatonin Helps Control Weight Gain as It Stimulates the Appearance of ‘beige
Fat’ That Can Burn Calories Instead of Storing Them, Study Suggests -
Science Daily, 9/25/13 - "chronic administration of
melatonin sensitizes the thermogenic effect of exposure to cold, heightens the
thermogenic effect of exercise and, therefore, constitutes excellent therapy
against obesity. The fact is that one of the key differences between 'beige
fat', which appears when administering melatonin, and 'white fat', is that
'beige fat' cell mitochondria express levels of UCP1 protein, responsible for
burning calories and generating heat"
Topical Agents for Hair
Growth Promotion - Medscape, 7/22/13 - "androgenetic
alopecia (AGA), i.e., male pattern hair loss and female pattern hair loss ...
Melantonin has long been known to modulate hair growth. Animal testing has shown
that melatonin stimulates the anagen phase of hair growth. In a
double-blind, randomized, placebocontrolled study 40 women with diffuse alopecia
(n=28) or AGA (n=12) were treated topically for 6 months with 1 ml daily of 0.1%
melatonin-alcohol solution versus vehicle. Trichograms were used to determine
efficacy in the frontal and occipital scalp areas. At the end of the study, the
AGA group demonstrated a statistically significant increase in anagen hairs in
the occiput region compared to placebo (mean 78 to 82 hairs), but no difference
was shown with placebo in the frontal area. The group with diffuse alopecia
showed a substantial increase in frontal hair. Plasma melatonin levels were
elevated under treatment with melatonin, but did not exceed the physiological
Melatonin for Migraine?
- Medscape, 5/21/13 - "Participants were randomly
assigned to 3 mg of melatonin, 25 mg of amitriptyline, or placebo for 3 months
... The mean reduction in headache frequency was 2.7 in the melatonin group,
2.18 in the amitriptyline group, and 1.18 in the placebo group. The proportion
of responders was greatest in the melatonin group at 54% vs 39% for
amitriptyline and 20% for placebo ... Patients gained weight in both the
amitriptyline and placebo groups, but melatonin was associated with weight loss"
melatonin at Amazon.com.
Therapeutic Applications of
Melatonin - Medscape, 4/25/13 - "Melatonin is a
hormone with multiple actions. It is involved in the regulation of biological
rhythms, in sleep regulation, it has potent antioxidant action and protects the
organism from carcinogenesis and neurodegenerative disorders. The hormone
possesses immune-enhancing activity. Therapeutically, it may be used for the
management of insomnia, jet lag, the resynchronization of circadian rhythms, as
an adjuvant in cancer therapy and in the inhibition of disease progression in
Alzheimer's disease and other neurodegenerative disorders"
Melatonin Delays ALS Symptom Onset and Death in Mice - Science Daily,
4/25/13 - "Melatonin is a naturally occurring hormone
that is best known for its role in sleep regulation. After screening more than a
thousand FDA-approved drugs several years ago, the research team determined that
melatonin is a powerful antioxidant that blocks the release of enzymes that
activate apoptosis, or programmed cell death ... Our experiments show for the
first time that a lack of melatonin and melatonin receptor 1, or MT1, is
associated with the progression of ALS ... We saw similar results in a
Huntington's disease model in an earlier project, suggesting similar biochemical
pathways are disrupted in these challenging neurologic diseases"
Decreased melatonin secretion associated with higher risk of developing type 2
diabetes - Science Daily, 4/2/13 - "The analysis
consisted of a case-control study nested within the Nurses' Health Study cohort
... participants in the lowest category of urinary ratio of 6-sulfatoxymelatonin
to creatinine had a 2.2 times higher odds of developing type 2 diabetes compared
to participants in the highest category" - [Abstract]
OTC Supplement May
Aid in Migraine Prevention - Medscape, 3/26/13 - "3
mg of melatonin was more effective than placebo and had efficacy similar to that
of 25 mg of amitriptyline. Furthermore, it was better tolerated than
amitriptyline, with lower rates of daytime sleepiness and no weight gain ... The
mean reduction in headache frequency was 2.7 in the melatonin group, 2.18 in the
amitriptyline group, and 1.18 in the placebo group ... Although patients gained
weight in both the amitriptyline (n = 3) and placebo (n = 1) groups, melatonin
was associated with weight loss ... melatonin should be taken between 10 pm and
11 pm to mimic the physiologic peak. In addition, a fast-acting rather than a
slow-release formula should be used"
Melatonin Secretion May Play a Role in Premenstrual Syndrome - Science
Daily, 12/20/12 - "PMDD sufferers can experience
depression, tension, and irritability of sufficient intensity to interfere with
daily activities and relationships. Disturbed sleep is also a common symptom of
the disorder, with up to 70% of patients frequently reporting either poor sleep
quality with increased awakenings or excessive sleepiness during the symptomatic
phase ... compared to healthy controls, PMDD women had significantly decreased
melatonin secretion levels during the night-time hours ... Clinical implications
of reduced melatonin in PMDD The prevalence of insomnia and depression are both
about twice as high in women than in me"
Ups the Risk for Various Cancers in Men - Medscape, 10/31/12 -
"The study compared 3137 men with cancer and 512 matched
control subjects who completed a detailed questionnaire about occupational work
and lifestyle from 1979 to 1985 ... Compared with men who never worked at night,
men who worked night shifts had an increased risk for prostate cancer (odds
ratio [OR], 2.77), non-Hodgkin's lymphoma (OR, 2.31), pancreatic cancer (OR,
2.27), rectal cancer (OR, 2.09), colon cancer (OR, 2.03), bladder cancer (OR,
1.74), and lung cancer (OR, 1.76) ... "When I first proposed the light-at-night
hypothesis, it linked circadian disturbance to hormone disruption and breast
cancer," Dr. Stevens explained. Since then, circadian disruption has been linked
to many other adverse effects, it has been demonstrated that melatonin has a
direct effect on tumor growth, and some of the latest research he has been
involved with has shown that circadian disruption has an epigenetic impact"
Melatonin and exercise work against Alzheimer's in mice - Science Daily,
9/26/12 - "The mice were divided into one control group
and three other groups which would undergo different treatments: exercise
-unrestricted use of a running wheel-, melatonin -a dose equivalent to 10 mg per
kg of body weight-, and a combination of melatonin and voluntary physical
exercise ... After six months, the state of the mice undergoing treatment was
closer to that of the mice with no mutations than to their own initial
pathological state. From this we can say that the disease has significantly
regressed ... The results, which were published in the journal Neurobiology of
Aging, show a general improvement in behaviour, learning, and memory with the
three treatments ... These procedures also protected the brain tissue from
oxidative stress and provided good levels of protection from excesses of amyloid
beta peptide and hyperphosphorylated TAU protein caused by the mutations"
- Note: That's a huge amount of melatonin though but then on the other hand it
was a short six month period but on the third hand, mice have a much shorter
life span so it might interpolate to a much longer time span for humans.
from self-luminous tablet computers can affect evening melatonin, delaying sleep
- Science Daily, 8/27/12 - "To produce white light,
these electronic devices must emit light at short wavelengths, which makes them
potential sources for suppressing or delaying the onset of melatonin in the
evening, reducing sleep duration and disrupting sleep. This is particularly
worrisome in populations such as young adults and adolescents, who already tend
to be night owls ... Melatonin suppression after a one-hour exposure to the
tablet was not significantly affected. However, after a two-hour exposure there
was significant suppression"
Melatonin might help in controlling weight gain and preventing heart diseases
associated to obesity - Science Daily, 4/28/11 -
"melatonin -a natural hormone produced by the body- helps in controlling weight
gain -even without reducing the intake of food-, improves blood lipid profile
-as it reduces triglicerids-, increases HDL cholesterol and reduces LDL
cholesterol ... analyzed in young Zucker diabetic obese rats the effects of
melatonin on obesity, dyslipidemia and high blood pressure associated to
obesity. Melatonin was found to be beneficial for young rats that had not still
developed any methabolic or heart disease"
light before bedtime may impact sleep quality, blood pressure and diabetes risk
- Science Daily, 1/13/11 - "exposure to electrical light
between dusk and bedtime strongly suppresses melatonin levels and may impact
physiologic processes regulated by melatonin signaling, such as sleepiness,
thermoregulation, blood pressure and glucose homeostasis ... researchers
evaluated 116 healthy volunteers aged 18-30 years who were exposed to room light
or dim light in the eight hours preceding bedtime for five consecutive days. An
intravenous catheter was inserted into the forearms of study participants for
continuous collection of blood plasma every 30-60 minutes for melatonin
measurements. Results showed exposure to room light before bedtime shortened
melatonin duration by about 90 minutes when compared to dim light exposure.
Furthermore, exposure to room light during the usual hours of sleep suppressed
melatonin by greater than 50 percent"
light at night at night may lead to obesity, study finds - Science Daily,
10/11/10 - "mice exposed to a relatively dim light at
night over eight weeks had a body mass gain that was about 50 percent more than
other mice that lived in a standard light-dark cycle ... Something about light
at night was making the mice in our study want to eat at the wrong times to
properly metabolize their food ... So how does light at night lead to changes in
metabolism? The researchers believe the light could disrupt levels of the
hormone melatonin, which is involved in metabolism. In addition, it may disrupt
the expression of clock genes, which help control when animals feed and when
they are active"
Melatonin: The Fountain Of Youth? - Science Daily, 6/22/09 -
"Melatonin can slow down the effects of aging. A team at
laboratoire Arago in Banyuls sur Mer (CNRS / Université Pierre et Marie Curie)
has found that a treatment based on melatonin can delay the first signs of aging
in a small mammal ... studied the long-term effects of melatonin on the Greater
White-toothed shrew, a small nocturnal insectivorous mammal. Under normal
conditions, this animal shows the first signs of aging after reaching 12 months,
mainly through the loss of circadian rhythm in its activities. By continuously
administering melatonin, starting a little before 12 months, the appearance of
these first signs was delayed by at least 3 months, which is a considerable
period in relation to the lifespan of this shrew ... Melatonin is now known to
play several beneficial roles. These include being an antioxidant, an
anti-depressant, and helping to remediate sleep problems"
Melatonin May Save Eyesight In Inflammatory Disease, Study Suggests -
Science Daily, 11/23/08
Melatonin Associated with Increased Risk of Breast Cancer in Postmenopausal
Women - Science Daily, 6/15/08 - "women with the
lowest levels of melatonin had a statistically significantly higher incidence of
breast cancer than those with the highest levels"
Night Shift Work May Cause Cancer - WebMD, 11/30/07 -
"They note that shift work may raise cancer risk by
suppressing production of melatonin, a chemical involved in the circadian
Melatonin Content Can Help Delay Aging, Mouse Study Suggests - Science
Daily, 4/24/07 - "Therefore, the researcher asserts,
daily melatonin intake in humans from the age of 30 or 40 could prevent – or, at
least, delay – illnesses related to aging, free radicals and inflammatory
processes, such as many neurodegenerative disorders (e.g. Parkinson's disease)
and complications linked to other illnesses, like diabetes"
Salivary Melatonin May Help Fight Gum Disease - Science Daily, 9/13/06 -
"the melatonin may fight against infection and
inflammation possibly due to its antioxidant, anti-aging and immunoenhancing
Grapes May Help With Sleep - WebMD, 6/19/06 -
"The juicy fruit might be packing melatonin, a sleep
Another Grape Excuse To Hit The Bottle - Science Daily, 6/16/06 -
"the grapes used to make some of the most popular
red wines contain high levels of the sleep hormone melatonin"
Best Time to Take Melatonin? - WebMD, 5/3/06
Melatonin Improves Mood In Winter Depression - Science Daily, 5/2/06 -
"melatonin, a naturally occurring brain substance,
can relieve the doldrums of winter depression, also known as seasonal
affective disorder, or SAD"
Melatonin Most Effective For Sleep When Taken For Off-hour Sleeping -
Science Daily, 5/1/06 - "sleep efficiency during the
six hour, 40 minute episodes was significantly higher in the groups that
took melatonin during times when the body was not producing melatonin. At
those times, participants taking 5.0mg of melatonin had a sleep efficiency
of 83 percent and those taking 0.3mg melatonin had a sleep efficiency of 84
Melatonin Supplements review - ConsumerLab.com, 4/5/06
Melatonin Pills May Help Ease Tinnitus - WebMD, 2/24/06
Melatonin could help tinnitus, improve sleep - Nutra USA, 2/23/06
Melatonin for Travelers' Sleep Woes? - WebMD, 2/9/06
Melatonin may cut hypertension - Nutra USA, 2/2/06 -
"A 10 per cent decline of BP over daytime values is
considered appropriate to reduce the cardiovascular risk ... During placebo
use only 39 per cent of the subjects reached this value, but this rate
surged to 84 per cent during melatonin administration"
Study Demonstrates Role Of Exercise In Modifying Melatonin Levels; Increase
Believed To Offer Breast Cancer Protection - Science Daily, 12/3/05
Stopping Jet Lag Before It Starts - WebMD, 11/2/05 -
"The body clocks of those who took melatonin adapted
better to the new schedule. The higher dose of melatonin fared best in that
regard, but not by much. Plus, people who took the higher dose were sleepier
in the evenings after taking the pill"
Travelers Can Avoid Jet Lag By Resetting Their Body Clocks - Science
Melatonin to Fight Insomnia: Timing Is Key - WebMD, 10/25/05 -
"melatonin was most effective in resetting the
body's internal, or circadian, clock when it was timed to the individual's
sleep patterns ... If you only want to induce sleep you can take it about
two hours before you want to go to sleep"
Melatonin May Reduce the Pain of Irritable Bowel Syndrome - Medscape,
10/14/05 - "Use of 3 mg of melatonin once daily for
two weeks in IBS patients is associated with
improvement in bowel pain and rectal distension thresholds for urgency and
pain but not with a change in stool frequency, type, or quality of life"
Add-On Melatonin Improves Sleep Behavior in Children With Epilepsy:
Randomized, Double-Blind, Placebo-Controlled Trial - Medscape, 5/24/05
Melatonin Modestly Effective for Sleep - WebMD, 3/3/05
Melatonin study could 'jump-start' interest in supplement
- Nutra USA, 3/2/05
Popular Supplement Melatonin Found To Have Broader Effects In Brain Than
Once Thought - Science Daily, 2/11/05 -
"In experiments on the Japanese quail, the
researchers found that melatonin switches on a recently discovered hormone
called gonadotropin inhibitory hormone (GnIH), which has been found to have
the opposite effect to the key hormone priming the body for sex –
gonadotropin releasing hormone (GnRH). In birds, switching off GnRH causes
the gonads – testes and ovary – to shrink as part of the birds' yearly
U.S. Study Sees Little Benefit From Melatonin - HealthDay, 12/22/04 -
"The one area where melatonin did seem to work was
with a group of people with a condition called "delayed sleep phase
syndrome," which means that otherwise healthy people have a biological quirk
that prevents a normal sleep cycle"
Supplements May Not Help Sleep - WebMD, 12/10/04
Melatonin May Improve Sleep Quality in Patients With Asthma - Medscape,
Melatonin Effective in Relieving Pain But Not Sleep Disturbance Related to
Irritable Bowel Syndrome - Doctor's Guide, 9/30/04
Melatonin May Help Prevent Migraines - WebMD, 9/9/04
- Melatonin Decreases
Migraine Frequency and Intensity
- Medscape, 9/9/04 -
"Of 32 patients who completed the study, 25 patients
(78.1%) had at least a 50% reduction in headache frequency from baseline,
eight patients (25%) had no headaches, and none of the patients had
increased headaches after three months of therapy"
- Melatonin Relieves
Stabbing Headaches - Healthwell Exchange Daily News, 2/26/04
- Melatonin to Lower Blood
Pressure? - Dr. Weil, 2/24/04
Melatonin May Ease Jet Lag - WebMD, 2/6/04
Nightime Melatonin Supplementation May Be Useful in the Treatment of
Essential Hypertension - Doctor's Guide, 2/4/04 -
"2.5 mg/day ... mean sleep systolic blood pressure
decreased by 6 mm Hg and mean sleep diastolic
decreased by 4 mm Hg ... Repeated melatonin significantly increased sleep
efficiency from 80% to 85% and increased actual sleep time from 5.6 to 6.1
hours. Melatonin therapy also reduced sleep latency from 33 to 22 minutes"
- Jet Lag Hormone
Lowers Blood Pressure - WebMD, 1/20/04
Melatonin May Cut Hypertension Risk - HealthDay, 1/19/04 -
"The men were randomly assigned to receive either a
placebo, a single dose of melatonin or 2.5 milligrams of melatonin one hour
before bedtime for three weeks ... those taking the hormone each night
throughout the three weeks had lower nighttime systolic and diastolic
blood pressure. Systolic blood pressure (the top number in the reading)
decreased by an average of six millimeters of mercury while the diastolic
blood pressure (the bottom number) decreased by an average of four
millimeters of mercury" - See
melatonin at Amazon.com.
Melatonin and Cancer Treatment - Life Extension Magazine, 1/04
- Melatonin Helpful for
Delayed Sleep Onset in Children With ADHD
- Medscape, 10/21/03
People With Asthma Cautioned About Melatonin Use - Doctor's Guide,
Melatonin Slows Breast Cancer - WebMD, 7/14/03 -
"The nighttime hormone melatonin puts breast cancer
cells to sleep. It also slows breast cancer growth by 70%"
Computer Users May Lose Sleep - WebMD, 6/20/03 -
"the bright light of a computer screen may alter the body's biological clock
and suppress the natural production of melatonin that's critical to the
normal sleep-wake cycle"
- Night Shifts
May Raise Cancer Risk - WebMD, 6/3/03 - "Data
from an ongoing study of almost 80,000 nurses already suggest that working
nights increases a woman's risk of
breast cancer ... a new analysis points to a
similar association for colorectal cancer ...
"The peak production of melatonin occurs at about 1 or 2 a.m." Exposure to
light at night stops the production of melatonin" - See
- Melatonin Effective
Treatment for Chronic Insomnia in Children
- New Hope Natural Media, 5/15/03
Melatonin Appears Safe for Child Insomniacs - Clinical Psychiatry News,
3/03 - "Melatonin appears to be a safe and effective
treatment for children with
insomnia ... The average age of the patients was 9.6 years ... Dr.
Ivanenko, who is a child psychiatrist at the University of Louisville (Ky.),
said she typically starts children at 1-5 mg of melatonin and titrates up to
as much as 8-10 mg in adolescents" - See
melatonin at Amazon.com.
- Melatonin: What Is the
Scoop? - Dr. Weil, 1/28/03
Melatonin May Worsen Asthma - WebMD, 10/9/02
Melatonin Helps Shorten Recovery Time from Jet Lag - New Hope Natural
Neuroprotective Effects of Melatonin Assessed - Doctor's Guide, 4/30/02
- "The neuroprotective effects of melatonin appear
to be related to
antioxidant and antiamyloidogenic features of the hormone, not to the
involvement of melatonin receptors"
Can Melatonin Put Tumors to Sleep? - Nutrition Science News, 12/01
- Melatonin Helps Children
Sleep Through Magnetic Resonance Studies
- Doctor's Guide, 11/26/01
Study: Power Lines May Aid Cancer Cells - Intelihealth, 10/29/01 -
"electromagnetic fields disrupted the functioning of
the hormone melatonin in individual cells ... Scientists have accepted since
1987 that the substance suppresses the multiplication of cancer cells ...
They exposed two batches of the [breast cancer] cell to two different levels
of electromagnetic field ... In both cases, the ability of melatonin to
suppress the growth of the cancer cells was found to have declined. In some
cells with smaller concentrations of melatonin, the suppressive effect was
of melatonin on sleep and quality of life in patients with advanced breast
cancer - Support Care Cancer. 2015 Aug 11 -
"Thirty-two patients with metastatic breast cancer, receiving hormonal or
trastuzumab therapy, took 5 mg of melatonin at bedtime for 2 months ... Bedtime
melatonin was associated with a significant improvement in a marker of objective
sleep quality, sleep fragmentation and quantity, subjective sleep, fatigue
severity, global quality of life, and social and cognitive functioning scales.
Morning clock gene expression was increased following bedtime melatonin intake"
melatonin at Amazon.com.
I like the peppermint flavored by Source Naturals.
Melatonin can help you get a good night's sleep in a noisy environment -
Science Daily, 3/19/15 - "intensive care unit (ICU) ...
participants were randomly divided into four equal groups but continued to sleep
in the simulated ICU. The first group did not receive any sleep aid. The second
were provided with eye masks and earplugs. The third group took 1mg of
fast-release oral melatonin when going to bed. The final group of participants
was given a placebo ... all sleep patterns were disturbed by exposure to the
simulated ICU environment. This resulted in feelings of anxiety and reduced
quality of sleep ... Those who took melatonin were found to have decreased
awakenings during the night even compared to the eye mask and earplugs group.
The quality of the sleep was also found to be much improved for those taking
melatonin, with reported lower anxiety levels and increased REM sleep -- thought
to be linked to improved cognitive restoration"
protective effect of melatonin against brain oxidative stress and
hyperlocomotion in a rat model of mania induced by ouabain - Behav Brain
Res. 2014 Jun 21 - "Our study showed that Melatonin,
similarly to lithium, protected against OUA-induced brain oxidative stress and
hyperlocomotion in rats. Thus, our findings reinforce the notion that oxidative
stress may play an important role in the manic-like behavioural. Therefore, we
indicate that Melatonin has antimanic-like action, suggesting a potential role
for this substance in the pharmacological management of Bipolar disorder"
and melatonin-abated ovariectomy and fructose diet-induced obesity and metabolic
alterations in female rats - Menopause. 2014 Jan 27 -
"Ovariectomy caused an increase in body weight, body
mass index, feed efficiency, serum glucose, cholesterol, triglycerides, and free
fatty acids, which was further exacerbated by fructose diet. These parameters
were significantly decreased by resveratrol, alone and in combination with
melatonin. Histopathological examination revealed reduced hypertrophy of
adipocytes in adipose tissue and reduced macrophage infiltration in the liver"
resveratrol products at Amazon.com
melatonin at Amazon.com.
prevents gentamicin-induced testicular toxicity and oxidative stress in rats
- Andrologia. 2013 Nov 4 - "This study investigated the
protective effects of melatonin (MT) against gentamicin (GM)-induced testicular
toxicity and oxidative damage in rats ... These results indicate that MT
prevents testicular toxicity induced by GM in rats, presumably due to its potent
antioxidant activity, and its ability to inhibit lipid peroxidation, and restore
antioxidant enzyme activity"
modulates microsomal prostaglandin E synthase 1 and nuclear factor-E2-related
factor-2-regulated antioxidant enzyme expressions in LPS-induced murine
peritoneal macrophages - Br J Pharmacol. 2013 Sep 30 -
"Increasing evidences demonstrate that melatonin
regulates inflammatory and immune processes acting as both an activator and
inhibitor of these responses ... melatonin might be a promising target for
diseases associated with overactivation of macrophages"
and Prostate-Specific Antigen in the National Health and Nutrition Examination
Survey - J Natl Cancer Inst. 2013 Aug 13 -
"Shiftwork has been implicated as a risk factor for prostate cancer. Results
from prior studies have been mixed but generally support an association between
circadian disruption and prostate cancer ... We combined three NHANES surveys
(2005-2010) to obtain current work schedule among employed men aged 40 to 65
years with no prior history of cancer (except nonmelanoma skin cancer) ... We
found a statistically significant, age-adjusted association between current
shiftwork and elevated PSA at the 4.0ng/mL or greater level (odds ratio = 2.48,
95% confidence interval [CI] = 1.08 to 5.70; P = .03)" - Note: Many
believe that the increased risk of breast cancer in shift workers is attributed
to melatonin. Maybe it's the same for prostate cancer.
melatonin levels are inversely associated with sarcopenia in postmenopausal
women - Menopause. 2013 Jun 10 - "Seventy-eight
Korean postmenopausal women participated ... Our study shows an inverse
association between urine melatonin and sarcopenia, suggesting that melatonin
may have a protective role in the pathophysiology of sarcopenia"
Work and Levels of 6-Sulfatoxymelatonin and Cortisol in Men - Cancer
Epidemiol Biomarkers Prev. 2013 Apr 5 - "We investigated
whether male nightshift workers demonstrated changes in levels of melatonin and
cortisol, potential biomarkers of cancer risk ... Nightshift workers had
significantly lower 6-sulfatoxymelatonin levels during daytime sleep, nighttime
work, and nighttime sleep on off-nights (57%, 62% and 40% lower, respectively),
relative to the dayshift workers during nighttime sleep (p<0.0001); urinary
cortisol in nightshift workers was 16% higher during daytime sleep and 13% lower
during nighttime sleep on off-nights (p<0.05). Morning serum cortisol post-work
and post-sleep in nightshift workers were 24% and 43% lower, respectively, than
post-sleep levels among dayshift workers (p<0.0001). Within-subject comparisons
among the nightshift workers revealed significantly lower melatonin levels and
significantly higher urinary cortisol levels during daytime sleep and nighttime
work, relative to nighttime sleep (p<0.01); morning serum cortisol levels
post-work were lower than those post-sleep ... Shiftwork could be an important
risk factor for many types of cancer"
a free radical scavengr in the ovarian follicle [Review] - Endocr J. 2012
Nov 22 - "Melatonin reduces oxidative stress as an
antioxidant, and contribute to oocyte maturation, embryo development and
luteinization of granulosa cells. Our clinical study demonstrated that melatonin
treatment for infertile women increases intra-follicular melatonin
concentrations, reduces intra-follicular oxidative damage, and elevates
fertilization and pregnancy rates. Melatonin treatment also improves
progesterone production by corpus luteum in infertile women with luteal phase
defect. Melatonin treatment could become a new cure for improving oocyte quality
and luteal function in infertile women"
effects of melatonin against oxidative injury in rat testis induced by wireless
(2.45 GHz) devices - Andrologia. 2012 Nov 12 - "In
conclusion, wireless (2.45 GHz) EMR caused oxidative damage in testis by
increasing the levels of lipid peroxidation and decreasing in vitamin A and E
levels. Melatonin supplementation prevented oxidative damage induced by EMR and
also supported the antioxidant redox system in the testis"
Prolonged Release : In the Treatment of Insomnia in Patients Aged ≥55 years
- Drugs Aging. 2012 Oct 9 - "Melatonin prolonged release
(PR) 2 mg is approved for the treatment of primary insomnia characterized by
poor sleep quality in patients aged ≥55 years in the EU and elsewhere ...
Administration of melatonin PR 2 mg 1-2 h before bedtime mimics the natural
secretion pattern of melatonin, thereby leading to improvements in the circadian
regulation of the sleep-wake cycle. In older adults, melatonin PR 2 mg had no
effect on psychomotor functions, memory recall or driving skills during the
night or the next morning relative to placebo, and was associated with
significantly less impairment on many of these tasks relative to zolpidem 10 mg
alone or in combination with melatonin PR 2 mg. In 3-week and 6-month,
randomized, double-blind clinical trials in patients with primary insomnia aged
≥55 years, melatonin PR 2 mg 1-2 h before bedtime was associated with
significant improvements relative to placebo in many sleep and daytime
parameters, including sleep quality and latency, morning alertness and
health-related quality of life. Melatonin PR 2 mg was very well tolerated in
clinical trials in older patients, with a tolerability profile that was similar
to that of placebo. Short- or longer-term treatment with melatonin PR 2 mg was
not associated with dependence, tolerance, rebound insomnia or withdrawal
prevents testicular damage in hyperlipidaemic mice - Andrologia. 2012 Jan 20
- "Hyperlipidaemia was induced in ApoE-knockout C57BL/6J
male mice fed with high-fat diet alone (group A), or with high-fat diet and
melatonin (group B) ... The results suggest that melatonin may be potential to
attenuate testicular damage by improving histopathological changes and reducing
germ cell apoptosis in hyperlipidaemic mice"
improves the restoration of endothelium-derived constricting factor signalling
and inner diameter in the rat femoral artery after cessation of L-NAME treatment
- J Hypertens. 2010 Sep;28 Suppl 1:S19-2 - "Although
melatonin did not accelerate blood pressure reduction, it attenuated
EDCF-contractions and oxidative load and enlarged arterial diameter. These
effects may be beneficial for cardiovascular protection"
light and L-NAME-induced left ventricular remodelling: different protection with
melatonin and captopril - J Hypertens. 2010 Sep;28 Suppl 1:S13-8 -
"In hypertension induced by a combination of
continuous light and L-NAME treatment, melatonin and captopril protect the heart
against pathological left ventricular remodelling differently"
hypertrophy and remodelling: pathophysiological consequences and protective
effects of melatonin - J Hypertens. 2010 Sep;28 Suppl 1:S7-12 -
"Whereas melatonin did not reduce left ventricular
hypertrophy in spontaneously hypertensive rats or in nitric oxide-deficient
hypertension, it did have other beneficial effects, e.g. it curtailed
oxidative damage to the heart that resulted in an attenuation of left
ventricular fibrosis. In contrast to the findings in hypertensive rats,
melatonin administration was effective in overcoming cardiac enlargement
resulting from induced hyperthyroidism or chronic hypoxia exposure. In
addition, in these situations, melatonin also conferred protection against
free radical-mediated damage at the level of cardiomyocytes. Collectively,
the results of the publications summarized herein along with numerous other
published reports on other aspects of cardiovascular physiology indicate
that, when damage to the heart is a result of free radicals, melatonin is
clearly protective. This is not unexpected considering the now well
documented potent antioxidative actions of both melatonin and its
metabolites. In general, melatonin improves cardiovascular physiology and
melatonin and risk of incident hypertension among young women J
Hypertens. 2010 Jan 19 - "During 8 years of
follow-up, a total of 125 women developed hypertension. The relative risk
for incident hypertension among women in the highest quartile of urinary
melatonin (>27.0 ng/mg creatinine) as compared with the lowest quartile
(<10.1 ng/mg creatinine) was 0.49 (95% confidence interval 0.28-0.85, P <
0.001). CONCLUSION: First morning melatonin levels are independently and
inversely associated with incident hypertension; low melatonin production
may be a pathophysiologic factor in the development of hypertension"
Melatonin Treatment for Insomnia in Pediatric Patients with
Attention-Deficit/Hyperactivity Disorder (January) - Ann Pharmacother.
2009 Dec 22 - "Available data suggest that melatonin
is a well-tolerated and efficacious treatment option for pediatric patients
with chronic SOI and ADHD"
correlates of urinary 6-sulfatoxymelatonin concentrations in the Nurses'
Health Study cohorts2 - Am J Clin Nutr. 2009 Aug 12 -
"In multivariate analyses, we found no significant
associations between the intake of various nutrients, including tryptophan
and urinary melatonin concentrations. A higher intake of meat, particularly
red meat, was associated with lower concentrations of aMT6s (adjusted mean
concentrations of aMT6s across increasing quartiles of red meat intake were
17.9, 17.0, 18.1, and 15.3 ng/mg creatinine; P for trend = 0.02). In
contrast, neither intake of poultry (including turkey) nor fish was
associated with aMT6s concentrations ... Although no specific nutrients were
associated with altered concentrations of melatonin, our findings raise the
possibility that several specific foods, including red meat, could affect
cancer risk through the lowering of melatonin concentrations"
circadian melatonin rhythm and its modulation: possible impact on
hypertension - J Hypertens. 2009 Aug;27 Suppl 6:S17-20 -
"The chronic administration of melatonin to
individuals with hypertension induces a measurable drop in night time
systolic and diastolic blood pressure. Moreover, the higher the night time
level of endogenous melatonin (estimated from urinary metabolite of
melatonin, 6-hydroxymelatonin sulphate), the greater the reduction in
arterial blood pressure at night. The implication of these findings is that
melatonin may have utility as an antihypertensive agent"
of melatonin, captopril, spironolactone and simvastatin on blood pressure
and left ventricular remodelling in spontaneously hypertensive rats - J
Hypertens. 2009 Aug;27 Suppl 6:S5-10 - "It is
concluded that although melatonin, in comparison with captopril, did not
reverse left ventricle hypertrophy, it reversed left ventricular fibrosis.
This protection by melatonin may be caused by its prominent antioxidative
melatonin levels and postmenopausal breast cancer risk in the nurses' health
study cohort - Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):74-9 -
"An increased concentration of urinary aMT6s was
statistically significantly associated with a lower risk of breast cancer
(odds ratio for the highest versus lowest quartile of morning urinary aMT6s,
0.62 ... Results from this prospective study add substantially to the
growing literature that supports an inverse association between melatonin
levels and breast cancer risk"
Endocrine regulation of the course of menopause by oral melatonin: first
case report - Menopause. 2007 Nov 8 - "The data
obtained in this case report show that melatonin administration was able to
delay the characteristic endocrine changes that occur during the course of
Night Shift Work and the Risk of Endometrial Cancer - Cancer Res. 2007
Nov 1;67(21):10618-10622 - "Women who worked 20+
years of rotating night shifts had a significantly increased risk of
endometrial cancer [MVRR, 1.47 ... obese women working rotating night shifts
doubled their baseline risk of endometrial cancer (MVRR, 2.09; 95% CI,
1.24-3.52) compared with obese women who did no night work ... Women working
rotating night shifts for a long duration have a significantly increased
risk of endometrial cancer, particularly if they are obese. We speculate
that this increased risk is attributable to the effects of melatonin on
hormonal and metabolic factors"
Acute effect of metformin on exercise capacity in active males -
Diabetes Obes Metab. 2007 Oct 29 - "A single dose of
metformin does not acutely influence maximal oxygen consumption or
ventilatory threshold in healthy active males. The lower lactate
concentration observed during continuous exercise with metformin was an
unexpected finding considering that, in the resting state, metformin has
been previously associated with a modest increase in lactate concentrations"
Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years:
quality of sleep and next-day alertness outcomes - Curr Med Res Opin. 2007
Sep 14 - "PR-melatonin results in significant and
clinically meaningful improvements in sleep quality, morning alertness, sleep
onset latency and quality of life in primary insomnia patients aged 55 years and
Effects of melatonin and rilmazafone on nocturia in the elderly - J Int
Med Res. 2007 Sep-Oct;35(5):685-91 - "melatonin (2
mg/day; n = 20) or rilmazafone (2 mg/day; n = 22) for 4 weeks ... After 4
weeks' treatment, the number of nocturnal urinations was significantly
decreased and the QoL score was significantly improved in both groups. There
was no significant difference between the patient-reported effectiveness
ratings between the two groups" - See
melatonin at Amazon.com.
Daily nighttime melatonin reduces blood pressure in male patients with
essential hypertension - Hypertension. 2004 Feb;43(2):192-7 -
"In patients with essential hypertension, repeated
intake significantly reduced nocturnal blood pressure"- See
melatonin at Amazon.com.
Melatonin-induced reduction in age-related accumulation of oxidative damage
in mice - Biogerontology. 2003;4(3):133-9 - "The
findings indicate that low-dose chronic administration of melatonin acts as
a free radical scavenger and anti-aging agent"
Melatonin treatment for tardive dyskinesia: a double-blind,
placebo-controlled, crossover study - Arch Gen Psychiatry 2001
Melatonin inhibits testosterone secretion by acting at
hypothalamo-pituitary-gonadal axis in the rat - Neuroendocrinol Lett
Antioxidative effects of melatonin in protection against cellular damage
caused by ionizing radiation - Proc Soc Exp Biol Med. 2000
Oct;225(1):9-22 - "The radioprotective effects of
melatonin against cellular damage caused by oxidative stress and its low
toxicity make this molecule a potential supplement in the treatment or
co-treatment in situations where the effects of ionizing radiation are to be
Evidence for a local action of melatonin on the rat prostate - J Urol
1998 Mar;159(3):1069-73 - "The results demonstrate
putative melatonin receptors in the rat prostate and suggest a direct
suppression by melatonin of testosterone-dependent prostate growth"
Bioavailability of oral melatonin in humans - Neuroendocrinology 1984
Oct;39(4):307-13 (shows that melatonin has a short half-life)
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