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Anti-aging Research > Ginkgo
GinkGold is the EGB 761 Formula (U.S. Patent #5399348), manufactured by
Schwabe Company in Germany, and distributed in U.S. under Nature's Way
Brand. It's the patented extract used in most clinical studies. See
Medline search of EGB 761
Ginkgo
Product Suggestions:
General Information:
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Ginkgo biloba
- Vitacost Health Library
- Ginkgo - The Natural
Pharmacist
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Ginkgo - Compiled by Chad Bradshaw, Pharm.D
Research & News:
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Depression Protocol - Life Extension Foundation
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Are there any herbal alternatives to Viagra? - Dr. Murray
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Ginkgo Extract May Reduce Stroke Damage - Medscape, 10/10/08 -
"They found that mice pretreated with EGb761 had
smaller brain infarcts and less neurologic dysfunction than their untreated
counterparts ... Treatment with EGb761 after the stroke (4.5 hours
post-reperfusion) was also associated with a significant reduction in
infarct size"
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Gingko may boost memory - if you remember to take it - Nutra USA,
2/28/08 - "The new study involved 118 people age 85
and older with no memory problems. The elderly subjects were randomly
assigned to receive either a ginkgo biloba extract (240 mg daily, provided
by Thorne Research) or placebo for three years. The extracts were
independently verified to contain at least six per cent terpene lactones and
24 per cent flavone glycosides ... when the researchers considered only
people who followed the directions in taking the study pills, they found
that people took at least 84 per cent of the supplements as directed had a
68 per cent lower risk of developing mild memory problems"
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A randomized
placebo-controlled trial of ginkgo biloba for the prevention of cognitive
decline - Neurology. 2008 Feb 27 - "In the
secondary analysis, where we controlled the medication adherence level, the
GBE group had a lower risk of progression from CDR = 0 to CDR = 0.5 (HR =
0.33, p = 0.02), and a smaller decline in memory scores"
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Ginkgo Biloba Less Effective for Raynaud's Disease Than Nifedipine -
Medscape, 10/8/07 - "According to the poster, the
percentage change of attack rate after 8 weeks of treatment was 50.1% in the
group N and 31% in the group ... If the patient felt strongly about not
using the nifedipine, I probably would tell them [gingko] is something you
could use, but it's not as effective"
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Determining The Quality Of Ginkgo - Science Daily, 8/16/07
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Ginseng, Ginko Biloba Do Not Interfere With Drug Absorption If Taken At
Recommended Doses - Science Daily, 5/1/07 -
"found daily use of ginseng or
ginkgo biloba supplements at the recommended doses, or the combination of
both supplements, are unlikely to alter the pharmacokinetics - by which
drugs are absorbed, distributed, metabolized, and eliminated by the body -
of the majority of prescription or over-the counter drugs"
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Ginkgo's brain benefits questioned - Nutra USA, 3/16/07
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Ginkgo Biloba Extract: More Than Just For Memory? - Science Daily,
2/24/06 - "treating mice with an
extract of leaves of Ginkgo biloba both before and after implanting human
breast or brain (glioma) tumors decreased expression of a cell receptor
associated with invasive cancer. This decreased expression slowed the growth
of the breast tumors by 80 percent as long as the extract was used, compared
to untreated mice"
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Ginkgo Biloba
and Huperzine A -- Memory Enhancers - ConsumerLab.com, 12/5/05 -
"CL found significant amounts of
lead in supplements made with a form of ginkgo, while those made with
another form did not"
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Cortisol, Stress, and Health
- Life Extension Magazine, 12/05 - "Supplements to reduce high cortisol levels
secondary to stress ... Vitamin C: 1000-3000
mg/day ... Fish oil (omega-3 fatty
acids):1-4 gm/day ... Phosphatidylserine: 300-800
mg/day ... Rhodiola rosea: 100-200
mg/day, standardized extract ... Ginseng:
100-300 mg/day, standardized extract ... Ginkgo biloba: 100-200 mg/day,
standardized extract ... DHEA: 25-50 mg/day (any
hormone supplementation should be monitored by your physician)"
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Gingko biloba may reduce ovarian cancer risk - Nutra USA, 11/2/05 -
"Women who took gingko supplements
for six months or longer were shown to have a 60 per cent lower risk for
ovarian cancer"
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Complementary and
Integrative Approaches to Dementia - Medscape, 7/5/05 -
"Ginkgo biloba, an herbal product
long used in traditional Chinese medicine, has been studied extensively and
found to be well tolerated with mild benefit, approximating that of the 2nd
generation cholinesterase inhibitors"
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Ginkgo May Ease Some Attention Problems in MS - WebMD, 5/6/05 -
"they were assigned to take a
placebo or ginkgo biloba (120 milligrams twice daily) for three months ...
The ginkgo group shaved four seconds off their time on the Stroop test, a
13% decrease compared with their performance prior to starting ginkgo. The
placebo group's time remained unchanged"
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Newly Discovered Anti-Aging Effects of Ginkgo Biloba
- Life Extension Magazine, 4/4/05 - "Not only can it improve memory and help relieve the symptoms of Alzheimer’s
disease, but recent evidence also suggests that it can improve mental health
in healthy older adults and has uses in treating conditions as various as
diabetic retinopathy, intermittent claudication, erectile dysfunction,
ulcers, and arthritis"
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Natural Sex Boosters Gaining Ground - WebMD, 5/5/04
- Ginkgo
Does Not Cause Bleeding - Healthwell Exchange
Daily News, 11/13/03
- Ginkgo
Extract Effective Treatment for Vitiligo - New
Hope Natural Media, 8/21/03
- Ginkgo
Improves Some Glaucoma - New Hope Natural Media,
5/16/03 - "27 people with normal
tension glaucoma and visual field losses were
randomly assigned to one of two groups. One group received 40 mg of Ginkgo
biloba extract three times per day for four weeks, followed by eight weeks
with no treatment and finally four weeks of placebo. The other group
received placebo for four weeks, followed by the same eight weeks with no
treatment and ending with four weeks of Ginkgo
biloba. Both groups
experienced significant improvement (approximately 24%) in indices used to
evaluate visual fields after treatment with Ginkgo
biloba. There were no
improvements for either group during placebo phases ... Ginkgo
biloba extract has several
properties that might have contributed to the beneficial effects observed in
this trial. Its antioxidant activity might have protected the optic nerve
from oxidative damage, and its ability to increase blood flow and oxygen
utilization might have protected the optic nerve from damage due to lack of
oxygen"
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Ginkgo Biloba Analysis: Few Pills Pass Quality Test - WebMD, 4/21/03 -
"Brands that flunked random quality tests include ginkgo biloba products
sold under the labels of Rite Aid and Longs drug stores. Only two of nine
randomly tested products passed -- Maxi Ginkgo Biloba and Nature's Way
Ginkgold. Nutrilite Ginkgo Biloba, whose manufacturer paid for
quality assurance, also passed the tests ... Many people taking ginkgo
are not getting the effect they expected. This may be why ...
ConsumerLab also tested four off-the-shelf brands of
huperzine A ... One of these products -- Solaray Dietary Supplement --
contained unacceptably high levels of lead"
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Ginkgo for Alzheimer's Disease - Clinical Psychiatry News, 12/02 -
"A 4-point gain on the ADAS-Cog is roughly equivalent to a 6-month delay in
disease progression. “It is noteworthy that 29% of the patients with
Alzheimer's disease treated with
EGb for at
least 26 weeks improved by 4 or more points, compared with 13% treated with
the placebo,” ... In a German multicenter study, 156 patients with
Alzheimer's or multi-infarct dementia were randomized to 240 mg/day of EGb
761 or placebo; efficacy was assessed by three validated scales. By the end
of the 24-week study, 28% of patients in the ginkgo group were classified as
responders, compared with 10% in the placebo group, a significant
difference" - There are many different extracts of ginkgo. Note
that they specify the EGb 761 extract.
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Ginkgo Studies Find Conflicting Results on Cognition - Clinical
Psychiatry News, 12/02
- Ginkgo
Extract May Reduce Severity of Altitude Sickness - New Hope Natural
Media, 10/31/02
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Ginkgo Supplements Useful for SSRI-Related Sexual Dysfunction - Clinical
Psychiatry News, 9/02 - "Ginkgo has multiple systemic effects. It acts as a free-radical scavenger,
inhibits platelet aggregation, causes vasodilation, and allows more
efficient cellular uptake of oxygen and glucose. The effects of ginkgo on
sexual arousal are thought to result from increased blood circulation to the
genital area ... The proprietary multi-ingredient ginkgo preparation
ArginMax (Daily Wellness Co.) is “one of the best things I've ever seen
for SSRI sexual dysfunction,”" - See
ArginMax at drugstore.com
- The Bias is Overwhelming
- Vitacost, 8/21/02 -
"It is rather appalling that the news media has been giving so much
attention to this ridiculously short term negative study on ginkgo. It is
even more appalling that some media sources come up with catchy phrases like
“Forget the ginkgo”. Six weeks is not enough time for any supplement or drug
to work when it comes to memory"
- Ginkgo Doesn't Help Memory - WebMD, 8/20/02 -
"Ginkgo
was found to have no impact on memory or learning in a group of healthy
older adults who took it for six weeks" - Ginkgo
is an antioxidant. If you're link me and believe that memory loss
is partially do to free radical damage, it would make sense that ginkgo
might help prevent memory loss long term. It would also make sense
that if memory loss was partially caused by free radical damage, ginkgo or
anything else would not reverse that damage. The media always seems to
report things in black and white. See the following article, which I
feel the media should have mentioned:
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Ginkgo Extract Efficacious for Alzheimer's/Dementia - Medscape,
8/3/00 - "New analysis of the
breakthrough study published in The Journal of the American Medical
Association (JAMA) shows that a patented Ginkgo biloba extract, EGb 761,
effectively improves the mental function of patients with
Alzheimer's disease and multi-infarct dementia within the first 26
weeks of treatment"
- Colchicine Found in Ginkgo Was a Case of Mistaken Identity
- New Hope Natural Media, 7/18/02
- Ginkgo May Boost Mental Function in MS - WebMD,
4/18/02 - "Millions of people take
the herbal supplement ginkgo biloba
in the belief that it boosts brain power, and several studies suggest it
improves mental function in some patients with
Alzheimer's disease. New research now shows that it may do the same
thing for patients with multiple sclerosis (MS)."
- Basic Science Research: Effects of Ginkgo biloba Extract on Collagen-Induced
Aggregation and Thromboxane B2 Synthesis in Platelets
- Medscape, 4/02
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Sustain the Brain - Nutrition Science News, 2/01
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Study: Supplement Can Help Take the 'Dys' Out of Female Sexual Dysfunction,
Researchers Promote Idea of 'Sexual Wellness' - WebMD, 6/5/01 -
"ArginMax -- a dietary cocktail consisting of
ginseng, ginkgo, B vitamins, calcium, folic acid, and other vitamins and
minerals -- is being heralded as one component of a lifestyle that improves
sexual performance and helps prevent problems associated with intimacy"
- Ginkgo
Extract Efficacious for Alzheimer's/Dementia - Medscape, 8/3/00 -
"New analysis of the breakthrough study published in The Journal of the
American Medical Association (JAMA) shows that a patented Ginkgo biloba
extract, EGb 761, effectively improves the mental function of patients with
Alzheimer's disease and multi-infarct dementia within the first 26 weeks
of treatment"
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What is the best dosage of ginkgo I can recommend to my customers? -
Nutrition Science News, 8/00
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Ginkgo Biloba A Treasure from the Past - Life Extension Magazine, 5/00
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Want a love potion? What to know before you try - CNN, 6/15/00
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Natural Alternatives to Viagra with Ellen Kamhi - WebMD, 5/26/00
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Animal Tests Show Ginkgo Reduces Stroke Damage - WebMD, 5/2/00
- Ginkgo may protect brain from stroke damage
- Vitacost, 5/2/00
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Ginkgo Biloba May Help Some With Painful Leg Cramps - WebMD, 3/30/00
- Ginkgo biloba, a potential to treat heart disease
- CNN, 8/6/99
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Be All That You Can Be - Life Enhancement Magazine, 7/99
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Gingko Extends Life Span - Life Extension Magazine, 4/99
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Sidestep Heart Disease - Nutrition Science News, 3/99
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Natural Remedies for Depression - Nutrition Science News, 2/99
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Anti-Cortisols May Offer New Hope For Retinitis Pigmentosa - Doctor's
Guide, 11/17/97 - "According to Sapse, RP can be treated initially with a cocktail of anti-cortisol
nutritional compounds including vitamin A, zinc, ginkgo biloba and
acetyl-L-carnitine . . ."
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Study: 'Memory herb' helped some Alzheimer's patients - CNN, 10/21/97
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Ginkgo biloba touted as herb for the absent-minded - CNN, 2/12/97
Abstracts:
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