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Home > Anti-aging Research > N-acetyl-L-cysteine (NAC)

N-acetyl-L-cysteine (NAC)

Related Topics:

• l-glutathione

Specific Recommendations:

• NAC products at iHerb
• L-cysteine products at iHerb
• Vitacost NAC products
• Drugstore.com/GNC l-cysteine products

News & Research:

• N-Acetyl Cysteine - Vitacost Health Library
• Cysteine - Vitacost Health Library
• N-Acetyl Cysteine (NAC) - The Natural Pharmacist
• NAC: The Best Flu and Cold Remedy Yet? - thenutritionreporter.com
• N-Acetylcysteine Boosts Immunity, Reduces Flu Symptoms - thenutritionreporter.com
• Before A CT Scan Or Angiogram, Many People Should Take Inexpensive Drug To Protect Kidneys - Science Daily, 2/18/08 - "The inexpensive drug, called N-acetylcysteine, can prevent serious kidney damage that can be caused by the iodine-containing "dyes" that doctors use to enhance the quality of such scans ... N-acetylcysteine is already widely used to clear mucus in cystic fibrosis patients, and to treat overdoses of acetaminophen"
• Treatment With NAC Is Associated With Better Outcomes For Children With Liver Failure, Study Suggests - Science Daily, 1/3/08 - "The children who received NAC spent fewer days in intensive care, and in the hospital overall. 43 percent survived with their native liver, compared to 22 percent of children who did not receive NAC. And death rates while awaiting transplant, after transplant, and after ten years were notably lower in children who had received NAC"
• N-acetyl Cysteine May Aid in Treatment of Schizophrenia - Doctor's Guide, 10/16/07 - "The study showed that NAC improves certain symptoms of schizophrenia, and therefore implicated glutathione deficiency in the pathogenesis"
• Short-Course N-Acetylcysteine Effective for Acetaminophen Overdose - Medscape, 10/4/07 - "A shortened course of as few as six oral doses of N-acetylcysteine appears to be an effective treatment for certain patients with acute acetaminophen poisoning"
• Health Food Supplement May Curb Addiction Of Pathological Gamblers - Science Daily, 9/11/07
• How Vitamin C Stops Cancer - Science Daily, 9/10/07 - "Both of these cancers produce high levels of free radicals that can be suppressed by feeding the mice supplements of antioxidants, either vitamin C or N-acetylcysteine (NAC) ... Some rapidly growing tumors consume enough energy to easily suck out the available oxygen in their vicinity, making HIF-1 absolutely critical for their continued survival. But HIF-1 can only operate if it has a supply of free radicals. Antioxidants remove these free radicals and stop HIF-1, and the tumor, in its tracks" - See vitamin C products at iHerb.
• One Type Of Antioxidant May Not Be As Safe As Once Thought - Science Daily, 9/4/07 - "The research team administered both NAC and nitrosothiols to mice for three weeks. The NAC was converted by red blood cells into the nitrosothiol, S-nitroso-N-acetylcysteine (SNOAC). The normal mice that received NAC and SNOAC developed PAH. Mice missing an enzyme known as endothelial nitric oxide synthase did not convert NAC to SNOAC, and were protected from the adverse effects of NAC, but not SNOAC. This suggests that NAC must be converted to SNOAC to cause PAH ... Could regular use of NAC produce the same effects in humans? The next step is to determine a threshold past which antioxidant use becomes detrimental to heart or lung function"
• N-Acetylcysteine May Reduce Cocaine Craving - Medscape, 7/26/07
• Cysteine Containing Chewing Gum For The Prevention Of Upper Digestive Tract Cancers? - Science Daily, 5/22/06
• Intravenous N-Acetylcysteine During Haemodialysis Reduces the Plasma Concentration of Homocysteine in Patients With End-Stage Renal Disease - Medscape, 5/16/06
• Addiction: Supplement May Stifle the Craving for Cocaine - New York Times, 12/20/05
• Acetylcysteine May Be Helpful for Pulmonary Fibrosis - Medscape, 11/23/05
• High Dose N--Acetylcysteine in Patients with COPD - Medscape, 7/18/05
• Antioxidant, B vitamin combo to slow dementia? - Nutra USA, 12/6/04 - "the glutathione precursor N-acetylcysteine (NAC) is not only a potent antioxidant but also a source of cysteine. Cysteine is required to generate hydrogen sulphide - an important neuromodulator and vasorelaxant. Levels of hydrogen sulphide levels are severely decreased in the brains of Alzheimer’s disease patients"
• No Difference between N-Acetylcysteine and Fenoldopam for Thwarting Contrast-Induced Nephropathy - Doctor's Guide, 11/8/04 - "A randomized study failed to show a significant difference in the ability of oral N-acetylcysteine (NAC) and intravenous fenoldopam (FEN) to prevent the deterioration in renal function"
• NAC supplement for brain damage in boys - Nutra USA, 5/4/04 - "Because it enhances the production of the enzyme glutathione, NAC is thought to both stave off disease and play an important role in boosting the immune system"
• N-Acetylcysteine Beneficial for Chronic Lung Disease - Healthwell Exchange Daily News, 10/2/03
• Pre-treatment With Acetylcysteine For Cardiac Catheterisation Reduces Contrast-Induced Nephropathy - Doctor's Guide, 12/5/03
• Thiol-Containing Antioxidant Shows Promise in Preventing Contrast Nephropathy - Doctor's Guide, 8/25/03 - "Treatment with acetylcysteine, a thiol-containing antioxidant, shows promise in preventing contrast nephropathy in patients with chronic renal insufficiency"
• High Cysteine Levels Linked to Lower Rates of Breast Cancer - Doctor's Guide, 7/15/03 - "Women in the highest quintile for measured cysteine levels in this study had a 56% lower risk of invasive or in situ breast cancer than women in the lowest quintile ... The findings were more pronounced when only invasive cancer was considered ... Cysteine or its precursors might have the potential to be chemoprotective against breast cancer"
• N-Acetyl Cysteine Prevents Kidney Damage from Coronary Procedure - New Hope Natural Media, 5/1/03 - "Up to 15% of people undergoing coronary angiography may experience kidney damage from the contrast dye ... randomly assigned to receive either 600 mg of oral NAC twice a day on the day before and the day of the procedure or a similar looking placebo ... Only 4% of those taking NAC, compared with 12% of those taking the placebo, experienced a 25% increase in blood creatinine within 48 hours of receiving the contrast dye"
• Cardiovascular End Points Reduced With Antioxidant Acetylcysteine In Haemodialysis Patients - Doctor's Guide, 2/28/03 - "They were assigned to receive either acetylcysteine 600 mg twice daily or a placebo ... Primary end point was a composite variable composed of cardiac events that included fatal and non-fatal myocardial infarction, death from cardiovascular disease, necessity for either coronary angioplasty or by-pass surgery, ischaemic stroke, peripheral vascular disease requiring amputation or need for angioplasty ... A primary end point was established in 18 of the 64 [28%] haemodialysed patients who received acetylcysteine, and 33 of 70 [47%] patients undergoing haemodialysis assigned to the control group" - [Abstract]
• N-Acetyl Cysteine Improves Insulin Resistance in Women with Polycystic Ovary Syndrome - New Hope Natural Media, 12/12/02 - "PCOS ... affects up to 10% of all women of reproductive age ... characterized by enlargement of the ovaries, irregular menstrual cycle, failure to ovulate, obesity, high levels of insulin in the blood and insulin resistance, excessive hair growth (due to increased testosterone) and infertility. More than 50% of all women with PCOS have high insulin levels, which may be a risk factor for diabetes, high blood pressure, blood clots and heart disease ... Women with high initial insulin levels who took NAC had a significant reduction in insulin levels following the glucose tolerance test and also showed improved insulin sensitivity"
• Acetylcysteine Can Reduce Cardiovascular Events in Patients with Endstage Renal Disease - Doctor's Guide, 10/1/02 - "therapy with acetylcysteine appears to significantly reduce cardiovascular events among haemodialysis patients" - See iHerb and Vitacost acetyl-l-cysteine products.
• N-Acetylcysteine Helpful for Eye Disorder - New Hope Natural Media, 9/26/02
• Getting More Glutathione? - Dr. Weil, 8/29/02 - "To my knowledge, the only supplement that effectively raises glutathione levels in the body is N-acetyl-L-cysteine (NAC). My colleague Kathleen Johnson, a dietician here at the Program in Integrative Medicine, tells me that other glutathione supplements are ineffective because they’re digested before they can get into the bloodstream"
• Putting Antioxidants To Use In Functional Formulas - Functional Foods & Nutraceuticals, 5/02 - "N-acetylcysteine (NAC), like alpha-lipoic acid, is a potential antioxidant and precursor to glutathione. However, NAC is also a powerful immune stimulant. For example, an Italian study of 262 elderly subjects found that 600mg NAC, taken twice daily, reduced flu symptoms by two-thirds.18 Large dosages of NAC—up to several grams daily—can extend the life expectancy of patients with AIDS,19 and some research suggests that it may also reduce the risk of cancer"
• Acetylcysteine Prevents Renal Problems After Angiography - Doctor's Guide, 3/18/02 - "Changes in creatinine mean values after 48 hours were -0.4 (±0.3) and +0.1 (±0.3) mg/dL for treatment and control groups, respectively (p<0.001). The benefit was larger in patients with baseline creatinine levels higher than 2 mg/dL, at -0.4 (±0.4) compared to +0.5 (±0.3) mg/dL (p<0.001)"
• Antioxidant Boosts Cognitive Function In Alzheimer's Patients - Intelihealth, 11/15/01 - "the antioxidant N-acetylcysteine (NAC) may improve certain cognitive skills in people with Alzheimer's disease ... Although participants in the NAC group did not outperform placebo patients in day-to-day activities, they did fare significantly better than the placebo group on certain cognitive tests"
• N-acetylcysteine Improves Blood Vessels - Nutrition Science News, 5/01 - "Researchers suspect this is because NAC enhances the bioavailability of the relaxing substance nitric oxide, but because nitric oxide has a short half-life and cannot be measured by current methodology, they were unable to determine this directly. In addition, NAC may act as an antioxidant that protects nitric oxide destruction"
• Glutathione: The Eye Healer Within - Nutrition Science News, 4/01 - "Supplementing with glutathione to boost glutathione levels is not well understood. Glutathione is a large molecule that is not easily absorbed, but it is a tripeptide with cysteine—a sulfur-bearing amino acid—in the middle. As cysteine is broken down in the digestive tract, its sulfur is absorbed and utilized to make more glutathione"
• Can Cirrhosis be Prevented? - Nutrition Science News, 1/99

Abstracts:

• N-Acetylcysteine prevents ifosfamide-induced nephrotoxicity in rats - Br J Pharmacol. 2008 Feb 18 - "NAC markedly reduces the severity of renal dysfunction induced by ifosfamide with a significant decrease in elevations of serum creatinine (57.8+/-2.3 vs 45.25+/-2.1 mumol l(-1)) as well as a reduced elevation of beta(2)-microglobulin excretion (25.44+/-3.3 vs 8.83+/-1.3 nmol l(-1)) and magnesium excretion (19.5+/-1.5 vs 11.16+/-1.5 mmol l(-1)). Moreover, NAC significantly improved the ifosfamide-induced glutathione depletion and the decrease of glutathione S-transferase activity, lowered the elevation of lipid peroxides and prevented typical morphological damages in renal tubules and glomeruli" - See NAC products at iHerb.
• Long Term N-Acetylcysteine and L-Arginine Administration Reduces Endothelial Activation and Systolic Blood Pressure in Hypertensive Patients with Type 2 Diabetes Mellitus - Diabetes Care. 2008 Feb 11 - "The NAC+ARG administration seems to be a potential well-tolerated antiatherogenic therapy since it improves the endothelial function in hypertensive patients with type 2 diabetes by improving NO bioavailability via reduction of the oxidative stress and increase of NO production. Our study's results give prominence to its potential use in the primary and secondary cardiovascular prevention in these patients"
• N-acetylcysteine for the prevention of postoperative atrial fibrillation: a prospective, randomized, placebo-controlled pilot study - Eur Heart J. 2008 Feb 8 - "The result of this study indicates that NAC treatment decreases the incidence of postoperative AF" - See NAC products at iHerb.
• Effects of folic acid and N-acetylcysteine on plasma homocysteine levels and endothelial function in patients with coronary artery disease - Acta Cardiol. 2007 Dec;62(6):579-85 - "either folic acid 5 mg or NAC 600 mg or placebo daily for eight weeks ... endothelium-dependent dilation (EDD) ... Folic acid and NAC therapies decreased plasma homocysteine (from 21.7 +/- 8.7 micromol/l to 12.5 +/- 2.5 micromol/l, P < 0.001; from 20.9 +/- 7.6 micromol/l to 15.6 +/- 4.3 micromol/l, P = 0.03, respectively), and increased EDD (6.7 +/- 6.1% P = 0.002, 4.4 +/- 2.6% P < 0.001, respectively) compared with placebo. There was no significant difference in improving EDD between the folic acid and the NAC group"
• Telmisartan, an Angiotensin II Type 1 Receptor Blocker, Inhibits Advanced Glycation End-product (AGE)-induced Monocyte Chemoattractant Protein-1 Expression in Mesangial Cells Through Downregulation of Receptor for AGEs via Peroxisome Proliferator-activated Receptor-gamma Activation - J Int Med Res. 2007 Jul-Aug;35(4):482-9 - "Candesartan, an Ang II type 1 receptor blocker, did not suppress AGEs-induced superoxide generation. Telmisartan and the antioxidant, N-acetylcysteine, completely inhibited AGEs-induced MCP-1 overproduction by mesangial cells"
• Acetylcysteine for Prevention of Acute Deterioration of Renal Function Following Elective Coronary Angiography and Intervention: A Randomized Controlled Trial - JAMA, 2/5/03 - "Acetylcysteine protects patients with moderate chronic renal insufficiency from contrast-induced deterioration in renal function after coronary angiographic procedures, with minimal adverse effects and at a low cost" - See iHerb or Vitacost acetyl-l-cysteine products.

Other possible n-acetyl-l-cysteine retailers:

Related Searches:

• Doctor's Guide search of l-cysteine
• Doctor's Guide (2) search of cysteine
• Intelihealth search of l-cysteine
• Life Extension Foundation search
• Medline search of l-cysteine
• Medscape search of cysteine
• The Natural Pharmacist search of l-cysteine
• Nutrition Science News search
• WebMD search of l-cysteine

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