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Anti-aging Research > L-Leucine
L-Leucine
Specific Recommendations:
News & Research:
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Research
from Everest: Can leucine help burn fat and spare muscle tissue during exercise?
- Science Daily, 8/28/11 - "Research on Mt. Everest climbers is adding to the
evidence that an amino acid called leucine -- found in foods, dietary
supplements, energy bars and other products -- may help people burn fat during
periods of food restriction, such as climbing at high altitude, while keeping
their muscle tissue ... We knew that leucine has been shown to help people on
very low-calorie, or so-called 'calorie-restricted diets', stay healthy at sea
level ... the findings also could help people at lower altitudes who want to
lose weight while preserving their lean body mass, or who are elderly and don't
eat or exercise enough to maintain their strength"
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Dietary leucine may fight pre-diabetes, metabolic syndrome: Study shows
improvements in animals with amino acid in diet - Science Daily, 6/22/11 -
"mice who had
been on a high-fat diet and who also received twice the usual intake of leucine,
an amino acid found in protein, showed reductions in their prediabetic
conditions with lower blood sugars and less fat in their livers, two of the
collection of medical problems associated with insulin resistance that make up
what is known as metabolic syndrome ... Their glucose tolerance tests improved
... Their bodies responded to insulin better than they would have before they
got the leucine. It improved their ability to metabolize sugar and fats. It
markedly improved their pre-diabetic condition. Their metabolic syndrome also
improved"
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Amino
acid supplement makes mice live longer - Science Daily, 10/5/10 -
"leucine,
isoleucine, and valine extend the life span of single-celled yeast ... Animals
that were given the extra amino acids over a period of months lived longer, with
a median life span of 869 days compared to 774 days for untreated control
animals, the researchers report. That's an increase of 12 percent ... The
findings in older mice suggest that the supplementary mixture may be
specifically beneficial for those who are elderly or ill" - See
Now Foods, Branched Chain Amino Acids, 240 Capsules at iHerb
 ,
it contains the three of these.
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Leucine supplements could help prevent muscle loss - Nutra USA, 12/8/05
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Feeling Old? Supplement Diet With Leucine Prevents Muscle
Loss Linked To Aging - Science Daily, 12/4/05 - "After the age of 40, humans start loosing muscle at around
0.5-2% per year ... adding leucine to the diet restored a balanced
metabolism"
Abstracts:
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Leucine supplements boost muscle synthesis by 33% during exercise - Nutra
USA, 10/6/11 - "In contrast with resistance exercise, sustained endurance
exercise is mainly catabolic, yielding simultaneous reductions in muscle protein
synthesis and plasma leucine concentrations during exercise, which may be
attributed to the metabolic demand for branched chain amino acids in exercising
skeletal muscle ... the leucine-enriched beverage was associated with a 33%
increase in muscle protein synthesis ... Our findings indicate that increasing
the leucine content of protein supplements provided for those populations
susceptible to muscle loss, including proteolytic conditions—such as cachexia,
sarcopenia, and calorie deprivation—may warrant further exploration" - [Abstract]
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Similar
effects of leucine rich and regular dairy products on muscle mass and
functions of older polymyalgia rheumatica patients: a randomized crossover
trial - J Nutr Health Aging. 2011;15(6):462-7 -
"Patients performed as many stand ups as possible twice a day after which
they ingested a regular (Control) or a whey protein enriched dairy product
with high leucine content (Test). The 8-week intervention periods were
separated by a 4-week wash-out ... The 16-week home-based post-exercise
supplementation resulted in a 1.8% increase (p = 0.052) in lower limb muscle
mass. Walking speed (+5.3%, p = 0.007) and chair stand test performance
(-12.2 %, p < 0.001) were also improved. Furthermore, a tendency for
increased jump power (+3.0%, p = 0.084) was observed. However, significant
and consistent differences were not found in the changes of muscle mass
indices or muscle functions between supplements, but the test supplement
tended to prevent accumulation of body fat. Conclusion: A low intensity home
based exercise program combined with post-exercise milk protein
supplementation is feasible despite some gastrointestinal complaints and
seems effective in improving the muscle mass and functions of older persons
with a inflammatory disease. Further studies are needed to establish,
whether and to what extent the use of leucine-enriched whey products prevent
or treat age-associated sarcopenia and whether they are superior to the
present commercial milk products"
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Leucine
and {alpha}-Ketoisocaproic Acid, but Not Norleucine, Stimulate Skeletal
Muscle Protein Synthesis in Neonatal Pigs - J Nutr. 2010 Jun 9
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Long-term leucine supplementation does not increase muscle mass or strength
in healthy elderly men - Am J Clin Nutr. 2009 Mar 25
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A high proportion of leucine is required for optimal stimulation of the rate
of muscle protein synthesis by essential amino acids in the elderly - Am
J Physiol Endocrinol Metab. 2006 Feb 28
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Amino acids and muscle loss with aging
- J Nutr. 2006 Jan;136(1):277S-80S - "Recent data suggest that excess leucine may be able to overcome this
age-related resistance of muscle proteins to leucine. For this reason,
long-term essential amino acid supplementation may be a useful tool for the
prevention and treatment of sarcopenia, particularly if excess leucine is
provided in the supplement"
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