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Anti-aging Research > Cranberry.
Cranberry
Specific Recommendation:
News & Research:
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Whole cranberry powder shows activity against recurrent UTIs - Nutra USA,
4/5/11 - "The volunteers were randomly assigned to receive no intervention, or a
low (500 mg) or high dose (1,000 mg) daily dose of the PACran whole cranberry
powder for 90 days ... At the end of the study, the control group did not show
any changes in concentrations of E. coli, while a significant reduction in the
cranberry groups were observed. Specifically, the researchers report a
reductions of E. coli in urine culture analysis of between 25 and 45 percent
after 10 days of cranberry consumption, and this was maintained over 90 days"
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Cranberry shows heart health benefits: Study - Nutra USA 3/25/11
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Cranberry’s benefits extend to prostates: Study - Nutra USA, 9/15/10 - [abstract]
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OPCs come out tops for heart health beverages - Nutra USA, 2/5/10 -
"Cranberry juice rich in antioxidant procyanidins is effective at boosting the
health of blood vessels ... oligomeric procyanidins (OPC) had “by far the most
potent effects” on the function of the endothelium (the cells lining blood
vessels)" - [Abstract] - See
Jarrow Formulas, Cran Clearance, 680 mg, 100 Capsules at iHerb
and
OPC + 95 products at iHerb.
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Science: The pick of cranberry’s health benefits - Science Daily,
12/7/09
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How
Cranberry Products Prevent Urinary Tract Infections - Science Daily,
5/9/08 - "Chemicals present in cranberries—and not
the acidity of cranberry juice, as previously thought—prevent
infection-causing bacteria from attaching to the cells that line the urinary
tract ... Chemicals found in cranberry products called proanthocyanidins
(PACs) prevent E. coli, which is the cause of about 85% of UTIs and 90% of
cases of acute pyelonephritis, from adhering to these urinary tract
epithelial cells by affecting the surface properties of the bacteria"
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Cranberry extracts may prevent colon cancer: Lab study - Nutra USA,
2/13/09 - "These findings are important because they
demonstrate that the F-κB signalling pathway provides a potential
mechanistic link between inflammation and cancer and that the
anti-inflammatory properties of crude cranberry extract or quercetin can be
used to modulate this pathway" - See
Jarrow Formulas, Cran Clearance, 680 mg, 100 Capsules at iHerb
.
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Cranberry near match for antibiotic UTI potential - study - Nutra USA,
12/23/08
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Cranberries Might Help Prevent Urinary Infections In Women - Science
Daily, 1/22/07 - "cranberry products significantly
reduced UTIs over 12 months compared to the placebo/control groups. The
cranberry treatment was more effective for women who suffered from recurrent
UTIs"
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Cranberries Help Combat Urinary Tract Infections In Women, Researcher Finds
- Science Daily, 1/14/08
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Compounds In Cranberries May Be Antibacterial Agents - Science Daily,
11/13/07
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Cranberry power helps fight infection - Nutra USA, 10/16/07
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Cranberries Give Boost to Cancer Drug - WebMD, 8/21/07 -
"compounds isolated from cranberries kill human
ovary, brain, and prostate cells in laboratory studies ... in the presence
of cranberry extract -- which came from a commercially available, 27% juice
cranberry drink -- platinum-based chemotherapy was six times more effective
against platinum-resistant ovarian cancer cells"
- Research
shows benefits of cranberries -MSNBC, 11/20/06 -
"A compound Howell discovered in
cranberries, proanthocyanidine, prevents plaque formation on teeth ...
Drinking cranberry juice daily may increase levels of HDL, or good
cholesterol and reduce levels of LDL, or bad cholesterol ... Cranberries may
prevent tumors from growing rapidly or starting in the first place ..."
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Cranberries Contain Possible Anti-caries, Anti-plaque Agents - Science
Daily, 6/29/06
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Cranberry Juice Cuts Cavities - WebMD, 11/23/05
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Give
Thanks For The Cranberry, Say Dental Researchers - Science Daily,
11/23/05
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Cranberry compound found to block cancer - Nutra USA, 10/17/05
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Cranberry juice no benefit for kidney stones - Nutra USA, 8/29/05
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Cranberry
Juice May Combat Gastro-Intestinal Viruses - CBS 2 Chicago, 6/6/05
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Cranberry May Help Fight Herpes Virus - WebMD, 10/20/04
- More Cranberries, Fewer Urine Infections - WebMD,
9/30/04
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What can women do about recurrent bladder infections? - Natural Foods
Merchandiser, 10/03
- Cranberry Extract Might Aid in Stroke Recovery -
WebMD, 9/8/03
- Cranberry Juice Fights Heart Disease - WebMD,
3/24/03 -
"Cranberry juice is higher in phenol antioxidants than other fruit juices
with the exception of grape juice ... levels of
high-density lipoprotein ("good" cholesterol) appeared to increase
significantly -- by as much as 121% -- after two or three glasses of juice a
day"
- Cranberry Juice May Prevent Urinary Tract Infections
- New Hope Natural Media, 7/18/02 -
"Women who consume cranberry juice (Vaccinium macrocarpon)
on a daily basis may help prevent the urinary tract infections (UTIs),
according to a new study in the Journal of the American Medical Association
... Another herbal treatment that may be helpful for
UTIs is
uva ursi"
- A Tiny Berry, A Pound Of Prevention -
Intelihealth, 11/21/01 - "Compared
with 19 other common fruits cranberries have the highest level of the
antioxidant, phenol"
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Cranberry Ups Kidney Stone Risk - Nutrition Science News, 6/01
- The Cranberry Cure, A Glass a Day Could Keep Urinary Infections Away
- WebMD, 6/29/01 - "After
six months, only eight women taking cranberry juice had experienced a UTI,
compared with 19 of those taking Lactobacillus, and 18 not taking
anything"
- Cranberry Juice Helps Urinary Tract -
Intelihealth, 6/29/01
- Cranberry
Juice As Urinary Tract Infection Preventative Not Cost Effective
- Doctor's Guide, 6/4/01
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The Cranberry Cure, A Glass a Day Could Keep Urinary Infections Away -
WebMD, 9/14/00
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Does drinking cranberry juice stop bladder infections? - Nutrition
Science News, 5/99
- Scientists
See Anti-Aging, Cancer-Fighting Properties In Wild Blueberries -
Doctor's Guide, 9/23/00
Abstracts:
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The
effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower
urinary tract symptoms Br J Nutr. 2010 Aug 31:1-9 - "In contrast to the
control group, patients in the cranberry group had statistically significant
improvement in International Prostate Symptom Score, QoL, urination parameters
including voiding parameters (rate of urine flow, average flow, total volume and
post-void residual urine volume), and lower total PSA level on day 180 of the
study" - [Nutra
USA]
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Plasma
Matrix Metalloproteinase (MMP)-9 Levels Are Reduced following Low-Calorie
Cranberry Juice Supplementation in Men - J Am Coll Nutr. 2009
Dec;28(6):694-701 - "Matrix metalloproteinase (MMP)-9, also known as gelatinase
B, is implicated in the development of hypertension and atherosclerotic plaque
vulnerability to rupture, an important step in the etiology of cardiovascular
diseases ... cranberry juice cocktail (CJC) ... We found that CJC
supplementation significantly decreased plasma MMP-9 concentrations (mean +/-
SEM: -36% +/- 9%, p < 0.0005; week 12 vs. baseline) while baseline plasma MMP-9
concentrations strongly correlated with the changes noted over the entire
intervention (r = -0.71, p < 0.0001). We also show that the reduction in plasma
MMP-9 levels was associated with a change in plasma nitrites/nitrates (NOx)
concentration over the entire intervention (r = -0.38, p < 0.05; week 12 vs.
baseline). Significant correlations were also noted between changes in plasma
MMP-9 levels and those of systolic (r = 0.39, p < 0.05) and diastolic (r = 0.60,
p < 0.001) blood pressure during the course of the study (week 12 vs. baseline).
CONCLUSIONS: Our results show that daily CJC consumption is associated with a
decrease in plasma MMP-9 concentrations in abdominally obese men. We hypothesize
that polyphenolic compounds from cranberries may be responsible for this effect,
supporting the notion that the consumption of flavonoid-rich foods can exert
cardioprotective effects"
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Regulation of Vascular Endothelial Function by Procyanidin-Rich Foods and
Beverages (dagger) - J Agric Food Chem. 2010 Jan 28 -
"Evaluation of the
relative effects of extracts of cranberry juice compared to apple, cocoa, red
wine, and green tea showed inhibition of ET-1 synthesis was dependent primarily
on their oligomeric procyanidin content. Procyanidin-rich extracts of cranberry
juice triggered morphological changes in endothelial cells with reorganization
of the actin cytoskeleton and increased immunostaining for phosphotyrosine
residues ... procyanidin tetramer, pentamer, hexamer, and heptamer produced
concentration-dependent decreases with IC(50) values of 5.4, 1.6, 0.9, and 0.7
muM, respectively. Levels of ET-1 mRNA showed a similar pattern of decreases,
which were inversely correlated with increased expression of Kruppel-like factor
2 (KLF2), a key endothelial transcription factor with a broad range of
antiatherosclerotic actions including suppression of ET-1 synthesis" - See
Jarrow Formulas, Cran Clearance, 680 mg, 100 Capsules at iHerb
and
OPC + 95 products at iHerb.
-
Effect
of cranberry extracts on lipid profiles in subjects with Type 2 diabetes
- Diabet Med. 2008 Dec;25(12):1473-7 - "Changes in
lipid profiles, oxidized low-density lipoprotein (ox-LDL), glycaemic
control, components of the metabolic syndrome, C-reactive protein (CRP) and
urinary albumin excretion (UAE) were assessed after cranberry or placebo
treatment for 12 weeks ... Low-density lipoprotein (LDL) cholesterol
decreased significantly in the cranberry group (from 3.3 +/- 0.2 to 2.9 +/-
0.2 mmol/l, P = 0.005) and the decrease was significantly greater than that
in the placebo group (-0.4 +/- 0.1 vs. 0.2 +/- 0.1 mmol/l, P < 0.001). Total
cholesterol and total : high-density lipoprotein (HDL) cholesterol ratio
also decreased significantly (P = 0.020 and 0.044, respectively) in the
cranberry group and the reductions were significantly different from those
in the placebo group (P < 0.001 and P = 0.032, respectively) ... Cranberry
supplements are effective in reducing atherosclerotic cholesterol profiles,
including LDL cholesterol and total cholesterol levels, as well as total :
HDL cholesterol ratio, and have a neutral effect on glycaemic control in
Type 2 diabetic subjects taking oral glucose-lowering agents"
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Favourable impact of low-calorie cranberry juice consumption on plasma
HDL-cholesterol concentrations in men - Br J Nutr. 2006 Aug;96(2):357-64
- "daily CJC consumption is
associated with an increase in plasma HDL-cholesterol concentrations in
abdominally obese men. We hypothesise that polyphenolic compounds from
cranberries may be responsible for this effect, supporting the notion that
the consumption of flavonoid-rich foods can be cardioprotective"
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Potential of cranberry-based herbal synergies for diabetes and hypertension
management - Asia Pac J Clin Nutr. 2006;15(3):433-41 -
"The analysis of alpha
-glucosidase,alpha -amylase, and ACE-I inhibitory activities suggested that
inhibition depend on the phenolic profile of each unique extract and by
bringing together synergistic combinations to cranberry, health beneficial
functionality was enhanced. This enhanced functionality in terms of high
alpha -glucosidase and alpha -amylase inhibitory activities indicate the
potential for diabetes management, and high ACE-I inhibitory activity
indicates the potential for hypertension management"
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Efficacy of Cranberry Juice on Helicobacter pylori Infection: a
Double-Blind, Randomized Placebo-Controlled Trial - Helicobacter. 2005
Apr;10(2):139-45 - "These results
are significant ... Regular consumption of cranberry juice can suppress H.
pylori infection in endemically afflicted populations"
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