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Home > Anti-aging Research > Chrysin.
News & Research:
- Chrysin: Is It An
Effective Aromatase Inhibitor? - vrp.com - "Unfortunately, there does not
appear to be any effective natural inhibitor of aromatase"
Testosterone Naturally - Life Extension Magazine, 1/00 -
"chrysin and 10 other flavonoids were compared to an aromatase-inhibiting drug (aminoglutethimide). The study tested the aromatase-inhibiting effects of these natural flavonoids (such as genistein, rutin, tea
catechins, etc.) in human fat cell cultures. Chrysin was the most potent aromatase-inhibitor, and was shown to be similar in potency and effectiveness to the aromatase-inhibiting drug ... Chrysin, for example, is a potent antioxidant that possesses vitamin-like effects in the body ... Chrysin was shown to produce
anti-anxiety effects comparable with diazepam, but without sedation and muscle relaxation. In other words, chrysin produced a relaxing effect in the brain, but with no impairment of motor activity ... chrysin can reduce anxiety without inducing the common side-effects associated with benzodiazepine drugs ... chrysin
displayed potent anti-anxiety effects in rats, but did not interfere with cognitive performance ... chrysin selectively inhibits anxiety in the brain but, unlike diazepam, does not induce the cognitive impairment ... Chrysin may therefore offer libido-enhancing effects in the aging male by: Increasing free
testosterone, - Decreasing excess estrogen, - Producing a safe anti-anxiety effect"
Hormone Modulation Therapy - Life Extension Magazine, 11/99
- Monthly Updates - Hair Loss Research, 10/01 -
"While finasteride (Propecia/Proscar) decreases serum DHT,
it also is thought to increase estrogen which suggests that men over 35 may want to consider using it in conjunction with a systemic aromatase inhibitor such as Chrysin/Piperine
(Super Miraforte), Arimidex,
or stinging nettle extract, to maximize its hair growth effects and minimize potential side effects (that are listed in the PDR)
such as Gynocaemastia (breast enlargement in males), sexual side effects, and an increase in fat deposition. These compounds have been reliably shown to increase
testosterone and reduce excess estrogen, resulting in a youthful hormone profile that optimizes immune function and to some degree, body composition"
Suppresses IL-6-Induced Angiogenesis via Down-regulation of JAK1/STAT3 and
VEGF: An in Vitro and in Ovo Approach - J Agric Food Chem. 2010 May 5 -
"Chrysin may provide new therapeutic potential for
IL-6-induced pathological angiogenesis"
Chrysin sensitizes tumor necrosis factor-alpha-induced apoptosis in human
tumor cells via suppression of nuclear factor-kappaB - Cancer Lett. 2010
Feb 2 - "In the present study, we found that,
pretreatment with chrysin greatly sensitized various human cancer cells to
tumor necrosis factor-alpha (TNFalpha)-induced apoptosis"
Inhibition of aromatase activity by flavonoids - Arch Pharm Res. 1999 Jun;22(3):309-12
- Flavonoid inhibition of aromatase enzyme activity in human preadipocytes - J Steroid Biochem Mol Biol. 1993 Sep;46(3):381-8 -
"Chrysin, the most
potent of the naturally-occurring flavonoids, was similar in potency and effectiveness to AG, a pharmaceutical aromatase inhibitor used clinically in cases of estrogen-dependent carcinoma."
- Inhibition of human estrogen synthetase (aromatase) by flavones - Science. 1984 Sep 7;225(4666):1032-4 -
"7,8-Benzoflavone and chrysin were
potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450"