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Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.
Home > Anti-aging Research > Interleukin 6 (IL-6)
Interleukin 6 (IL-6)
Related Topics:
Alternative News:
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Red
Wine's Resveratrol May Help Battle Obesity - Science Daily, 6/16/08 -
"resveratrol inhibited the pre-fat cells from
increasing and prevented them from converting into mature fat cells. Also,
resveratrol hindered fat storage. Most interesting, according to Fischer-Posovszky,
was that resveratrol reduced production of certain cytokines (interleukins 6
and 8), substances that may be linked to the development of obesity-related
disorders, such as diabetes and clogged coronary arteries. Also, resveratrol
stimulated formation of a protein known to decrease the risk of heart
attack. Obesity decreases this substance, called adiponectin" - See
Jarrow Resveratrol 100 at iHerb
 .
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Probiotics may offer hay fever hope - Nutra USA, 6/3/08 -
"Hayfever is an allergic reaction to pollen or
fungal spores, most commonly grass pollen. The immune system mistakes the
spores for harmful invaders and white blood cells - T-helper type 2 (Th2)
lymphocytes - produce protein-like cytokines, such as interleukin-4 (IL-4),
IL-5 and IL-6, which in turn promote the synthesis of the immune chemicals
immunoglobulins (Ig) to bind to the pollen and fight them off ... However,
supplementation with the probiotic led to reduced production of IL-5 and
IL-6, as well as decreased in the production of IgE ... The
probiotic-supplemented volunteers had significantly reduced levels of IL-5
and IL-6" - [Abstract]
- See
probiotic products at iHerb.
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Oral delivery of
Lactobacillus casei Shirota modifies allergen-induced immune responses in
allergic rhinitis - Clin Exp Allergy. 2008 May 28 -
"Lactobacillus casei Shirota (LcS) ... Volunteers
treated with LcS showed a significant reduction in levels of antigen-induced
IL-5, IL-6 and IFN-gamma production compared with volunteers supplemented
with placebo. Meanwhile, levels of specific IgG increased and IgE decreased
in the probiotic group" - See
probiotic products at iHerb.
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Luteolin reduces IL-6 production in microglia by inhibiting JNK
phosphorylation and activation of AP-1 - Proc Natl Acad Sci U S A. 2008
May 19 - "Luteolin consumption reduced LPS-induced
IL-6 in plasma 4 h after injection. Furthermore, luteolin decreased the
induction of IL-6 mRNA by LPS in hippocampus but not in the cortex or
cerebellum. Taken together, these data suggest luteolin inhibits LPS-induced
IL-6 production in the brain by inhibiting the JNK signaling pathway and
activation of AP-1 in microglia. Thus, luteolin may be useful for mitigating
neuroinflammation" - See
luteolin products at iHerb.
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Plant
Flavonoid In Celery And Green Peppers Found To Reduce Inflammatory Response In
The Brain - Science Daily, 5/20/08 - "The new study looked at luteolin
(LOO-tee-OH-lin), a plant flavonoid known to impede the inflammatory response in
several types of cells outside the central nervous system ... Those cells that
were also exposed to luteolin showed a significantly diminished inflammatory
response. Jang showed that luteolin was shutting down production of a key
cytokine in the inflammatory pathway, interleukin-6 (IL-6). The effects of
luteolin exposure were dramatic, resulting in as much as a 90 percent drop in
IL-6 production in the LPS-treated cells ... Inflammatory cytokines such as
interleukin-6 are very well known to inhibit certain types of learning and
memory that are under the control of the hippocampus, and the hippocampus is
also very vulnerable to the insults of aging ... If you had the potential to
decrease the production of inflammatory cytokines in the brain you could
potentially limit the cognitive deficits that result" - See
luteolin products at iHerb.
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Dietary choline and betaine intakes in relation to concentrations of
inflammatory markers in healthy adults: the ATTICA study - Am J Clin
Nutr. 2008 Feb;87(2):424-30 - "Compared with the
lowest tertile of choline intake (<250 mg/d), participants who consumed >310
mg/d had, on average, 22% lower concentrations of C-reactive protein (P <
0.05), 26% lower concentrations of interleukin-6 (P < 0.05), and 6% lower
concentrations of tumor necrosis factor-alpha" - See
Citi Choline products at iHerb.
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Adherence to the Mediterranean Diet Is Inversely Associated With Circulating
Interleukin-6 Among Middle-Aged Men. A Twin Study - Circulation. 2007
Dec 17 - "A 1-unit within-pair absolute difference
in the diet score was associated with a 9% (95% CI, 4.5 to 13.6) lower
interleukin-6 level"
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Study gives vitamin K anti-inflammation boost - Nutra USA, 12/3/07 -
"Limited in vitro data support the inverse
association between vitamin K and interleukin-6, and this may influence the
association between vitamin K and other cytokines, such as osteoprotegerin"
- [Abstract]
- See
vitamin K products at iHerb.
-
Vitamin K and Vitamin D Status: Associations with Inflammatory Markers in
the Framingham Offspring Study - Am J Epidemiol. 2007 Nov 15 -
"Vitamin K status, measured by plasma phylloquinone
concentration and phylloquinone intake, was inversely associated with
circulating inflammatory markers as a group and with several individual
inflammatory biomarkers" - See
vitamin K products at iHerb.
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Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis
patients - J Ren Nutr. 2007 Sep;17(5):296-304 -
"gamma tocopherol (308 mg) and DHA (800 mg) ... In the treatment group, but
not in the placebo group, there were significant decreases in IL-6 (21.4 +/-
3.5 to 16.8 +/- 3.7 pg/mL), white blood cell (WBC) count (7.4 +/- 0.3 to 6.9
+/- 0.4 10(3)/microL), and neutrophil fraction of WBCs (4.8 +/- 0.3 to 4.4
+/- 0.3 10(3)/microL), at P < .05 for all"
- Clinical Update on Benefits of DHEA - A4M, 4/6/04 -
"Recently, researchers discovered important anti-inflammatory properties of DHEA. It was known that DHEA can lower the levels of
interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha)" - See
iHerb
 or
Vitacost
DHEA products.
- Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers - Atherosclerosis. 2003 Oct;170(2):261-7
- "short term administration of vitamins C (2 g/day) and E (800 IU/day) reduces serum levels of IL-1b, IL-6, sVCAM-1 and sICAM-1, and improves forearm vasodilatory response to
reactive hyperemia in healthy young smokers, while monotherapy with vitamin C alone is ineffective" - See
iHerb or
Vitacost
vitamin E products.
- Mediterranean Diet Lowers C-reactive Protein Levels - Medscape, 11/11/03 -
"For each 10-point increase in diet score, there was a corresponding 0.22 mg/dL
reduction in C-reactive protein levels, a 0.21 pg/ml reduction in interleukin-6, a 12.5 mg/dL decrease in fibrinogen, and a 0.87 mmol/L
decrease in homocysteine levels (P < .05), he said. Also, white blood cell count decreased significantly"
- Plasma interleukin-6 is associated with psychological coronary risk factors: Moderation by use of multivitamin supplements - Brain Behav Immun. 2003
Aug;17(4):296-303 - "Plasma IL-6 was independently associated with anger, hostility, and severity of depressive symptoms ... Multivitamin use was associated with lower plasma IL-6 levels, but only among men with high composite factor scores ... These data suggest that plasma
IL-6 is elevated among healthy men characterized by a propensity for anger, a hostile disposition, and greater severity of depressive symptoms and that multivitamin supplements could ameliorate plasma IL-6 levels among these men"
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Omega-3 Fatty Acid Reduces Pro-Inflammatory Cytokines In Heart Transplant Patients - Doctor's Guide, 4/11/02 -
"gave 25 stable heart transplant
patients two capsules of omega-3 fatty acid daily - each capsule contained 500 mg of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) ... The results suggest that omega-3 fatty acid supplementation increased concentrations of the anti-inflammatory interleukin (IL)-10, from
119 to 268 pg/mL (p=0.00008). There were reductions in systemic levels of pro-inflammatory IL-12, from 473 to 376 pg/mL (p=0.001), and IL-6, from 695 to 569 pg/mL (p<0.0001)"
Other News:
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Inflammatory Markers and Albuminuria Independently Predict Heart Failure
- Medscape, 5/2/08 - "Interleukin (IL)-6, C-reactive
protein, and macroalbuminuria are significant predictors of congestive heart
failure, independent of obesity and other established risk factors" -
Also see my inflammation page for ways to
reduce it.
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Elevated IL-6 Levels Associated With Increased Atrial Fibrillation Risk
- Medscape, 2/26/08 - "a doubling of IL-6 level was
independently associated with a 49% increase in the odds of developing AF"
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Effects of Ramipril on
Endothelial Function and the Expression of Proinflammatory Cytokines and
Adhesion Molecules in Young Normotensive Subjects With Successfully Repaired
Coarctation of Aorta A Randomized Cross-Over Study - J Am Coll Cardiol.
2008 Feb 19;51(7):742-749 - "Ramipril reversed the
impaired endothelial function and decreased the expression of
proinflammatory cytokine IL-6, sCD40L, and adhesion molecules in
normotensive subjects with SCR. These findings imply that ramipril treatment
may have antiatherogenic effects in subjects with SCR, even in the absence
of arterial hypertension" - Note: Ramipril was my
first line choice
for combo therapy.
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Mild Depression Tied to Bone Loss - WebMD, 11/26/07 -
"Even mild depression may significantly increase a
woman's risk for developing osteoporosis ... An inflammatory protein that
has specifically been linked to bone loss -- interleukin-6 -- was found to
be significantly elevated in the women with depression"
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The role of interleukin-6 in insulin resistance, body fat distribution and
energy balance - Obes Rev. 2007 Oct 23 - "Its
quantitative release from adipose tissue results in a subclinical, systemic
elevation of IL-6 plasma levels with increasing body fat content, which may
be implicated in the proinflammatory state leading to insulin resistance. On
the other hand, IL-6 produced in the working muscle during physical activity
could act as an energy sensor by activating AMP-activated kinase and
enhancing glucose disposal, lipolysis and fat oxidation. In addition, both
impaired IL-6 secretion and action are risk factors for weight gain"
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Human C-reactive Protein Regulates Myeloma Tumor Cell Growth And Survival
- Science Daily, 9/15/07 - "CRP protects myeloma
cells from apoptosis induced by chemotherapy drugs and stimulates myeloma
cells to secrets more IL-6, which in turn provides additional protection to
myeloma from apoptosis and stimulates liver cells to secrete more CRP. Thus,
CRP could be a therapeutic target for breaking the vicious circle of myeloma
to improve the therapeutic efficacy of currently available treatments"
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Why
Liver Cancer Is More Prevalent In Males Than In Females - Science Daily,
7/5/07 - "By eliminating IL-6, we reduced the
incidence of liver cancer in the males by close to 90%"
- The
Role of IL-6 in Inflammatory Diseases - Medscape, 6/4/07
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Two
Markers Strongly Linked To Prostate Cancer Incidence And Mortality Almost A
Decade Prior To Diagnosis - Science Daily, 11/14/06 -
"Increased levels of two markers of
inflammation, interleukin-6 (IL-6) and C-reactive protein (CRP), are
significantly associated with prostate cancer incidence and mortality almost
a decade prior to diagnosis"
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Cytokines Play Role in Sleep Disorders, Obesity - Clinical Psychiatry
News, 10/06 - "Interventions to
reduce or neutralize proinflammatory cytokines may be novel treatments in
patients with sleep disorders and obesity ... Three inflammation-associated
cytokines—tumor necrosis factor-α (TNF-α, interleukin-1 (IL-1), and IL-6—are
elevated in obese and sleep-deprived patients, and may mediate excessive
daytime sleepiness and fatigue"
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Researchers Find Added Benefit of Statins in Those at High Risk for Heart
Disease, Diabetes - Doctor's Guide, 9/13/06 -
"found marked reductions in two
pivotal biomarkers of inflammation: C-reactive protein (CRP) and
interleukin-6. While these markers are typically elevated in insulin
resistance, a condition that precedes the development of diabetes, statin
therapy reduced these levels by 36% and 44%, respectively"
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Chemical can slow memory - USA Today, 3/1/06 -
"The team discovered that people with the highest IL-6 levels had the worst
scores. These low performers didn't have scores that signaled Alzheimer's,
but they had a less-than-stellar ability to multi-task or to remember new
information"
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Is Interleukin-6 The "Holy Grail" Of Exercise Mediation? - Science Daily, 10/11/04
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Interleukin-6 stimulates lipolysis and fat oxidation in humans - J Clin Endocrinol Metab. 2003 Jul;88(7):3005-10
- Low-dose Periostat (Doxycycline) Shows Benefits in Patients with Heart Failure - Doctor's Guide, 11/20/02 -
"At six-month follow-up,
sub-antimicrobial dose doxycyline significantly reduced CRP levels by 45.8 percent compared to baseline values (p<0.05). The drug was also associated with a 33.5 percent reduction in interleukin-6 and a 50 percent reduction in metalloproteinase ... The findings are
exciting, since research is now showing that CRP is both a key marker of inflammation leading to future acute coronary events, but also that CRP itself may contribute to the initiation and progression of atherosclerosis"
- C-Reactive Protein, IL-6 Levels Tied to Heart Disease in Postmenopausal Women - Doctor's Guide, 8/28/02 -
"Baseline levels
of the inflammatory biomarkers C-reactive protein (CRP) and interleukin-6 (IL-6) are independently associated with a two-fold increase in risk of healthy postmenopausal women developing coronary heart disease (CHD)"
- Another Study Suggests Inflammation May Trigger Diabetes - WebMD, 7/17/01 -
"The immune system and inflammation may be factors causing type 2 diabetes ... women who had high
levels of immune system substances called C-reactive protein or interleukin-6, or both, in their blood were more likely to develop type 2 diabetes ... Both C-reactive protein, called CRP, and interleukin-6, or IL-6, are considered indicators for inflammation"
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