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Home > Health Conditions > Endometrial Cancer
Endometrial Cancer
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Legume, Soy, Tofu, and Isoflavone Intake and Endometrial Cancer Risk in
Postmenopausal Women in the Multiethnic Cohort Study - J Natl Cancer
Inst. 2011 Dec 12 - "conducted a prospective
analysis of 46 027 nonhysterectomized postmenopausal women who were
recruited into the Multiethnic Cohort (MEC) Study between August 1993 and
August 1996 and provided detailed baseline information on diet and other
endometrial cancer risk factors ... A total of 489 women diagnosed with
incident endometrial cancer were identified through the Surveillance,
Epidemiology, and End Results tumor registry linkages during a median
follow-up period of 13.6 years ... A reduced risk of endometrial
cancer was associated with total isoflavone intake (highest vs lowest
quintile, ≥7.82 vs <1.59 mg per 1000 kcal/d, RR = 0.66, 95% CI = 0.47 to
0.91), daidzein intake (highest vs lowest quintile, ≥3.54 vs <0.70 mg per
1000 kcal/d, RR = 0.64, 95% CI = 0.46 to 0.90), and genistein intake
(highest vs lowest quintile, ≥3.40 vs <0.69 mg per 1000 kcal/d, RR = 0.66,
95% CI = 0.47 to 0.91). No statistically significant association with
endometrial cancer risk was observed for increasing intake of legumes, soy,
tofu, or glycitein. Truncated age-adjusted incidence rates of endometrial
cancer for the highest vs lowest quintile of total isoflavone intake were 55
vs 107 per 100 000 women per year, respectively. The partial population
attributable risk percent for total isoflavone intake lower than the highest
quintile was 26.7% (95% CI = 5.3% to 45.8%)" - See
isoflavone products at iHerb
 .
- A
Prospective Cohort Study of Coffee Consumption and Risk of Endometrial
Cancer over a 26-Year Follow-Up - Cancer Epidemiol Biomarkers Prev. 2011
Nov 22 - "Coffee has been reported to lower levels
of estrogen and insulin, two hormones implicated in endometrial
carcinogenesis, but prospective data on the relation between coffee
consumption and risk of endometrial cancer are limited ... Fewer than 4 cups
of coffee per day were not associated with endometrial cancer risk. However,
women who consumed 4 or more cups of coffee had 25% lower risk of
endometrial cancer than those who consumed less than 1 cup per day
(multivariable RR = 0.75; 95% CI = 0.57-0.97; P(trend) = 0.02). We found the
similar association with caffeinated coffee consumption (RR for ≥4 vs. <1
cup/d = 0.70; 95% CI = 0.51-0.95). For decaffeinated coffee consumption, a
suggestive inverse association was found among women who consumed 2 or more
cups per day versus <1 cup/mo. Tea consumption was not associated with
endometrial cancer risk"
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Metformin Treatment Exerts Antiinvasive and Antimetastatic Effects in Human
Endometrial Carcinoma Cells - J Clin Endocrinol Metab. 2010 Dec 29 -
"In vitro invasion in ECC-1 cells was significantly
attenuated by sera from PCOS women after 6 months of metformin treatment
(850 mg twice daily) compared to matched controls (P < 0.01). These effects
appear to be associated with NF-κB, MMP-2/9, as well as Akt and Erk1/2
pathways that are known to be important regulators of inflammation, tumor
invasion and metastasis. Conclusions: Metformin, potentially, may serve as
adjuvant treatment in the management of patients with endometrial cancer"
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Exercise may reduce risk of endometrial cancer - Science Daily, 11/9/10
- "Those who exercised for 150 minutes a week or
more had a 34 percent reduced risk of endometrial cancer compared with those
women who were inactive"
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Vitamin D protects against obesity-induced endometrial cancer, study
suggests - Science Daily, 9/21/10 - "25 percent
of obese mice fed a vitamin D supplemented diet developed endometrial
cancer, while 67 percent of obese mice not treated with the vitamin
developed cancer ... vitamin D offered no protective effects for normal
weight mice ... Vitamin D has been shown to be helpful in a number of
cancers, but for endometrial cancer, our study suggests it protects only
against cancer that develops due to obesity ... Still, if these results are
confirmed in women, use of vitamin D may be a wonderfully simple way to
reduce endometrial cancer risk" - See
vitamin D products at iHerb.
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Coffee
and tea consumption and endometrial cancer risk in a population-based study
in New Jersey - Cancer Causes Control. 2010 May 14 -
"There was a moderate inverse association with
coffee consumption, with an adjusted OR of 0.65 (95% CI: 0.36-1.17) for
women who reported more than two cups/day of coffee compared to none. Tea
consumption appeared to increase risk (OR: 1.93; 95% CI: 1.08-3.45), but
after including the variables sugar/honey and cream/milk added to tea in the
model, the risk estimate was attenuated and no longer statistically
significant (OR: 1.77; 95% CI: 0.96-3.28 for those consuming more than one
cup/day of tea compared to nonusers). There was a suggestion of a decreased
risk associated with green tea, but the confidence interval included one
(adjusted OR for one or more cups/week vs. none: 0.75; 95% CI: 0.48-1.18).
We found an association with adding sugar/honey to tea, with those adding
two or more teaspoons/cup having an OR of 2.66 (95% CI: 1.42-4.98; p for
trend <0.01) after adjusting for relevant confounders. For sugar/honey added
to coffee the corresponding OR was 1.43 (95% CI: 0.81-2.55). Our results
indicate that sugars and milk/cream added to coffee and tea should be
considered in future studies evaluating coffee and tea and endometrial
cancer risk"
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Dietary
iron intake and risk of endometrial cancer: a population-based case-control
study in Shanghai, China - Nutr Cancer. 2010;62(1):40-50 -
"Dietary red meat and animal fat have been linked to
endometrial cancer (EC) risk, but the impact of bioavailable iron in
animal-derived foods has been less well studied ... Animal-derived iron
intake was positively associated with EC risk [adjusted OR = 1.9; 95% CI =
1.4-2.7, P(trend) < 0.01, highest vs. lowest quartile], predominantly after
menopause (OR = 2.2; 95%CI = 1.4-3.4, P(trend) < 0.01) and in women with BMI
>or= 25 kg/m(2)(OR = 3.2; 95% CI = 1.4-7.5 in postmenopausal obese women,
P(trend) < 0.01). Animal-derived fat was also associated with postmenopausal
EC risk (OR = 1.7; 95% CI = 1.2-2.5, P(trend) < 0.01). Multiplicative
interactions between animal-derived iron and BMI or animal-derived fat
intake were not observed. Animal-derived iron intake is associated with
increased risk of EC after menopause and among obese women. Avoidance of
animal-derived (heme) iron may reduce the risk of EC in these women"
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Coffee
drinking and risk of endometrial cancer-A population-based cohort study
- Int J Cancer. 2009 Apr 27 - "Each additional cup
(200 g) of coffee per day was associated with a rate ratio (RR) of 0.90 [95%
confidence interval (CI), 0.83-0.97]. In women drinking 4 or more cups of
coffee a day, the RR for the risk reduction of endometrial cancer was 0.75
(95% CI, 0.58-0.97) when compared with those who drank 1 cup or less"
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Antioxidant vitamins may protect against female cancer - Nutra USA,
6/3/09 - "for every 1,000 microgram increase per
1,000 kcal of diet of beta-carotene was associated with a 12 per cent
reduction in the risk of endometrial cancer ... Similarly, for every 50
milligram increase per 1,000 kcal of vitamin C the risk of endometrial
cancer was reduced by 15 per cent, and for every 5 milligram increase per
1,000 kcal of vitamin E the risk of endometrial cancer was reduced by 9 per
cent" - [Abstract]
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Antioxidant vitamins
and the risk of endometrial cancer: a dose-response meta-analysis -
Cancer Causes Control. 2009 Jul;20(5):699-711 -
"Based on case-control data, the random-effects summary odds ratios (OR)
were, for beta-carotene: 0.88 (95% CI: 0.79-0.98) per 1,000 mcg/1,000 kcal
(I2: 77.7%; p < 0.01); for vitamin C: 0.85 (95% CI: 0.73-0.98) per 50
mg/1,000 kcal (I2: 66.1%; p < 0.01); and, for vitamin E: 0.91 (95% CI:
0.84-0.99) per 5 mg/1,000 kcal (I2: 0.0%; p: 0.45)"
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Higher
regular coffee and tea consumption is associated with reduced endometrial
cancer risk - Int J Cancer. 2008 Oct 30 - "Compared
to nondrinkers, we observed a nonsignificant negative association with
endometrial cancer risk among women who reported >2 cups/d regular coffee
(OR 0.71, 95% CI 0.49-1.03), a significant inverse association with >2
cups/d black tea (OR 0.56, 95% CI 0.35-0.90) and a significant inverse
association with >4 cups/d combined coffee and tea consumption (OR 0.47, 95%
CI 0.28-0.80). These findings suggest coffee and tea may be important in
reducing endometrial cancer risk"
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Antioxidant vitamins and the risk of endometrial cancer: a dose-response
meta-analysis - Cancer Causes Control. 2008 Dec 16 -
"Based on case-control data, the random-effects
summary odds ratios (OR) were, for beta-carotene: 0.88 (95% CI: 0.79-0.98)
per 1,000 mcg/1,000 kcal (I(2): 77.7%; p < 0.01); for vitamin C: 0.85 (95%
CI: 0.73-0.98) per 50 mg/1,000 kcal (I(2): 66.1%; p < 0.01); and, for
vitamin E: 0.91 (95% CI: 0.84-0.99) per 5 mg/1,000 kcal (I(2): 0.0%; p:
0.45)"
- Coffee consumption
and risk of endometrial cancer: A prospective study in Japan - Int J
Cancer. 2008 Aug 18 - "After adjustment for age,
study area, body mass index, menopausal status, age at menopause for
postmenopausal women, parity, use of exogenous female hormones, smoking
status and by consumption of green vegetables, beef, pork and green tea, the
multivariate HRs (95% CI) of endometrial cancer in women who drank coffee
</=2 days/week, 3-4 days/week, 1-2 cups/day and >/=3 cups/day were 1.00,
0.97 (0.56-1.68), 0.61 (0.39-0.97) and 0.38 (0.16-0.91), respectively ...
Coffee consumption may be associated with a decreased risk of endometrial
cancer"
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Glycemic index, glycemic load, and cancer risk: a meta-analysis - Am J
Clin Nutr. 2008 Jun;87(6):1793-801 - "Overall, both
GL and GI were significantly associated with a greater risk of colorectal
(summary RR = 1.26; 95% CI: 1.11, 1.44 and RR = 1.18; 95% CI: 1.05, 1.34,
respectively) and endometrial (RR = 1.36; 95% CI: 1.14, 1.62 and RR = 1.22;
95% CI: 1.01, 1.49) cancer than of breast and pancreatic cancer"
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Meta-analysis supports fibre for uterus cancer protection - Nutra USA,
12/18/07 - "For every five grams of dietary fibre
per 1000 calories, women may reduce their risk of endometrial cancer by over
20 per cent" - [Abstract]
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Association between dietary fiber and endometrial cancer: a dose-response
meta-analysis - Am J Clin Nutr. 2007 Dec;86(6):1730-7 -
"the random-effects summary risk estimate was 0.82
(95% CI: 0.75, 0.90) per 5 g/1000 kcal dietary fiber"
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Deficiency In Exposure To Sunlight Linked To Endometrial Cancer -
Science Daily, 11/14/07 - "In general, endometrial
cancer incidence was highest at the highest latitudes in both hemispheres
... This is the third environmental paper from this research team to show a
strong association between vitamin D and cancer using global incidence data
(GLOBOCAN). The first paper, which illuminated a similar pattern for kidney
cancer, was published Sept. 15, 2006, in the International Journal of
Cancer. The second, on ovarian cancer, was published Oct. 31, 2006, in the
American Journal of Preventive Medicine" - See
vitamin D products at iHerb.
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Night Shift Work and the Risk of Endometrial Cancer - Cancer Res. 2007
Nov 1;67(21):10618-10622 - "Women who worked 20+
years of rotating night shifts had a significantly increased risk of
endometrial cancer [MVRR, 1.47 ... obese women working rotating night shifts
doubled their baseline risk of endometrial cancer (MVRR, 2.09; 95% CI,
1.24-3.52) compared with obese women who did no night work ... Women working
rotating night shifts for a long duration have a significantly increased
risk of endometrial cancer, particularly if they are obese. We speculate
that this increased risk is attributable to the effects of melatonin on
hormonal and metabolic factors" - See
Melatonin products at iHerb.
- Lots of Soy Lessens Endometrial Cancer Risk - WebMD, 5/27/04 -
"Regular intake of soya foods is associated with a reduced risk of endometrial cancer"
- Physical Activity May Reduce Endometrial Cancer Risk - Doctor's Guide, 3/31/04
- Phytoestrogens May Shield Against Endometrial Cancer - Natural Foods Merchandiser, 11/03
- Soy May Cut Endometrial Cancer Risk - WebMD, 8/5/03 -
"consumption of isoflavones and lignans,
but not coumestans, were associated with a reduced risk of endometrial cancer, particularly among postmenopausal women" - See Revival Soy
Products.
- Glycemic index and glycemic load in endometrial cancer - Int J Cancer. 2003 Jun 20;105(3):404-7 - "Our study supports the
hypothesis of a direct association between GI and endometrial cancer risk"
General Information:
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Endometrial Cancer - American Academy of Family Physicians
- Endometrial Cancer - emedicine.com
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Endometrial Cancer - familydoctor.org
General Information:
Other News:
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Sucrose,
high-sugar foods and risk of endometrial cancer - a population-based cohort
study - Cancer Epidemiol Biomarkers Prev. 2011 Jul 15 -
"During 18.4 years of follow-up, 729 participants
were diagnosed with incident endometrial cancer. Total sucrose intake and
consumption of sweet buns and cookies was associated with increased risk of
endometrial cancer. RRs (with 95% CIs) for consuming more than 35 grams of
sucrose/day and consuming sweet buns and cookies more than 3 times/week were
1.36 (1.04-1.77) and 1.42 (1.15-1.75) as compared to less than 15 grams of
sucrose/day and consuming sweet buns and cookies less than 0.5 times/week,
respectively. RRs for consuming more than 15 grams of sucrose/day as
compared to 15 grams or less were 1.97 (1.27-3.04) among obese women and
1.56 (1.20-2.04) among women with low fat intake"
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Risk of
endometrial cancer in relation to individual nutrients from diet and
supplements - Public Health Nutr. 2011 Jul 14:1-13 -
"endometrial cancer (EC) ... There existed little
evidence of an association with EC for the majority of macronutrients and
micronutrients examined. We observed a statistically significant increased
risk associated with the highest, compared with the lowest, quartile of
intake of dietary cholesterol (multivariable-adjusted OR = 1·51, 95 % CI
1·08, 2·11; P for trend = 0·02). Age-adjusted risk at the highest level of
intake was significantly reduced for Ca from food sources (OR = 0·73, 95 %
CI 0·54, 0·99) but was attenuated in the multivariable model (OR = 0·82, 95
% CI 0·59, 1·13). When intake from supplements was included in Ca intake,
risk was significantly reduced by 28 % with higher Ca
(multivariable-adjusted OR = 0·72, 95 % CI 0·51, 0·99, P for trend = 0·04).
We also observed unexpected increased risks at limited levels of intakes of
dietary soluble fibre, vitamin C, thiamin, vitamin B6 and lutein/zeaxanthin,
with no evidence for linear trend"
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Impaired
glucose metabolism and diabetes and the risk of breast, endometrial, and
ovarian cancer - Cancer Causes Control. 2011 Jun 19 -
"Diabetes was associated with an increased risk of
postmenopausal breast cancer (HR = 1.22, 95% CI 1.04-1.43). An indication of
a slightly elevated breast cancer risk was also found in postmenopausal
women with impaired glucose metabolism (HR = 1.11, 95% CI 0.96-1.28).
Diabetes (HR = 1.46, 95% CI 1.09-1.96) and impaired glucose metabolism (HR =
1.41, 95% CI 1.08-1.85) were associated with an increased risk of
endometrial cancer"
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Diabetes
treatment may also provide protection against endometrial cancer - Science
Daily, 4/5/11 - "Recent research has found that metformin has anti-cancer
properties, e.g., in breast cancer ... samples from PCOS women who had completed
the 6 month course of metformin the rate of spread of endometrial cancer cells
was around 25% lower than in the serum samples from PCOS women who had not
started that treatment" - See
metformin at IAS.
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Endometrial cancer associated with various forms of postmenopausal hormone
therapy: A case control study - Int J Cancer. 2011 Apr 1;128(7):1644-51
- "evaluates the effect of different modes of
estradiol-progestagen therapy (EPT) regimens on the postmenopausal
endometrial cancer risk in Finland ... For use of <5 years, the OR for
sequential EPT was 0.67 (95% confidence interval 0.52-0.86), for continuous
EPT 0.45 (0.27-0.73), and for estradiol plus levonorgestrel-releasing
intrauterine device system (LNG-IUS) 0.39 (0.17-0.88). A decreased risk
persisted for the use of continuous EPT and estradiol plus LNG-IUS of up to
10 years. The use of long-cycle EPT showed a tendency toward an elevated
risk both for exposure of <5 years (1.40; 0.82-2.38) and for estimated use
of >5 years (1.63; 1.12-2.38). For an estimated exposure of >10 years, the
risk for endometrial cancer was elevated for both users of long-cycle EPT
(2.95; 2.40-3.62) and sequential EPT (1.38; 1.15-1.66). Norethisterone
acetate and medroxyprogesterone acetate as parts of EPT did not differ in
their endometrial cancer risk. The use of tibolone showed no endometrial
risk. The use of sequential and long-cycle EPT is associated with an
increased risk of endometrial cancer, whereas the use of continuous EPT or
estradiol plus LNG-IUS shows a decreased risk"
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New
chemotherapy combination shows promise in endometrial cancer, researchers
find - Science Daily, 3/17/10
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New
Treatment Shows Promise Against Recurrent Gynecologic Cancers - Science
Daily, 4/21/09
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Younger Women With Endometrial Cancer Can Safely Keep Ovaries, Avoid Early
Menopause, Study Suggests - Science Daily, 1/28/09
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Long-term Alcohol Consumption and Risk of Endometrial Cancer Incidence: A
Prospective Cohort Study - Cancer Epidemiol Biomarkers Prev. 2009
Jan;18(1):355-8 - "During a mean follow-up of 17.6
years, 687 endometrial cancer cases were identified in the Swedish cancer
registries. We found no association between alcohol consumption and
endometrial cancer risk after adjustment for age, body mass index, and
smoking"
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New
Endometrial Cancer Treatment Stops Growth Of Tumors And Kills Cancer Cells,
Study Shows - Science Daily, 9/2/08
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Diabetes Linked
to Risk of Endometrial Cancer - Medscape, 3/13/08 -
"An association was observed between type 2 diabetes
and endometrial cancer (odds ratio = 1.7)"
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Internal Radiotherapy Better Than External for Quality of Life in
Endometrial Cancer Patients - Doctor's Guide, 9/24/07
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Hazards:
Heavy Drinking May Raise Risk of Endometrial Cancer - New York Times,
9/18/07 - "women who had less than two drinks a day
had no increased risk of endometrial cancer. But those who had more than two
drinks a day had slightly more than twice the risk. It made no difference
whether the women drank beer, wine or hard liquor"
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Waist Size Can Increase Endometrial Cancer Risk - Doctor's Guide,
2/20/07 - "Women with a waist
measurement of more than 34 inches have nearly double the risk of
endometrial cancer than women whose waist is 31 inches or less"
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Extensive Lymph-Node Dissection Indicates Improved Survival From Endometrial
Cancer - Doctor's Guide, 3/28/06
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Lymphadenectomy Does Not Improve Survival From Endometrial Cancer -
Doctor's Guide, 3/27/06
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Laparoscopic Surgery Associated With Better Short-Term Quality of Life Among
Endometrial-Cancer Patients - Doctor's Guide, 3/27/06
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Most Women Can Avoid Open Surgery for Endometrial-Cancer Staging -
Doctor's Guide, 3/27/06
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Treatment for Early Stage Endometrial Cancer Hinge on Risk Factors in New
Guidelines - Doctor's Guide, 3/10/06
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Supplemental Radiation Therapy Beneficial for Stage I Endometrial Cancer
- Doctor's Guide, 1/25/06
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Chemotherapy after Surgery Extends Survival for Patients with Advanced
Endometrial Cancer - Doctor's Guide, 12/6/05
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Glycaemic index, glycaemic load and risk of endometrial cancer: a
prospective cohort study - Public Health Nutr. 2005 Oct;8(7):912-9 -
"Our data suggest that diets with
high glycaemic index or high glycaemic load may be associated with
endometrial cancer risk overall, and particularly among obese women,
premenopausal women and postmenopausal women who use hormone replacement
therapy"
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Intensive Chemotherapy Offers Pluses, Minuses in Advanced Endometrial Cancer
- Doctor's Guide, 8/31/05
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Raloxifene May Help Prevent Endometrial Cancer - Doctor's Guide, 5/18/05
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Evista May Help Prevent Endometrial Cancer - WebMD, 5/16/05
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Studies Find African-American Women with Endometrial Cancer Have More
Aggressive Form than Caucasian Women - Doctor's Guide, 3/30/05
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Adiponectin Level Found to be Independent Risk Factor for Endometrial Cancer
- Doctor's Guide, 3/34/05
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Mayo Clinic Recommends Broadening Treatment To Battle Recurrence Of Endometrial Cancer - Science Daily, 1/27/05
- Mayo Clinic Recommends Broadening Treatment to Battle Recurrence of Endometrial Cancer - Doctor's Guide, 1/18/05
- Obesity, Height Linked to Endometrial Cancer - WebMD, 11/2/04
- Stress May Increase Endometrial Cancer Risk - WebMD, 7/9/04
- Anastrozole Protective Against Endometrial Cancer - Doctor's Guide, 3/22/04
- Full Staging of Endometrial Cancer Reduces Unnecessary Radiotherapy and Need for Further Surgery - Doctor's Guide, 6/4/03
- Combination Chemotherapy May Have Greater Benefit To Advanced Endometrial Cancer, But Higher Toxicity - Doctor's Guide, 6/3/03
- Pelvic Lymph Node Metastasis And Endometrial Cancer - Doctor's Guide, 3/19/03
- Combined Doxorubicin/Cisplatin Increases Response Rate In Endometrial Adenocarcinoma - Doctor's Guide, 3/4/03
- Suboptimal Cytoreduction In Endometrial Cancer Associated With Decreased Survival - Doctor's Guide, 2/10/03
- Antipsychotic Use A Risk Factor For Endometrial Cancer - Doctor's Guide, 2/6/03
- Younger Women with Endometrial Cancer May Have Other Health Problems As Well - Doctor's Guide, 2/4/03
- Interstitial Brachytherapy Can Salvage Vaginal Recurrences of Endometrial Cancer - Doctor's Guide, 9/19/02
- Laparoscopy Safe, Effective In Endometrial Cancer - Doctor's Guide, 9/17/02
- No Higher Risk of Endometrial Cancer Seen With Long-Term Combined Hormone Replacement Therapy - Doctor's Guide, 8/1/02
- Survival Better Among Endometrial Cancer Patients Whose Treatment is Delayed - Doctor's Guide, 7/25/02
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