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Anti-aging Research > Branched-Change Amino Acids (BCAA}
Branched-Change Amino Acids (BCAA)
Specific Recommendations:
News & Research:
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Amino acid-rich supplements boost muscle mass with exercise - Nutra USA,
11/8/11 - "Supplements containing a combination of amino acids and protein
before and after resistance training may boost upper body strength by 13% ...
The commercial supplements NO-Shotgun and NO-Synthesize by VPX were also
associated with a 21% increase in lower-body strength ... The commercial
supplements contain a list of ingredients including creatine, arginine,
glutamine, beta-alanine, keto-isocaproate (KIC), and leucine, casein and whey
protein, branched-chain amino acids, lysine, phenylalanine, threonine, histidine,
and methionine ... the primary active ingredients are whey protein, creatine,
leucine, beta-alanine, and KIC" - [Abstract] - See VPX Sports products at iHerb
.
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The effects
of branched-chain amino acid granules on the accumulation of tissue
triglycerides and uncoupling proteins in diet-induced obese mice - Endocr J.
2011 Mar 1 - "It has been demonstrated the involvement of branched-chain amino
acids (BCAA) on obesity and related metabolic disorder. We investigated the
effects of branched-chain amino acids (BCAA) on obesity and on glucose/fat
homeostasis in mice fed on a high-fat (45%) diet. BCAA was dissolved in 0.5%
methylcellulose and added to the drinking water (BCAA-treated group). A high-fat
diet was provided for 6 weeks and BCAA was given for 2 weeks. The BCAA-treated
group gained almost 7% less body weight and had less epididymal adipose tissue
(WAT) mass than the control group (p<0.05). BCAA supplementation also reduced
the hepatic and skeletal muscle triglyceride (TG) concentrations (p<0.05). The
hepatic levels of PPAR-alpha and uncoupling protein (UCP) 2, and the level of
PPAR-alpha and UCP3 in the skeletal muscle were greater in the BCAA-treated
group than in the control mice (p<0.05). These results demonstrate that the
liver and muscle TG concentration are less in BCAA-treated group. BCAA affects
PPAR-alpha and UCP expression in muscle and liver tissue"
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Amino
acid supplement makes mice live longer - Science Daily, 10/5/10 -
"leucine,
isoleucine, and valine extend the life span of single-celled yeast ... Animals
that were given the extra amino acids over a period of months lived longer, with
a median life span of 869 days compared to 774 days for untreated control
animals, the researchers report. That's an increase of 12 percent ... The
findings in older mice suggest that the supplementary mixture may be
specifically beneficial for those who are elderly or ill"
Abstracts:
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A
multi-nutrient supplement reduced markers of inflammation and improved physical
performance in active individuals of middle to older age: a randomized,
double-blind, placebo-controlled study - Nutr J. 2011 Sep 7;10(1):90 -
"While exercise acts to combat inflammation and aging, the ability to exercise
may itself be compromised by inflammation and inflammation's impact on muscle
recovery and joint inflammation. A number of nutritional supplements have been
shown to reduce inflammation and improve recovery. The purpose of the current
investigation was to examine the effect of a multi-nutrient supplement
containing branched chain amino acids, taurine, anti-inflammatory plant
extracts, and B vitamins on inflammatory status, endothelial function, physical
function, and mood in middle-aged individuals ...Thirty-one healthy and active
men (N=16, mean age 56+/-6.0 yrs) and women (N=15, mean age=52+/-7.5 yrs)
participated in this investigation. Subjects completed one 28 day cycle of
placebo supplementation and one 28 day cycle of multi-nutrient supplementation
(separated by a one week washout period) in a balanced, randomized,
double-blind, cross-over design ... IL-6 significantly decreased in both men
(from 1.2 +/- 0.2 to 0.7+/-0.4 pg * mL-1) and women (from 1.16+/-0.04 to
0.7+/-0.4 pg * mL-1). Perceived energy also improved for both men (placebo: 1.8
+/- 0.7; supplement: 3.7+/-0.8 AUC) and women (placebo: 1.2 +/- 0.7; supplement:
2.8+/-0.8 AUC). Alpha-1-antichymotrypsin (from 108.9+/-38.6 to 55.5+/-22.2 ug *
mL-1), Creatine Kinase (from 96+/-34 to 67+/-23 IU * L-1), general pain, and
joint pain decreased in men only, while anxiety and balance (from 0.52+/-0.13 to
0.45+/-0.12 cm) improved in women only. Men showed increased performance in
vertical jump power (from 2642+/-244 to 3134+/-282 W) and grip strength (from
42.1+/-5.9 to 48.5+/-4.9 kg)" - See
taurine products at iHerb
and
branched-chain amino acid products at iHerb.
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Effect of
essential amino acid supplementation on quality of life, Amino acid profile and
strength in institutionalized elderly patients - Clin Nutr. 2011 May 31 -
"Oral supplementation with essential amino acids improved several determinants
of quality of life in institutionalized elderly patients, including depressive
symptoms, nutrition, muscle function and daily life activity"
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Dietary L-Arginine
Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle and Brown
Fat Masses in Diet-Induced Obese Rats - J Nutr. 2008 Dec 23 -
"l-arginine-HCl
... Despite similar energy intake, absolute weights of white fat pads increased
by 98% in control rats over a 12-wk period but only by 35% in arginine-supplemented
rats. The arginine treatment reduced the relative weights of white fat pads by
30% and enhanced those of soleus muscle by 13%, extensor digitorum longus muscle
by 11%, and brown fat by 34% compared with control rats ... arginine treatment
resulted in lower serum concentrations of leptin, glucose, triglycerides, urea,
glutamine, and branched-chain amino acids, higher serum concentrations of
nitric-oxide metabolites, and improvement in glucose tolerance. Thus, dietary
arginine supplementation shifts nutrient partitioning to promote muscle over fat
gain and may provide a useful treatment for improving the metabolic profile and
reducing body white fat in diet-induced obese rats" - See
Jarrow Formulas, Arginine 1000, 1000 mg, 100 Easy-Solv Tablets
at iHerb.
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Proline- and
acidic amino acid-rich basic leucine zipper proteins modulate peroxisome
proliferator-activated receptor {alpha} (PPAR{alpha}) activity - Proc Natl
Acad Sci U S A. 2011 Mar 7 - "In mammals, many aspects
of metabolism are under circadian control. At least in part, this regulation is
achieved by core-clock or clock-controlled transcription factors whose abundance
and/or activity oscillate during the day. The clock-controlled proline- and
acidic amino acid-rich domain basic leucine zipper proteins D-site-binding
protein, thyrotroph embryonic factor, and hepatic leukemia factor have
previously been shown to participate in the circadian control of xenobiotic
detoxification in liver and other peripheral organs. Here we present genetic and
biochemical evidence that the three proline- and acidic amino acid-rich basic
leucine zipper proteins also play a key role in circadian lipid metabolism by
influencing the rhythmic expression and activity of the nuclear receptor
peroxisome proliferator-activated receptor α (PPARα). Our results suggest that,
in liver, D-site-binding protein, hepatic leukemia factor, and thyrotroph
embryonic factor contribute to the circadian transcription of genes specifying
acyl-CoA thioesterases, leading to a cyclic release of fatty acids from
thioesters. In turn, the fatty acids act as ligands for PPARα, and the activated
PPARα receptor then stimulates the transcription of genes encoding proteins
involved in the uptake and/or metabolism of lipids, cholesterol, and glucose
metabolism"
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