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Home > Anti-aging Research > Isoflavones.

Isoflavones

Related Topics:

• phytoestrogens / red clover / bioflavonoids / phytochemicals / soy

Specific Recommendation:

• Isoflavone products at iHerb
• Nature's Way EstroSoy Plus Fermented Soy Extract + Black Cohosh at iHerb
• Revival Soy Products
• Isoflavone products at Vitacost
• Vitacost menopause formulas
• Vitacost men's formulas

News & Research:

• Ipriflavone - Vitacost Health Library
• Methoxyisoflavone - Vitacost Health Library
• Methoxyisoflavone for Sports & Fitness - Vitacost Health Library
• Soy - Vitacost Health Library
• Isoflavones - The Natural Pharmacist
• Soy Compound May Halt Spread Of Prostate Cancer - Science Daily, 3/14/08 - "the amount of the chemical, an antioxidant known as genistein, used in the experiments was no higher than what a human would eat in a soybean-rich diet ... genistein decreased metastasis of prostate cancer to the lungs by 96 percent compared with mice that did not eat the compound in their chow"
• Daidzein-rich supplement shows menopause potential - Nutra USA, 1/11/08 - "The new study, led by George Blackburn, assigned the subjects to receive daily supplements of the daidzein-rich isoflavone-aglycone (DRI) supplement at a dose of either 40 or 60 milligrams, or placebo for 12 weeks ... At the end of the study, the researchers report that the number of hot flushes in the group receiving the lower dose was reduced by 52 per cent, while the women receiving the higher dose experienced a 51 per cent reduction in the number of hot flushes. The placebo group reported a 39 per cent reduction in hot flush frequency" - [Abstract]
• Daidzein-rich isoflavone aglycones are potentially effective in reducing hot flashes in menopausal women - Menopause. 2007 Jul 18 - "DRI supplementation may be an effective and acceptable alternative to hormone treatment for menopausal hot flashes"
• Isoflavones may stop benign breast lumps: study - Nutra USA, 12/18/07 - "the highest plasma levels of genistein (more than 76.95 nanograms per millilitre) were 74 per cent less likely to have breast cancer, and 60 per cent less likely to have benign conditions, relative to women with the lowest average levels (less than 9.42 ng/mL)"
• New Proof of Genistein's Efficacy and Safety for Osteopenia and Osteoporosis Published in Annals of Internal Medicine - Doctor's Guide, 7/16/07 - "85% of the women taking genistein showed a gain in bone density ... In addition, women taking genistein with calcium and vitamin D achieved a gain in bone density of approximately 3% per year over baseline and 6% per year over those taking the placebo"
• Soy Compound May Bolster Women's Bones - WebMD, 6/18/07 - "After two years, the DEXA scans showed increases in bone mineral density in women taking genistein"
• Broccoli, soy anti-cancer benefits suggested - Nutra USA, 4/16/07 - "this attraction between CXCR4 and CXCL12 draws cancer cells to the organs they spread to ... exposure with either DIM or genistein cut movement by 80 per cent"
• Soy isoflavones linked to lower prostate cancer risk - Nutra USA, 3/8/07 - "The highest intake of soy isoflavones (at least 32.8 milligrams of genistein per day) had a 40 per cent reduced risk compared to those with the lowest intake (less than 13.2 mg/d)"
• Isoflavone treatment for acute menopausal symptoms - Menopause. 2007 Feb 6 - "In women receiving 60 mg isoflavones daily, hot flashes and night sweats were reduced by 57% and 43%, respectively"
• Meta-analysis supports isoflavones for hot flushes - Nutra USA, 1/15/07
• Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer - J Nutr. 2007 Jan;137(1):205S-10S - "the combination of calcitriol and genistein is an attractive therapeutic option for the treatment of PCa"
• Soy Isoflavones Protect Postmenopausal Women From Bone Loss - Medscape, 7/14/06 - "There was a significant, linear dose-related response for isoflavones vs placebo in terms of bone density at the lumbar spine and femoral neck, but not at the trochanter"
• Soy isoflavones could improve mood, mental function - Nutra USA, 6/28/06
• Daidzein from soy linked to heart health benefits - Nutra USA, 6/23/06
• Soy isoflavones attenuate bone loss in early postmenopausal Chinese women : A single-blind randomized, placebo-controlled trial - Eur J Nutr. 2006 Jun 8 - "There is a significantly dose-dependent effect of soy isoflavones on attenuating bone loss at the spine and femoral neck possibly via the inhibition of bone resorption in non-obese postmenopausal Chinese women with high Kuppermann Scale"
• Isoflavones for bone health depends on other factors - Nutra USA, 7/15/04
• Soy: Prevent Prostate Cancer, Male Baldness? - WebMD, 3/30/04 - "A little-known molecule called equol ... is showing promise as a powerful blocker of a potent male hormone involved in prostate cancer, male baldness, even acne ... Actually, the protective effects occur when two chemicals in soy protein -- genistin and daidzin -- reach the digestive system, Setchell explains. There, they are metabolized to form genistein and daidzein. Daidzein is metabolized once again, to form equol"
• Soy blocks prostate cancer? - Nutra USA, 3/30/04 - "Equol, the major metabolite of the phytoestrogen daidzein - one of the main isoflavones found abundantly in soybeans - completely stops in its tracks the male hormone dihydrotestosterone (DHT), which normally stimulates prostate growth and causes male pattern baldness"
• Phytoestrogens May Not Prevent Breast Cancer - WebMD, 2/4/04
• Soy Isoflavones May Improve Cognition in Postmenopausal Women - Healthwell Exchange Daily News, 10/2/03 - "Women taking soy isoflavones had significant improvements in recall, logical thinking, planning tasks, and attention compared with women taking a placebo, which translates to better memory and ability to focus on a particular task"
• Soy For Prevention of Memory Decline Still Under Investigation - Doctor's Guide, 9/23/03
• Soy May Cut Endometrial Cancer Risk - WebMD, 8/5/03 - "consumption of isoflavones and lignans, but not coumestans, were associated with a reduced risk of endometrial cancer, particularly among postmenopausal women"
• Chemical in Miso and Other Soy Foods Believed to Block Certain Tumors - WebMD, 6/17/03 - "identified 21,852 women between the ages of 40 and 59 and surveyed them about various lifestyle issues ... They traced the women 10 years later ... Women with the most isoflavones in their diet had the lowest risk of breast cancer. This was especially true of postmenopausal women"
• Soy Protein May Be Better Than Supplements for Menopause - WebMD, 4/24/03
• Got Milk - WebMD, 9/27/02 - "A combination of soy and cow's milk could have some beneficial, anti-cancer nutrients ... He says he thinks the most potent cancer-fighting component of soy is a compound called genistein ... He demonstrated that by feeding rats a diet containing genistein before exposing them to a cancer-causing drug. The number of breast tumors was reduced by 50%"
• Diet Rich In Soy Protein Lowers Estrogens Associated With Breast Cancer - Intelihealth, 9/24/02 - "Isoflavones, the main constituent of soybeans, are believed to be responsible for anti-cancer effects observed in an accumulating number of human and animal studies ... However, the effect of soy on the breast is controversial ... There are some in vitro studies of breast cancer cells - animal studies, as well as short-term soy intervention studies in women - suggesting that soy isoflavines may have stimulatory effects"
• Ipriflavone in Osteoporosis Prevention and Treatment - Medscape, 9/4/02
• Red Clover May Tame Hot Flashes - WebMD, 8/16/02 - "Promensil is an isoflavone supplement produced from red clover and contains the same key isoflavones commonly found in soy foods. Isoflavones are plant compounds -- found commonly in soy -- that act like weak form of the female sex hormone estrogen ... Only red clover contains all four isoflavones that women need ... 30 women were given either 40 mg of Promensil or a placebo for 16 weeks. The group taking Promensil reported a 48% reduction in frequency of hot flashes, whereas the control group had an 11% decrease" - See iHerb or  Vitacost Promensil products.
• Soy Protein In The Diet Produces Health Benefits, Regardless Of Isoflavone Content - Intelihealth, 7/25/02 - "After each soy diet, total cholesterol, the ratio of low-density lipoprotein (LDL) to high-density lipoprotein (HDL) cholesterol, homocysteine concentrations, and estimated overall cardiovascular risk were lower than they were after the control diet. Additionally, serum concentrations of LDL were lower after the high-isoflavone diet. The only significant difference between the sexes was a tendency toward reduced blood pressure in men after the high-soy isoflavone diet ... the soy diets continued to improve the subjects' blood lipid profiles even after dietary saturated fat consumption was maximally reduced"
• Phytoestrogen review - ConsumerLab.com, 7/16/02
• Soy Comparable to Some Diabetes Drugs - WebMD, 6/20/02 - "Soy may help people with diabetes control their blood sugar as well as some prescription drugs ... One group sprinkled their food daily with a white powder containing 30 grams of soy protein and 132 milligrams of soy isoflavones for 12 weeks ... The soy products lowered the women's blood sugar as much as some prescription diabetes drugs"
• Soy Isoflavone May Improve Bone Metabolism in Perimenopausal Women - Doctor's Guide, 5/27/02 - "The isoflavone group (n=12) received daily capsules of soy isoflavone extract (61.8 mg of isoflavones) ... Excretion of bone resorption markers was reduced significantly in the isoflavone group"
• Soy Formulas May Weaken Immune System - WebMD, 5/20/02 - "the researchers examined immune system effects in mice fed diets high in the isoflavone. At levels similar to those found in soy-fed infants, genistein appeared to produce a large decrease in thymus size and immune cell function ... The study appears to contradict recently published research, sponsored by a soy formula manufacturer, suggesting that infants fed soy-based diets have normal immune development as measured by response to routine childhood immunizations. Infants fed soy-based formulas also demonstrated immune status similar to infants who were breastfed ... But a Danish study assessing soy supplementation in postmenopausal women did find evidence of immune suppression"
• Ovulatory Cycles Not Affected By Isoflavones Supplement - Doctor's Guide, 3/21/02
• Phytoestrogens May Reduce Heart Disease Risk In Older Women - Intelihealth, 2/21/02 - "phytoestrogen consumption was associated with a reduced risk of heart disease. Women who consumed the highest amount of isoflavones and lignans had significantly lower triglyceride (fatty material found in blood) levels than those who consumed the least amount of phytoestrogens. Similarly, those who consumed significant amounts of lignan-rich foods had less weight concentrated around their waists than those who ate little or no lignan-rich food. (Excessive weight around the waist is a risk factor for heart disease.)"
• The Magic of Soy Beans - Life Extension Magazine, 11/99 - "In the group receiving the highest doses of soy isoflavones, there was a 74% reduction in the median number of metastatic tumors to the lungs. The study showed that the higher doses of isoflavones significantly decreased tumor size and volume, in addition to reducing the number of metastatic lesions."
• Long-Term Soy Consumption Does Not Effect Hormones In Postmenopausal Women - Intelihealth, 12/21/01 - "Though small hormonal fluctuations occurred in all three groups over time, the researchers found no significant changes in serum estrogen, cortisol, dehydroepiandrosterone sulfate, or follicle stimulating hormone in any of the subject groups. Circulating thyroid hormone levels were modestly increased in women taking the highest dose of soy isoflavones for more than 6 months. Other effects of soy isoflavones observed in the study, such as increased bone mineral density and higher HDL concentrations in women who took the highest dose for 6 months, suggest that soy may possess estrogen effects that are better reflected in these end-points rather than in serum hormone concentrations"
• Soy And Breast Cancer: Safe Or Unsafe? - Intelihealth, 11/8/01
• Soy Isoflavone Stimulates Breast Cancer Tumor Growth - Intelihealth, 11/8/01
• Product Review: Phytoestrogens -- Soy and Red Clover Isoflavones - ConsumerLab, 8/15/01
• Soy Isoflavones May Protect Postmenopausal Women From Alzheimer's - WebMD, 4/3/01
• Widely Used Supplement Doesn't Stop Bone Loss, Study Finds No Postmenopausal Benefit From Ipriflavone - WebMD, 3/22/01
• Osteoporosis Supplement Doesn't Prevent Bone Loss In Study - Intelihealth, 3/20/01 - "ipriflavone, a synthetic form of an estrogen-like substance found in plants such as soybeans ... ipriflavone supplements had no effect on preserving bone density. But women who took the supplements, in standard doses of 600 milligrams daily, were more likely than those on dummy pills to develop a reduction in disease-fighting white blood cells called lymphocytes ...  The women remained otherwise healthy, but low lymphocyte counts are a symptom of an immune system that is potentially more vulnerable to infection ... The study was funded by Chiesi Pharmaceuticals Inc., an Italian maker of ipriflavone (so it may have been that brand)"
• Soy and Health: What's the Scoop? Most Recent Addition to Soy Research Shows Lower Breast Cancer Risk - WebMD, 12/21/00 - "eating a diet rich in soy products may cut the risk of breast cancer in half"
• Bone Up on Osteoporosis - Nutrition Science News, 11/00 - "Most research demonstrates that soy foods also increase mineral density in menopausal women and reduce bone loss"
• Soy Isoflavones Reduce Bone Loss In Perimenopausal Women - Doctor's Guide, 9/1/00
• Does Ipriflavone have the same effects as the isoflavones found in soy? - Nutrition Science News, 8/00
• Isoflavone Concentrations Of Different Soy Foods - Nutrition Science News, 8/00
• Any Soy Has Isoflavones - Nutrition Science News, 8/00
• Phytochemicals: Nutrients Whose Time Has Come - Nutrition Science News, 7/00
• Menopause-Related Consensus Opinion on Isoflavones Developed - Medscape, 7/6/00
• Flavonoids may help fight cancer, study finds - CNN, 3/30/00
• Anti-Cancer Agent Sought In Soybean - Intelihealth, 9/20/99
• Cancer Prevention Diet - Nutrition Science News, 8/99
• USDA-Iowa State University Database on the Isoflavone Content of Foods - 1999 - USDA
• Isoflavones May Cut Menopausal Cardiovascular Risk - Nutrition Science News, 7/99
• Isoflavone Concentration in Soyfoods - Indiana Soybean Board
• Soy Phytoestrogens Prevent Stroke As Much As Premarin - Doctor's Guide, 3/20/98
• Key Ingredient In Soy Is What Lowers Cholesterol - Doctor's Guide, 3/20/98
• Diet Can Reduce Risk Of Breast Cancer - Doctor's Guide, 10/3/97
• Soy Intake May Reduce Risk of Uterine Cancer -- New Cancer Research Study in Hawaii - Doctor's Guide, 8/29/97
• Studies Show Soy Protein May Prevent, Treat Bone Loss - Doctor's Guide, 6/30/97

Abstracts:

• Plasma Isoflavone Level and Subsequent Risk of Breast Cancer Among Japanese Women: A Nested Case-Control Study From the Japan Public Health Center-Based Prospective Study Group - J Clin Oncol. 2008 Mar 3 - "We found a statistically significant inverse association between plasma genistein and risk of breast cancer, but no association for plasma daidzein. Adjusted odds ratios for the highest versus lowest quartile of plasma level were 0.34 for genistein (95% CI, 0.16 to 0.74; P for trend, .02) and 0.71 for daidzein (95% CI, 0.35 to 1.44; P for trend, .54). Median plasma genistein values in the control group were 31.9 ng/mL for the lowest and 353.9 ng/mL for the highest quartile groups"
• Effects of One-Year Treatment with Isoflavone Extract from Red Clover on Prostate, Liver Function, Sexual Function, and Quality of Life in Men with Elevated PSA Levels and Negative Prostate Biopsy Findings - Urology. 2008 Feb;71(2):185-90 - "isoflavonoid extract from red clover ... daily 60-mg dose of an isoflavone extract for 1 year ... The average PSA level was 10.16 ng/mL at baseline versus 7.15 ng/mL after 12 months, for a statistically significant reduction of 33% ... The sexual hormone levels did not change throughout the study. We registered a significant increase in all three liver transaminases after 3 months"
• Daidzein-rich isoflavone aglycones are potentially effective in reducing hot flashes in menopausal women - Menopause. 2008 Jan-Feb;15(1):125-32 - "When comparing the two treatment groups with the placebo group, there were significant reductions in mean daily hot flash frequency. The supplement (either 40 or 60 mg) reduced hot flash frequency by 43% at 8 weeks (P = 0.1) and 52% at 12 weeks (P = 0.048) but did not cause any significant changes in endogenous sex hormones or thyroid hormones" - See Nature's Way EstroSoy Plus Fermented Soy Extract + Black Cohosh at iHerb.
• Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials - Clin Nutr. 2007 Dec 4 - "Isoflavone intervention significantly attenuates bone loss of the spine in menopausal women. These favorable effects become more significant when more than 90mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women"
• Lycopene and soy isoflavones in the treatment of prostate cancer - Nutr Cancer. 2007;59(1):1-7 - "The data suggest that lycopene and soy isoflavones have activity in prostate cancer patients with PSA relapse disease and may delay progression of both hormone-refractory and hormone-sensitive prostate cancer"
• Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice - Diabetes Metab Res Rev. 2007 Oct 11 - "Blood glucose levels of genistein and daidzein groups were 40 and 36% of control value at the end of study (9th week). The genistein and daidzein supplements increased insulin/glucagon ratio and C-peptide level with preservation of insulin staining beta-cell of pancreas in the NOD mice ... The supplementation of genistein and daidzein are seemingly helpful for preventing IDDM onset"
• Isoflavone intake in persons at high risk of cardiovascular events: implications for vascular endothelial function and the carotid atherosclerotic burden - Am J Clin Nutr. 2007 Oct;86(4):938-945 - "In persons at high risk of cardiovascular events, a greater isoflavone intake is associated with better vascular endothelial function and lower carotid atherosclerotic burden"
• Exposure to the phytoestrogen daidzein attenuates apomorphine-induced penile erection concomitant with plasma testosterone level reduction in dose and time-related manner in adult rats - Urology. 2007 Sep;70(3):613-7 - "The phytoestrogen daidzein has the potential to adversely affect erectile function in a dose and time-related manner that is at least partly attributable to androgen deficiency. These findings implicate that phytoestrogens, especially isoflavones, if overconsumed for a long period, might be a novel risk factor for erectile dysfunction"
• Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study - J Clin Endocrinol Metab. 2007 Aug;92(8):3068-75 - "Compared with placebo, genistein significantly reduced fasting glucose and insulin as well as homeostasis model assessment for insulin resistance after both 12 and 24 months of treatment"
• Genistein induces the metastasis suppressor kangai-1 which mediates its anti-invasive effects in TRAMP cancer cells - Biochem Biophys Res Commun. 2007 Jul 16 - "This work provides the first evidence that genistein treatment may counteract KAI1 downregulation, which is observed in many cancer types and therefore, could be used in anti-metastatic therapies"
• Dietary Isoflavones May Protect against Prostate Cancer in Japanese Men - J Nutr. 2007 Aug;137(8):1974-1979 - "Isoflavones and their aglycones (genistein and daidzein) were significantly associated with decreased risk. The odds ratio for the highest category (>/=89.9 mg/d) compared with the lowest category (<30.5 mg/d) of isoflavone intake was 0.42 (95% CI = 0.24-0.72) and the linear trend was significant"
• Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials - Eur J Clin Nutr. 2007 Mar 28 - "Isoflavone intervention significantly inhibits bone resorption and stimulates bone formation"
• Effect of 6 months of exercise and isoflavone supplementation on clinical cardiovascular risk factors in obese postmenopausal women: a randomized, double-blind study - Menopause. 2007 Feb 6 - "Compared to an aerobic exercise program alone, 70 mg/day of isoflavones combined with exercise may promote significant improvements in body composition parameters that are known to influence cardiovascular disease risk in postmenopausal women"
• Six months of isoflavone supplement increases fat-free mass in obese-sarcopenic postmenopausal women: a randomized double-blind controlled trial - Eur J Clin Nutr. 2007 Feb 21 - "fat-free mass (FFM) and muscle mass index (MMI=appendicular FFM/height(2)) ... The isoflavone group increased significantly appendicular (P=0.034), leg (P=0.016) FFM and MMI (P=0.037), but not the placebo group"
• Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer - Functional Foods and Nutraceuticals, 11/04 - "a genistein-rich extract as the sole treatment for prostate cancer does not appear to be an effective treatment for prostate cancer when given alone. However, eight of 13 evaluated patients in the active surveillance group had either no rise or a decline in PSA levels of less than 50 per cent"
• The specific role of isoflavones in reducing prostate cancer risk - Prostate. 2004 May 1;59(2):141-7 - "These data suggest that supplementing early stage prostate cancer patients with soy isoflavones, even in a study of short duration, altered surrogate markers of proliferation such as serum PSA and free testosterone in a larger number of subjects in the isoflavone supplemented group than the group receiving placebo"
• The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial - Am J Clin Nutr. 2004 Feb;79(2):326-33 - "These data suggest that, through attenuation of bone loss, isoflavones have a potentially protective effect on the lumbar spine in women"
• Usual dietary isoflavone intake and body composition in postmenopausal women - Menopause. 2003 Sep-Oct;10(5):427-32 - "A significant inverse relation was shown between genistein consumption and weight, body mass index, waist circumference, and total body fat mass by bioelectric impedance analysis ... This study suggests that usual dietary isoflavone intake is associated with reduced total body fat and may consequently have a role in the prevention of chronic disease"
• Phytoestrogen supplement use by women - J Nutr 2003 Jun;133(6):1983S-6S - "Until safety with respect to breast cancer is established, phytoestrogen supplements should not be recommended, particularly for women at high risk of breast cancer"
• Bioavailability of phyto-oestrogens - Br J Nutr 2003 Jun;89 Suppl 1:838-52
• Phyto-oestrogens and osteoporosis: what is a safe dose? - Br J Nutr 2003 Jun;89 Suppl 1:898-906
• Isoflavones and cognitive function in older women: the Soy and Postmenopausal Health In Aging (SOPHIA) Study - Menopause. 2003 May-Jun;10(3):196-202 - "Women randomized to active treatment (n = 27) took two pills per day, each containing 55 mg of soy-extracted isoflavones (110 mg total isoflavones per day ... Comparisons of percentage change in cognitive function between baseline and follow-up showed greater improvement in category fluency for women on active treatment as compared with the case of those on placebo (P = 0.02) and showed (nonsignificantly) greater improvement on the two other tests of verbal memory"
• Lack of significant genotoxicity of purified soy isoflavones (genistein, daidzein, and glycitein) in 20 patients with prostate cancer - Am. J. of Clin. Nutr., 4/03 - "Although isoflavones are capable of inducing genetic damage in vitro, a similar effect was not observed in subjects treated with a purified soy unconjugated isoflavone mixture"
• Potential risks and benefits of phytoestrogen-rich diets - Int J Vitam Nutr Res 2003 Mar;73(2):120-6 - "Phytoestrogens are strikingly similar in chemical structure to the mammalian oestrogen, oestradiol, and bind to oestrogen receptors (ER) with a preference for the more recently described ER beta ... Whether phytoestrogens have any biological activity in humans, either hormonal or non hormonal is a contentious issue and there is currently a paucity of data on human exposure ... The limited studies conducted so far in humans clearly confirm that soya isoflavones can exert hormonal effects. These effects may be of benefit in the prevention of many of the common diseases observed in Western populations (such as breast cancer, prostate cancer, menopausal symptoms, osteoporosis) where the diet is typically devoid of these biologically active naturally occurring compounds"

Other possible isoflavones retailers:

Related Searches:

• Doctor's Guide search of isoflavones
• Doctor's Guide (2) search of isoflavones
• Intelihealth search of isoflavones
• Life Extension Foundation search
• Medline search of isoflavone
• Medscape search of isoflavone
• The Natural Pharmacist search of isoflavones
• Nutrition Science News search
• WebMD search of isoflavones

Related Sites:

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