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Anti-aging Research > Deprenyl.
Deprenyl (Selegiline,
Eldepryl, Emsam, etc.)
Related Topics:
Where to purchase:
News & Research:
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Deprenyl
- Life Extension Foundation
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Deprenyl - extending lifespan - article by James South -
"At normally used clinical dosages (10-15 mg/day), deprenyl is a selective
MAO-B inhibitor, so it doesn’t prevent intestinal MAO-A from digesting
dietary tyramine. (1) In addition, deprenyl has the unique ability to
prevent tyramine from getting into noradrenalin-using nerve calls, and it’s
only when tyramine enters noradrenalin nerve cells that control arterial
blood pressure that it triggers the “cheese effect.”"
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Deprenyl- A multi-functional anti-aging drug - Ward Dean MD -
"In addition to its potential as a life-extending drug, Deprenyl also
appears to have a number of other beneficial effects. One of the most
significant is its libido promoting/aphrodisiac effects, in both men and
women. . . . Deprenyl has also been found to protect neurons from toxic
substances, act as an anti-oxidant, and as an inducer of the anti-oxidant
enzymes superoxide dismutase (SOD) and catalase (CAT)"
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Deprenyl - International Antiaging Systems
- Deprenyl: A
Universal Anti-Aging Strategy - CERI
- The Responsible
Parent's Guide to Healthy Mood-Boosters for all the Family - BLTC
Research
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Study Will Test Antidepressant Patch That May Help Smokers Kick The Habit
- Science Daily, 1/8/07
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Valeant Pharmaceuticals Announces Availability of Zelapar(R) for Parkinson's
Disease Patients - Doctor's Guide, 7/21/06
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Patch Approval: ‘Big Moment’ in Psychopharm: Resistant depression patients
may benefit - Clinical Psychiatry News, 4/06 -
"Probably 30% of people who present with depressive complaints have an
MAO-inhibitor responsive condition that will not respond well or not at all
to [selective serotonin reuptake inhibitors, selective norepinephrine
reuptake inhibitors, or tricyclics]"
-
FDA Approves Emsam (selegiline transdermal system), the First Transdermal
Patch for the Treatment of Major Depressive Disorder - Doctor's Guide,
2/28/06 - "the U.S. Food and Drug
Administration (FDA) approved Emsam® (selegiline transdermal system), the
first transdermal patch for the treatment of major depressive disorder (MDD)
in adults"
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FDA OKs Patch to
Treat Depression - WebMD, 2/28/06 -
"At its lowest strength, Emsam can
be used without the dietary restrictions that are needed for all oral MAO
inhibitors that are approved for treating major depression"
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FDA Panel Backs Selegiline Patch For Depression: Majority view 20-mg
formulation as safe - Clinical Psychiatry News, 12/05 -
"Unlike
the transdermal formulation, the oral formulation does not achieve
antidepressant levels in the central nervous system"
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Fast-dissolving Selegiline (Zelapar Zydis) Reduces "Off-Time" in Up to 4
Years of Follow-Up - Doctor's Guide, 10/3/05
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Parkinson's Drug May Be Safer Than Thought
- WebMD, 8/12/04
-
Transdermal Selegiline Can Prevent Depression Relapse - Clinical
Psychiatry News Online, 11/03
-
Transdermal MAO Inhibitor Patch Effective for ADHD - Clinical Psychiatry
News, 6/03 - "A transdermal patch
containing the selective monoamine oxidase inhibitor selegiline applied
daily appeared effective and well tolerated in a pilot study of children and
adolescents with attention-deficit hyperactivity
disorder ... Selegiline is a specific monoamine oxidase (MAO) type B
inhibitor, so it “is essentially devoid of the tyramine-cheese effect we
think about with MAO [type A] inhibitors"
- Selegiline Transdermal System Shows Modest But Significant Antidepressant
Effect - Doctor's Guide, 3/19/03 - "Use of a selegiline transdermal
system offers modest but statistically significant antidepressant benefit in
outpatients with major depressive disorder"
- Zelapar (Selegiline) Receives Approvable Letter From FDA
- Doctor's Guide, 2/18/03
- Parkinson's Drug May Help Smokers Quit - WebMD,
1/24/03
- Selegiline Helps Smokers Quit - Medscape, 1/23/03
- "Its effect was about half that of
buproprion but comparable to that of nicotine replacement ... selegiline
doses greater than 10 mg/day are associated with increased risk of
hypertensive crises"
- Selegiline Might Aid Smoking Cessation - Doctor's
Guide, 9/12/02
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Transdermal MAO Inhibitor Appears Safe Without Dietary Restrictions -
Clinical Psychiatry News, 9/01 - "Selegiline
is a MAO-B inhibitor that has been shown to have a significant antidepressant
effect at oral doses of 30-60 mg/day. But at this level, the drug also
inhibits MAO-A and requires the restriction of dietary
tyramine and sympathomimetic
amines"
- Deprenyl
May Result In AD/HD Symptom Improvements - Doctor's Guide, 10/26/99 -
"Ten children (ages six to 13) with AD/HD participated in the study. These
children had very severe AD/HD and presented many co-morbid problems.
Placebo and deprenyl tablets (5 mg) were given twice a day for one month
each ... Results showed that three tasks were significantly improved
(paired-associate learning, math computation and Beery shape copying) with
deprenyl treatment as determined by a two-tailed statistical test. This
pilot study indicates that deprenyl may have some benefits for the task
performance and classroom behavior of some children with AD/HD."
-
A
Good Dose of Deprenyl How Much is Too Much? - Life Extension Magazine,
8/99
- Selegiline - BLTC
Research
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Youthful Brain, Youthful Body - Life Extension Magazine, 5/98
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Effect Of Long-Term Deprenyl Treatment On Age-Dependent Changes In The Rat
Brain - Life Extension Magazine, 9/96
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Top Ten
Life Extension Drugs - Life Extension Magazine, 9/95
- Eldepryl
Shows Encouraging Results In Alzheimer's Study - Doctor's Guide, 4/24/97
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Report: Vitamin E, Parkinson's drug slow Alzheimer's disease - CNN,
4/23/97
Abstracts:
-
Transdermal Selegiline in Major Depression: A Double-Blind,
Placebo-Controlled, Parallel-Group Study in Outpatients - Am J
Psychiatry, 11/02 - "Transdermal selegiline (20 mg applied once daily by means of a 20-cm2
patch) administered for 6 weeks was an effective and well-tolerated
treatment for adult outpatients with major depression. The typical side
effects commonly seen with traditional monoamine oxidase inhibitor
antidepressants were not observed"
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MAO inhibitors and oxidant stress in aging brain tissue - Eur
Neuropsychopharmacol. 1999 Mar;9(3):247-52 - "By reducing the oxidant stress observed in aging brain, MAO inhibitors,
especially deprenyl, may contribute to the control of the aging process."
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Current status of antioxidant therapy for Alzheimer's Disease - J Am
Geriatr Soc. 1998 Dec;46(12):1566-72 - "High dose vitamin E, ginkgo biloba, and selegiline are three putative
antioxidants that have been tested in randomized multicenter trial
conditions in the US"
-
The striatal dopamine dependency of life span in male rats. Longevity study
with (-)deprenyl - Mech Ageing Dev. 1988 Dec;46(1-3):237-62
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Integrated medicine and the prevention and reversal of memory loss -
Altern Ther Health Med. 1998 Nov;4(6):38-43 - "The program includes a diet consisting of 15% fat and supplementation with
brain-specific nutrients such as vitamin B complex, vitamin E, ubiquinone,
ginkgo biloba, and phosphatidylserine. In addition, stress-relieving
meditation, mind-body and cognitive exercise, antiaging
drugs like L-deprenyl citrate, as well as hormones such as
dehydroepiandrosterone and pregnenolone complete the program"
-
Antitumor effect of L-deprenyl in rats with carcinogen-induced mammary
tumors - Cancer Lett. 1998 Jan 30;123(2):177-83 -
"These results suggest that the administration of deprenyl blocked the
development of mammary tumors . . ."
Related Searches:
Related Sites:
Recommended Books:
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Books on deprenyl - Amazon.com
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Deprenyl - Past and Future, by W. Kuhn (Editor), W. Kraus (Editor), H.
Orzuntek (Editor)
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Deprenyl : The Anti-Aging Drug by Alastair Dow
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