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Anti-aging Research > Hydroxycitric Acid (HCA)
Hydroxycitric Acid (HCA)
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News & Research:
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Hydroxycitric Acid Slows Glucose Uptake, Cuts Insulin Peaks/Valleys A La
South Beach Diet - Science Daily, 5/23/05 -
"sugar that is normally absorbed
rather quickly -- within about 20 minutes -- took over 2 hours after HCA
ingestion. This delay is good because it reduces the high peaks of glucose,
which otherwise would require the body to produce a lot of insulin to deal
with the 'meal.' ... we don't know how this will translate into humans ...
Fast sugar is worse for you; slower is better"
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HCA may have role in diabetes prevention, suggests animal research -
Nutra USA, 5/23/05
Abstracts:
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Oral
hydroxycitrate supplementation enhances glycogen synthesis in exercised human
skeletal muscle - Br J Nutr. 2011 Aug 9:1-8 - "Glycogen stored in skeletal
muscle is the main fuel for endurance exercise. The present study examined the
effects of oral hydroxycitrate (HCA) supplementation on post-meal glycogen
synthesis in exercised human skeletal muscle. Eight healthy male volunteers
(aged 22·0 (se 0·3) years) completed a 60-min cycling exercise at 70-75 % \dot
{>V}O_{2\hairsp max} and received HCA or placebo in a crossover design repeated
after a 7 d washout period. They consumed 500 mg HCA or placebo with a
high-carbohydrate meal (2 g carbohydrate/kg body weight, 80 % carbohydrate, 8 %
fat, 12 % protein) for a 3-h post-exercise recovery. Muscle biopsy samples were
obtained from vastus lateralis immediately and 3 h after the exercise. We found
that HCA supplementation significantly lowered post-meal insulin response with
similar glucose level compared to placebo. The rate of glycogen synthesis with
the HCA meal was approximately onefold higher than that with the placebo meal.
In contrast, GLUT4 protein level after HCA supplementation was significantly
decreased below the placebo level, whereas expression of fatty acid translocase
(FAT)/CD36 mRNA was significantly increased above the placebo level.
Furthermore, HCA supplementation significantly increased energy reliance on fat
oxidation, estimated by the gaseous exchange method. However, no differences
were found in circulating NEFA and glycerol levels with the HCA meal compared
with the placebo meal. The present study reports the first evidence that HCA
supplementation enhanced glycogen synthesis rate in exercised human skeletal
muscle and improved post-meal insulin sensitivity"
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