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Home > Anti-aging Research > citrulline
L-citrulline
Specific Recommendations:
News & Research:
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Nitric Oxide Now -- Ask Me How - WashingtonPost.com, 10/6/03 -
"In the arteries, the innermost layer of cells releases
nitric oxide to signal smooth muscle cells to dilate (increase the diameter of) the arteries. This allows blood to flow more freely, particularly during exercise ... By the 1990s, many scientists saw nitric oxide as the next great weapon for treating heart disease, impotence and even bacterial infections ...
Niteworks has L-arginine and also L-citrulline, which recycles spent L-arginine by resupplying it with atoms it lost producing nitric oxide ... "Ninety dollars a month? That's obscene," Murad said. "You can probably get [vitamin] C and E for pennies a day. You can probably get arginine
for about a dollar a day"" - See
L-citrulline products at iHerb
 .
Abstracts:
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Oral
L-citrulline supplementation improves erection hardness in men with mild
erectile dysfunction - Urology. 2011 Jan;77(1):119-22 -
"L-arginine
supplementation improves nitric oxide-mediated vasodilation and endothelial
function; however, oral administration has been hampered by extensive
presystemic metabolism. In contrast, L-citrulline escapes presystemic metabolism
and is converted to L-arginine, thus setting the rationale for oral L-citrulline
supplementation as a donor for the L-arginine/nitric oxide pathway of penile
erection ... A total of 24 patients, mean age 56.5 ± 9.8 years, were entered and
concluded the study without adverse events. The improvement in the erection
hardness score from 3 (mild ED) to 4 (normal erectile function) occurred in 2
(8.3%) of the 24 men when taking placebo and 12 (50%) of the 24 men when taking
L-citrulline (P < .01). The mean number of intercourses per month increased from
1.37 ± 0.93 at baseline to 1.53 ± 1.00 at the end of the placebo phase (P = .57)
and 2.3 ± 1.37 at the end of the treatment phase (P < .01). All patients
reporting an erection hardness score improvement from 3 to 4 reported being very
satisfied"
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Oral
L-Citrulline Supplementation Attenuates Blood Pressure Response to Cold
Pressor Test in Young Men - Am J Hypertens. 2009 Oct 22 -
"Compared to placebo, oral L-citrulline treatment
decreased (P < 0.05) brachial SBP (-6 +/- 11 mm Hg), aortic SBP (-4 +/- 10
mm Hg), and aortic PP (-3 +/- 6 mm Hg) during CPT but not at rest. There was
an inverse correlation (r = -0.40, P < 0.05) between changes in aortic SBP
and Tr during CPT after L-citrulline supplementation"
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Regulation of nitric oxide production in health and disease Curr Opin
Clin Nutr Metab Care. 2009 Oct 16 - "The role of the
cofactor tetrahydrobiopterin in nitric oxide production and its relation
with arginine availability is indicated as an important explanation for the
arginine paradox. This offers potential for nitric oxide regulation by
dietary factors such as arginine or its precursors and vitamin C. Because
diets with a high saturated fat content induce high plasma fatty acid
levels, endothelial nitric oxide production is often impaired due to a
reduction in nitric oxide synthase 3 phosphorylation. Increasing the
arginine availability by arginine therapy or arginase inhibition was,
therefore, proposed as a potential therapy to treat hypertension. Recent
studies in septic patients and transgenic mice models found that inadequate
de-novo arginine production from citrulline reduces nitric oxide production.
Citrulline supplementation may, therefore, be a novel therapeutic approach
in conditions of arginine deficiency" - See
Jarrow Formulas, Arginine 1000, 1000 mg, 100 Easy-Solv Tablets
at iHerb
and
l-citrulline products at iHerb.
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Maternal Supplementation With Citrulline Increases Renal Nitric Oxide in
Young Spontaneously Hypertensive Rats and Has Long-Term Antihypertensive
Effects - Hypertension. 2007 Oct 15
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