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Anti-aging Research
> Collagen Peptides
Collagen Peptides
Specific Recommendations:
News & Research:
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Collagen supplement use growing in popularity, improves skin, hair and nails
- 10News, 5/20/19 - "After the age of 30, collagen
decreases by 1 percent, so by the time you're 50, you've lost 20 percent of your
collagen ... If you have injuries, collagen is going to help and repair tissue
... The experts say collagen powder works, but make sure it’s not your main
source of protein" - See collagen supplements at Amazon.com.
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Collagen supplements show early promise for skin and joints, but don’t stock
up yet - Washington Post, 3/26/18 - "As we age,
however, our bodies’ collagen production becomes less efficient, and the
tissues that depend on it, such as our skin and joints, don’t get repaired
the way they used to, which explains, at least in part, why our skin starts
to sag and we have more aches and pains as the years tick by ... That’s
where the supplements come in. Manufacturers have found a way to apply
enzymes to gelatin to create protein chains called collagen hydrolysates.
These small collagen chains (peptides) may be absorbed intact by the body to
be used directly in the tissues. Predictably, there is a lot of hype and
exaggerated claims around these supplements, but there is also a lot of
promising, bona fide research pointing to benefits, particularly for more
youthful-looking skin and help with joint pain ... A 2017 study in the
Journal of Agriculture and Food Chemistry showed that collagen hydrolysates
can be transferred through the bloodstream directly to the skin, which
explains the probable pathway for these effects ... Although the science is
building, it is relatively new and there is still a lot to learn,
particularly in identifying what types of collagen peptides work with
different conditions"
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Gelatin supplements: Good for your joints? - Science Daily, 12/20/16 -
"enrolled eight health young men in a trial of a
gelatin supplement enhanced with vitamin C. The volunteers drank the
supplement and had blood taken, and after one hour performed a short (five
minute) bout of high-impact exercise (skipping) ... The researchers tested
the blood for amino acids that could build up the collagen protein that
composes tendons, ligaments, and bones. They also tested blood samples for
their effect on Baar's lab-grown ligaments at UC Davis ... The gelatin
supplement increased blood levels of amino acids and markers linked to
collagen synthesis, and improved the mechanics of the engineered lab-grown
ligaments" - See gelatin supplements at
Amazon.com.
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Hydrolysed collagen may boost beauty from within: Rousselot studies -
Nutra USA, 5/7/09 - "According to the company, women
receiving the collagen supplement experienced a 28 per cent improvement in
the skin hydration levels, compared to placebo, with 91 per cent of these
women reporting increased skin hydration levels after eight weeks ...
Furthermore, the number of micro-relief furrows and deep wrinkles decreased
by 26 and 30 per cent, compared with the placebo group" - See
collagen products at iHerb.
Abstracts:
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Novel Hydrolyzed Chicken
Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in
Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial
- Altern Ther Health Med. 2019 Jun 13 - "The
intervention consisted of twice daily oral administration of a supplement
containing BioCell Collagen, a chicken sternal cartilage derived dietary
ingredient composed of a naturally-occurring matrix of hydrolyzed collagen
type-II (≥300 mg), chondroitin sulfate (≥100 mg), hyaluronic acid (≥50 mg) ...
For the 113 participants completing the study, the dietary supplementation
compared to a placebo: (1) significantly reduced facial lines and wrinkles (P =
.019) and crow's feet lines and wrinkles (P = .05), (2) increased skin
elasticity (P = .008) and cutaneous collagen content (P < .001) by 12%, (3)
improved indicators associated with a more youthful skin appearance based on
visual grading and wrinkle width (P = .046), and (4) decreased skin dryness and
erythema. No difference existed between the supplement and the placebo for
skin-surface water content or retention. The supplement was well tolerated, with
no reported adverse reactions" - [Nutra
USA] - See
BioCell Collagen at Amazon.com,
collagen UC-II at Amazon,
hyaluronic acid at Amazon.com
and
chondroitin sulfate at Amazon.com .
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Improvement of Functional
Ankle Properties Following Supplementation with Specific Collagen Peptides in
Athletes with Chronic Ankle Instability - J Sports Sci Med. 2018 May
14;17(2):298-304 - "chronic ankle instability (CAI) ...
collagen peptide supplementation (SCP) ... 50 male and female athletes with CAI
completed a randomized, double-blinded and placebo-controlled study with a daily
oral administration of either 5 g SCP or 5 g placebo (Maltodextrin) over a
period of six months ... the subjective ankle stability was improved in both the
CAIT (p < 0.001) and the FAAM-G (p < 0.001) following SCP supplementation
compared with placebo. No significant changes between the groups were detected
in the results of the ankle arthrometer. After six month the subjective report
of the ankle stability function significantly improved and the three month
follow-up revealed a significant decline in the number of ankle joint injuries
(p < 0.05). These data support the concept that specific collagen peptide
supplementation in athletes with chronic ankle instability results in
significant improvements in subjective perceived ankle stability. The reduction
in the re-injury rate of ankle sprains in the follow-up period suggests that
these findings have clinical relevance" - [Nutra
USA] - See collagen supplements at Amazon.com.
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Effects of 12 Weeks of
Hypertrophy Resistance Exercise Training Combined with Collagen Peptide
Supplementation on the Skeletal Muscle Proteome in Recreationally Active Men
- Nutrients. 2019 May 14;11(5) - "Evidence has shown
that protein supplementation following resistance exercise training (RET) helps
to further enhance muscle mass and strength. Studies have demonstrated that
collagen peptides containing mostly non-essential amino acids increase fat-free
mass (FFM) and strength in sarcopenic men ... In conclusion, the use of RET in
combination with collagen peptide supplementation results in a more pronounced
increase in BM, FFM, and muscle strength than RET alone. More proteins were
upregulated in the COL intervention most of which were associated with
contractile fibers" - [Nutra
USA]
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Oral Supplementation of
Specific Collagen Peptides Combined with Calf-Strengthening Exercises Enhances
Function and Reduces Pain in Achilles Tendinopathy Patients - Nutrients
2019, 11(1), 76 - "We conclude that oral supplementation
of specific collagen peptides may accelerate the clinical benefits of a
well-structured calf-strengthening and return-to-running program in Achilles
tendinopathy patients" - [Nutra
USA] - See collagen supplements at Amazon.com.
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Daily oral supplementation with collagen peptides combined with vitamins other
bioactive compounds improves skin elasticity and has a beneficial effect on
joint and general wellbeing - Nutr Res, Jun 9 2018 - "We hypothesized that
daily oral supplementation with a liquid nutraceutical containing hydrolyzed
fish collagen, vitamins, antioxidants, and other active ingredients could
improve skin texture and elasticity, and in addition have a protective effect on
joint health. A double-blind, randomized, placebo-controlled clinical trial was
conducted on 120 subjects who consumed either the test product or placebo on a
daily basis for 90 days. Subjects consuming the test product had an overall
significant increase in skin elasticity (+40%; P < .0001) when compared to
placebo. Histological analysis of skin biopsies revealed positive changes in the
skin architecture, with a reduction in solar elastosis and improvement in
collagen fiber organization in the test product group. As reported in the
self-perception questionnaires, these results were confirmed by the subjects'
own perceptions in that participants agreed their skin was more hydrated and
more elastic. In addition, the consumption of the test product reduced joint
pain by −43% and improved joint mobility by +39%. Oral supplementation with
collagen bioactive peptides combined with chondroitin, glucosamine, L-carnitine,
vitamins, and minerals significantly improved the clinical parameters related to
skin aging and joint health, and therefore, might be an effective solution to
slow down the hallmarks of aging" - [Nutra
USA] - See collagen supplements at Amazon.com.
The Active Gold Collagen used in this
study is expensive.
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Oral Intake of
Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and
Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study
- Nutrients. 2018 Jun 26;10(7) - "Collagen-peptide
supplementation could be an effective remedy to improve hydration, elasticity,
and wrinkling in human skin. The aim of this study was to conduct a
double-blind, randomized, placebo-controlled trial to clinically evaluate the
effect on human skin hydration, wrinkling, and elasticity of
Low-molecular-weight Collagen peptide (LMWCP) with a tripetide (Gly-X-Y) content
>15% including 3% Gly-Pro-Hyp. Individuals (n = 64) were randomly assigned to
receive either placebo or 1000 mg of LMWCP once daily for 12 weeks ... Compared
with the placebo group, skin-hydration values were significantly higher in the
LMWCP group after 6 weeks and 12 weeks. After 12 weeks in the LMWCP group,
visual assessment score and three parameters of skin wrinkling were
significantly improved compared with the placebo group. In case of skin
elasticity, one parameter out of three was significantly improved in the LMWCP
group from the baseline after 12 weeks, while, compared with the placebo group,
two parameters out of three in the LMWCP group were higher with significance
after 12 weeks" - [Nutra
USA]
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Oral supplementation with
specific bioactive collagen peptides improves nail growth and reduces symptoms
of brittle nails - J Cosmet Dermatol. 2017 Aug 8 -
"Bioactive collagen peptides treatment promoted an increase of 12% nail growth
rate and a decrease of 42% in the frequency of broken nails. Additionally, 64%
of participants achieved a global clinical improvement in brittle nails, and 88%
of participants experienced an improvement 4 weeks post-treatment. The majority
of participants (80%) agreed that the use of BCP improved their nails'
appearance, and were completely satisfied with the performance of the treatment"
- [Nutra
USA] - See
Peptan® Hydrolyzed Collagen Protein Powder - For Hair - Nails - Joint Pain Relief - Skin Care - Appetite Suppressant - Building Muscle - Bone Density - Osteopenia
at Amazon.com
.
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Daily oral consumption of
hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine
posttraumatic osteoarthritis - PLoS One. 2017 Apr 6 -
"posttraumatic OA (PTOA) ... These findings establish
that in the context of murine knee PTOA, daily oral consumption of hCol1 is
chondroprotective, anti-apoptotic in articular chondrocytes, and
anti-inflammatory. While the underlying mechanism driving these effects is yet
to be determined, these findings provide the first tissue and cellular level
information explaining the already published evidence of symptom relief
supported by hCol1 in human knee OA. These results suggest that oral consumption
of hCol1 is disease modifying in the context of PTOA" - [Nutra
USA] - See
Peptan® Hydrolyzed Collagen Protein Powder - For Hair - Nails - Joint Pain Relief - Skin Care - Appetite Suppressant - Building Muscle - Bone Density - Osteopenia
at Amazon.com
.
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Vitamin C-enriched gelatin
supplementation before intermittent activity augments collagen synthesis -
Am J Clin Nutr. 2016 Nov 16 - "These data suggest that
adding gelatin to an intermittent exercise program improves collagen synthesis
and could play a beneficial role in injury prevention and tissue repair"
- [Nutra
USA] - See gelatin supplements at
Amazon.com.
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Dietary Supplementation
with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial
Effect on Cellulite Morphology - J Med Food. 2015 Dec;18(12):1340-8 -
"specific bioactive collagen peptides (BCP)
on the cellulite treatment of normal and overweight women. In total,
105 women aged 24-50 years with moderate cellulite ... 105 women
aged 24-50 years with moderate cellulite were randomized to orally
receive a daily dosage of 2.5 g BCP or a placebo over 6 months ...
The results of the study demonstrated that a regular ingestion of
BCP over a period of 6 months led to a clear improvement of the skin
appearance in women suffering from moderate cellulite. Based on the
current data, it can be concluded that a long-term therapy with
orally administered BCP leads to an improvement of cellulite and has
a positive impact on skin health" - [Nutra USA] - Here's what
I take: Peptan® Hydrolyzed Collagen Protein Powder - For Hair - Nails - Joint Pain Relief - Skin Care - Appetite Suppressant - Building Muscle - Bone Density - Osteopenia
at Amazon.com
.
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The effect of oral
collagen peptide supplementation on skin moisture and the dermal collagen
network: evidence from an ex vivo model and randomized, placebo-controlled
clinical trials - J Cosmet Dermatol. 2015 Sep 12 - "Skin dryness and an
accelerated fragmentation of the collagen network in the dermis are hallmarks of
skin aging. Nutrition is a key factor influencing skin health and consequently
its appearance. A wide range of dietary supplements is offered to improve skin
health. Collagen peptides are used as a bioactive ingredient in nutricosmetic
products and have been shown in preclinical studies to improve skin barrier
function, to induce the synthesis of collagen and hyaluronic acid, and to
promote fibroblast growth and migration ... Oral collagen peptide
supplementation significantly increased skin hydration after 8 weeks of intake.
The collagen density in the dermis significantly increased and the fragmentation
of the dermal collagen network significantly decreased already after 4 weeks of
supplementation. Both effects persisted after 12 weeks. Ex vivo experiments
demonstrated that collagen peptides induce collagen as well as glycosaminoglycan
production, offering a mechanistic explanation for the observed clinical
effects" - [Nutra
USA] - See Protein Essentials Hydrolyzed Collagen Protein Powder with Peptan® (16oz)
at Amazon.com
. It's
the Rousselot Peptan collagen brand talked about in the
Nutra USA article. See their websites:
Rousselot Peptan collagen website and
Protein
Essentials.
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Oral Intake
of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases
Dermal Matrix Synthesis - Skin Pharmacol Physiol. 2013 Dec 24;27(3):113-119
- "In this double-blind, placebo-controlled study, the effectiveness of the
specific bioactive collagen peptide (BCP) VERISOL® on eye wrinkle formation and
stimulation of procollagen I, elastin and fibrillin biosynthesis in the skin was
assessed. A hundred and fourteen women aged 45-65 years were randomized to
receive 2.5 g of BCP or placebo, once daily for 8 weeks, with 57 subjects being
allocated to each treatment group ... The ingestion of the specific BCP used in
this study promoted a statistically significant reduction of eye wrinkle volume
(p < 0.05) in comparison to the placebo group after 4 and 8 weeks (20%) of
intake. Moreover a positive long-lasting effect was observed 4 weeks after the
last BCP administration (p < 0.05). Additionally, after 8 weeks of intake a
statistically significantly higher content of procollagen type I (65%) and
elastin (18%) in the BCP-treated volunteers compared to the placebo-treated
patients was detected" - See
Verisol at Amazon.com
.
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