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Anti-aging Research > Isoflavones.
News & Research:
Soy-based compound may reduce tumor cell proliferation in colorectal cancer
- Science Daily, 4/11/13 - "The development of
colorectal cancer (CRC) is largely driven by cellular signaling in the Wnt
pathway, a network of proteins critical to cellular growth ... the research
team treated colon cancer cell lines with genistein and found that it
inhibited cell growth and blocked Wnt signaling hyperactivity ... Genistein
is a natural product with low toxicity and few side effects and our research
shows that it may be beneficial in treating colorectal cancer" - See
genistein products at iHerb.
Soy-based formula? Neonatal plant estrogen exposure leads to adult
infertility in female mice - Science Daily, 5/2/12 -
"A paper published May 2 in Biology of Reproduction
describes the effects of brief prenatal exposure to plant estrogens on the
mouse oviduct, modeling the effects of soy-based baby formula on human
infants. The results suggest that exposure to estrogenic chemicals in the
womb or during childhood has the potential to affect a woman's fertility as
an adult, possibly providing the mechanistic basis for some cases of
unexplained female infertility ... part of the National Institutes of
Health, previously demonstrated that neonatal exposure to the plant estrogen
genistein results in complete infertility in female adult mice. Causes of
infertility included failure to ovulate, reduced ability of the oviduct to
support embryo development before implantation, and failure of the uterus to
support effective implantation of blastocyst-stage embryos ... The team now
reports that neonatal exposure to genistein changes the level of immune
response in the mouse oviduct, known as mucosal immune response. Some of the
immune response genes were altered beginning from the time of genistein
treatment, while others were altered much later, when the mouse was in early
pregnancy. Together, those changes led to harmfully altered immune responses
and to compromised oviduct support for preimplantation embryo development,
both of which would likely contribute to infertility ... estrogenic chemical
exposure to the female fetus, infant, child, and adolescent all have
potential impacts on mucosal immunity in the reproductive tract and,
therefore, on adult fertility. The authors present the view that limiting
such exposures, including minimizing use of soy-based baby formula, is a
step toward maintaining female reproductive health"
Soy Supplements Can Cool Hot Flashes - WebMD, 4/9/12 -
"look at 19 published studies ... What this study
shows is that ingesting soy isoflavones will help you ... Soy supplements
with higher amounts of the isoflavone called genistein were more than twice
as good at reducing hot flash frequency than those with low amounts"
genistein products at iHerb.
Plant compound reduces breast cancer mortality, study suggests - Science
Daily, 9/13/11 - "The most important type of
phytoestrogens in our Western diet are lignans, which are contained in
seeds, particularly flaxseeds, as well as in wheat and vegetables. In the
bowel, these substances are turned into enterolactone, which is absorbed by
the mucous tissue and which was determined by the Heidelberg researchers as
a biomarker in the patients' blood ... Compared to the study subjects with
the lowest enterolactone levels, the women with the highest blood levels of
this biomarker had an approximately 40 percent lower mortality risk ...
Another observation that may be interpreted in this direction is that Asian
women are less frequently affected by breast cancer. Their soy-rich diet
contains large amounts of another type of phytoestrogens, isoflavones. On
the other hand, scientists fear that isoflavones might imitate the
growth-promoting properties of real hormones and, thus, accelerate
hormone-dependent tumors such as breast cancer and prostate cancer. "It has
not yet been finally determined whether lignans in the body imitate the
hormone effect or, on the contrary, counteract it,""
increases radiation's ability to kill lung cancer cells, study shows -
Science Daily, 4/1/11 - "These natural soy isoflavones can sensitize cancer
cells to the effects of radiotherapy, by inhibiting survival mechanisms which
cancer cells activate to protect themselves ... At the same time, soy
isoflavones can also act as antioxidants in normal tissues, which protect them
against unintended damage from the radiotherapy ... soy isoflavones increase
killing of cancer cells by radiation via blocking DNA repair mechanisms, which
are turned on by the cancer cells to survive the damage caused by radiation ...
Researchers used a formulation consisting of the three main isoflavones found in
soybeans, including genistein, daidzein and glycitein ... Previously,
researchers had found that pure genistein demonstrated antitumor activity in
human NSCLC cell lines and enhanced the effects of EGFR-tyrosine kinase
inhibitors. This study showed that the soy mixture had an even greater antitumor
effect than pure genistein"
Isoflavones May Reduce Insomnia Symptoms in Postmenopausal Women - Medscape,
2/9/11 - "For the isoflavone group vs the placebo group, sleep efficiency
measured by polysomnography increased significantly (from 77.9% to 83.9% vs from
77.6% to 81.2%). In addition, frequency of insomnia was reduced more readily in
the isoflavone group. At the beginning of the study, 94.7% of women in the
placebo group had moderate or intense insomnia compared with 63.2% at the end of
the study; whereas in the isoflavone group these percentages were 89.5% and
36.9%, respectively ... Isoflavones were also effective in reducing the number
of hot flashes in postmenopausal women with insomnia compared with the placebo
group (P = .001). This trend became apparent after 2 months of treatment, but
the results became significant only after the fourth month of treatment. The
intensity of hot flashes was significantly lower in the isoflavone group than in
the placebo group at both evaluation points (months 2 and 4 of treatment; 1.6 vs
5.8 and 0.5 vs 3.8; P < .001)"
isoflavones may modify risk of breast cancer - Science Daily, 11/8/10 -
"Those women with the highest isoflavone intake had an approximately 30 percent
decreased risk of having an invasive breast tumor, and an approximately 60
percent decreased risk of having a grade 1 tumor ... Among premenopausal women,
the highest intake of isoflavones had a 30 percent decreased risk of stage I
disease, a 70 percent decreased risk of having a tumor larger than 2 cm, and a
60 percent decreased risk of having stage 2 breast cancer. These connections
were not seen among postmenopausal women"
may stop prostate cancer spread: Experimental soy-based drug shows benefits
in men with localized prostate cancer - Science Daily, 11/8/10 -
"A recent phase II randomized study of 38 men with
localized prostate cancer found that genistein, when given once a day as a
pill, one month prior to surgery, had beneficial effects on prostate cancer
cells ... genistein increased the expression of genes that suppress the
invasion of cancer cells and decreased the expression of genes that enhance
invasion" - See
genistein products at iHerb.
intake associated with lower recurrence of breast cancer in hormone-sensitive
cancers - Science Daily, 10/18/10 - "The recurrence rate of estrogen- and
progesterone- positive breast cancer was 12.9% lower among patients in the
highest quartile of soy isoflavone intake than among those in the lowest
quartile and was 18.7% lower for patients receiving anastrozole therapy in the
Isoflavone Use May Improve Endothelial Function in Postmenopausal Women
- Medscape, 12/11/09 - "In the overall analysis,
isoflavone use significantly increased FMD"
Resveratrol could prove HRT alternative, study - Nutra USA, 11/23/09 -
"While genistein, resveratrol and glycitein all
increased apoptosis and reduced the Bcl-2/Bax ratio, resveratrol reduced
this ratio more than either genistein or glycitein ... Because it
(resveratrol) stimulated the transcription of endogenous estrogen receptor
(ER) and proapoptotic effects, this phytoestrogen is the most promising
candidate as an HRT alternative and chemopreventive reagent for breast
cancer ... The researchers added that their results indicated that daidzein
causes a slight cell-stimulating effect in the absence of E2, which may lead
to an increased risk of breast cancer in postmenopausal women taking
supplements containing these phytoestrogens" - [Abstract]
Jarrow Resveratrol 100 at iHerb.
Could soy isoflavones extend life? - Nutra USA, 9/11/09
Reduces Diabetes Risk - Science Daily, 10/6/09 -
"They found that daidzein and equol enhanced adipocyte differentiation, or the
formation of fat cells, through activation of a key transcription regulator, the
same receptor that mediates the insulin-sensitizing effects of anti-diabetes
drugs. Thus, daidzein and equol daidzein and equol seem to work in a similar
manner as anti-diabetic drugs currently in the market"
Soy may help men remember anniversaries: Study - Nutra USA, 7/9/09 -
"men receiving the isoflavones required 18 per cent
fewer attempts to correctly complete the tasks, committed 23 per cent fewer
errors, and achieved the tasks in 17 per cent less time than they did during the
placebo phase" - [Abstract]
Teen soy intake linked to lower breast cancer risk - Nutra USA, 6/1/09 -
"Adolescent intakes of soy foods were associated with a
43 per cent reduction in pre-menopausal breast cancer risk, while high intakes
of soy protein and isoflavones were associated with 59 and 56 per cent
reductions in the risk of breast cancer before the menopause" - [Abstract]
Soy Consumption Linked to Colorectal Cancer Risk in Postmenopausal Women
- Medscape, 1/29/09 - "For each 5-g/day increment in
dietary intake of soy as measured by dry weight (equivalent to approximately
1 oz [28.35 g] tofu/day), there was an 8% reduction in risk ... Compared
with women in the lowest tertile of soy intake, those in the highest tertile
had a multivariate relative risk (RR) of 0.67 ... were similar for soy
protein and isoflavone intakes"
Genistein Safely Improves Bone Formation in Osteopenic, Postmenopausal Women
- Medscape, 1/14/09 - "Usually, the drugs used in
the management of osteopenia/osteoporosis have been classified as
predominantly 'antiresorptive agents' or as 'bone-forming agents' but, on
the basis of our results, genistein might represent the first therapy that
overcomes this classification by combining a powerful bone-forming as well
as an antiresorptive activity ... All postmenopausal women with bone loss
would be ideal candidates for genistein aglycone treatment ... Genistein
aglycone has a good safety profile, and in addition it is effective against
climacteric syndrome (i.e., hot flushes and night sweats)"
Isoflavone Dietary Supplement Improves Functioning Of Arteries In Stroke
Patients - Science Daily, 9/23/08 - "A dietary
supplement containing isoflavone – a chemical found in soybeans, chickpeas,
legumes and clovers – can improve artery function in stroke patients ... 12
weeks of isoflavone supplement, at a dose of 80 mg a day, significantly
improved brachial FMD and, therefore, vascular endothelial dysfunction in
patients who had suffered an ischaemic stroke (a stroke caused by blood
clots or other obstructions)"
Dietary Supplement Genistein Can Undermine Breast Cancer Treatment -
Science Daily, 9/23/08
Isoflavones and Flavonols Reduce Ovarian Cancer Risk - oncologystat.com,
8/22/08 - "Women with the highest flavonoid intake
had a 37% lower risk of ovarian cancer than those with the lowest intake. A
high intake of isoflavones, in particular, was associated with a 49%
decreased ovarian cancer risk"
Compound May Halt Spread Of Prostate Cancer - Science Daily, 3/14/08 -
"the amount of the chemical, an antioxidant known as
genistein, used in the experiments was no higher than what a human would eat
in a soybean-rich diet ... genistein decreased metastasis of prostate cancer
to the lungs by 96 percent compared with mice that did not eat the compound
in their chow"
Daidzein-rich supplement shows menopause potential - Nutra USA, 1/11/08
- "The new study, led by George Blackburn, assigned
the subjects to receive daily supplements of the daidzein-rich isoflavone-aglycone
(DRI) supplement at a dose of either 40 or 60 milligrams, or placebo for 12
weeks ... At the end of the study, the researchers report that the number of
hot flushes in the group receiving the lower dose was reduced by 52 per
cent, while the women receiving the higher dose experienced a 51 per cent
reduction in the number of hot flushes. The placebo group reported a 39 per
cent reduction in hot flush frequency" - [Abstract]
isoflavone aglycones are potentially effective in reducing hot flashes in
menopausal women - Menopause. 2007 Jul 18 - "DRI
supplementation may be an effective and acceptable alternative to hormone
treatment for menopausal hot flashes"
Isoflavones may stop benign breast lumps: study - Nutra USA, 12/18/07 -
"the highest plasma levels of genistein (more than
76.95 nanograms per millilitre) were 74 per cent less likely to have breast
cancer, and 60 per cent less likely to have benign conditions, relative to
women with the lowest average levels (less than 9.42 ng/mL)"
New Proof of Genistein's Efficacy and Safety for Osteopenia and Osteoporosis
Published in Annals of Internal Medicine - Doctor's Guide, 7/16/07 -
"85% of the women taking genistein showed a gain in
bone density ... In addition, women taking genistein with calcium and
vitamin D achieved a gain in bone density of approximately 3% per year over
baseline and 6% per year over those taking the placebo"
Soy Compound May Bolster Women's Bones - WebMD, 6/18/07 -
"After two years, the DEXA scans showed increases in
bone mineral density in women taking genistein"
Broccoli, soy anti-cancer benefits suggested - Nutra USA, 4/16/07 -
"this attraction between CXCR4 and
CXCL12 draws cancer cells to the organs they spread to ... exposure with
either DIM or genistein cut movement by 80 per cent"
Soy isoflavones linked to lower prostate cancer risk - Nutra USA, 3/8/07
- "The highest intake of soy
isoflavones (at least 32.8 milligrams of genistein per day) had a 40 per
cent reduced risk compared to those with the lowest intake (less than 13.2
Isoflavone treatment for acute menopausal symptoms - Menopause. 2007 Feb
6 - "In women receiving 60 mg
isoflavones daily, hot flashes and night sweats were reduced by 57% and 43%,
Meta-analysis supports isoflavones for hot flushes - Nutra USA, 1/15/07
Calcitriol and genistein actions to inhibit the prostaglandin pathway:
potential combination therapy to treat prostate cancer - J Nutr. 2007
Jan;137(1):205S-10S - "the
combination of calcitriol and genistein is an
attractive therapeutic option for the treatment of PCa"
Isoflavones Protect Postmenopausal Women From Bone Loss - Medscape,
7/14/06 - "There was a significant,
linear dose-related response for isoflavones vs placebo in terms of bone
density at the lumbar spine and femoral neck, but not at the trochanter"
Soy isoflavones could improve mood, mental function - Nutra USA, 6/28/06
Daidzein from soy linked to heart health benefits - Nutra USA, 6/23/06
Soy isoflavones attenuate bone loss in early postmenopausal Chinese women :
A single-blind randomized, placebo-controlled trial - Eur J Nutr. 2006
Jun 8 - "There is a significantly
dose-dependent effect of soy isoflavones on attenuating bone loss at the
spine and femoral neck possibly via the inhibition of bone resorption in
non-obese postmenopausal Chinese women with high Kuppermann Scale"
Isoflavones for bone health depends on other factors
- Nutra USA, 7/15/04
- Soy: Prevent Prostate Cancer, Male Baldness? -
WebMD, 3/30/04 - "A little-known
molecule called equol
... is showing promise as a powerful blocker of a potent male hormone
involved in prostate cancer, male baldness, even acne ... Actually, the
protective effects occur when two chemicals in soy protein --
genistin and daidzin
-- reach the digestive system,
Setchell explains. There,
they are metabolized to form genistein and daidzein.
Daidzein is metabolized once
again, to form equol"
- Soy blocks prostate cancer? - Nutra USA, 3/30/04 -
the major metabolite of the phytoestrogen
daidzein - one of the main
isoflavones found abundantly in soybeans - completely stops in its tracks
the male hormone
which normally stimulates prostate growth and causes male pattern baldness"
- Phytoestrogens May Not Prevent Breast Cancer -
Isoflavones May Improve Cognition in Postmenopausal Women
- Healthwell Exchange Daily News, 10/2/03 -
"Women taking soy isoflavones had significant improvements in recall,
logical thinking, planning tasks, and attention compared with women taking a
placebo, which translates to better memory and
ability to focus on a particular task"
- Soy For Prevention of Memory Decline Still Under Investigation
- Doctor's Guide, 9/23/03
- Soy May Cut Endometrial Cancer Risk - WebMD,
8/5/03 - "consumption of isoflavones
but not coumestans,
were associated with a reduced risk of
endometrial cancer, particularly among postmenopausal women"
- Chemical in Miso and Other Soy Foods Believed to Block Certain Tumors
- WebMD, 6/17/03 -
"identified 21,852 women between the ages of 40 and 59 and surveyed them
about various lifestyle issues ... They traced the women 10 years later ...
Women with the most isoflavones in their
diet had the lowest risk of breast cancer. This was especially true of
- Soy Protein May Be Better Than Supplements for Menopause
- WebMD, 4/24/03
- Got Milk - WebMD, 9/27/02 -
"A combination of soy and cow's
milk could have some beneficial,
anti-cancer nutrients ... He says he thinks the most potent
cancer-fighting component of soy is a compound called
genistein ... He demonstrated that by feeding rats a diet containing
genistein before exposing them to a cancer-causing drug. The number of
breast tumors was reduced by 50%"
Diet Rich In Soy Protein Lowers Estrogens Associated With Breast Cancer
- Intelihealth, 9/24/02 -
"Isoflavones, the main constituent of soybeans, are believed to be
responsible for anti-cancer effects observed in an accumulating number of
human and animal studies ... However, the effect of soy on the breast is
controversial ... There are some in vitro studies of breast cancer cells -
animal studies, as well as short-term soy intervention studies in women -
suggesting that soy isoflavines may have stimulatory effects"
- Ipriflavone in Osteoporosis Prevention and Treatment
- Medscape, 9/4/02
- Red Clover May Tame Hot Flashes - WebMD, 8/16/02 -
"Promensil is an isoflavone supplement produced from
red clover and contains the same key isoflavones commonly found in soy
foods. Isoflavones are plant compounds -- found commonly in soy -- that act
like weak form of the female sex hormone estrogen
... Only red clover contains all four isoflavones that women need ... 30
women were given either 40 mg of Promensil or a placebo for 16 weeks. The
group taking Promensil reported a 48% reduction in frequency of
hot flashes, whereas the control group had an 11% decrease" - See
or Promensil products.
- Soy Protein In The Diet Produces Health Benefits, Regardless Of Isoflavone
Content - Intelihealth, 7/25/02 -
soy diet, total
cholesterol, the ratio of low-density lipoprotein (LDL) to high-density
lipoprotein (HDL) cholesterol,
homocysteine concentrations, and estimated overall cardiovascular risk
were lower than they were after the control diet. Additionally, serum
concentrations of LDL were lower after the high-isoflavone diet. The only
significant difference between the sexes was a tendency toward reduced
blood pressure in men after the high-soy isoflavone diet ... the soy
diets continued to improve the subjects' blood lipid profiles even after
dietary saturated fat consumption was maximally reduced"
- Phytoestrogen review - ConsumerLab.com, 7/16/02
- Soy Comparable to Some Diabetes Drugs - WebMD,
6/20/02 - "Soy
may help people with diabetes control their
blood sugar as well as some prescription drugs ... One group sprinkled their
food daily with a white powder containing 30 grams of soy protein and 132
milligrams of soy isoflavones for 12 weeks ... The soy products lowered the
women's blood sugar as much as some prescription diabetes drugs"
- Soy Isoflavone May Improve Bone Metabolism in Perimenopausal Women
- Doctor's Guide, 5/27/02 - "The
isoflavone group (n=12) received daily capsules of soy isoflavone extract
(61.8 mg of isoflavones) ... Excretion of bone
markers was reduced significantly in the isoflavone group"
Formulas May Weaken Immune System - WebMD, 5/20/02
researchers examined immune system effects in mice fed diets high in the
isoflavone. At levels similar to those found in soy-fed infants, genistein
appeared to produce a large decrease in thymus size and immune cell function
... The study appears to contradict recently published research, sponsored
by a soy formula manufacturer, suggesting that infants fed soy-based diets
immune development as measured by response to
routine childhood immunizations. Infants fed soy-based
formulas also demonstrated immune status similar to infants who were
breastfed ... But a Danish study assessing soy supplementation in
postmenopausal women did find evidence of immune suppression"
- Ovulatory Cycles Not Affected By Isoflavones Supplement
- Doctor's Guide, 3/21/02
- Phytoestrogens May Reduce Heart Disease Risk In Older Women
- Intelihealth, 2/21/02 - "phytoestrogen
consumption was associated with a reduced risk of heart disease. Women who
consumed the highest amount of isoflavones and
lignans had significantly
lower triglyceride (fatty material found in blood) levels than those who
consumed the least amount of phytoestrogens. Similarly, those who consumed
significant amounts of lignan-rich
foods had less weight concentrated around their waists than those who ate
little or no lignan-rich
food. (Excessive weight around the waist is a risk factor for heart
Magic of Soy Beans - Life Extension Magazine, 11/99 -
"In the group receiving the highest doses of soy isoflavones, there was a
74% reduction in the median number of metastatic tumors to the lungs. The
study showed that the higher doses of isoflavones significantly decreased
tumor size and volume, in addition to reducing the number of metastatic
- Long-Term Soy Consumption Does Not Effect Hormones In Postmenopausal Women
- Intelihealth, 12/21/01 - "Though
small hormonal fluctuations occurred in all three groups over time, the
researchers found no significant changes in serum estrogen, cortisol,
sulfate, or follicle stimulating hormone in any of the subject groups.
Circulating thyroid hormone levels were modestly increased in women taking
the highest dose of soy isoflavones for more than 6 months. Other effects of
soy isoflavones observed in the study, such as increased bone mineral
density and higher HDL concentrations in women who took the highest dose for
6 months, suggest that soy may possess estrogen effects that are better
reflected in these end-points rather than in serum hormone concentrations"
- Soy And Breast Cancer: Safe Or Unsafe? -
- Soy Isoflavone Stimulates Breast Cancer Tumor Growth
- Intelihealth, 11/8/01
- Product Review: Phytoestrogens -- Soy and Red Clover Isoflavones
- ConsumerLab, 8/15/01
Soy Isoflavones May Protect Postmenopausal Women From Alzheimer's -
Widely Used Supplement Doesn't Stop Bone Loss, Study Finds No Postmenopausal
Benefit From Ipriflavone - WebMD, 3/22/01
Osteoporosis Supplement Doesn't Prevent Bone Loss In Study -
Intelihealth, 3/20/01 -
"ipriflavone, a synthetic form of an estrogen-like substance found in plants
such as soybeans ... ipriflavone supplements had no effect on preserving
bone density. But women who took the supplements, in standard doses of 600
milligrams daily, were more likely than those on dummy pills to develop a
reduction in disease-fighting white blood cells called lymphocytes ...
The women remained otherwise healthy, but low lymphocyte counts are a
symptom of an immune system that is potentially more vulnerable to infection
... The study was funded by Chiesi Pharmaceuticals Inc., an Italian maker of
ipriflavone (so it may have been that brand)"
Soy and Health: What's the Scoop? Most Recent Addition to Soy Research Shows
Lower Breast Cancer Risk - WebMD, 12/21/00 -
"eating a diet rich in soy products may cut the risk of breast cancer in
Bone Up on Osteoporosis - Nutrition Science News, 11/00 -
"Most research demonstrates that soy foods also increase mineral density in
menopausal women and reduce bone loss"
|Beef(Not) textured soy
protein granules, 1/4 c. dry
|Nutlettes breakfast cereal,
|Roasted soy nuts, 1/4 c.
|Tempeh, 1/2 c.
|Tufu, low-fat and regular,
|Take Care High Protein
Beverage Powder, 2 scoops
|Regular soy milk, 1 c.
|Low-fat soy milk, 1 c.
|Roasted soy butter, 2 tbsp.
|Morningstar Farms Ground
Meatless all-vegetable crumbles, 1/2 c.
effects of isoflavones on tumor growth and cachexia in newly established
cachectic mouse models carrying human stomach cancers - Nutr Cancer.
2013;65(4):578-89 - "Isoflavone treatment on the models
induced tumor cytostasis, attenuation of cachexia, and prolonged survival
whereas discontinuation of the treatment resulted in progressive tumor growth
and weight loss" - See
isoflavone products at iHerb.
Dietary Isoflavone Intake Is Associated with Decreased C-Reactive Protein
Concentrations among Healthy Premenopausal Women - J Nutr. 2013 Apr 24 -
"Between 2005 and 2007, 259 healthy, regularly
menstruating women were enrolled in the BioCycle Study, and followed for up to 2
menstrual cycles ... Diet was assessed up to 4 times per cycle by using 24-h
recalls ... Compared with the lowest quartile of total isoflavone intake, women
in the highest quartile had, on average, 27% lower serum CRP concentrations"
versus hospital controls in the assessment of dietary intake of isoflavone for
case-control studies on cancers in china - Nutr Cancer. 2013 Apr;65(3):390-7
- "Three parallel case-control studies on leukemia,
breast, and colorectal cancers in China in 2009-2010 were conducted, using
population and hospital outpatient controls to separately match 560 incident
cases at a 1:1 ratio ... Risk estimates for breast cancers were adjusted ORs
(95% CI) of 0.39 (0.23-0.66) and 0.31 (0.18-0.55) for daidzein, 0.35 (0.20-0.61)
and 0.28 (0.16-0.52) for genistein, 0.66 (0.41-1.08) and 0.53 (0.32-0.88) for
glycitein, and 0.53 (0.33-0.85) and 0.43 (0.26-0.71) for total isoflavone using
hospital outpatient and population controls respectively"
isoflavone intake and breast cancer risk in Japan: From the takayama study -
Int J Cancer. 2013 Feb 6 - "We assessed the associations
of soy and isoflavone intake with breast cancer incidence in a population-based
prospective cohort study in Japan. Participants were members from the Takayama
study, aged 35 years or older in 1992 ... Soy and isoflavone intakes were
assessed with a validated food-frequency questionnaire ... The relative risks of
postmenopausal breast cancer were lower among women with higher intakes of soy
(trend p=0.023) and isoflavone (trend p=0.046), although the relative risks of
premenopausal breast cancer were not associated with intakes of soy and
isoflavone. Decreased risks of breast cancer were found even among women with a
moderate intake of soy and isoflavone. These results suggested that soy and
isoflavone intake have a protective effect on postmenopausal breast cancer"
Soy Isoflavone and Endogenous Oestrogen on Breast Cancer in MMTV-erbB2
Transgenic Mice - J Int Med Res. 2012;40(6):2073-82 -
"Five-week-old mouse mammary tumour virus (MMTV)-erbB2
female transgenic mice (n = 180) were divided into three equal groups: low-,
normal- and high-oestrogen groups. Each group was then subdivided into an
experimental group (given soybean feed) and a control group (given control feed)
... In the high-oestrogen environment, breast cancer incidence was significantly
lower in the experimental versus the control group, whereas in the low-oestrogen
environment, breast cancer incidence was significantly higher in the
experimental versus the control group"
effect of genistein on lowering blood pressure and kidney toxicity in
fructose-fed hypertensive rats - Br J Nutr. 2012 Sep 21:1-7 -
"The study evaluates the effects of genistein on blood
pressure (BP) and ultrastructural changes in kidney of fructose-fed hypertensive
rats ... Genistein administration lowered BP, restored ACE, PKC-βII and eNOS
expression and preserved renal ultrastructural integrity. These findings
demonstrate that genistein has effects on eNOS activity in renal cells, leading
to eNOS activation and NO synthesis. These effects could have been mediated by
activation of PKC-βII. The observed benefits of genistein make it a promising
candidate for therapy of diabetic kidney disease" - See
genistein products at iHerb.
Between Serum Isoflavone Levels and Disability-Free Survival Among
Community-Dwelling Elderly Individuals: Nested Case-Control Study of the
Tsurugaya Project - J Gerontol A Biol Sci Med Sci. 2012 Oct 9 -
"The longer healthy life expectancy observed in Japan
may be partly attributed to the Japanese diet ... The researchers used a nested
case-control study to compare serum isoflavones (daidzein, genistein, glycitein,
and equol) levels between 165 participants that died or were certificated as
disabled (cases) and 177 controls ... Higher serum equol levels, but not any
other isoflavones, were inversely associated with the composite endpoint of
disability and death. Although it cannot be concluded that equol per se has
preventive effects on disability or death, higher equol levels appear associated
with better health"
isoflavone supplements is associated with reduced postmenopausal breast cancer
risk - Int J Cancer. 2012 Aug 13 - "Associations
between ever use of 28 isoflavone supplements and breast cancer risk in Ontario,
Canada were evaluated using cases (n=3101) identified in 2002-2003 from the
Ontario Cancer Registry and controls (n=3471) identified through random digit
dialing methods ... Several individual supplements were associated with reduced
breast cancer risk (e.g. Natural HRT; AOR = 0.39; 95% CI: 0.22, 0.69; n(users)
=58). Use of any isoflavone supplements was associated with reduced risk when ≥3
were ever used (AOR = 0.68; 95% CI: 0.54, 0.86; n(users) =332; P(trend) =0.008)
or any was taken >5 years (AOR = 0.75; 95% CI: 0.60, 0.94; n(users) =325;
P(trend) =0.01); high content supplements were consistently associated with
reduced risk. Risk reduction was confined to postmenopausal breast cancer for
both individual and combined supplements, and was strongest in the latter among
high content users who ever took ≥3 supplements (AOR = 0.55; 95% CI: 0.38, 0.81;
n(users) =118; P(trend) =0.04) or any >5 years (AOR = 0.47; 95% CI: 0.27, 0.81;
n(users) =60; P(trend) =0.03). Associations did not differ by
estrogen-progesterone tumor receptor status" - See
isoflavone products at iHerb.
Soy Phytoestrogen, Reverses Severe Pulmonary Hypertension and Prevents Right
Heart Failure in Rats - Hypertension. 2012 Jul 2 -
"PH was induced in male rats by 60 mg/kg of monocrotaline. After 21 days, when
PH was well established, rats received daily injection of genistein (1 mg/kg per
day) for 10 days or were left untreated to develop RHF by day 30. Effects of
genistein on human pulmonary artery smooth muscle cell and endothelial cell
proliferation and neonatal rat ventricular myocyte hypertrophy were assessed in
vitro. Severe PH was evident 21 days after monocrotaline, as peak systolic right
ventricular pressure increased to 66.35±1.03 mm Hg and right ventricular
ejection fraction reduced to 41.99±1.27%. PH progressed to RHF by day 30 (right
ventricular pressure, 72.41±1.87 mm Hg; RV ejection fraction, 29.25±0.88%), and
mortality was ≈75% in RHF rats. Genistein therapy resulted in significant
improvement in lung and heart function as right ventricular pressure was
significantly reduced to 43.34±4.08 mm Hg and right ventricular ejection
fraction was fully restored to 65.67±1.08% similar to control. Genistein
reversed PH-induced pulmonary vascular remodeling in vivo and inhibited human
pulmonary artery smooth muscle cell proliferation by ≈50% in vitro likely
through estrogen receptor-β. Genistein also reversed right ventricular
hypertrophy (right ventricular hypertrophy index, 0.35±0.029 versus 0.70±0.080
in RHF), inhibited neonatal rat ventricular myocyte hypertrophy, and restored
PH-induced loss of capillaries in the right ventricle. These improvements in
cardiopulmonary function and structure resulted in 100% survival by day 30.
Genistein restored PH-induced downregulation of estrogen receptor-β expression
in the right ventricle and lung. In conclusion, genistein therapy not only
rescues preexisting severe PH but also prevents the progression of severe PH to
RHF" - See
genistein products at iHerb.
observational study of isoflavone and the risk of stroke recurrence: potential
clinical implications beyond vascular function -J Nutr Health Aging.
2012;16(4):383-8 - "Stroke recurrence and major adverse
cardiovascular events (MACE) were documented. Brachial flow-mediated dilatation
(FMD) was measured using high-resolution ultrasound. Isoflavone intake was
estimated using a validated food frequency questionnaire. Results: Median
isoflavone intake was 6.9 (range: 2.1 - 14.5) mg/day. Isoflavone intake was
independently associated with increased FMD (Pearson R=0.23, p=0.012). At 30
months, there were 10 stroke recurrence and 12 MACE. Kaplan-Meier analysis
showed that patients with isoflavone intake higher than median value had
significantly longer median stroke recurrence-free survival time (19.0 [range:
10.4 - 27.6] mth versus 5.0 [range: 4.1 - 5.9] mth, p=0.021) and MACE-free
survival time (19.0 [range: 10.4 - 27.6] mth versus 4.0 [range: 2.4 - 5.6] mth,
p=0.013). Using multivariate cox regression, higher isoflavone intake was an
independent predictor for lower risk of stroke recurrence (hazards ratio 0.18
[95%CI: 0.03 - 0.95], risk reduction 82%, p=0.043) and MACE (hazards ratio 0.16
[95%CI: 0.03 - 0.84], risk reduction 84%, p=0.030)"
isoflavone consumption in relation to carotid intima-media thickness in Chinese
equol excretors aged 40-65 years - Br J Nutr. 2012 Feb 29:1-7 -
studies have suggested that the daidzein metabolite equol rather than daidzein
itself contributes to the beneficial effect of soya foods in the prevention of
CVD. The aim of the present study is to examine the proportion of equol
excretion in Chinese adults and compare plasma lipids and carotid artery intima-media
thickness (IMT) between equol excretors and non-excretors, and to evaluate the
effect of soya isoflavone intakes on serum lipids and IMT in either equol
excretors or non-excretors ... Compared with non-excretors, equol excretors
showed significantly lower serum TAG ( - 38.2 (95 % CI - 70.4, - 5.9) %, P =
0.012) and CCA-IMT ( - 4.9 (95 % CI - 9.7, - 0.3) %, P = 0.033). Equol excretors
with higher daily isoflavone intakes ( - 5.4 mg/d) had significantly lower IMT (
- 16.2 %, P = 0.035) and tended to have higher HDL-cholesterol (P = 0.055) than
did those with lower daily isoflavone intakes (1.5 mg/d), while no association
was observed between soya isoflavone intakes and serum lipids or IMT in non-excretors.
In conclusion, the benefits of soya isoflavones in preventing CVD may be
apparent among equol excretors only"
Influence of Dietary Soy Intake on the Risk of Breast Cancer Recurrence Related
to HER2 Status - Nutr Cancer. 2012 Jan 2 - "Legume
intake (mostly from black soybeans) was inversely associated with the risk of
breast cancer recurrence in HER2 negative cancer patients (HR: 0.27, 95% CI:
0.13-0.57, P for trend < 0.01), whereas legume intake was positively associated
in HER2 positive cancer patients (P for trend = 0.02). In HER2 negative cancer
patients, isoflavone was inversely associated with breast cancer recurrence (HR:
0.23, 95% CI: 0.06-0.89; P for trend = 0.01). Total soy intake was not
associated with an increased risk of cancer recurrence. In conclusion, overall
soy food intake might not affect the risk of cancer recurrence, but high intake
of soy isoflavones increased the risk of cancer recurrence in HER2-positive
breast cancer patients. However, further research is needed to confirm these
results due to the small number of cancer recurrence events"
Mitigates Radiation-induced Testicular Injury - Phytother Res. 2011 Dec 9 -
"Genistein significantly attenuated radiation-induced
reduction in testis weight, seminiferous tubular diameter, seminiferous
epithelial depth and sperm head count in the testes (p < 0.05 vs vehicle-treated
irradiated mice at 21 days post-irradiation). Repopulation and stem cell
survival indices of the seminiferous tubules were increased in the
genistein-treated group compared with the vehicle-treated irradiation group at
21 days post-irradiation (p < 0.01). The irradiation-mediated decrease in the
sperm count and sperm mobility in the epididymis was counteracted by genistein
(p < 0.01), but no effect on the frequency of abnormal sperm was evident.
Reactive oxygen species (ROS) were evaluated using DCFDA method and exposure to
irradiation elevated ROS levels in the testis and genistein treatment resulted
in a significant attenuation of radiation-induced ROS production"
Tofu, and Isoflavone Intake and Endometrial Cancer Risk in Postmenopausal Women
in the Multiethnic Cohort Study - J Natl Cancer Inst. 2011 Dec 12 -
"conducted a prospective analysis of 46 027
nonhysterectomized postmenopausal women who were recruited into the Multiethnic
Cohort (MEC) Study between August 1993 and August 1996 and provided detailed
baseline information on diet and other endometrial cancer risk factors ... A
total of 489 women diagnosed with incident endometrial cancer were identified
through the Surveillance, Epidemiology, and End Results tumor registry linkages
during a median follow-up period of 13.6 years ... A reduced risk of
endometrial cancer was associated with total isoflavone intake (highest vs
lowest quintile, ≥7.82 vs <1.59 mg per 1000 kcal/d, RR = 0.66, 95% CI = 0.47 to
0.91), daidzein intake (highest vs lowest quintile, ≥3.54 vs <0.70 mg per 1000
kcal/d, RR = 0.64, 95% CI = 0.46 to 0.90), and genistein intake (highest vs
lowest quintile, ≥3.40 vs <0.69 mg per 1000 kcal/d, RR = 0.66, 95% CI = 0.47 to
0.91). No statistically significant association with endometrial cancer risk was
observed for increasing intake of legumes, soy, tofu, or glycitein. Truncated
age-adjusted incidence rates of endometrial cancer for the highest vs lowest
quintile of total isoflavone intake were 55 vs 107 per 100 000 women per year,
respectively. The partial population attributable risk percent for total
isoflavone intake lower than the highest quintile was 26.7% (95% CI = 5.3% to
Effects of Combination of Lycopene and Genistein on 7,12- Dimethyl Benz(a)anthracene-Induced
Breast Cancer in Rats - Nutr Cancer. 2011 Sep 29 - "Breast cancer is one of
the most common cancers in women. Carotenoids and soy isoflavones have been
postulated to have breast cancer preventive effects ... 7,12-dimethylbenz[a]anthracene
(DMBA), a carcinogen known to induce breast tumors ... Tumor weight decreased by
48%, 61%, and 67%, and mean tumor volume decreased by 18%, 35%, and 65% with
lycopene, genistein, and lycopene + genistein, respectively (P < 0.01 for the
combination). The proportions of adenocarcinoma masses decreased with lycopene
and genistein combination (P < 0.05). Administration of lycopene and genistein
combination suppressed breast cancer development and was associated with a
decrease in MDA, 8-isoprostane, and 8-OhdG levels and with an increase in serum
lycopene and genistein levels. Animals administered DMBA developed breast
cancer, which was associated with increased expression of Bcl-2 and decreased
expression of Bax, caspase 3, and caspase 9 in mammary tissues. Administration
of genistein and lycopene in combination was more effective in inhibiting
DMBA-induced breast tumors and modulating the expression of apoptosis associated
proteins than the administration of each agent alone" - See
lycopene products at iHerb
genistein products at iHerb.
soy isoflavones on blood pressure: A meta-analysis of randomized controlled
trials - Nutr Metab Cardiovasc Dis. 2011 Feb 8 - "A total of eleven trials
were reviewed. Meta-analysis results showed a mean decrease of 2.5 mm Hg (95%
CIs, - 5.35 to 0.34 mm Hg; P = 0.08) for systolic blood pressure and 1.5 mm Hg
(95% CIs, - 3.09 to 0.17 mm Hg; P = 0.08) for diastolic blood pressure in the
soy isoflavones-treated group compared to placebo. Meta-regression and subgroup
analyses indicated that blood pressure status was a significant predictor of
heterogeneity for the effect of soy isoflavones on blood pressure. Subgroup
analysis of hypertensive subjects revealed that a greater blood pressure
reduction was identified in the soy isoflavone-treated group compared to placebo
(5 trials; SBP: - 5.94, 95% CIs [- 10.55, - 1.34] mm Hg, P = 0.01; DBP: - 3.35,
95% CIs [- 6.52, - 0.19] mm Hg, P = 0.04). In contrast, treatment with soy
isoflavones did not lead to a significant reduction in blood pressure in normotensive subjects (6 trials; SBP: 0.29, 95% CIs [- 2.39, 2.97] mm Hg, P =
0.83; DBP: - 0.43, 95% CIs [- 1.66, 0.81] mm Hg, P = 0.50)"
isoflavones and the risk of lung cancer in women: A nested case-control study in
Japan - Cancer Epidemiol Biomarkers Prev. 2011 Jan 14 -
"After exclusion of
20 lung cancer cases diagnosed in the first 3 years after blood collection, an
inverse association was found between plasma genistein concentration and lung
cancer risk. The multivariate-adjusted OR (95% CI) of lung cancer in the highest
quintile of plasma genistein concentration as compared with that in the lowest
quintile was 0.31 (0.12, 0.86) (P for trend = 0.085). Other isoflavones and
total isoflavones were not associated with a significant decrease in the risk of
lung cancer" - See
genistein products at iHerb.
of dietary and nutrient interventions on arterial stiffness: a systematic review
- Am J Clin Nutr. 2010 Dec 8 - "Of the 75 relevant studies located, we
considered 38 studies to be appropriate for review. Results revealed support for
intakes of omega-3 (n-3) fish oils (Cohen's d = 0.21-0.81) and soy isoflavones
(Cohen's d = 0.35-0.39) in the treatment of arterial stiffness. There was
limited but consistent evidence to suggest that salt restriction (Cohen's d =
0.28-0.37) as well as consumption of fermented-milk products (Cohen's d =
0.15-0.33) that contain bioactive peptides improved arterial stiffness. The
evidentiary support for intakes of vitamins, micronutrients, and herbal
medicines was insufficient. Limited but consistent evidence suggested that
caffeine intake acutely increased arterial stiffness (Cohen's d = 0.34-0.51) ...
Current evidence from several small studies suggests that omega-3 and soy
isoflavone supplementation provides an effective means of reducing arterial
stiffness" - See
Isoflavone products at iHerb
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
Soy food and
isoflavone intake and colorectal cancer risk: the Fukuoka Colorectal Cancer
Study - Scand J Gastroenterol. 2010 Oct 24 -
"Energy-adjusted intakes of soy foods (dry weight) and isoflavones were
inversely associated with colorectal cancer risk in men and postmenopausal
women, but not in premenopausal women. The multivariate-adjusted OR for the
highest versus lowest quintile was 0.65 (95% CI 0.41-1.03, p for trend = 0.03)
for soy foods and 0.68 (95% CI 0.42-1.10, p for trend = 0.051) for isoflavones
in men. The corresponding values for postmenopausal women were 0.60 (95% CI
0.29-1.25, p for trend = 0.053) and 0.68 (95% CI 0.33-1.40, p for trend =
isoflavones in conjunction with radiation therapy in patients with prostate
cancer - Nutr Cancer. 2010 Oct;62(7):996-1000 - "Soy isoflavones sensitize
prostate cancer cells to radiation therapy by inhibiting cell survival pathways
activated by radiation. At the same time, soy isoflavones have significant
antioxidant and anti-inflammatory activity, which may help prevent the side
effects of radiation ... Adverse effects of radiation therapy on bladder, bowel,
and sexual function were assessed by a self-administered quality of life
questionnaire at 3 and 6 mo. Only 26 and 27 patients returned completed
questionnaires at 3 and 6 mo, respectively. At each time point, urinary, bowel,
and sexual adverse symptoms induced by radiation therapy were decreased in the
soy isoflavone group compared to placebo group. At 3 mo, soy-treated patients
had less urinary incontinence, less urgency, and better erectile function as
compared to the placebo group. At 6 mo, the symptoms in soy-treated patients
were further improved as compared to the placebo group. These patients had less
dripping/leakage of urine (7.7% in Group 1 vs. 28.4% in Group 2), less rectal
cramping/diarrhea (7.7% vs. 21.4%), and less pain with bowel movements (0% vs.
14.8%) than placebo-treated patients. There was also a higher overall ability to
have erections (77% vs. 57.1%). The results suggest that soy isoflavones taken
in conjunction with radiation therapy could reduce the urinary, intestinal, and
sexual adverse effects in patients with prostate cancer"
decrease insomnia in postmenopause - Menopause. 2010 Aug 19 -
"Polysomnography revealed a significant increase in sleep efficiency in the
isoflavone group (from 77.9% to 83.9%) when compared with the placebo group
(from 77.6% to 81.2%). Isoflavones induced a decrease in the intensity and
number of hot flashes and the frequency of insomnia: among the women in the
placebo group, 94.7% had moderate or intense insomnia at the beginning of the
study, compared with 63.2% at the end, whereas in the isoflavone group, these
percentages were 89.5% and 36.9%, respectively"
reduced the neural apoptosis in the brain of ovariectomised rats by modulating
mitochondrial oxidative stress - Br J Nutr. 2010 Jun 28:1-7 -
(Gen) ... these results suggest that Gen confers protection against Ovx-induced
neurodegeneration by attenuating oxidative stress, lipid peroxidation and the
mitochondria-mediated apoptotic pathway in a region- and dose-dependent manner"
induces growth inhibition and g2/m arrest in nasopharyngeal carcinoma cells
- Nutr Cancer. 2010 Jul;62(5):641-7 - "These findings
provide new insights into the potential intervention of NPC with genistein"
intake and breast cancer survival - JAMA. 2009 Dec 9;302(22):2437-43 -
"Soy food intake, as measured by either soy protein or
soy isoflavone intake, was inversely associated with mortality and recurrence.
The hazard ratio associated with the highest quartile of soy protein intake was
0.71 (95% confidence interval [CI], 0.54-0.92) for total mortality and 0.68 (95%
CI, 0.54-0.87) for recurrence compared with the lowest quartile of intake. The
multivariate-adjusted 4-year mortality rates were 10.3% and 7.4%, and the 4-year
recurrence rates were 11.2% and 8.0%, respectively, for women in the lowest and
highest quartiles of soy protein intake. The inverse association was evident
among women with either estrogen receptor-positive or -negative breast cancer
and was present in both users and nonusers of tamoxifen. CONCLUSION: Among women
with breast cancer, soy food consumption was significantly associated with
decreased risk of death and recurrence"
isoflavone supplementation enhances spatial working memory in men - Br J
Nutr. 2009 Jun 1:1-7 - "Compared with placebo
supplementation, there were 18 % fewer attempts (P = 0.01), 23 % fewer errors (P
= 0.02) and 17 % less time (P = 0.03) required to correctly identify the
requisite information" - See
isoflavone products at iHerb.
studies show no effects of soy protein or isoflavones on reproductive hormones
in men: results of a meta-analysis - Fertil Steril. 2009 Jun 11 -
"No significant effects of soy protein or isoflavone
intake on T, SHBG, free T, or FAI were detected regardless of statistical model"
isoflavone supplementation enhances spatial working memory in men - Br J
Nutr. 2009 Jun 1:1-7 - "Volunteers were randomised to
take four capsules/d containing soya isoflavones (116 mg isoflavone
equivalents/d: 68 mg daidzein, 12 mg genistein, 36 mg glycitin) or placebo for 6
weeks, and the alternate treatment during the following 6 weeks. Assessments of
memory (verbal episodic, auditory and working), executive function (planning,
attention, mental flexibility) and visual-spatial processing were performed at
baseline and after each treatment period. Isoflavone supplementation
significantly improved spatial working memory (P = 0.01), a test in which
females consistently perform better than males. Compared with placebo
supplementation, there were 18 % fewer attempts (P = 0.01), 23 % fewer errors (P
= 0.02) and 17 % less time (P = 0.03) required to correctly identify the
requisite information. Isoflavones did not affect auditory and episodic memory
(Paired Associate Learning, Rey's Auditory Verbal Learning Task, Backward Digit
Span and Letter-Number Sequencing), executive function (Trail Making and Initial
Letter Fluency Task) or visual-spatial processing (Mental Rotation Task).
Isoflavone supplementation in healthy males may enhance cognitive processes
which appear dependent on oestrogen activation"
Adolescent and adult soy food intake and breast cancer risk: results from the
Shanghai Women's Health Study - Am J Clin Nutr. 2009 Jun;89(6):1920-6 -
"Adult soy food consumption, measured either by soy
protein or isoflavone intake, was inversely associated with the risk of
premenopausal breast cancer, and the association was highly statistically
significant (P for trend < 0.001). The multivariate-adjusted relative risks
(RRs) for the upper intake quintile compared with the lowest quintile were 0.41
(95% CI: 0.25, 0.70) for soy protein intake and 0.44 (95% CI: 0.26, 0.73) for
isoflavone intake. High intake of soy foods during adolescence was also
associated with a reduced risk of premenopausal breast cancer (RR: 0.57; 95% CI:
0.34, 0.97). Women who consumed a high amount of soy foods consistently during
adolescence and adulthood had a substantially reduced risk of breast cancer. No
significant association with soy food consumption was found for postmenopausal
cancer cell response to genistein is conditioned by BRCA1 mutations -
Biochem Biophys Res Commun. 2009 Jan 3 - "We showed that
growth of BRCA1 mutant cells was strongly inhibited by genistein whereas it only
had a weak effect in cells expressing wild-type BRCA1 protein. BRCA1 mutant
cells hypersensitivity could be linked to higher expression of ERbeta gene,
which suggests that genistein may be an efficient inhibitor of cancer
development in BRCA1 mutant breast cancer cells"
Genistein protects against polycyclic aromatic hydrocarbon-induced oxidative DNA
damage in non-cancerous breast cells MCF-10A - Br J Nutr. 2008 Jun 23:1-6 -
"These enzymes, in turn, will metabolise the PAH into
their ultimate carcinogenic forms. Genistein can significantly suppress the
expressions within 5 mum. The comet assay indicated that DMBA introduced DNA
damage to these cells, and co-treatment with genistein at 5 or 10 mum could
alleviate the damage. In addition to the chelation of DMBA metabolites to DNA,
flow cytometry results revealed that oxidation was also a factor of DNA damage.
The oxidative DNA damage could be removed by co-treating with 10 mum-genistein.
Because no increased oxidative DNA repair was observed, suppression on the
cytochrome enzymes appeared to be the underlying mechanism"
phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice
- J Nutr. 2008 Jul;138(7):1360-4 - "soy phytochemicals
slow the in vivo growth of NSCLC xenografts; the modulation of the Akt-signaling
pathway observed in tumors of SSE-treated mice may have a role in the activity
observed. Our research provides further support for the concept that consumption
of phytoestrogens may be effective in delaying lung cancer progression"
Genistein reduced the invasive activity of human breast carcinoma cells as a
result of decreased tight junction permeability and modulation of tight junction
proteins - Cancer Lett. 2008 Jun 14 - "Taken
together our results indicate a possible role of genistein as an inhibitor of
cancer cell invasion through the tightening of TJs, which may counteract the
up-regulation of claudins. In addition, our results indicate that may be
beneficial for the inhibition of tumor metastasis"
and isoflavone intake and prostate cancer risk: The Multiethnic Cohort Study
- Int J Cancer. 2008 Jun 2 - "legume intake is
associated with a moderate reduction in prostate cancer risk and that the
isoflavones in soy products are probably not responsible for this effect"
flavonoid intake and risk of cancer in postmenopausal women: The Iowa Women's
Health Study - Int J Cancer. 2008 May 19 - "Isoflavone
intake was inversely associated with overall cancer incidence (HR = 0.93, 95%
Plasma Isoflavone Level and Subsequent Risk of Breast Cancer Among Japanese
Women: A Nested Case-Control Study From the Japan Public Health Center-Based
Prospective Study Group - J Clin Oncol. 2008 Mar 3 -
"We found a statistically significant inverse
association between plasma genistein and risk of breast cancer, but no
association for plasma daidzein. Adjusted odds ratios for the highest versus
lowest quartile of plasma level were 0.34 for genistein (95% CI, 0.16 to
0.74; P for trend, .02) and 0.71 for daidzein (95% CI, 0.35 to 1.44; P for
trend, .54). Median plasma genistein values in the control group were 31.9
ng/mL for the lowest and 353.9 ng/mL for the highest quartile groups"
Effects of One-Year Treatment with Isoflavone Extract from Red Clover on
Prostate, Liver Function, Sexual Function, and Quality of Life in Men with
Elevated PSA Levels and Negative Prostate Biopsy Findings - Urology.
2008 Feb;71(2):185-90 - "isoflavonoid extract from
red clover ... daily 60-mg dose of an isoflavone extract for 1 year ... The
average PSA level was 10.16 ng/mL at baseline versus 7.15 ng/mL after 12
months, for a statistically significant reduction of 33% ... The sexual
hormone levels did not change throughout the study. We registered a
significant increase in all three liver transaminases after 3 months"
Daidzein-rich isoflavone aglycones are potentially effective in reducing hot
flashes in menopausal women - Menopause. 2008 Jan-Feb;15(1):125-32 -
"When comparing the two treatment groups with the
placebo group, there were significant reductions in mean daily hot flash
frequency. The supplement (either 40 or 60 mg) reduced hot flash frequency
by 43% at 8 weeks (P = 0.1) and 52% at 12 weeks (P = 0.048) but did not
cause any significant changes in endogenous sex hormones or thyroid
hormones" - See
Nature's Way EstroSoy Plus Fermented Soy Extract + Black Cohosh at iHerb.
Soy isoflavone intake increases bone mineral density in the spine of
menopausal women: Meta-analysis of randomized controlled trials - Clin
Nutr. 2007 Dec 4 - "Isoflavone intervention
significantly attenuates bone loss of the spine in menopausal women. These
favorable effects become more significant when more than 90mg/day of
isoflavones are consumed. And soy isoflavone consumption for 6 months can be
enough to exert beneficial effects on bone in menopausal women"
Lycopene and soy isoflavones in the treatment of prostate cancer - Nutr
Cancer. 2007;59(1):1-7 - "The data suggest that
lycopene and soy isoflavones have activity in prostate cancer patients with
PSA relapse disease and may delay progression of both hormone-refractory and
hormone-sensitive prostate cancer"
Genistein and daidzein prevent diabetes onset by elevating insulin level and
altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese
diabetic (NOD) mice - Diabetes Metab Res Rev. 2007 Oct 11 -
"Blood glucose levels of genistein and daidzein
groups were 40 and 36% of control value at the end of study (9th week). The
genistein and daidzein supplements increased insulin/glucagon ratio and
C-peptide level with preservation of insulin staining beta-cell of pancreas
in the NOD mice ... The supplementation of genistein and daidzein are
seemingly helpful for preventing IDDM onset"
Isoflavone intake in persons at high risk of cardiovascular events:
implications for vascular endothelial function and the carotid
atherosclerotic burden - Am J Clin Nutr. 2007 Oct;86(4):938-945 -
"In persons at high risk of cardiovascular events, a
greater isoflavone intake is associated with better vascular endothelial
function and lower carotid atherosclerotic burden"
Exposure to the phytoestrogen daidzein attenuates apomorphine-induced penile
erection concomitant with plasma testosterone level reduction in dose and
time-related manner in adult rats - Urology. 2007 Sep;70(3):613-7 -
"The phytoestrogen daidzein has the potential to
adversely affect erectile function in a dose and time-related manner that is
at least partly attributable to androgen deficiency. These findings
implicate that phytoestrogens, especially isoflavones, if overconsumed for a
long period, might be a novel risk factor for erectile dysfunction"
Effects of the phytoestrogen genistein on some predictors of cardiovascular
risk in osteopenic, postmenopausal women: a two-year randomized,
double-blind, placebo-controlled study - J Clin Endocrinol Metab. 2007
Aug;92(8):3068-75 - "Compared with placebo,
genistein significantly reduced fasting glucose and insulin as well as
homeostasis model assessment for insulin resistance after both 12 and 24
months of treatment"
Genistein induces the metastasis suppressor kangai-1 which mediates its
anti-invasive effects in TRAMP cancer cells - Biochem Biophys Res Commun.
2007 Jul 16 - "This work provides the first evidence
that genistein treatment may counteract KAI1 downregulation, which is
observed in many cancer types and therefore, could be used in
Dietary Isoflavones May Protect against Prostate Cancer in Japanese Men
- J Nutr. 2007 Aug;137(8):1974-1979 - "Isoflavones
and their aglycones (genistein and daidzein) were significantly associated
with decreased risk. The odds ratio for the highest category (>/=89.9 mg/d)
compared with the lowest category (<30.5 mg/d) of isoflavone intake was 0.42
(95% CI = 0.24-0.72) and the linear trend was significant"
Soy isoflavone intake inhibits bone resorption and stimulates bone formation
in menopausal women: meta-analysis of randomized controlled trials - Eur
J Clin Nutr. 2007 Mar 28 -
"Isoflavone intervention significantly inhibits bone resorption and
stimulates bone formation"
Effect of 6 months of exercise and isoflavone supplementation on clinical
cardiovascular risk factors in obese postmenopausal women: a randomized,
double-blind study - Menopause. 2007 Feb 6 -
"Compared to an aerobic exercise
program alone, 70 mg/day of isoflavones combined with exercise may promote
significant improvements in body composition parameters that are known to
influence cardiovascular disease risk in postmenopausal women"
Six months of isoflavone supplement increases fat-free mass in
obese-sarcopenic postmenopausal women: a randomized double-blind controlled
trial - Eur J Clin Nutr. 2007 Feb 21 -
"fat-free mass (FFM) and muscle mass index (MMI=appendicular FFM/height(2))
... The isoflavone group increased significantly appendicular (P=0.034), leg
(P=0.016) FFM and MMI (P=0.037), but not the placebo group"
Effects of a genistein-rich extract on PSA levels in men with
a history of prostate cancer - Functional Foods
and Nutraceuticals, 11/04 - "a
genistein-rich extract as the sole treatment for prostate cancer does not
appear to be an effective treatment for prostate cancer when given alone.
However, eight of 13 evaluated patients in the active surveillance group had
either no rise or a decline in PSA levels of less than 50 per cent"
- The specific role of isoflavones in reducing prostate cancer risk
- Prostate. 2004 May 1;59(2):141-7 - "These data suggest that supplementing early stage prostate
cancer patients with soy isoflavones, even in a study of short duration,
altered surrogate markers of proliferation such as serum PSA and free
testosterone in a larger number of subjects in the isoflavone supplemented
group than the group receiving placebo"
The effects of phytoestrogen isoflavones on bone density in women: a
double-blind, randomized, placebo-controlled trial - Am J Clin Nutr.
2004 Feb;79(2):326-33 - "These data suggest
that, through attenuation of bone loss, isoflavones have a potentially
protective effect on the lumbar spine in women"
- Usual dietary isoflavone intake and body composition in postmenopausal women
- Menopause. 2003 Sep-Oct;10(5):427-32 - "A significant inverse
relation was shown between genistein consumption and weight, body mass
index, waist circumference, and total body fat mass by bioelectric impedance
analysis ... This study suggests that usual dietary isoflavone intake is
associated with reduced total body fat and may consequently have a role in
the prevention of chronic disease"
- Phytoestrogen supplement use by women - J Nutr
2003 Jun;133(6):1983S-6S -
"Until safety with respect to breast cancer is established, phytoestrogen
supplements should not be recommended, particularly for women at high risk
of breast cancer"
- Bioavailability of phyto-oestrogens - Br J Nutr
2003 Jun;89 Suppl 1:838-52
- Phyto-oestrogens and osteoporosis: what is a safe dose?
- Br J Nutr 2003 Jun;89 Suppl 1:898-906
- Isoflavones and cognitive function in older women: the Soy and
Postmenopausal Health In Aging (SOPHIA) Study -
Menopause. 2003 May-Jun;10(3):196-202 -
"Women randomized to active treatment
(n = 27) took two pills per day, each containing 55 mg of soy-extracted
isoflavones (110 mg total isoflavones per day ... Comparisons of percentage
change in cognitive function between baseline and follow-up showed greater
improvement in category fluency for women on active treatment as compared
with the case of those on placebo (P = 0.02) and showed (nonsignificantly)
greater improvement on the two other tests of verbal memory"
Lack of significant genotoxicity of purified soy isoflavones (genistein,
daidzein, and glycitein) in 20 patients with prostate cancer - Am. J. of
Clin. Nutr., 4/03 - "Although isoflavones are capable of
inducing genetic damage in vitro, a similar effect was not observed in
subjects treated with a purified soy unconjugated
- Potential risks and benefits of phytoestrogen-rich diets
- Int J Vitam Nutr Res 2003 Mar;73(2):120-6 -
"Phytoestrogens are strikingly similar in chemical structure to the
mammalian oestrogen, oestradiol,
and bind to oestrogen receptors (ER) with a preference for the more recently
described ER beta ... Whether phytoestrogens have any biological activity in
humans, either hormonal or non hormonal is a contentious issue and there is
currently a paucity of data on human exposure ... The limited studies
conducted so far in humans clearly confirm that soya isoflavones can exert
hormonal effects. These effects may be of benefit in the prevention of many
of the common diseases observed in Western populations (such as breast
cancer, prostate cancer, menopausal symptoms, osteoporosis) where the diet
is typically devoid of these biologically active naturally occurring