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Home > Health Conditions > ApoB.

ApoB (apolipoprotein B)

Alternative News:

Effect of a traditional Mediterranean diet on apolipoproteins B, A-I, and their ratio: A randomized, controlled trial - Atherosclerosis. 2011 May 6 - "Apolipoprotein (Apo)B, ApoA-I, and their ratio could predict coronary heart disease (CHD) risk more accurately than conventional lipid measurements. Our aim was to assess the effect of a traditional Mediterranean diet (TMD) on apolipoproteins ... Participants assigned to a low-fat diet (control) (n=177), or TMDs (TMD+virgin olive oil (VOO), n=181 or TMD+nuts, n=193) received nutritional education and either free VOO (ad libitum) or nuts (dose: 30g/day). A 3-month evaluation was performed ... Both TMDs promoted beneficial changes on classical cardiovascular risk factors. ApoA-I increased, and ApoB and ApoB/ApoA-I ratio decreased after TMD+VOO, the changes promoting a lower cardiometabolic risk. Changes in TMD+VOO versus low-fat diet were -2.9mg/dL (95% CI, -5.6 to -0.08), 3.3mg/dL (95% CI, 0.84 to 5.8), and -0.03mg/dL (-0.05 to -0.01) for ApoB, ApoA-I, and ApoB/ApoA-I ratio, respectively ... Individuals at high-cardiovascular risk who improved their diet toward a TMD pattern rich in virgin olive oil, reduced their Apo B and ApoB/ApoA-I ratio and improved ApoA-I concentrations" - The question is; is it the polyphenols or the omega-9 or both in the virgin olive oil responsible for the benefit? See olive Leaf extracts at iHerb.
Combination of niacin extended-release and simvastatin results in a less atherogenic lipid profile than atorvastatin monotherapy - Vasc Health Risk Manag. 2010 Nov 24;6:1065-75 - "niacin extended-release + simvastatin (NER/S) ... NER/S treatment significantly improved apo A-I levels and the apo B:A-I ratio, significantly lowered the number of atherogenic LDL particles and VLDL and chylomicron particles, and increased the mean size of LDL and VLDL particles, compared with atorvastatin" - See Twinlab niacin 1000mg at iHerb.
Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells - Lipids Health Dis. 2008 Oct 17;7(1):38 - "Higher concentrations of serum lipids and apolipoprotein B100 (apoB) are major individual risk factors of atherosclerosis and coronary heart disease ... The results demonstrated that an addition of taurine to the culture media reduces triacylglycerol (TG)-mass in the cells and the medium. Similarly, cellular cholesterol-mass was decreased. Taurine inhibited the incorporation of [14C] oleate into cellular and medium TG, suggesting the inhibition of TG synthesis. In addition, taurine reduced the synthesis of cellular cholesterol ester and its secretion, suggesting the inhibition of acyl-coenzyme A:cholesterol acyltransferase activity. Furthermore, taurine reduced the secretion of apoB, which is a major protein component of very low-density lipoprotein ... This is a first report to demonstrate that taurine inhibits the secretion of apoB from HepG2 cells" - See taurine products at iHerb.
Omega-3 fatty acid containing diets decrease plasma triglyceride concentrations in mice by reducing endogenous triglyceride synthesis and enhancing the blood clearance of triglyceride-rich particles - Clin Nutr. 2008 Mar 22 - "Levels of hepatic TG and apoB synthesis were 30-50% and 42% lower in mice fed with the fish oil diet compared to the other three diets. In addition, compared to soy oil diet, fish oil feeding significantly increased blood clearance of chylomicron-like lipid emulsions by 21-26%" - See Mega Twin EPA at iHerb.
Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters - Biochem Biophys Res Commun. 2007 Dec 28 - "The concentrations of serum total cholesterol and triglyceride were significantly lower in the resveratrol-fed group than in the control group. The resveratrol contained diet significantly decreased Apo B, Lp(a), and cholesterol-ester-transport protein (CETP) concentrations, but increased Apo A-I levels and the Apo A-I/Apo B ratio. The contents of cholesterol and triglyceride in hepatic tissue were significantly lower in the resveratrol group than in the control group. Real-time PCR analysis revealed that HMGR mRNA expression was significantly lower in the resveratrol group than in the control group" - See Jarrow Resveratrol 100 at iHerb.
Broccoli compound identified for heart benefits - Nutra USA, 10/3/07 - "the indole-based compound, indole-3-carbinol, was able to reduce the secretion of apolipoprotein B-100 (apoB) by 56 per cent, and thereby confer cardiovascular benefits" - See I3C products at iHerb.
Novel Dietary Supplement [Sytrinol™] Shows Dramatic Effects in Lowering Cholesterol, LDL, and Triglycerides - Life Extension Magazine, 11/04 - "those with the highest ratios of apolipoprotein B to apolipoprotein A were at the greatest risk of dying from a heart attack ... treatment with Sytrinol™ substantially cut levels of plasma total cholesterol (-20%), LDL (-22%), apolipoprotein B (-21%), and triglycerides (-28%). Additionally, subjects in the second trial benefited from a significant 5% increase in apolipoprotein A1, an important structural protein of HDL" - See Sytrinol products at iHerb.
Fish Oil May Augment Atorvastatin As Treatment For Dyslipidemia In Obese, Insulin-Resistant Men - Doctor's Guide, 8/7/02 - "fish oils significantly decreased plasma levels of triglycerides and very low density lipoprotein-apoB, decreased the very low density lipoprotein-apoB secretion rate" - See TwinLab TwinEPA at iHerb and Vitacost.
Randomized controlled trial of the effect of n–3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity1 - Am. J. of Clin. Nutr., 2/03 - "Fish oil supplementation significantly (P < 0.05) lowered plasma concentrations of triacylglycerols (-18%) and VLDL apo B (-20%) and the hepatic secretion of VLDL apo B (-29%) compared with placebo" - Doing the math, 45% of 4 grams equals 1,800 mg of EPA, 39% of 4 grams equals 1,560 mg of DHA.

Other News:

ApoB/apoA-I ratio is better than LDL-C in detecting cardiovascular risk - Nutr Metab Cardiovasc Dis. 2010 Feb 18 - "An unfavourable apoB/apoA-I (>/=0.9 for males and >/=0.8 for females) was present in 13.9% of 108 patients with LDL-C <100mg/dL: compared to subjects with lower apoB/apoA-I (<0.9 for males and <0.8 for females), they had more elements of MetS and their lipid profile strongly correlated with high CV risk. Out of 314 patients with lower apoB/apoA-I, 40.12% had LDL-C >/=130mg/dL: these retained a more favourable lipid profile than corresponding subjects with elevated apoB/apoA-I ratio. Finally, we found a significant correlation between LDL-C and apoB/apoA-I ratio (r=0.48, p<0.0001). CONCLUSIONS: In NGT with LDL-C <100mg/dL, a higher apoB/apoA-I exhibited an atherogenic lipid profile, indicating that LDL-C alone is insufficient to define CV risk. Independent from LDL-level, when apoB/apoA-I is lower, the lipid profile is, in fact, less atherogenic. This study demonstrates that apoB/apoA-I is at least complementary to LDL-C in identifying the "effective" CV risk profile of asymptomatic NGT subjects"
High apoB/apoA-I ratio is associated with increased progression rate of carotid artery intima-media thickness in clinically healthy 58-year-old men: Experiences from very long-term follow-up in the AIR study - Atherosclerosis. 2008 Dec 3 - "The results indicate that apoB/apoA-I ratio is an important risk factor for predicting atherosclerotic progression rate during very long-term follow-up in clinically healthy middle-aged men"
Cholesterol Testing Not Enough for Some - WebMD, 3/27/08 - "once LDL cholesterol is lowered to recommended levels in high-risk patients, testing for the protein ApoB may more accurately identify those still at risk for cardiovascular events"
HDL cholesterol and large HDL particles not cardioprotective when adjusted for apoA-1 and apoB - theheart.org, 2/4/08
Improving The Assessment Of Coronary Heart Disease Risk In Chinese - Science Daily, 10/12/07 - "the risk of developing coronary heart disease was more than three times as high in participants with the highest values of both apolipoprotein B and the ratio of the total cholesterol over HDL-C than patients who did not have the disease"
ApoB/apoA-I ratio: an independent predictor of insulin resistance in US non-diabetic subjects - Eur Heart J. 2007 Sep 1 - "In the US population, apoB/apoAI ratio is significantly associated with insulin resistance in non-diabetic subjects"
The apo B/A-I Ratio -- A Stronger Predictor of Cardiovascular Events Than LDL, HDL, or Total Cholesterol, Triglycerides, or Lipid Ratios - Medscape, 7/28/06 - "the predictive power of the apo B/A-I ratio is superior to, and cannot be improved by adding, any other lipid parameter or ratio"
Rosuvastatin Provides Better Rates of Lipid Lowering Compared to Other Statins - Doctor's Guide, 10/27/04 - "switching to rosuvastatin from another statin agent helped more patients achieve primary treatment goals for low-density lipoprotein cholesterol (LDL-C) and secondary apolipoprotein (apo) B treatment goals in coronary heart disease (CHD) patients with high lipid levels"
Scientists Tout New Cholesterol Test - Intelihealth, 9/1/04 - "Globally, 50 percent of the risk of a heart attack is predicted by the apo B/apo A1 ratio"
Non-HDL Cholesterol and Apolipoprotein B Predict Cardiovascular Disease Events Among Men With Type 2 Diabetes - Diabetes Care. 2004 Aug;27(8):1991-7 - "Non-HDL cholesterol and apoB are more potent predictors of CVD incidence among diabetic men than LDL cholesterol. Statistically, the ratio of total to HDL cholesterol is the best predictor of CVD in this cohort of diabetic men"
Bad Cholesterol, Worst Cholesterol - WebMD, 10/28/03
Rosuvastatin Improves Apolipoprotein Levels - Doctor's Guide, 10/1/03
FDA Approves New Lescol Indication To Reduce Triglycerides And Apo B - Doctor's Guide, 3/9/99