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Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.
Home > Anti-aging Research > HbA1c
HbA1c
Alternative News:
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Effects of niacin on glucose control in patients with dyslipidemia -
Mayo Clin Proc. 2008 Apr;83(4):470-8 - "the effects
of niacin (</=2.5 g/d), alone or in combination with statins, on fasting
glucose (an increase of 4%-5%) and hemoglobin A1c levels (an increase of
</=0.3%) are modest, transient or reversible, and typically amenable to
adjustments in oral hypoglycemic regimens without discontinuing niacin.
Niacin therapy was infrequently associated with incident diabetes or the
need for new insulin prescriptions. Studies showed important clinical
benefits of niacin or niacin-statin regimens despite modest effects on
glucose control. On a population basis, significant reductions in incidences
of cardiovascular events and the degree of atherosclerotic progression
associated with long-term niacin (or niacin-statin) therapy in patients with
diabetic dyslipidemia outweigh the typically mild effects of this therapy on
glycemic regulation"
-
Randomized controlled trial for an effect of green tea-extract powder
supplementation on glucose abnormalities - Eur J Clin Nutr. 2007 Jun 6 -
"consumed a packet of green
tea-extract powder containing 544 mg polyphenols (456 mg catechins) daily
... A significant reduction in hemoglobin A1c level and a borderline
significant reduction in diastolic blood pressure were associated with the
intervention" - See
Jarrow green tea at iHerb
 .
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Study Results Show Diachrome(R) Improves Poorly-Controlled Blood Sugar
Levels for People on Antidiabetic Prescription Medications - Doctor's
Guide, 9/13/05 - "Study participants
taking Diachrome with one or more antidiabetic medications saw an average
range of 0.7 - 1.9% point reduction in HbA1c levels. The study also showed
that insulin resistance was significantly reduced (P<0.05) in those taking
thiazolidinediones and Diachrome ... Diachrome is a nutritional supplement
specifically formulated for people with diabetes. It contains 600 mcg of
chromium as Chromax(R) chromium picolinate and 2 mg of biotin" - See
chromium
 and
biotin at iHerb.
-
The effect of the ingestion of Ginkgo biloba extract (EGb 761) on the
pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects-A
double blind placebo-controlled, crossover study - Clin Nutr. 2006 May
12 - "Ingestion of EGb 761 produced
no significant changes in diagnostic laboratory tests in either group,
except reducing glycosylated hemoglobin A(1c) levels (from 7.7+/-1.2 to
7.2+/-0.9%, P<0.05) in T2DM the subjects"
-
Supplemental Chromium Picolinate and Biotin Appear to Decrease Blood Glucose
and Lipid Levels in Type 2 Diabetics: Presented at ADA - Doctor's Guide,
6/17/05 - "Our most important
finding is that chromium picolinate and biotin help to decrease hemoglobin
A1c [HbA1c] values in poorly controlled diabetics ... 600 mcg chromium
picolinate and biotin 2 mg/per day" - See
biotin products at iHerb.
-
Uses of Metformin May Extend Beyond Patients with Type 2 Diabetes - Doctor's Guide, 9/4/03 -
"In type 2 diabetics,
metformin appears to decrease plasma fasting glucose and HbA1c levels without causing weight gain. Metformin may also have a positive influence on a variety of cardiovascular risk factors and may be useful in preventing diabetes in overweight individuals with mild hyperglycaemia ...
while further study is necessary before more widespread use is encouraged, the role of metformin may be expanded for glucose control in children and teenagers with type 2 diabetes, in non-diabetic women with PCOS, and to prevent progression to diabetes"
- Chromium Supplements Appear to Improve Glucose Sensitivity in Diabetics - Medscape, 8/29/03 -
"We think that chromium picolinate can influence a
person's diabetic treatment so that levels of insulin required may be reduced ... HbA1c levels decreased from 9.5% to 9% during a six-month period in patients receiving a higher dose of the supplement, a difference that was statistically significant ... The study also showed a significant reduction in cholesterol
levels and trends for improvement in triglycerides in both chromium picolinate groups as well as a reduction in blood pressure in all groups" - See
iHerb or
Vitacost
chromium products.
General Information:
-
HbA1c - American Academy of Family Physicians
- HbA1c - emedicine.com
- HbA1c - FamilyDoctor.org
Other News:
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HbA1c Tied to Cardiovascular Risks in Patients With Symptomatic HF -
Medscape, 8/28/08 - "Over a median follow-up period
of almost 3 years, the researchers found that for each 1% rise in HbA1c, the
risk of cardiovascular death, heart failure hospitalization and overall
mortality rose by about 25%. Moreover, this was true in subjects with and
without a history of diabetes and whether or not ejection fraction was
reduced or preserved"
-
Comparison of the
effects of telmisartan and olmesartan on home blood pressure, glucose, and
lipid profiles in patients with hypertension, chronic heart failure, and
metabolic syndrome - Hypertens Res. 2008 May;31(5):921-9 -
"telmisartan had more beneficial effects on glucose
and lipid profiles in patients with relatively high HbA1c, serum total and
low-density lipoprotein cholesterol, and triglyceride levels. Therefore, we
concluded that telmisartan was more beneficial than olmesartan for
controlling blood pressure in the early morning, as well as for improving
glucose and lipid profiles in patients with hypertension, chronic heart
failure, and metabolic syndrome" -
Click here for why I
feel that telmisartan should be the first line treatment for hypertension.
-
HbA1C, but not serum
glycated albumin, is elevated in late pregnancy due to iron deficiency -
Diabetes Care. 2008 Jul 3 - "HbA(1C) levels were
elevated in late pregnancy due to iron deficiency. Serum GA may offer a
better index for monitoring glycemic control in pregnancy"
-
Translating the A1C Assay Into Estimated Average Glucose Values -
Diabetes Care. 2008 Jun 7 - "28.7 x A1C - 46.7"
-
Hemoglobin A1C Levels Strongly Linked to Subsequent Mortality in Diabetes
- Medscape, 6/9/08 - "For participants without a
previous diagnosis of diabetes, HRs for all-cause mortality steadily
increased from the A1C reference category to the highest category (≥ 7.0%;
HR, 2.36; 95% confidence interval [CI], 1.72 - 3.25). In addition, A1C was
associated with mortality from circulatory, endocrine, nutritional,
metabolic, and immune diseases as well as from other and unknown causes"
-
New
Insights In Diagnosing Diabetes May Help The Millions Who Are Undiagnosed
- Science Daily, 5/27/08 - "The measurement of HbA1c
does not require fasting, while current accepted tests require the patient
to fast for at least eight hours. Furthermore, HbA1c more accurately
reflects longer-term glucose concentration in the blood; other tests can
easily be affected by short-term lifestyle changes, such as a few days of
dieting or exercise. And finally, HbA1c laboratory methods are now well
standardized and reliable ... HbA1c greater than 6 percent would qualify as
being in need of follow-up; HbA1c greater than or equal to 6.5 percent
confirmed by a glucose-dependent test should establish the diagnosis of
diabetes" - Note: I feel there is something to this. My
fasting glucose is always high yet my HbA1c is 4.97 (normal 4.7 to 6.2) and
my 2 hour fasting glucose bounces a point or two about the low normal.
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The Relationship Between A1C Levels & PAD Severity - Physician's Weekly,
11/19/07
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Rosiglitazone Reduces Liver Fat and Insulin Requirements While Improving
Hepatic Insulin Sensitivity And Glycemic Control In Patients With Type 2
Diabetes Requiring High Insulin Doses - J Clin Endocrinol Metab. 2007
Oct 23 - "During rosiglitazone, HbA1c decreased from
8.9+/-0.4% to 7.8+/-0.3% (p=0.007) and insulin requirements from 218+/-22 to
129+/-20 IU/day (p=0.002). Liver fat content decreased by 46+/-9% from
20+/-3% to 11+/-3% (p=0.0002). Hepatic insulin sensitivity, measured from
the % suppression of endogenous glucose production by insulin, increased
from -40+/-7% to -89+/-12% (p=0.001). The % change in liver fat correlated
with the % decrease in HbA1c (r=0.53, p=0.06), insulin dose (r=0.66,
p=0.014), and suppression of endogenous glucose production (r=0.76,
p=0.003)"
-
Insulin Linked to Colonic Polyps, Neoplasia - oncologystat.com, 10/23/07
- "those with poorly controlled diabetes, identified
by a high serum level of hemoglobin A 1c (HbA 1c ), were significantly more
likely to have advanced colonic adenomatous polyps, compared with diabetic
patients with better glycemic control ... patients with poorly controlled
diabetes were more than sixfold as likely to have advanced polyps and nearly
sixfold as likely to have right-sided polyps, compared with patients who had
better glycemic control. The average number of polyps found in poorly
controlled patients was 5.5; in better-controlled patients, the average was
2.5 polyps per patient. Results from a third study reported at the meeting
showed that having three or more polyps was the strongest predictor of risk
for recurrent advanced neoplasia in the colon"
-
The Association of Elevated HbA1c on the Behavior of Adenomatous Polyps in
Patients with Type-II Diabetes Mellitus - Dig Dis Sci. 2007 Oct 16 -
"colonic adenomatous polyps (APs) ... univariate
analysis (UA) ... UA demonstrated that patients with poorly controlled DM-2
had a significantly increased incidence of right-sided APs (P = 0.001), a
greater number of APs (P < 0.005), more advanced APs (P < 0.005), a younger
age of presentation (P = 0.001), a history of smoking (P = 0.05), and
greater use of exogenous insulin (P = 0.01). Logistic regression, as
measured by HbA1c, demonstrated that poorly controlled DM-2 independently
predicted a greater prevalence of right-sided AP, a more advanced lesion at
the time of presentation, a greater number of polyps, and greater use of
exogenous insulin"
-
Hemoglobin A1c predicts diabetes but not cardiovascular disease in
nondiabetic women - Am J Med. 2007 Aug;120(8):720-7 -
"HbA1c levels are elevated well in advance of the
clinical development of type 2 diabetes, supporting recent recommendations
for lowering of diagnostic thresholds for glucose metabolic disorders. In
contrast, the association of HbA1c with incident cardiovascular events is
modest and largely attributable to coexistent traditional risk factors"
-
Thiazolidinedione increases serum soluble receptor for advanced glycation
end-products in type 2 diabetes - Diabetologia. 2007 Jul 18 -
"At 6 months, both rosiglitazone and sulfonylurea
resulted in a significant reduction in HbA(1c), fasting glucose and AGE"
-
Relation of increased hemoglobin a(1c) levels to severity of peripheral
arterial disease in patients with diabetes mellitus - Am J Cardiol. 2007
May 15;99(10):1468-9 - "the higher
the hemoglobin A(1c) levels in patients with diabetes with PAD, the higher
the prevalence of severe PAD"
-
New Data Shows Rimonabant Benefited Patients with Type 2 Diabetes by
Improving Blood Sugar Control, Reducing Weight and Acting on Other
Cardiometabolic Risk Factors - Doctor's Guide, 12/5/06 -
"treatment-naive type 2 diabetes
patients receiving
rimonabant 20mg per day for a duration of six months significantly
lowered their HbA1c levels by 0.8% from a baseline value of 7.9 as compared
to a reduction of 0.3% in the placebo group (P =.002). In addition, patients
with an HbA1c level greater than or equal to 8.5% at baseline, significantly
reduced their HbA1c by 1.9% with rimonabant as compared to 0.7% with
placebo" - See rimonabant at
International Antiaging Systems.
-
HbA1c - the gold standard in the assessment of diabetes treatment? -
Dtsch Med Wochenschr. 2006 Dec;131 Suppl 8:S243-6
-
Chronically High Blood Sugar Linked To Risk Of Cognitive Impairment -
Science Daily, 8/9/06 - "Women with
a glycosylated hemoglobin of seven percent or higher at baseline were four
times more likely to develop MCI or dementia than women who tested at less
than seven percent"
-
Periodontal Therapy May Help Diabetic Patients Improve Sugar Control -
Doctor's Guide, 4/12/06 -
"periodontal therapy may reduce a diabetic patient's HbA1c count by as much
as 20% at three and six months following treatment"
-
High Blood Sugar Levels a Risk Factor for Heart Disease
- Doctor's Guide, 9/14/05 - "Lowering blood sugar levels could reduce the risk of
coronary heart disease in both diabetics and non-diabetics ... Non-diabetic
persons with HbA1c levels of 6% or higher had almost a two-fold greater
heart disease risk compared to persons with an HbA1c level below 4.6%"
-
Rimonabant Study Shows Significant Improvements in Hba1c and Cardiometabolic
Risk Factors in People With Type 2 Diabetes - Doctor's Guide, 6/16/05
-
Metabolic Effect of Telmisartan [Micardis] and Losartan
[Cozaar] in Hypertensive Patients with Metabolic Syndrome
- Cardiovasc
Diabetol. 2005 May 15;4(1):6 - "Telmisartan, but not
losartan, significantly (p < 0.05) reduced free plasma glucose, free plasma
insulin, homeostasis model assessment of insulin resistance and HbAic.
Following treatment, plasma glucose and insulin were reduced during the oral
glucose tolerance test by telmisartan, but not by losartan. Telmisartan also
significantly reduced 24-hour mean systolic blood pressure (p < 0.05) and
diastolic blood pressure (p < 0.05) compared with losartan"
-
Glycosylated haemoglobin levels and the severity of erectile function in diabetic men - BJU Int. 2005 Mar;95(4):615-7 -
"This study suggests that the severity of ED is associated with increasing HbA(1c) levels in diabetic men"
-
High-Dose Atorvastatin Associated with Worsening Glycemic
Control - Doctor's Guide, 11/10/04 -
"Atorvastatin was associated with a statistically significant increased risk
of developing an HbA1c greater than 6 -- both in non-diabetics and in
diabetics"
-
Death Risk Rises With Blood Sugar - WebMD, 9/20/04 -
"As your blood sugar level goes up, so does your risk of death and heart disease - even if you don't have diabetes ...
every 1% increase in HbA1c ups the risk of death -- from all causes -- by 24% for men and 28% for women ... These are important studies because they show we should be concerned about blood glucose elevations even in people who do not have diabetes"
-
Hormone Therapy May Need to be Used Cautiously in Patients
Taking Rosiglitazone - Doctor's Guide, 9/19/03 -
"rosiglitazone
reduced glucose levels from a mean of 9.15 to 7.5 mM/L; (P=0.013), insulin
from 11.7 to 8.8 mU/L (P=0.026), haemoglobin A1c from 8.0% to 6.9%
(P=0.001), triglycerides from 2.3 to 1.8 mM/L (P=0.009), systolic BP from
130 to 117 mm Hg (P=0.02), diastolic BP from 72 to 67 mm"
- Indications and Management Strategies for Insulin Therapy in the Treatment of Type 2 Diabetes - Doctor's Guide, 9/8/03 -
"The American Diabetes
Association goals for glucose control are a haemoglobin A1c level of less than 7%, a fasting glucose level between 90 and 130 mg/dL,
and a post-prandial glucose concentration of less that 180 mg/dL"
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