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Dopamine
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Supplements that may increase dopamine:
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General Information:
| Neurotransmitters in Various Disorders: |
News & Research:
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Differential D1 and D5
Receptor Regulation and Degradation of the Angiotensin Type 1 Receptor -
Hypertension. 2008 Jan 2
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Green Tea May Protect Brain Cells Against Parkinson's Disease - Science
Daily, 12/13/07 - "green tea polyphenols protect
dopamine neurons that increases with the amount consumed. They also show
that this protective effect is mediated by inhibition of the ROS-NO pathway,
a pathway that may contribute to cell death in Parkinson's" - See
Jarrow green tea at iHerb
 .
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Insulin's Brain Impact Links Drugs And Diabetes - Science Daily,
10/17/07 - "The researchers then restored insulin by
pulsing the hormone back into the brain of the diabetic animals and found
that the system returns to normal, indicating that the lack of insulin in
the striatum directly affected amphetamine action"
-
Antidepressant-Like Effect of Cordyceps sinensis in the Mouse Tail
Suspension Test - Biol Pharm Bull. 2007 Sep;30(9):1758-62 -
"Cordyceps sinensis (CS) has been known as a
component of traditional medicines that elicit various biological effects
such as anti-fatigue, immunomodulatory, and hypoglycemic actions. Since it
has been well-established that fatigue is closely related to depression, we
used the tail suspension test (TST) in mice to examine the
antidepressant-like effects of hot water extract (HWCS) and supercritical
fluid extract (SCCS) of CS ... these results suggest that SCCS may elicit an
antidepressant-like effect by affecting the adrenergic and dopaminergic
systems, but not by affecting the serotonergic system" - See
Cordyceps products at iHerb.
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ADHD Appears to Be Associated With Depressed Dopamine Activity in the Brain
- Doctor's Guide, 8/6/07
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Dopamine-related Drugs Affect Reward-seeking Behavior - Science Daily,
4/27/07
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Functional Roles of Norepinephrine and Dopamine in ADHD - Medscape,
3/9/06
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Brain Chemical May Be Key in Eating Disorders - WebMD, 9/6/05 -
"Dopamine is a chemical involved in
weight, feeding behaviors, reinforcement, and reward. Now they are reporting
that women who have recovered from eating disorders show abnormal levels of
serotonin"
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Dopamine May Play New Role in Depression - WebMD, 7/28/05 -
"Current antidepression treatments
are mostly based on the deficiency or imbalance of the brain chemicals
serotonin and norepinephrine ... This new study highlights the importance of
the dopamine system"
- Study Links Low Iron to ADHD - WebMD, 12/17/04 -
"Low iron levels in the brain are known to alter the activity of dopamine, a chemical involved in
controlling movement. The researchers suggest that this could explain the observed link between iron stores and ADHD"
- CU Researchers Find That Dopamine Is Key To Learning Likes And Dislikes - Science Daily, 11/8/04
- Sex, Sexuality, and Serotonin - Medscape, 7/20/04 -
"From our study of the brain, we have some nice evidence that elevated activity of dopamine is involved in that intense sense of
passion and arousal of romantic love. I also maintain in my book, Why We Love, that we're going to find out sometime that norepinephrine is also involved, largely because heightened activity of norepinephrine is also associated with focused attention, elevated energy, motivation to win a reward, elation, and 2
characteristics of romantic love -- obsessional following and object imprinting ... low activity levels of serotonin are going to be involved"
- Reduction of Brain Dopamine Concentration With Dietary Tyrosine Plus Phenylalanine Depletion - Am J Psychiatry 160:1887-1889, October 2003 -
"Healthy male subjects were scanned on two occasions: once after receiving a balanced amino acid drink and once after receiving a drink mixture from which tyrosine and phenylalanine were omitted ... Dietary tyrosine and phenylalanine depletion
increased [11C]raclopride binding in the striatum by a mean of 6%. The change in [11C]raclopride binding correlated significantly with the fall in the ratio of tyrosine and phenylalanine to large neutral amino acids"
- See
iHerb products.
- Nonsteroidal Anti-Inflammatory Drugs May Protect Against Parkinson's Disease - Doctor's Guide, 11/14/02 -
"Studies
show that NSAIDs can reduce dopaminergic neuron degeneration in Parkinsonian animal models"
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Phosphatidylserine
(PS) The Essential Brain Nutrient - Life Extension Magazine, 9/02 -
"Among its list of functions, phosphatidylserine stimulates the release of dopamine (a mood regulator that also control physical sensations, and movement), increases the production
of acetylcholine (necessary for learning and memory), enhances brain glucose metabolism (the fuel used for brain activity), reduces cortisol levels (a stress hormone), and boosts the activity of nerve growth factor (NGF),
which oversees the health of cholinergic neurons"
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Testosterone
Deficiency & Depression, Does DHEA Raise the Levels of Bioavailable Testosterone in Men? - Life Extension Magazine, 8/02 -
"The mood-improving action of testosterone is more likely to be due to the direct action of testosterone on the brain-possibly through raising the
levels of dopamine, a very important "reward" neurotransmitter"
- Depression Linked to Parkinson's - WebMD, 5/28/02 -
"About 1.4% (19) of the depressed people (about 1.4%) developed Parkinson's compared with
only 0.4% of the others ... the link may have a biological explanation, known as the "serotonin hypothesis." Not only do people with Parkinson's disease have lower levels of dopamine in the brain, studies have also shown that the brains of these patients also have reduced levels of another brain chemical,
serotonin. Low levels of serotonin are known to be a key factor in depression" - Note: St. Johns wort is believed to increase all three of the brain's primary chemicals, serotonin,
norepinephrine and dopamine.
- Seeing, Smelling Food Triggers Drug-Like Effect on Brain - WebMD, 5/23/02 -
"the dopamine system can be triggered by food when there is no pleasure
associated with it, since the subjects don't eat the food"
-
Methamphetamines Kill Dopamine Transporters - Clinical Psychiatry News, 4/02
- St. John's Wort: Effective, with Caveats - Nutrition Science News, 3/02 -
"Using the Hamilton Rating Scale for Depression, 47 percent of those taking
St. John's wort improved compared with 40 percent of those taking the sertraline ... Hyperforin increases the effectiveness of norepinephrine, dopamine, L-glutamate, and gamma-amino butyric acid (GABA),
as well as serotonin. Researchers in the Department of Pharmacology at the University of Frankfurt in Germany concluded, "no other antidepressant compound exhibits a similar broad uptake-inhibiting profile.""
- Happily ever after? It's all in your head - CNN, 2/14/02 - See the video. Claims that love is dependent on a cocktail of chemicals (dopamine, norepinephrine and
PEA) and that oxytocin is responsible for bonding and that vasopressin is responsible for monogamy.
- Parkinson's Drugs Not to Blame - WebMD, 1/22/02 -
"But people on Mirapex or Requip
were not any more likely to have daytime sleepiness. And they were no more likely to fall asleep while driving compared with people not on these drugs. In fact, sleepiness was not associated with any particular type of Parkinson's drug"
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Augmentation Strategy Aids Treatment-Resistant Depression - Clinical Psychiatry News, 11/01 -
"Pramipexole, a dopamine
agonist, may be an effective augmentation agent for patients with treatment-resistant depression"
-
A
New Natural Relaxant - Life Extension Magazine, 10/01 -
"Theanine also increases levels of dopamine, another brain chemical with mood-enhancing effects"
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Researchers Explore New Meds for Mood Disorders - Clinical Psychiatry News, 10/01 -
"The dopamine system is an "underresearched
area,""
- Parkinson's Defense - Nutrition Science News, 5/01 -
"In vitro studies support the theory that vitamins C and E suppress oxidative destruction of dopamine ... One
approach has been to increase internal dopamine levels by molecules that occur naturally in the body, such as nicotinamide adenine dinucleotide (NADH) and cytidinediphosphocholine (CDP-choline). Another strategy has been Co-Q10 therapy to prevent mitochondrial oxidative damage that occurs in PD patients ... CDP-Choline
(citicholine) occurs in the body and is closely related to choline, a nutrient in the B-vitamin family. Some evidence suggests citicholine may enhance the effects of L-dopa, possibly by increasing dopamine levels in the brain"
- Caution in Treating PD Depression - Nutrition Science News, 5/01 -
"SAMe
depletes dopamine and can produce PD-like changes in animals ... Similarly, the herb kava (Piper methysticum) may counter the effects of dopamine"
- Improving Dopamine May Help Obese - Doctor's Guide, 2/5/01 -
"Neurotransmitters such as dopamine, GABA, norepinephrine and serotonin, as well as peptides and
aminoacids, are involved in the regulation of food intake ... Of particular interest is dopamine since this neurotransmitter seems to regulate food intake by modulating food reward via the meso-limbic circuitry of the brain. In fact, drugs that block dopamine D2
receptors increase appetite and result in significant weight gain, whereas drugs that increase brain dopamine concentration are anorexigenic"
- Brain dopamine and obesity - Lancet 2001;357:354-57 -
"Strategies aimed at improving dopamine function may be beneficial
in the treatment of obese individuals"
- New study links obesity to brain receptors - CNN, 2/2/01 -
"What this new study seems to say is that obese people don't have the normal amount of dopamine
receptors in their brains"
- Java Deters Parkinson's Disease - Doctor's Guide, 10/00 -
"there is evidence that coffee, which keeps dopamine levels up, may help prevent
Parkinson's disease in the first place"
- Catecholamines Kick Out the Demons of Depression - Life Enhancement Magazine, 7/99 - "the amino acid phenylalanine converts to
tyrosine, which transforms to dopamine"
- St. John's wort continuing CME - Nutrition Science News, 7/98 -
"Surprisingly, the extract was also shown to inhibit the synaptosomal
uptake of norepinephrine as well as dopamine with potencies similar to those found with serotonin. The authors point out that while other antidepressant drugs inhibit synaptosomal uptake of both serotonin and norepinephrine
(e.g. imipramine, desipramine) and others both dopamine and norepinephrine (e.g.
nomifensine, amineptine), no drug shows this action on all three uptake systems."
- St. John's wort - The Natural Pharmacist -
"More recent research suggests that St. John's wort inhibits the reuptake of serotonin, dopamine, and norepinephrine"
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Depression
Protocol - Life Extension Foundation - "Tyrosine is used by the body to make the neurotransmitters dopamine, norepinephrine, and epinephrine, which play a role in elevating mood and keeping us alert; 500 to 1500 mg a day is recommended"
- 5-HTP : The Natural Way to Overcome Depression, Obesity, and Insomnia - Dr. Murray -
"either L-tyrosine or D,L-phenylalanine used alone produced improvements in mood comparable to
those seen with antidepressant drugs, but without the side effects (Table 2.7)." The reason appears to be that tyrosine and phenylalanine have many roles in the body. Besides being converted to dopamine and norepinephrine, they can be converted to other substances that have stimulant and mood-elevating properties.
Phenylalanine (both in its D- and L-forms) increases the level of phenylethylamine (PEA), while L-tyrosine increases the levels of PEA and two other neurotrans-mitters, octopamine and tyramine. These compounds have stimulant and mood-elevating properties, and depressed patients have been found to have low levels of
them."
- NADH - The Natural Pharmacist -
"NADH particularly plays a role in the production of energy. It also participates in the production of L-dopa, which the body turns into the important neurotransmitter dopamine"
- Deprenyl Info and Studies - International Anti-aging Systems - "Actions of selegiline at different dosages include; MAO-B inhibition, dopamine re-uptake inhibition,
reinforcement of defense against "oxidative stress", and substitution for trophic factors"
- NADH, the supervitamin body and mind energizer - by James South MA -
"The Birkmayers also found increased urinary excretion of dopamine
metabolites in the patients, indicating there was an actual NADH induced increase in dopamine production"
Related Searches:
| Neurotransmitter Regulation of Mood, Cognition, and Behavior |
Stahl. Essential Psychopharmacology 1996 Foote. Psychopharmacology 1995. |
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