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Anti-aging Research > Melatonin
Melatonin
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Specific Recommendations:
General Information:
-
Melatonin
- Vitacost Health Library
-
Melatonin and Cancer - Life Extension Magazine, 6/01
- Melatonin - M. D. Anderson Cancer Center
- Melatonin - The Natural
Pharmacist
- What
is the best way to use melatonin to prevent or relieve jet lag? - Dr.
Murray
- I suffer
from seasonal affective disorder. Do you have any suggestions? - Dr.
Murray -
"Melatonin supplementation may improve
SAD because it not only increases brain melatonin levels, but also
because it may suppress cortisol secretion"
-
Melatonin, Nature's Sleeping Pill - Ray Sahelian, M.D.
- Melatonin
as anti prostatitis - prostatitis.org
News & Research:
-
Night Shift Work May Cause Cancer - WebMD, 11/30/07 -
"They note that shift work may raise cancer risk by
suppressing production of melatonin, a chemical involved in the circadian
rhythm"
-
High
Melatonin Content Can Help Delay Aging, Mouse Study Suggests - Science
Daily, 4/24/07 - "Therefore, the
researcher asserts, daily melatonin intake in humans from the age of 30 or
40 could prevent – or, at least, delay – illnesses related to aging, free
radicals and inflammatory processes, such as many neurodegenerative
disorders (e.g. Parkinson's disease) and complications linked to other
illnesses, like diabetes"
-
Salivary Melatonin May Help Fight Gum Disease - Science Daily, 9/13/06 -
"the melatonin may fight against
infection and inflammation possibly due to its antioxidant, anti-aging and immunoenhancing ability"
-
Grapes May Help With Sleep - WebMD, 6/19/06 -
"The juicy fruit might be packing
melatonin, a sleep hormone"
-
Another Grape Excuse To Hit The Bottle - Science Daily, 6/16/06 -
"the grapes used to make some of the
most popular red wines contain high levels of the sleep hormone melatonin"
-
Best Time to Take Melatonin? - WebMD, 5/3/06
-
Melatonin Improves Mood In Winter Depression - Science Daily, 5/2/06 -
"melatonin, a naturally occurring
brain substance, can relieve the doldrums of winter depression, also known
as seasonal affective disorder, or SAD"
-
Melatonin Most Effective For Sleep When Taken For Off-hour Sleeping -
Science Daily, 5/1/06 - "sleep
efficiency during the six hour, 40 minute episodes was significantly higher
in the groups that took melatonin during times when the body was not
producing melatonin. At those times, participants taking 5.0mg of melatonin
had a sleep efficiency of 83 percent and those taking 0.3mg melatonin had a
sleep efficiency of 84 percent"
-
Melatonin Supplements review - ConsumerLab.com, 4/5/06
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Melatonin Pills May Help Ease Tinnitus - WebMD, 2/24/06
-
Melatonin could help tinnitus, improve sleep - Nutra USA, 2/23/06
-
Melatonin for Travelers' Sleep Woes? - WebMD, 2/9/06
-
Melatonin may cut hypertension - Nutra USA, 2/2/06 -
"A 10 per cent decline of BP over
daytime values is considered appropriate to reduce the cardiovascular risk
... During placebo use only 39 per cent of the subjects reached this value,
but this rate surged to 84 per cent during melatonin administration"
-
Study Demonstrates Role Of Exercise In Modifying Melatonin Levels; Increase
Believed To Offer Breast Cancer Protection - Science Daily, 12/3/05
-
Stopping Jet Lag Before It Starts - WebMD, 11/2/05 -
"The body clocks of those who took
melatonin adapted better to the new schedule. The higher dose of melatonin
fared best in that regard, but not by much. Plus, people who took the higher
dose were sleepier in the evenings after taking the pill"
-
Travelers Can Avoid Jet Lag By Resetting Their Body Clocks - Science
Daily, 11/2/05
-
Melatonin to Fight Insomnia: Timing Is Key - WebMD, 10/25/05 -
"melatonin was most effective in
resetting the body's internal, or circadian, clock when it was timed to the
individual's sleep patterns ... If you only want to induce sleep you can
take it about two hours before you want to go to sleep"
-
Melatonin May Reduce the Pain of Irritable Bowel Syndrome - Medscape,
10/14/05 - "Use of 3 mg of melatonin
once daily for two weeks in IBS patients is
associated with improvement in bowel pain and rectal distension thresholds
for urgency and pain but not with a change in stool frequency, type, or
quality of life"
-
Add-On Melatonin Improves Sleep Behavior in Children With Epilepsy:
Randomized, Double-Blind, Placebo-Controlled Trial - Medscape, 5/24/05
-
Melatonin Modestly Effective for Sleep - WebMD, 3/3/05
-
Melatonin study could 'jump-start' interest in supplement
- Nutra USA, 3/2/05
- Popular Supplement Melatonin Found To Have Broader Effects In Brain Than
Once Thought - Science Daily, 2/11/05 -
"In experiments on the Japanese quail, the researchers found that melatonin
switches on a recently discovered hormone called gonadotropin inhibitory
hormone (GnIH),
which has been found to have the opposite effect to the key hormone priming
the body for sex –
gonadotropin releasing
hormone (GnRH).
In birds, switching off GnRH
causes the gonads – testes and ovary – to shrink as part of the birds'
yearly cycle"
-
U.S. Study Sees Little Benefit From Melatonin - HealthDay, 12/22/04 -
"The one area where melatonin did seem to work was with a group of people
with a condition called "delayed sleep phase syndrome," which means that
otherwise healthy people have a biological quirk that prevents a normal
sleep cycle"
- Melatonin Supplements May Not Help Sleep - WebMD,
12/10/04
-
Melatonin May Improve Sleep Quality in Patients With Asthma - Medscape,
11/1/04
- Melatonin Effective in Relieving Pain But Not Sleep Disturbance Related to
Irritable Bowel Syndrome - Doctor's Guide, 9/30/04
-
Melatonin May Help Prevent Migraines - WebMD, 9/9/04
- Melatonin Decreases Migraine Frequency and Intensity
- Medscape, 9/9/04 -
"Of 32 patients who completed the study, 25 patients (78.1%) had at least a
50% reduction in headache frequency from baseline, eight patients (25%) had
no headaches, and none of the patients had increased headaches after three
months of therapy"
- Melatonin Relieves Stabbing Headaches - Healthwell
Exchange Daily News, 2/26/04
- Melatonin to
Lower Blood Pressure? - Dr. Weil, 2/24/04
- Caffeine, Melatonin May Ease Jet Lag - WebMD,
2/6/04
- Nightime Melatonin Supplementation May Be Useful in the Treatment of
Essential Hypertension - Doctor's Guide, 2/4/04 -
"2.5 mg/day ... mean sleep systolic blood pressure decreased by 6 mm Hg and
mean sleep diastolic blood pressure
decreased by 4 mm Hg ... Repeated melatonin significantly increased sleep
efficiency from 80% to 85% and increased actual sleep time from 5.6 to 6.1
hours. Melatonin therapy also reduced sleep latency from 33 to 22 minutes"
- Jet Lag Hormone Lowers Blood Pressure - WebMD,
1/20/04
-
Melatonin May Cut Hypertension Risk - HealthDay, 1/19/04 -
"The men were randomly assigned to receive either a placebo, a single dose
of melatonin or 2.5 milligrams of melatonin one hour before bedtime for
three weeks ... those taking the hormone each night throughout the three
weeks had lower nighttime systolic and diastolic
blood pressure. Systolic blood pressure (the top number in the reading)
decreased by an average of six millimeters of mercury while the diastolic
blood pressure (the bottom number) decreased by an average of four
millimeters of mercury" - See
iHerb
or
Vitacost
melatonin products.
-
Melatonin and Cancer Treatment - Life Extension Magazine, 1/04
- Melatonin Helpful for Delayed Sleep Onset in Children With ADHD
- Medscape, 10/21/03
- People With Asthma Cautioned About Melatonin Use -
Doctor's Guide, 9/8/03
- Hormone Melatonin Slows Breast Cancer - WebMD,
7/14/03 - "The nighttime hormone
melatonin puts breast cancer cells to sleep. It
also slows breast cancer growth by 70%"
- Nighttime Computer Users May Lose Sleep - WebMD,
6/20/03 - "the bright light of a
computer screen may alter the body's biological clock and suppress the
natural production of melatonin that's critical to the
normal sleep-wake cycle"
- Night Shifts May Raise Cancer Risk - WebMD, 6/3/03
- "Data from an ongoing study of
almost 80,000 nurses already suggest that working nights increases a woman's
risk of
breast cancer ... a new analysis points to a
similar association for colorectal cancer ...
"The peak production of melatonin occurs at about 1 or 2 a.m." Exposure to
light at night stops the production of melatonin" - See
iHerb
or
Vitacost
melatonin products.
- Melatonin Effective Treatment for Chronic Insomnia in Children
- New Hope Natural Media, 5/15/03
-
Melatonin Appears Safe for Child Insomniacs - Clinical Psychiatry News,
3/03 - "Melatonin appears to be a
safe and effective treatment for children with
insomnia ... The average age of the patients was 9.6 years ... Dr.
Ivanenko, who is a child psychiatrist at the University of Louisville (Ky.),
said she typically starts children at 1-5 mg of melatonin and titrates up to
as much as 8-10 mg in adolescents" - See
iHerb
or
Vitacost
melatonin products.
- Melatonin:
What Is the Scoop? - Dr. Weil, 1/28/03
-
Melatonin May Worsen Asthma - WebMD, 10/9/02
-
Melatonin Helps Shorten Recovery Time from Jet Lag - New Hope Natural
Media, 7/11/02
- Neuroprotective Effects of Melatonin Assessed -
Doctor's Guide, 4/30/02 - "The neuroprotective
effects of melatonin appear to be related to
antioxidant and
antiamyloidogenic
features of the hormone, not to the involvement of melatonin receptors"
- Can Melatonin Put Tumors to Sleep? - Nutrition
Science News, 12/01
- Melatonin
Helps Children Sleep Through Magnetic Resonance Studies
- Doctor's Guide, 11/26/01
- Study: Power Lines May Aid Cancer Cells -
Intelihealth, 10/29/01 -
"electromagnetic fields disrupted the functioning of the hormone melatonin
in individual cells ... Scientists have accepted since 1987 that the
substance suppresses the multiplication of cancer cells ... They exposed two
batches of the [breast cancer] cell to two different levels of
electromagnetic field ... In both cases, the ability of melatonin to
suppress the growth of the cancer cells was found to have declined. In some
cells with smaller concentrations of melatonin, the suppressive effect was
entirely absent"
- Melatonin Helps Break Valium Dependence -
Nutrition Science News, 3/01
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Study bolsters melatonin sleep claims - CNN, 10/12/00
-
Setting the Body Clock in the Dark - WebMD, 10/12/00
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Hormone Can Regulate Internal Clock - Intelihealth, 10/12/00
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Not Getting Your Zs? Melatonin Can Help - WebMD, 6/23/00
- Melatonin
helps kids with sleep-onset insomnia - Doctor's
Guide, 5/2/00
- A Supplement Plan for Seniors - Nutrition Science
News, 12/99
-
Electric Magnetic Fields Reduce Melatonin - Nutrition Science News,
10/99
-
Sleep's healing properties - CNN, 8/25/99
Abstracts:
-
Endocrine regulation of the course of menopause by oral melatonin: first
case report - Menopause. 2007 Nov 8 - "The data
obtained in this case report show that melatonin administration was able to
delay the characteristic endocrine changes that occur during the course of
menopause"
-
Night Shift Work and the Risk of Endometrial Cancer - Cancer Res. 2007
Nov 1;67(21):10618-10622 - "Women who worked 20+
years of rotating night shifts had a significantly increased risk of
endometrial cancer [MVRR, 1.47 ... obese women working rotating night shifts
doubled their baseline risk of endometrial cancer (MVRR, 2.09; 95% CI,
1.24-3.52) compared with obese women who did no night work ... Women working
rotating night shifts for a long duration have a significantly increased
risk of endometrial cancer, particularly if they are obese. We speculate
that this increased risk is attributable to the effects of melatonin on
hormonal and metabolic factors"
-
Acute effect of metformin on exercise capacity in active males -
Diabetes Obes Metab. 2007 Oct 29 - "A single dose of
metformin does not acutely influence maximal oxygen consumption or
ventilatory threshold in healthy active males. The lower lactate
concentration observed during continuous exercise with metformin was an
unexpected finding considering that, in the resting state, metformin has
been previously associated with a modest increase in lactate concentrations"
-
Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years:
quality of sleep and next-day alertness outcomes - Curr Med Res Opin. 2007
Sep 14 - "PR-melatonin results in significant and
clinically meaningful improvements in sleep quality, morning alertness, sleep
onset latency and quality of life in primary insomnia patients aged 55 years and
over"
-
Effects of melatonin and rilmazafone on nocturia in the elderly - J Int
Med Res. 2007 Sep-Oct;35(5):685-91 - "melatonin (2
mg/day; n = 20) or rilmazafone (2 mg/day; n = 22) for 4 weeks ... After 4
weeks' treatment, the number of nocturnal urinations was significantly
decreased and the QoL score was significantly improved in both groups. There
was no significant difference between the patient-reported effectiveness
ratings between the two groups" - See
melatonin products at iHerb
 .
-
Daily nighttime melatonin reduces blood pressure in male patients with
essential hypertension - Hypertension. 2004
Feb;43(2):192-7 -
"In patients with essential
hypertension, repeated bedtime melatonin
intake significantly reduced nocturnal blood pressure"- See
iHerb
or
Vitacost
melatonin products.
- Melatonin-induced reduction in age-related accumulation of oxidative damage
in mice - Biogerontology. 2003;4(3):133-9 - "The findings indicate
that low-dose chronic administration of melatonin acts as a free radical
scavenger and anti-aging agent"
- Melatonin treatment for tardive dyskinesia: a double-blind,
placebo-controlled, crossover study - Arch Gen
Psychiatry 2001 Nov;58(11):1049-52
- Melatonin inhibits testosterone secretion by acting at
hypothalamo-pituitary-gonadal axis in the rat -
Neuroendocrinol Lett 2000;21(4):301-306
-
Antioxidative effects of melatonin in protection against cellular damage
caused by ionizing radiation - Proc Soc Exp Biol Med. 2000
Oct;225(1):9-22 - "The radioprotective effects of
melatonin against cellular damage caused by oxidative stress and its low
toxicity make this molecule a potential supplement in the treatment or
co-treatment in situations where the effects of ionizing radiation are to be
minimized."
-
Evidence for a local action of melatonin on the rat prostate - J Urol
1998 Mar;159(3):1069-73 - "The
results demonstrate putative melatonin receptors in the rat prostate and
suggest a direct suppression by melatonin of testosterone-dependent prostate
growth"
-
Bioavailability of oral melatonin in humans - Neuroendocrinology 1984
Oct;39(4):307-13 (shows that melatonin has a short half-life)
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