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Anti-aging Research > Krill oil
Krill oil
Specific Recommendations:
News & Research:
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How Does Krill Oil
Compare With Fish Oil? - Medscape, 3/5/12 -
"More research is needed to determine whether krill oil is similar to fish
or fish oil with regard to cardiovascular benefits"
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Krill oil again shows obesity benefits: Mouse study - Nutra USA, 7/20/11
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Krill oil may aid fat metabolism: Rat study - Nutra USA, 3/23/11 -
"Six
weeks of supplementation of diets with 2.5 percent krill oil or 2.5 percent fish
oil were associated with cholesterol reduction of 33 and 21 percent,
respectively, and liver triglyceride level reductions of 20 and 10 percent,
respectively ... These data suggest a higher potency of krill oil in decreasing
hepatic lipogenesis when compared to fish oil at relatively short periods of
dietary treatment (2–3 weeks). Whether this effect is due to a better
bioavailability of n-3 polyunsaturated fatty acids in krill oil, or to a
different ratio of EPA to DHA in the two oils is currently unknown"
- [Abstract] - See
krill oil products at iHerb.
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Krill oil may counter metabolic dysfunctions: Human study - Nutra USA,
2/9/11
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Krill oil may reduce arthritis symptoms: Mouse study - Nutra USA, 9/17/10 -
"Results showed that animals supplemented with krill or fish oil
experienced significant reductions in measures of arthritis and swelling of the
hind paw compared to a control animals not supplemented with EPA and DHA. The
effects were greater for the krill oil than fish oil ... the arthritis score was
reduced by 47 percent in the krill oil group compared with 26 percent for
animals in fish oil group" - [Abstract]
Abstracts:
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Incorporation of EPA and DHA into plasma phospholipids in response to different
omega-3 fatty acid formulations - a comparative bioavailability study of fish
oil vs. krill oil - Lipids Health Dis. 2011 Aug 22;10(1):145 -
"In a
double-blinded crossover trial, we compared the uptake of three EPA+DHA
formulations derived from fish oil (re-esterified triacylglycerides [rTAG],
ethyl-esters [EE]) and krill oil (mainly PL). Changes of the FA compositions in
plasma PL were used as a proxy for bioavailability. Twelve healthy young men
(mean age 31 y) were randomized to 1680 mg EPA+DHA given either as rTAG, EE or
krill oil. FA levels in plasma PL were analyzed pre-dose and 2, 4, 6, 8, 24, 48,
and 72 h after capsule ingestion. Additionally, the proportion of free EPA and
DHA in the applied supplements was analyzed ... The highest incorporation of
EPA+DHA into plasma PL was provoked by krill oil (mean AUC 0-72h: 80.03 +/-
34.71 %*h), followed by fish oil rTAG (mean AUC 0-72h: 59.78 +/- 36.75 %*h) and
EE (mean AUC 0-72h: 47.53 +/- 38.42 %*h). Due to high standard deviation values,
there were no significant differences for DHA and the sum of EPA+DHA levels
between the three treatments. However, a trend (p = 0.057) was observed for the
differences in EPA bioavailability. Statistical pair-wise group comparison's
revealed a trend (p = 0.086) between rTAG and krill oil. FA analysis of the
supplements showed that the krill oil sample contained 22% of the total EPA
amount as free EPA and 21% of the total DHA amount as free DHA, while the two
fish oil samples did not contain any free FA" - See
krill oil products at iHerb,
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb. -
Note: Eyeballing the math, it krill oil doesn't seem cost effective to me.
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A krill
oil supplemented diet reduces the activities of the mitochondrial tricarboxylate
carrier and of the cytosolic lipogenic enzymes in rats - J Anim Physiol Anim
Nutr (Berl). 2011 Feb 25 - "The mitochondrial
tricarboxylate carrier supplies cytosol with the carbon units necessary for
hepatic lipogenesis. The activities of cytosolic acetyl-CoA carboxylase and
fatty acid synthetase are therefore strictly connected to the function of
mitochondrial tricarboxylate carrier. Dietary polyunsaturated fatty acids (PUFA)
are potent modulators of hepatic lipogenesis. In rats fed with a diet enriched
with 2.5% krill oil (KO), a novel source of dietary n-3 PUFA, a time-dependent
decrease in the activities of the mitochondrial tricarboxylate carrier and of
the lipogenic enzymes was found. The KO induced inhibition of hepatic
lipogenesis was more pronounced than that found in fish oil (FO)-fed rats, at
least at short feeding times. The decrease in the activity of the mitochondrial
tricarboxylate carrier caused by KO was due to a reduced expression of the
protein. Furthermore, in the KO-fed animals a greater reduction in the levels of
hepatic triglycerides and cholesterol was found in comparison to FO-fed rats"
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Supplementation of diet with krill oil protects against experimental rheumatoid
arthritis - BMC Musculoskelet Disord. 2010 Jun 29;11:136 -
"Consumption of
krill oil and supplemented diet significantly reduced the arthritis scores and
hind paw swelling when compared to a control diet not supplemented with EPA and
DHA. However, the arthritis score during the late phase of the study was only
significantly reduced after krill oil administration. Furthermore, mice fed the
krill oil diet demonstrated lower infiltration of inflammatory cells into the
joint and synovial layer hyperplasia, when compared to control. Inclusion of
fish oil and krill oil in the diets led to a significant reduction in
hyperplasia and total histology score. Krill oil did not modulate the levels of
serum cytokines whereas consumption of fish oil increased the levels of
IL-1alpha and IL-13 ... The study suggests that krill oil may be a useful
intervention strategy against the clinical and histopathological signs of
inflammatory arthritis"
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