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Home > Health Conditions > Infertility

Infertility

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  • Rapamycin improves the quality and developmental competence of in vitro matured oocytes in aged mice and humans - Aging (Albany NY) 2022 Nov 26 - "Women over age 35 suffer from the inadequate number and poor quality of oocytes during assisted reproductive treatment, and making full use of the oocytes by in vitro maturation (IVM) is crucial. Rapamycin could improve the developmental competences of the post-maturation oocytes during in vitro aging, yet its effects on the IVM process of oocytes from an aged population were not clear ... Overall, rapamycin improved IVM outcomes of oocytes from aged mice and older women. The specific mechanism of the positive effects of rapamycin on IVM outcomes might be reducing ROS levels, mitigating DNA damage, and promoting developmental potential" - See Siromus (rapamycin) at ReliableRXPharmacy.
  • Effects of fish oil on methotrexate-induced reproductive damage in rats - Andrologia 2022 Nov 11 - "Methotrexate (MTX) is a folic acid antagonist that is commonly used in paediatric and adult oncology to treat a variety of malignancies. Internal organs, including the testis, are severely cytotoxic and genotoxic to MTX. Omega-3, as an antioxidant, has been shown to protect rat testis tissue from injury. The effect of fish oil (FO) on MTX-induced reproductive damage in rats was investigated in this work ... All sperm quality measures were significantly lowered in the MTX group, while FO had a recovery effect. There were no notable variations in histopathology across groups except for germ cell thickness, which reduced considerably in the MTX group and recovered with FO treatment. As a result, FO has been shown to reduce testicular toxicity following MTX treatment in rats" - See omega-3 supplements at Amazon.com.I
  • nvestigation of the effect of hesperidin on some reproductive parameters in testicular toxicity induced by Bisphenol A - Andrologia 2022 Aug 19 - "Bisphenol A (BPA) is one of the chemicals that cause dysfunction and infertility in testicles. Therefore, it is crucial to develop effective treatments against this damage. In this study, the effects of Hesperidin (HESP), a flavonoid in testicular toxicity induced by BPA in rats, on oxidative stress, inflammation, apoptosis, histological damage, spermatogenesis, steroidogenic enzymes and reproductive hormones were investigated ... Bisphenol A (BPA) is one of the chemicals that cause dysfunction and infertility in testicles. Therefore, it is crucial to develop effective treatments against this damage. In this study, the effects of Hesperidin (HESP), a flavonoid in testicular toxicity induced by BPA in rats, on oxidative stress, inflammation, apoptosis, histological damage, spermatogenesis, steroidogenic enzymes and reproductive hormones were investigated" - See hesperidin at Amazon.com.
  • Trehalose Suppresses Lysosomal Anomalies in Supporting Cells of Oocytes and Maintains Female Fertility - Nutrients 2022 May 22 - "Our results suggest that autophagy maintains the healthy state of the supporting cells of human oocytes by suppressing the formation of lysosomes. Thus, our results provide insights into the therapeutic effects of trehalose on female fertility" - See trehalose at Amazon.com.
  • Coenzyme Q 10 alleviates testicular endocrine and spermatogenic dysfunction induced by high-fat diet in male Wistar rats: Role of adipokines, oxidative stress and MAPK/ERK/JNK pathway - Andrologia 2022 Jul 27 - "The current study investigated the possible protective effects of Coenzyme Q10 (Co Q10 ) on rat model of high-fat diet (HFD) induced testicular dysfunction ... In comparison to the untreated HFD group, the Co Q10 treated group revealed significantly increased serum testosterone, adiponectin levels, and decreased LH, FSH, and leptin levels. In addition, HFD resulted in significant increase in testicular oxidative stress (increased MDA, iNOS, NO, XO & decreased catalase, SOD, GSH) and inflammation (increased pJNK/JNK, pERK/ERK, and p-p38MAPK/MAPK), while Co Q10 was effective to ameliorate these changes. In addition, Co Q10 significantly increased sperm count, motility and viability that were markedly deteriorated by HFD. Regarding testicular ultrastructure, seminiferous tubular diameter and epithelium height were reduced in HFD group and Co Q10 significantly improved these testicular changes. Finally, a significant reduction in spermatogenic cell proliferation was detected by PCNA fluorescent expression and Co Q10 significantly reversed this change" - See ubiquinol products at Amazon.com.
  • Short-term resveratrol treatment restored the quality of oocytes in aging mice - Aging (Albany NY) 2022 Jul 8 - "The quality of oocytes declines by aging, resulting in their low competences for fertility. Here, resveratrol treatment showed increases in the rates of implantation and live offspring as well as decreases in the abortion rate as short as one week after treatment, although the number of ovulated oocytes and the rates of fertilization and blastocyst formation were not changed following resveratrol treatment. Resveratrol treatment did not cause abnormalities mouse estrous cycles and body weights. No abnormality was detected in both fetuses and placentas after 22 weeks of resveratrol treatment and the fetuses had normal fertility. Positive correlations were found between serum resveratrol levels and pregnancy and live offspring rates as well as ovarian expression levels of Sirt1, Sirt3, Sirt4, Sirt5, and Sirt7. The mitochondrial membrane potential and ATP content but not copy number of mitochondrial DNA in oocytes was increased in aging mice with resveratrol treatment. In conclusion, we demonstrated the restoration of oocyte quality in aging mice in addition to the prevention of their quality decline during aging by restoring mitochondrial functions by resveratrol treatment without adverse effects in the animals and their offspring" - See resveratrol products at Amazon.com.
  • Genistein lowers fertility with pronounced effect in males: Meta-analyses on pre-clinical studies - Andrologia 2022 Jun 27 - "Genistein, an isoflavonoid, is found in a plethora of plant-based foods, and has been approved for use in various therapies. A couple of studies in adult men observed a negative correlation between genistein exposure and reproductive parameters ... Pooled analysis showed significant decreases in sperm count in males exposed to genistein during adulthood (Hedges's g = -2.51, p = 0.013) and in utero (Hedges's g = -0.861, p = 0.016) compared with controls. In males exposed to genistein in utero, serum testosterone levels decreased (Hedges's g = -6.301, p = 0.000) and luteinizing hormone (LH) (Hedges's g = 7.127, p = 0.000) and FSH (Hedges's g = 6.19, p = 0.000) levels increased in comparison with controls. In females, the number of corpora lutea (Hedges's g = -2.103, p = 0.019) and the litter size (Hedges's g = -1.773, p-value = 0.000) decreased; however, female reproductive hormones remained unaffected. These meta-analyses show that genistein has detrimental effects on male reproductive system and on the progression and sustenance of pregnancy, with more pronounced adverse impact in males, particularly when exposed in utero"
  • Silymarin abrogates acrylamide-induced oxidative stress-mediated testicular toxicity via modulation of antioxidant mechanism, DNA damage, endocrine deficit and sperm quality in rats - Andrologia 2022 Jun 26 - "Acrylamide (ACR) is a toxic chemical formed in foods processed at high temperature; it is a food-borne toxicant with increasing public health attention due to its carcinogenic, neurotoxic and reproductive toxicities. However, till date, it is unknown whether silymarin (SIL) could attenuate ACR testicular toxicity ... Overall, SIL prevents ACR-induced testicular reproductive deficits via modulation of antioxidant mechanism in rats" - See silymarin at Amazon.com.
  • Beneficial effect of L-Proline supplementation on the quality of human spermatozoa - Andrologia 2022 Jun 18 - "L-Proline is a natural anti-oxidative and osmoprotectant agent, playing a versatile role in cell metabolism and physiology. The present study aimed to explore the antioxidant effects of L-Proline on human sperm function during incubation. Thirty healthy, normozoospermic men (27-40 years) were enrolled. Sperm samples were incubated in an unsupplemented sperm medium (control group), or supplemented with L-Proline (1, 2 and 4 mmol/L) to evaluate its effect during 0, 1, 4 and 24 h of incubation ... The results indicated that 2 mmol/L of L-Proline significantly improved the maintenance of sperm motility, viability, normal morphology, chromatin and DNA integrity, and TAC levels compared to the control group during 24 h of incubation (p < 0.05). However, 1 and 4 mmol/L of L-Proline could not significantly preserve sperm parameters, chromatin quality, and antioxidant status during different incubation times compared to the control group (p > 0.05). Collectively, the inclusion of L-Proline (2 mmol/L) in the human sperm medium maintains sperm parameters and chromatin quality probably by modulating the oxidative status" - See L-Proline at Amazon.com.
  • Silymarin modulates cadmium-induced oxidative stress in human spermatozoa - Andrologia 2022 May 31 - "Environmental pollutants such as cadmium can negatively affect sperm parameters and decrease male fertility by inducing oxidative stress. Antioxidants are considered a useful strategy for oxidative stress conditions to neutralize free radicals and strengthen the antioxidant defence system ... silymarin attenuated oxidative stress biomarkers in human sperm treated with cadmium, and consequently improved the sperm quality. In summary, cadmium-induced oxidative stress impaired human sperm structures and silymarin with its antioxidant properties compensated for the adverse effects of oxidative stress on human spermatozoa" - See silymarin at Amazon.com.
  • Trehalose Suppresses Lysosomal Anomalies in Supporting Cells of Oocytes and Maintains Female Fertility - Nutrients 2022 May 22 - "Electron microscopy analysis revealed the proliferation of abnormal lysosomes in chloroquine-treated KGN cells. Conversely, the addition of an autophagy inducer, trehalose, suppressed chloroquine-driven problematic lysosomal anomalies and ameliorated ovulation problems. Our results suggest that autophagy maintains the healthy state of the supporting cells of human oocytes by suppressing the formation of lysosomes. Thus, our results provide insights into the therapeutic effects of trehalose on female fertility" - See trehalose at Amazon.com.
  • Curcumin improves the protective effects of quercetin against atrazine-induced testicular injury in adult Wistar rats - Andrologia 2022 Apr 18 - "This study evaluated the beneficial protective effect of cotreatment of curcumin (CUR) and quercetin (QUE) on atrazine (ATZ)-induced testicular toxicity in rats. ATZ challenge diminished luteinizing hormone, follicular stimulating hormone, testosterone and myeloperoxidase enzyme activity, but these effects were attenuated on co-treatment with CUR and QUE. Also, co-treatment of CUR + QUE was better than separate administration of QUE at diminishing malondialdehyde and glutathione and improving tumour necrosis factor-α concentration, germ cell numbers (spermatogonia, spermatocytes and round spermatids) and epididymal sperm quality ... We conclude that CUR can improve the protective effects of QUE against ATZ-induced testicular injury by enhancing the levels of reproductive hormones, recovering testicular biochemical parameters and improving the histological features of the testes" - See curcumin at Amazon.com and quercetin at Amazon.com.
  • Predictors of pregnancy and time to pregnancy in infertile men with idiopathic oligoasthenospermia pre- and post-coenzyme Q10 therapy - Andrologia 2022 Feb 1 - "Different antioxidants including coenzyme Q10 (CoQ10) have been tried to treat idiopathic male infertility (IMI) with variable results. Therefore, this study aimed to determine the clinical and biochemical predictors of pregnancy outcome and time to pregnancy (TTP) in infertile men with idiopathic oligoasthenospermia (OA) pre- and post-CoQ10 therapy ... CoQ10 therapy of 6 months is a potential treatment for men with idiopathic OA. CoQ10 level, male age, semen parameters, ROS and GPx could potentially be used as diagnostic biomarkers for male fertility and predictors for pregnancy outcome and TTP in these patients" - See ubiquinol products at Amazon.com.
  • Quercetin and vitamin E attenuate diabetes-induced testicular anomaly in Wistar rats via the mitochondrial-mediated apoptotic pathway - Andrologia 2021 Jul 18 - "The role of quercetin and vitamin E treatment against streptozotocin (STZ)-induced testicular abnormalities in diabetic rats and the possible mechanism of action they use for protection were investigated ... The study showed a positive correlation in the levels of LH, FSH and testosterone; it was further established that all treatments normalised diabetes-induced alterations. Treatment with quercetin and vitamin E resulted in 34% decrease of apoptogenic cytochrome c release. This protected the testes against excessive apoptosis by decreasing caspase 3 and caspase 9 activation by up to 30 and 28% respectively (p < .05). Histology also showed that treatment prevented testicular cell death. The findings show that quercetin/vitamin E possess free radical scavenging properties that protected against testicular damage in diabetes. This suggests the possibility of pharmaco-therapeutic intervention" - See quercetin at Amazon.com and iHerb and Vitamin E at Amazon.com and iHerb.
  • Strawberry fruit (Fragaria x ananassa Romina) juice attenuates oxidative imbalance with concomitant modulation of metabolic indices linked to male infertility in testicular oxidative injury - Andrologia 2021 Jul 13 - "High-performance liquid chromatography analysis of SFE revealed the presence of rutin, caffeic acid, p-coumarin and cinnamic acid. These data imply the protective potentials of strawberry fruits against testicular oxidative injury" - See strawberry powder at Amazon.com.
  • The effect of Quercetin on the quality of sperm parameters in frozen-thawed semen of patients with Asthenospermia - Andrologia 2021 Jul 5 - "The mean percentage of total motility and progressive motility, normal morphology, viability and antioxidant enzyme activity had significant increase in the Quercetin group than the control group. In the Quercetin group, the MDA level and DNA damage also had significant reduction in comparison with the control group (p ≤ 0.001). Therefore, the Quercetin supplementation improves the quality of cryopreserved human semen" - See quercetin at Amazon.com and iHerb.
  • Taurine ameliorates cytotoxic effects of Di(2-ethylhexyl) phthalate on Leydig cells - Andrologia 2021 Jun 24 - "It has been revealed that di(2-ethylhexyl)phthalate (DEHP) has toxic impacts on the male reproductive system. Taurine (TAU) is an amino acid with antioxidant property and beneficial impacts on the male reproductive system ... DEHP could significantly decrease the cell viability percentage, reduce testosterone level, increase apoptosis, elevate Bax/ Bcl-2 ratio and enhance caspase-3 and -9 activity in the TM3 cells. Additionally, DEHP significantly elevated malondialdehyde contents and reactive oxygen species levels. It also augmented superoxide dismutase and catalase activity in the Leydig cells. Co-treatment of DEHP with TAU increased viability and testosterone level, while oxidative stress and apoptosis significantly reduced. TAU could decrease Bax/Bcl-2 ratio and caspase-3 and -9 activity in the DEHP-intoxicated cells. Our results have clearly shown that TAU protects TM3 cells against oxidative stress and apoptosis induced by DEHP" - See taurine at Amazon.com and iHerb.
  • Protective role of vitamin E in testicular development of mice exposed to valproic acid - Andrologia 2021 Jun 21 - "Valproic acid (VPA) is a teratogenic antiepileptic, causing alterations in oxidative stress in prenatal development, being altered the development of the male reproductive system. The purpose of this study was to determine the protective effect of vitamin E (VE) on the testicular development in embryos, foetuses and pubertal mice exposed to VPA, VPA+VE and only VE ... VE reduces the effects caused by VPA throughout testicular development, from embryonic stages, continuing until pubertal stages" - See vitamin E at Amazon.com and iHerb.
  • Effects of resveratrol on female reproduction: A review - Phytother Res 2021 Jun 7 - "The analysis of the available information suggests that RSV has a number of properties which enable its influence on various physiological processes including female reproduction at various regulatory levels via various extra- and intracellular signalling pathways. Despite some contradictions and limitations in the available data, they indicate applicability of both stimulatory and inhibitory effects of RSV for control and influence of various reproductive and non-reproductive processes and treatment of their disorders in phytotherapy, animal production, medicine, biotechnology and assisted reproduction" - See resveratrol products at Amazon.com.
  • Evaluation of the effect of vitamin D supplementation on spermatogram, seminal and serum levels of oxidative stress indices in asthenospermia infertile men: a study protocol for a triple-blind, randomized controlled trial - Nutr J 2021 Jun 2 - "It is suggested that vitamin D may have a beneficial role in male reproduction. The male reproductive system is a target tissue for vitamin D. This study will aim to evaluate the effects of vitamin D supplementation on sperm parameters, seminal and serum levels of oxidative stress and serum endocrine factors in asthenospermia infertile men ... The deficiency of vitamin D as an antioxidant is common all over the world. Numerous observational studies have shown a positive association between vitamin D levels and semen quality. However, few clinical studies have been conducted in this area. So considering with the high prevalence of this antioxidant deficiency specifically in infertile men, it seems that the supplementation of vitamin D in infertile men with insufficient levels or deficiency may improve the status of oxidative stress and thereby may affect sperm parameters and endocrine factors involved in male fertility" - See vitamin D at Amazon.com.
  • Turmeric and vitamin C mitigate testicular atrophy induced by lead diacetate via regulation of GRP-78/17β-HSD pathways in rat's model - Andrologia 2021 May 24 - "TMRC or VIT-C specially in combination group prevents Lead diAC testicular damage via reduction of oxidative injury as well as inflammation, downregulation of GRP-78/BAX and upregulation of 17β-HSD and STAR expression as well as improvement in the histological architecture of the testis" - See turmeric extract at Amazon.com and American Health Ester-c With Citrus Bioflavonoids 500 Mg, 240 Count.
  • N-acetyl cysteine co-treatment abates perfluorooctanoic acid-induced reproductive toxicity in male rats - Andrologia 2021 Mar 16 - "Perfluorooctanoic acid is a synthetic perfluoroalkyl-persistent in the environment and toxic to humans. N-acetylcysteine is a pro-drug of both amino acid l-cysteine and glutathione-a non-enzymatic antioxidant. N-acetylcysteine serves as an antidote for paracetamol poisoning and alleviates cellular oxidative and inflammatory stressors ... Co-treatment with N-acetylcysteine significantly (p < .05) reversed perfluorooctanoic acid-mediated decreases in reproductive enzyme activities, and adverse effect on testosterone, luteinising and follicle-stimulating hormone concentrations. N-acetylcysteine treatment alone, improved sperm motility, count and viability, and reduced total sperm abnormalities. Co-treatment with N-acetylcysteine mitigated perfluorooctanoic acid-induced alterations in sperm function parameters. N-acetylcysteine abated (p < .05) perfluorooctanoic acid-induced oxidative stress in experimental rats testes and epididymis, and generally improved antioxidant enzyme activities and cellular thiol levels. Furthermore, N-acetylcysteine suppressed inflammatory responses and remedied perfluorooctanoic acid-mediated histological injuries in rat. Cooperatively, N-acetylcysteine enhanced reproductive function in perfluorooctanoic acid dosed rats, by lessening oxidative and nitrative stressors and mitigated inflammatory responses in the examined organ." - See See n-acetyl cysteine at Amazon.com.
  • Antioxidant effects of N-acetylcysteine on the male reproductive system: A systematic review - Andrologia 2020 Nov 9 - "It is undeniable that N-acetyl cysteine as a powerful antioxidant compound can medicate many diseases such as cardiovascular, kidney, liver and reproductive system disorders. With the increasing environmental pollution that has a direct adverse effect on male fertility, the use of this compound is able to positively function on human fertility health. In this study, we have been collected the main data of scientific articles (1994-2020) about N-acetyl cysteine effects. By searching in the scientific databases of PubMed, Google Scholar, Science Direct, Wiley and Web of Science, related articles were extracted. As a result, all observations have confirmed that N-acetyl cysteine can improve and normalise the spermatogenesis in the male reproduction system" - See n-acetyl cysteine at Amazon.com and iHerb.
  • Estimation of folic acid/micro nutrients levels; does it reflect sperm parameters - Int J Clin Pract 2020 Oct 30 - "It was declared that with every 1 unit increase in vitamin B12, FA and MMA the prevalence of infertility was decreased by 1%, 17% and 74% respectively. Multivariate analysis revealed that vitamin B12, FA and MMA had a significant association with total sperm count, motility and morphology. The sperm parameters were also affected by increase in; LH, BMI and body fat %. There was a significant positive correlation of; LH with Vitamin B12 and FA (0.423<0.001,0.338 <0.001) and testosterone with vitamin B12 and FA (0.326<0.001,0.291<0.001) respectively" - See folic acid products at Amazon.com and iHerb.
  • Fish Oil Supplements Tied to Sperm Health - NYT, 1/17/20 - "Researchers studied 1,679 Danish men taking physical examinations for compulsory military service. Their average age was 19, and 98 of them reported taking fish oil supplements during the previous three months ... Compared with those who took none, men who took fish oil supplements for at least 60 days during the previous three months had higher sperm count, a greater proportion of normal sperm cells, higher average semen volume and larger average testicular size. They also had significantly lower follicle-stimulating hormone levels and lower luteinizing hormone levels, both indicators of better testicular function" - See omega-3 supplements at Amazon.com.
  • Effect of lycopene on testicular androgenic and anti-oxidative enzymes in cyproterone acetate-induced male infertile Wistar strain albino rats: An in vitro study - Andrologia. 2020 Jan 8:e13494 - "Incidents of male infertility are mushrooming worldwide. Oxidative stress plays a prime role for its onset. Considering this background, the study was designed to focus the direct role of lycopene on cyproterone acetate (CPA) induced testicular hypofunction in rat. Four groups have been considered including the vehicle-treated control, lycopene-treated control, CPA-treated and CPA+ lycopene-treated groups. Androgenic, antioxidant and toxicity profiles were assessed ... lycopene exposure to the testicular tissue of CPA-treated rat (CPA+ lycopene-treated) exhibited a significant (p < .05, p < .001) rectification in testicular catalase, superoxide dismutase, peroxidase, glutathione-S-transferase activities towards the vehicle- and lycopene-treated control groups. Toxicity profile also showed a significant (p < .001) recovery in CPA-treated group after direct exposure of lycopene towards the vehicle- and lycopene-treated control groups. So, it can be concluded that direct exposure of lycopene may rectify the CPA-induced testicular hypofunction either by its free radical-quenching ability or by stimulating antioxidant enzyme activity without modulating androgenic key enzyme directly" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Lycopene improves sperm quality: A promising nutrient for the treatment of male infertility - Phytother Res. 2020 Jan 10 - Doesn't show the write-up but I guess the title covers it.  See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Carnosine treatment during human semen processing by discontinuous density gradient - Andrologia. 2019 Dec 3 - "20 mM of carnosine supplementation on the layers of Percoll; and (b) 50 mM carnosine supplementation ... The 50 mM carnosine supplementation led to improved sperm mitochondrial activity when compared to untreated samples. Motility variables, such as percentage of motile and progressively motile spermatozoa, average path velocity, straight line velocity, curvilinear velocity and linearity, showed an improvement after semen processing irrespective of carnosine supplementation. Both concentrations of carnosine increased the beat-cross frequency (BCF) when compared to samples before processing. We conclude that carnosine supplementation in semen samples benefits sperm mitochondrial activity and BCF" - See carnosine at Amazon.com
  • Curcumin improves asthenozoospermia by inhibiting reactive oxygen species reproduction through nuclear factor erythroid 2-related factor 2 activation - Andrologia. 2019 Dec 3:e13491 - "Our results have shown that curcumin might protect spermatozoa by regulating Nrf2 level" - See curcumin at Amazon.com.
  • Dietary supplement from tomatoes discovered to boost sperm quality - Science Daily, 10/9/19 - "The 12-week trial designed by Dr Williams involved 60 healthy volunteers aged 19 to 30. Half took LactoLycopene supplements and the other half took identical placebo (dummy pills) every day for 12 weeks ... The improvement in morphology -- the size and shape of the sperm, was dramatic. We used a computer system to make these measurements, which takes a lot of the human error out of the results. Also, the person using the computer didn't know who had taken LactoLycopene and who had taken the dummy pills either" - See lycopene at Amazon.com.
  • The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial - Phytother Res. 2019 Aug 30 - "44 infertile men with oligozoospermia were randomly divided into two groups: The experimental group was supplemented with 25 mg of lycopene, and the control group received placebo for 12 weeks ... At the end of the study, there was a significant increase in total sperm count and concentration in the lycopene group, and the latter total count remained significant after adjustment (p < .05). Intragroup analysis showed a significant increase in ejaculate volume, total sperm count, concentration total motility, nonprogressive, and nonmotility in lycopene group (p < .05). The TAC changes, in both groups, remained significant after adjustment (p < .05). Also, within-group analysis showed a significant increase in TAC levels (p < .05). Lycopene supplement can improve sperm parameters and oxidative stress biomarkers in oligozoospermia infertile men" - See lycopene at Amazon.com.
  • Largest study yet shows type of underwear is linked to men's semen quality - Science Daily, 8/8/18 - "Men who wear boxer shorts have higher sperm concentrations than men who wear tighter fitting underwear ... The researchers also found that boxer shorts-wearing men had lower levels of follicle-stimulating hormone (FSH), compared to men who most frequently wore briefs, "bikinis" (very brief briefs), "jockeys" (underwear that finishes just above the knee) or other tight-fitting underwear. FSH stimulates sperm production and the researchers say that these findings suggest that it kicks into gear when it needs to compensate for testicular damage from increasing scrotal temperatures and decreasing sperm counts and concentration ... Men who primarily wore boxer shorts had a statistically significant 25% higher sperm concentration, 17% higher total sperm count, 33% more swimming sperm in a single ejaculate and 14% lower FSH levels than men who did not usually wear boxers ... Other factors that might affect scrotal heat, such as type of trousers (e.g. skinny jeans) and underwear fabric, could also affect the results" - [NYT]
  • Adequate Vitamin D Levels Prior to Conception Improve Birth Odds - Medscape, 6/11/18 - "women with adequate preconception vitamin D concentrations were also more likely to achieve a clinical pregnancy, at a risk ratio (RR) of 1.10 ... Similarly, women with adequate preconception vitamin D concentrations were more likely to achieve a live birth, at an RR of 1.15, compared to women with insufficient vitamin D concentrations" - See vitamin D at Amazon.com.
  • Taurine deficiency in sperm causes male infertility - Science Daily, 5/11/18 - "The researchers keyed in on one telling clue, an unusual "kink" in the tail of the sperm. Sperm cells in CDO-deficient mice were nearly twice as likely to have a wrongly-angled tail when placed in an environment like that of a uterus. Strikingly, the defect disappeared when the sperm were supplied with extra taurine. These observations led the authors to conclude that, by controlling osmosis, taurine helped to maintain the right shape of sperm during fertilization" - See taurine at Amazon.com.
  • Dehydroepiandrosterone supplementation in women undergoing assisted reproductive technology with poor ovarian response. A prospective case-control study - J Int Med Res. 2017 Jan 1:300060517720005 - "poor ovarian response (POR) ... DHEA supplementation in women with POR had a positive effect on hormonal profiles, the quality of the endometrium, the number of oocytes retrieved, the quality of embryos, and the pregnancy and live birth rates" - See Pure Encapsulations 7-KETO at Amazon.com.
  • Vitamin D Supplements May Raise Sex Hormone Levels in Men - Medscape, 6/1/17 - "Testosterone is converted to estradiol, and SHBG binds testosterone and estradiol, Dr Lerchbaum observed, but only the unbound fraction of hormones is biologically active. Effectively, the lower SHBG levels result in more bioavailable testosterone. "We think that low SHBG levels should be an advantage for these men because they have more biologically active hormone." ... Maybe. Sufficient estradiol levels are important for the feedback mechanism with hypothalamus and the pituitary gland (LH and FSH levels) ... It may be speculated that the decrease in SHBG and the resultant increases in free testosterone levels might help improve the hypogonadism problem and fertility in these" - See vitamin D at Amazon.com.
  • High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction - Nutrients. 2015 Dec 2 - "Serum 25(OH)D levels are highly deficient in women seeking medical help for couple's infertility ... Importantly, this deficiency status may last during pregnancy with more severe consequences" - See vitamin D at Amazon.com.
  • Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight but not Obese Women - J Clin Endocrinol Metab. 2015 Nov 2 - "Dietary administration with omega-3 PUFA decreased serum FSH levels in NW but not in obese women with normal ovarian reserve. This effect is intriguing and is directionally consistent with murine data whereby higher dietary omega-3 PUFA extends reproductive lifespan. Our results imply that this nutritional intervention should be tested in women with diminished ovarian reserve in an attempt to delay ovarian aging" - See fish oil supplements at Amazon.com.
  • Quercetin mitigates fenitrothion-induced testicular toxicity in rats - Andrologia. 2015 Aug 11 - "Fenitrothion (FNT) is a widely used organophosphorus pesticide in agriculture. Quercetin (QR), a plant-derived flavonoid, has a free radical scavenging property ... FNT administration caused significant decreases in sperm count, motility and hormonal levels, a significant increase in abnormal sperm morphology and a significant down-regulation of steroidogenic and antioxidant genes in the testis. However, QR administration ameliorated FNT-induced toxic effects. Our results concluded that QR effectively mitigated testicular damage induced by FNT in rats" - See quercetin at Amazon.com.
  • Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males - Andrologia. 2014 Oct 30 - "Nineteen hyperinsulinaemic male patients were treated for 3 months with metformin alone (Group A), and fifteen patients used metformin in combination with the nutritional supplement (Group B) ... The improvement in sperm morphology after treatment was similar for the two respective groups (P < 0.05). The morphological normal sperm forms increased from the mean percentage of 3.9 to 5.5% and from 4.2 to 5.5% for Group A and B respectively. Where a combination of metformin and the supplement were used (Group B), the combination treatment proved to be superior in obtaining enhanced chromatin packaging quality although not statistically significant (P = 0.5929) when compared with the metformin (Group A) group. The chromatin packaging quality in Group B improved with 10% while the improvement in Group A was approximately 8.3%" - See metformin at The Antiaging Store.
  • Vitamin D Deficiency and Infertility: Insights From in vitro Fertilization Cycles - J Clin Endocrinol Metab. 2014 Aug 14 - "Subgroup analyses showed that the group of women with the highest serum levels (>30 ng/mL) had the highest chances of pregnancy ... Vitamin D is an emerging factor influencing female fertility and IVF outcome" - See vitamin D at Amazon.com.
  • Processed Meat Intake Is Unfavorably and Fish Intake Favorably Associated with Semen Quality Indicators among Men Attending a Fertility Clinic - J Nutr. 2014 May 21 - "Among the 155 men (median age: 36.1 y, 83% white non-Hispanic), processed meat intake was inversely related to sperm morphology. Men in the highest quartile of processed meat intake had, on average, 1.7 percentage units (95% CI: -3.3, -0.04) fewer morphologically normal sperm than men in the lowest quartile of intake (P-trend = 0.02). Fish intake was related to higher sperm count and percentage of morphologically normal sperm. The adjusted mean total sperm count increased from 102 million (95% CI: 80, 131) in the lowest quartile to 168 million (95% CI: 136, 207) sperm in the highest quartile of fish intake (P-trend = 0.005). Similarly, the adjusted mean percentages of morphologically normal sperm for men in increasing quartiles of fish intake were 5.9 (95% CI: 5.0, 6.8), 5.3 (95% CI: 4.4, 6.3), 6.3 (95% CI: 5.2, 7.4), and 7.5 (95% CI: 6.5, 8.5) (P-trend = 0.01)"
  • Protective effect of Pumpkin seed extract on sperm characteristics, biochemical parameters and epididymal histology in adult male rats treated with Cyclophosphamide - Andrologia. 2013 Oct 11 - "Cancer treatment with cyclophosphamide (CP) may result in reproductive toxicity as one of its side effects. The pumpkin seed is a rich natural source of antioxidant ... Male adult Wistar rats were categorised into four groups. Group 1 served as control and received intraperitoneal (IP) injection of isotonic saline solution. Group 2 rats were treated with CP by IP injection in a single dose of 100 mg/kg body weight, only once. Group 3 and 4 received CP plus 300 and 600 mg/kg pumpkin seed extract respectively. Six weeks after treatment, sperm characteristics, biochemical parameters and histopathological changes were examined. Results showed that, sperm characteristics in CP-treated rats were significantly decreased ... pumpkin seed extract could improve the above-mentioned parameters remarkably in CP-treated rats. Our findings indicated that pumpkin seed extract might be used as protective agent against CP-induced reproductive toxicity" - See pumpkin seed extracts at iHerb.
  • Nutrient Supplementation - Medscape, 9/25/13 - "men taking antioxidants had a statistically significant increase in both live birth rates and pregnancy rates. For those undergoing assisted reproduction, the odds ratio that antioxidant use would improve pregnancy rates was 4.18, with a 4.85-fold improvement in live birth rate also noted" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com and Garden of Life, Vitamin Code, 50 & Wiser Men at Amazon.com.
  • Coenzyme Q10 supplementation in infertile men with low-grade varicocele: an open, uncontrolled pilot study - Andrologia. 2013 Aug 22 - "38 patients were recruited from a pilot clinical trial. A standard semen analysis was also performed at baseline and 3 months after an oral supplementation with exogenous coenzyme Q10 100 mg per die ... Coenzyme Q10 therapy improved semen parameters and antioxidant status. This study highlights the importance of oxidative stress in the pathogenesis of male infertility, namely in varicocele, and strengthens the possibility of the usefulness of the antioxidant therapy" - See
  • ubiquinol products at Amazon.com
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  • Blueberries prevent the effect of intermittent hypobaric hypoxia in rat epididymis - Andrologia. 2013 Aug 19 - "Intermittent hypobaric hypoxia (IHH) induced a decrease in sperm count and oxidative damage in epididymis. We have previously demonstrated that a blueberry-enriched polyphenol extract (BB-4) reduced the adverse effects of oxidative stress in rat testis under hypobaric hypoxia. The aim of this study was to evaluate whether BB-4 could reverse oxidative stress in epididymis ... Our results showed a reduction in LPO and a decrease in GR activity in rat epididymis exposed to IHH. These results suggest that BB-4 can prevent the effects of IHH in rat epididymis" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Dietary Supplementation of Antioxidants Improves Semen Quality of IVF Patients in Terms of Motility, Sperm Count, and Nuclear Vacuolization - Int J Vitam Nutr Res. 2012 Dec 1;82(6):391-398 - "Patients were divided into oligoasthenoteratozoospermic (OAT) and non-OAT men. Between first and second semen analysis, patients were supplemented orally with an antioxidative preparation ... The results demonstrated a considerable improvement in semen quality, notably in OAT patients. Considering the putative relationship between semen quality on the one hand and reactive oxygen species on the other, the observed changes in the sperm parameters indicate that a decline in semen quality, and even subtle morphological changes, might be associated with oxidative stress. Our findings suggest that an antioxidative and micronutrient supplementation has a remarkable benefit for IVF patients having restricted sperm parameters, in particular" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Effect of different dietary omega-3/omega-6 fatty acid ratios on reproduction in male rats - Lipids Health Dis. 2013 Mar 13;12(1):33 - "These findings demonstrated that a balanced n-3/n-6 ratio was important in male rat reproduction. Therefore there is a necessity to determine an appropriate n-3/n-6 PUFA ratio in man and different male animals in the future" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Twenty Hours of TV a Week Linked to Almost Half Sperm Count of Those Who Watch Little TV - Science Daily, 2/5/13 - "Healthy young men who watch TV for more than 20 hours a week have almost half the sperm count of men who watch very little TV ... Conversely, men who do 15 or more hours of moderate to vigorous exercise every week have sperm counts that are 73% higher than those who exercise little ... light physical exercise made no difference to the sperm count, no matter how frequent it was"
  • Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial - Andrologia. 2013 Jan 7 - "Sixty infertile men with idiopathic oligoasthenoteratozoospermia (OAT) were randomised to receive 200 mg d(-1) of CoQ10 or placebo for 3 months ... CoQ10 levels increased from 44.74 +/- 36.47 to 68.17 +/- 42.41 ng ml(-1) following supplementation in CoQ10 ... There was a significant positive correlation between CoQ10 concentration and normal sperm morphology (P = 0.037), catalase (P = 0.041) and SOD (P < 0.001). Significant difference was shown between the mean of changes in seminal plasma 8-isoprostane in two groups (P = 0.003) after supplementation. Three-month supplementation with CoQ10 in OAT infertile men can attenuate oxidative stress in seminal plasma and improve semen parameters and antioxidant enzymes activity" - See ubiquinol products at Amazon.com.
  • High dietary intake of saturated fat is associated with reduced semen quality among 701 young Danish men from the general population - Am J Clin Nutr. 2012 Dec 26 - "The objective was to examine the association between dietary fat intake and semen quality among 701 young Danish men from the general population ... A lower sperm concentration and total sperm count in men with a high intake of saturated fat was found. A significant dose-response association was found, and men in the highest quartile of saturated fat intake had a 38% (95% CI: 0.1%, 61%) lower sperm concentration and a 41% (95% CI: 4%, 64%) lower total sperm count than did men in the lowest quartile. No association between semen quality and intake of other types of fat was found"
  • Melatonin as a free radical scavengr in the ovarian follicle [Review] - Endocr J. 2012 Nov 22 - "Melatonin reduces oxidative stress as an antioxidant, and contribute to oocyte maturation, embryo development and luteinization of granulosa cells. Our clinical study demonstrated that melatonin treatment for infertile women increases intra-follicular melatonin concentrations, reduces intra-follicular oxidative damage, and elevates fertilization and pregnancy rates. Melatonin treatment also improves progesterone production by corpus luteum in infertile women with luteal phase defect. Melatonin treatment could become a new cure for improving oocyte quality and luteal function in infertile women" - See melatonin at Amazon.com.
  • Epigallocatechin gallate affects survival and metabolism of human sperm - Mol Nutr Food Res. 2012 Nov;56(11):1655-64 - "estrogen receptor (ER) ... These results provide a novel mechanism involving ERs through which low doses of EGCG exerted benefits to sperm physiology, also detected data evidence the adverse action of high EGCG concentrations probably related to its prooxidant and antiestrogenic potential" - See green tea extract at Amazon.com.
  • Men who do exercise produce better quality semen, study finds - Science Daily, 10/31/12 - "conducted by researchers at the University of Cordoba ... The results conclude that the physically active subjects display better semen values. More specifically, the differences found were in the seminological parameters of total progressive velocity and morphology, in the FSH, LH and T hormones and in the T/C ratio. Hormone data thus supports the hypothesis of a more favourable environment for sperm formation"
  • Soy-based formula? Neonatal plant estrogen exposure leads to adult infertility in female mice - Science Daily, 5/2/12 - "A paper published May 2 in Biology of Reproduction describes the effects of brief prenatal exposure to plant estrogens on the mouse oviduct, modeling the effects of soy-based baby formula on human infants. The results suggest that exposure to estrogenic chemicals in the womb or during childhood has the potential to affect a woman's fertility as an adult, possibly providing the mechanistic basis for some cases of unexplained female infertility ... part of the National Institutes of Health, previously demonstrated that neonatal exposure to the plant estrogen genistein results in complete infertility in female adult mice. Causes of infertility included failure to ovulate, reduced ability of the oviduct to support embryo development before implantation, and failure of the uterus to support effective implantation of blastocyst-stage embryos ... The team now reports that neonatal exposure to genistein changes the level of immune response in the mouse oviduct, known as mucosal immune response. Some of the immune response genes were altered beginning from the time of genistein treatment, while others were altered much later, when the mouse was in early pregnancy. Together, those changes led to harmfully altered immune responses and to compromised oviduct support for preimplantation embryo development, both of which would likely contribute to infertility ... estrogenic chemical exposure to the female fetus, infant, child, and adolescent all have potential impacts on mucosal immunity in the reproductive tract and, therefore, on adult fertility. The authors present the view that limiting such exposures, including minimizing use of soy-based baby formula, is a step toward maintaining female reproductive health"
  • Fatty diets may be associated with reduced semen quality - Science Daily, 3/14/12 - "The study of 99 men in the USA found an association between a high total fat intake and lower total sperm count and concentration. It also found that men who ate more omega-3 polyunsaturated fats (the type of fat often found in fish and plant oils) had better formed sperm than men who ate less ... if men make changes to their diets so as to reduce the amount of saturated fat they eat and increase their omega-3 intake, then this may not only improve their general health, but could improve their reproductive health too ... the relationship between dietary fats and semen quality was largely driven by the consumption of saturated fats. Men consuming the most saturated fats had a 35% lower total sperm count than men eating the least, and a 38% lower sperm concentration"
  • Micronutrient combination may boost male fertility: Study - Nutra USA, 1/4/12 - "group received supplements providing total daily doses of 440 mg L-carnitine, 250 mg L-arginine, 40 mg zinc, 120 mg vitamin E, 80 mg glutathione, 60 micrograms of selenium, 15 mg coenzyme Q10, and 800 micrograms of folic acid ... men receiving the active supplement displayed a 33% improvement in ejaculatory volume, a 215% improvement in sperm cell density, and a 23% improvement in total sperm motility"
  • Effect of α-lipoic acid on sperm quality, reproductive tract measures in thinner exposed rats - Andrologia. 2011 Sep 15 - "The aim of this study was to investigate the effect of alpha lipoic acid (ALA, an universal antioxidant) on thinner-induced testicular toxicity regarding spermatological features, body and reproductive tract measures in rats. Adult male Sprague-Dawley rats were divided into five treatment groups, eight rats in each. Control group was treated with placebo. Group O was given only olive oil. The group L received only α-lipoic acid. Thinner + Lipoic Acid group received thinner + α-lipoic acid and group T received only thinner. Thinner alone administration caused significant decreases in body and some reproductive organ weights, sperm count, motility and sperm membrane integrity, and significant increases in seminal vesicle weight and abnormal sperm rates compared with the values in the control group. However, concomitant administration of thinner with α-lipoic acid provided significant improvements in sperm parameters compared with values in alone group T.  In conclusion, the results of this study suggest that α-lipoic acid has a protective effect against thinner-induced reproductive dysfunction in male rats" - See alpha lipoic acid products at Amazon.com.  I assume that the thinner is something like this:
  • Antioxidants of growing interest to address infertility, erectile dysfunction - Science Daily, 7/28/11 - "A growing body of evidence suggests that antioxidants may have significant value in addressing infertility issues in both women and men, including erectile dysfunction, and researchers say that large, specific clinical studies are merited to determine how much they could help ... Some commonly used antioxidants, such as vitamins C and E, could help, Hagen said. But others, such as lipoic acid, are a little more cutting-edge and set up a biological chain reaction that has a more sustained impact on vasomotor function and health ... Polyphenols, the phytochemicals that often give vegetables their intense color and are also found in chocolate and tea, are also of considerable interest"
  • Vitamin D increases speed of sperm cells, researchers discover - Science Daily, 5/25/11 - "A new study conducted in 300 normal men showed a positive correlation between the percentage of motile sperm and serum vitamin D levels. The study was recently published in the scientific journal Human Reproduction, and showed additionally that stimulation of human spermatooza in the laboratory with activated vitamin D can increase their forward movement" - See vitamin D at Amazon.com.
  • Antioxidants may improve chances of conceiving in male subfertility - Science Daily, 1/18/11 - "Compared to controls, a couple was more likely to have a pregnancy or live birth if the man took antioxidants"
  • Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study - Andrologia. 2011 Feb;43(1):38-47 - "Effective medical treatments of infertile men with idiopathic oligoasthenoteratospermia (OAT) have yet to be determined ... A significant improvement of sperm cell total count (from 38.7 +/- 8.7 ' 10(6) to 61.7 +/- 11.2 ' 10(6) , P = 0.001) and sperm cell concentration (from 15.6 +/- 4.1 ' 10(6) per ml to 28.7 +/- 4.4 ' 10(6) per ml, P = 0.001) was observed in the omega-3 group. A significant positive correlation was found between the EPA and DHA in seminal plasma and the semen parameters. Seminal plasma EPA and DHA concentrations were positively correlated with seminal plasma SOD-like and catalase-like activity (both P = 0.001). In seminal plasma, both SOD-like and catalase-like activity were positively correlated with sperm count, sperm motility, and sperm morphology. Oligoasthenoteratospermic men with low levels of EPA and DHA may benefit from omega-3 FA supplementation" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Increasing fertility threefold with DHEA? - Science Daily, 7/1/10 - "women being treated for infertility who also received supplements of DHEA were three times more likely to conceive than women being treated without the additional drug ... The latter group took 75mg of the supplement daily for 40 days before starting fertility treatments, and continued for up to five months ... In the DHEA group, there was a 23% live birth rate as opposed to a 4% rate in the control group ... More than that, of the pregnancies in the DHEA group, all but one ended in healthy deliveries" - See DHEA at Amazon.com.
  • Lack of omega-3 fatty acid linked to male infertility, study suggests - Science Daily, 4/12/10 - "In our experiment, we used 'knockout' mice that lacked the gene responsible for an enzyme important in making docosahexaenoic acid (DHA). In the absence of DHA, male mice are basically infertile, producing few if any misshaped sperm that can't get where they need to go ... But, when DHA was introduced into the diet, fertility was completely restored. "It was very striking. When we fed the mice DHA, all these abnormalities were prevented,"" - See Jarrow Max DHA at Amazon.com.
  • Omega-3 fish oils linked to better semen quality - Nutra USA, 8/10/09
  • Daily Sex Helps Reduce Sperm DNA Damage And Improve Fertility - Science Daily, 6/30/09
  • Daily Sex May Help Men's Fertility - WebMD, 6/30/09
  • CoQ10 may boost sperm quality: Study - Nutra USA, 6/16/09 - "randomly assigned them to receive a daily CoQ10 supplement (300 mg, Kaneka, Japan) or placebo for 26 weeks. This was followed by 30 weeks with no intervention ... The Tehran-based researchers reported a significant improvement in both sperm density and motility following supplements of the coenzyme. A positive association was also found with regards to sperm count. Further analysis showed an increase in the percent of normal forms of sperm" - [Abstract] - See ubiquinol products at Amazon.com.
  • Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men - J Urol. 2009 Jul;182(1):237-48 - "were randomly assigned to receive 300 mg coenzyme Q10 (Kaneka, Osaka, Japan) orally daily (106 in group 1) or a similar placebo regimen (106 in group 2) during a 26-week period, followed by a 30-week treatment-free phase ... Coenzyme Q10 supplementation resulted in a statistically significant improvement in certain semen parameters" - See ubiquinol products at Amazon.com.
  • Semen Quality May Depend Upon Antioxidants In Man's Diet - Science Daily, 6/2/09 - "Low antioxidant intake is associated with low reproductive capacity in semen"
  • Effects of N-acetylcysteine on Semen Parameters and Oxidative/Antioxidant Status - Urology. 2009 May 8 - "To examine whether a beneficial effect of N-acetylcysteine (NAC) on semen parameters and oxidative/antioxidant status in idiopathic male infertility exists ... NAC had significant improving effects on the volume, motility, and viscosity of semen" - See n-acetyl cysteine at Amazon.com.
  • Soy foods 'reduce sperm numbers' - BBC News, 7/23/08 - "A regular diet of even modest amounts of food containing soy may halve sperm concentrations" - [WebMD][Science Daily]
  • Dads-to-Be May Need Folate, Too - WebMD, 3/20/08 - "Sperm with chromosomal abnormalities called aneuploidy were rare for all of the men, but they were 18% to 30% rarer in men who reported high folate or folic acid intake" - See folic acid products at Amazon.com.
  • Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review - Asia Pac J Clin Nutr. 2007;16 Suppl:383-90 - "the administration of LC and/or LAC may be effective in improving pregnancy rate and sperm kinetic features in patients affected by male infertility"
  • The Fertility Diet: Eat Right to Get Pregnant - US News and World Report, 11/30/07
  • Iron Supplements May Reduce Risk for Ovulatory Infertility - Medscape, 11/1/06
  • Does folic acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men? - Int J Androl. 2006 Apr;29(2):339-45 - "intervention treatment significantly increased sperm concentration in subfertile males"
  • Sperm Swim Better With Carnitine - WebMD, 3/9/05 - "The finding could help men coping with fertility issues -- specifically, those men whose sperm don't move very well" - See iHerb carnitine products.
  • Low-Dose Aspirin May Increase Birth Rate From IVF - Medscape, 6/24/04
  • A nutritional supplement for improving fertility in women: a pilot study - J Reprod Med. 2004 Apr;49(4):289-93
  • Nutritional Supplement May Improve Female Fertility - Medscape, 5/7/04 - "Five of 15 women taking the supplement [FertilityBlend] for five months became pregnant compared with none of 15 women in the placebo group" - See FertilityBlendicon at drugstore.com.
  • Supplement raises fertility stakes - Nutra USA, 4/20/04 - See FertilityBlendicon at drugstore.com.
  • Coenzyme Q10 & Fertility - Physician's Weekly, 4/5/04
  • Laparoscopy Can Help Infertile Women Avoid Months of Unnecessary Treatments - Doctor's Guide, 2/24/04
  • Coenzyme Q10 May Play Positive Role in Treatment of Male Infertility - Medscape, 1/30/04 - "Patients underwent oral administration of CoQ10, 200 mg/day twice daily for six months ... After treatment, CoQ10 levels increased in seminal plasma; the mean value rising significantly from 42.0 +/- 5.1 ng/mL at baseline to 127.1 +/- 1.9 ng/mL after six months of CoQ10 administration" - See ubiquinol at Amazon.com.
  • Coenzyme Q10 Helps Sperm Movement - WebMD, 1/12/04 - "Researchers say coenzyme Q10 is known to be active in the testes and is an antioxidant that plays an important role in forming the membranes and other structures within cells by fighting the effects of oxidative stress ... researchers looked at the effects of daily oral supplementation with 200 mg of coenzyme Q10" - See ubiquinol at Amazon.com.
  • Fertility Supplement Looks Promising - WebMD, 11/24/03 - "includes ... Chasteberry ... Folic acid ... Green tea and vitamin E ... L-arginine ... Vitamins B-6 and B-12, iron, magnesium, selenium, and zinc"
  • Vitamin C Increases Fertility in Women with Luteal Phase Defect - Healthwell Exchange Daily News, 10/30/03
  • Coffee Drinkers Have Faster Sperm - Doctor's Guide, 10/23/03
  • A Magical Route to Pregnancy? - Dr. Weil, 8/9/02
  • Supplement May Help Women Get Pregnant - WebMD, 5/15/02 - See FertilityBlend at drugstore.comicon
  • Supplements Boost Sperm Count - WebMD, 3/20/02 - "Researchers found that the men with fertility problems who took 5 mg of folic acid a day and 66 mg of zinc sulfate a day for 26 weeks had a 74% increase in total normal sperm count"
  • Herbal Remedies For Reproductive Concerns - Natural Foods Merchandiser, 2/02
  • Can Vitamin C or E Help Male Infertility? - WebMD, 6/22/01 - "abnormal amounts of free radicals, naturally occurring but sometimes dangerous molecules that can damage cells, may be responsible for infertility in some men. Vitamins C and E, which are called antioxidants, may have the power to neutralize sperm-busting free radicals"

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