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Anti-aging Research > Cayenne/Capsicum (Capsicum frutescens).
Cayenne/Capsicum (Capsicum frutescens)
News & Research:
molecule inhibits growth of breast cancer cells - Science Daily, 12/21/16 -
"The researchers activated the TRPV1 receptor in the
cell culture with capsaicin or helional, by adding the substances to the culture
for a period of several hours or days. As a result, the cancer cells divided
more slowly. Moreover, the treatment caused tumour cells to die in larger
numbers. The surviving cells were no longer able to move as quickly as
heretofore; this implies that their ability to form metastases in the body was
impeded ... If we could switch on the TRPV1 receptor with specific drugs, this
might constitute a new treatment approach for this type of cancer" - See
capsaicin supplements at Amazon.com.
pepper compound could help hearts - Science Daily, 3/27/12 -
"The team found, for instance, that capsaicin and a
close chemical relative boost heart health in two ways. They lower cholesterol
levels by reducing accumulation of cholesterol in the body and increasing its
breakdown and excretion in the feces. They also block action of a gene that
makes arteries contract, restricting the flow of blood to the heart and other
organs. The blocking action allows more blood to flow through blood vessels"
peppers may come with blood pressure benefits - Science Daily, 8/3/10 -
"We found that long-term dietary consumption of
capsaicin, one of the most abundant components in chili peppers, could reduce
blood pressure in genetically hypertensive rats"
evidence that chili pepper ingredient fights fat - Science Daily, 6/2/10
- "The capsaicin-treated rats lost 8 percent of
their body weight and showed changes in levels of at least 20 key proteins
found in fat. The altered proteins work to break down fats. "These changes
provide valuable new molecular insights into the mechanism of the
antiobesity effects of capsaicin,""
Chilli extract may prevent obesity complications: Study - Nutra USA,
natural pain relievers - MSNBC, 9/14/08 -
"Capsaicin: For arthritis, shingles, or neuropathy ... InflaThera or
Zyflamend: For arthritis ... Aquamin: For osteoarthritis ... SAM-e (S
adenosylmethionine): For osteoarthritis ... Fish oil: For joint pain from
arthritis or autoimmune disorders ... Methylsulfonyl-methane (MSM): For
Fiery Pepper Fatal for Fat Cells? - WebMD, 3/6/07
Pepper: Hot Stuff For Fighting Fat? - Science Daily, 3/5/07
3 Herbal Medicines
May Ease Back Pain - WebMD, 4/18/06 -
"A 60-milligram daily dose of devil's claw also appeared to
cut back pain as much as a 12.5-milligram daily dose of Vioxx, a painkiller
no longer on the market due to a rise in the risk of cardiovascular events
-- such as heart attack and stroke -- in some patients"
Pepper Component Hot Enough To Trigger Suicide In Prostate Cancer Cells
- Science Daily, 3/19/06 - "Capsaicin induced approximately
80 percent of prostate cancer cells growing in mice to follow the molecular
pathways leading to apoptosis. Prostate cancer tumors treated with capsaicin
were about one-fifth the size of tumors in non-treated mice"
Spicy Spin on Treating Prostate Cancer - WebMD, 3/15/06 -
"Capsaicin prompted cancer cells to die and curbed tumor
growth ... Capsaicin was also linked to lower levels of prostate specific
Pepper extract could stop prostate cancer growth - Nutra USA, 3/15/06 -
"capsaicin has a profound inhibiting effect on the growth
of prostate cancer cells in vitro and in vivo , inducing apoptosis
[programmed cell death] of prostate cancer cell lines"
Fiery Hot Therapy
Improves Asthma - WebMD, 5/25/04
Topical Capsaicin Confers Moderate to Poor Pain Reduction for Neuropathic
and Musculoskeletal Disorders - Doctor's Guide, 3/23/04
- Capsaicin Patch Eases
Postherpetic Neuralgia Pain
- Medscape, 4/3/03
Women Rate Capsaicin Pain Stimulus as More Intense than Men
- Doctor's Guide, 8/22/02
Topical Capsaicin 0.075 Percent Best Choice For Double Blinded Studies
- Doctor's Guide, 8/21/02
Cayenne Is A Hot Therapeutic Ticket - Functional Foods & Nutraceuticals,
Capsaicinoids Supplementation Reduces Appetite and Body Circumferences in
Healthy Men and Women A Placebo Controlled Randomized Double Blind Study
- The FASEB Journal Mar 2016 - "randomly assigned by
fat mass to ingest either CAP (2mg CAP, CX1 or 4mg CAP, CX2 [CX, Capsimax®,
OmniActive Health Technologies Ltd.]) or placebo (corn starch, PLA) for 12
weeks ... baseline (T1), 6 weeks (T2) and 12 weeks (T3) ... Waist: hip ratio
measurements showed a main effect for time (p = 0.034) with post-hoc tests
revealing a significant (p = 0.024) decrease in CX1 from T1 to T2. Appetite
questionnaire responses indicated a significant main effect for time from T1
to T2 (p = 0.004) and T1 to T3 (p = 0.001) suggesting supplementation of CAP
reduced appetite" - [Nutra
USA] - See Capsimax® at Amazon.com.
Synergistic anti-cancer activity of Capsaicin and 3,3'-Diindolylmethane in
human colorectal cancer - J Agric Food Chem. 2015 Apr 15 -
"The present study suggests capsaicin and DIM work
synergistically to inhibit cell proliferation and induce apoptosis in
colorectal cancer through modulating transcriptional activity of NF-κB, p53
and target genes associated with apoptosis" - See
capsaicin supplements at Amazon.com
diindolylmethane at Amazon.com.
Dietary Capsaicin Ameliorates Pressure Overload-Induced Cardiac Hypertrophy
and Fibrosis Through the Transient Receptor Potential Vanilloid Type 1 -
Am J Hypertens. 2014 May 23 - "Dietary capsaicin
plays a protective role in hypertension, atherosclerosis, obesity, and
hyperlipidemia through activating the transient receptor potential vanilloid
type 1 (TRPV1), a nonselective cation channel ... Our results suggest that
dietary capsaicin protects against cardiac hypertrophy and fibrosis in
pressure overload mice through TRPV1"
Antitumor Activity of Capsaicin on Human Colon Cancer Cells in Vitro and
Colo 205 Tumor Xenografts in Vivo - J Agric Food Chem. 2010 Nov 17 -
"capsaicin induced cytotoxic effects in a time- and
dose-dependent manner and increased reactive oxygen species (ROS) and Ca(2+)
but decreased the level of mitochondrial membrane potential (ΔΨ(m)) in colo
205 cells. Data from Western blotting analysis indicated that the levels of
Fas, cytochrome c, and caspases were increased, leading to cell apoptosis.
Capsaicin decreased the levels of anti-apoptotic proteins such as Bcl-2 and
increased the levels of pro-apoptotic proteins such as Bax.
Capsaicin-induced apoptosis in colo 205 cells was also done through the
activations of caspase-8, -9 and -3. In vivo studies in immunodeficient
nu/nu mice bearing colo 205 tumor xenografts showed that capsaicin
effectively inhibited tumor growth. The potent in vitro and in vivo
antitumor activities of capsaicin suggest that capsaicin might be developed
for the treatment of human colon cancer"
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