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Home > Anti-aging Research > ApoA-I.
Apolipoprotein A-I (ApoA-I) & ApoA-1 Milano
Related Topics:
CME:
News & Research:
-
HDL cholesterol and
large HDL particles not cardioprotective when adjusted for apoA-1 and apoB -
theheart.org, 2/4/08
-
Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters
- Biochem Biophys Res Commun. 2007 Dec 28 - "The
concentrations of serum total cholesterol and triglyceride were significantly
lower in the resveratrol-fed group than in the control group. The resveratrol
contained diet significantly decreased Apo B, Lp(a), and
cholesterol-ester-transport protein (CETP) concentrations, but increased Apo A-I
levels and the Apo A-I/Apo B ratio. The contents of cholesterol and triglyceride
in hepatic tissue were significantly lower in the resveratrol group than in the
control group. Real-time PCR analysis revealed that HMGR mRNA expression was
significantly lower in the resveratrol group than in the control group" -
See
Jarrow Resveratrol 100 at iHerb
 .
-
Vitamin E dietary supplementation significantly affects multiple risk factors
for cardiovascular disease in baboons - Am J Clin Nutr. 2007
Sep;86(3):597-603 - "vitamin E caused 2 paradoxical
effects on HDL metabolism: higher apolipoprotein A-I (apo A-I) concentrations
and lower HDL sizes ... They also show 2 apparently paradoxical effects on HDL
metabolism: lower HDL(2), which is mediated by genes, and higher apo A-I, which
is not. These effects have contrasting associations with CVD risk and may help
account for the mixed results from clinical trials of dietary vitamin E"
-
ApoB/apoA-I ratio: an independent predictor of insulin resistance in US
non-diabetic subjects - Eur Heart J. 2007 Sep 1 -
"In the US population, apoB/apoAI ratio is significantly associated with insulin
resistance in non-diabetic subjects"
-
HDL Levels and
Particle Size: Does Size Matter at Both Ends of the Scale? - Medscape,
8/7/07 - "very large HDL particles would be
associated with an increased risk for coronary artery disease ... These data
suggest that very large HDL particles no longer seem to confer protection
against cardiovascular disease, at least when levels of apoA-1 and apoB are
kept constant, but this lack of protection does not seem to hold true for
apoA-1"
-
Low vitamin D levels may increase metabolic syndrome risk - Nutra USA,
7/17/07 - "The most relevant finding in our study
was the association of vitamin D concentrations with lipid levels. Our
results are in concordance with the concept that vitamin D appears to be
necessary to maintain adequate apolipoprotein A-I concentrations, the main
component of HDL cholesterol"
- [Abstract]
- See
vitamin D products at iHerb.
-
Blood Protein Ups Heart Risk - WebMD, 9/19/06
- The
apo B/A-I Ratio -- A Stronger Predictor of Cardiovascular Events Than LDL,
HDL, or Total Cholesterol, Triglycerides, or Lipid Ratios - Medscape,
7/28/06 - "the predictive power of
the apo B/A-I ratio is superior to, and cannot be improved by adding, any
other lipid parameter or ratio"
-
Novel
Dietary Supplement [Sytrinol™] Shows Dramatic Effects in Lowering Cholesterol, LDL, and Triglycerides - Life Extension Magazine, 11/04 -
"those with the highest ratios of apolipoprotein B to apolipoprotein A were at the greatest risk of dying from a
heart attack" - See
Sytrinol products at iHerb
 .
- Scientists Tout New Cholesterol Test - Intelihealth, 9/1/04 -
"Globally, 50 percent of the risk of a heart attack is predicted by the apo B/apo A1 ratio"
- Raising HDL in Clinical Practice - Medscape, 6/10/04 -
"The HDL particle is actually a protein complex consisting of several apolipoproteins, including ... apoA-I, which is abundant in all HDL particles"
- New Way to Unclog Arteries? - Dr. Weil, 1/19/04
- Genetically Engineered Molecule May Unclog Arteries - Physician's Weekly, 12/1/03
- Milano Apolipoprotein: A Newsmaker Interview With Steven E. Nissen, MD - Medscape, 11/11/03
- Simvastatin Increases HDL-C And Apo A-I More Than Atorvastatin in Patients With Hypercholesterolemia - Doctor's Guide, 11/10/03 -
"Simvastatin
appears to increase high-density lipoprotein cholesterol (HDL-C) and apolipoprotein (apo) A-I significantly more than does atorvastatin in patients with hypercholesterolaemia ... Liver toxicity occurred in significantly fewer patients treated with simvastatin
compared to atorvastatin"
- ‘Liquid Drano’ for the arteries - MSNBC, 11/4/03 - Note: The article calls it "HDL" but I believe they are referring to the synthetic version of ApoA-I. See the next article.
- Potential Heart Disease Breakthrough - WebMD, 11/4/03 -
"It's called ApoA-I Milano ... a genetically engineered version of this "good" HDL cholesterol protein has been tested
in a small human trial ... The findings exceed even the most optimistic expectations ... In five weeks, patients treated with ApoAI Milano had about a 4% decrease in plaque volume. That's 10 times greater reduction than ever seen before"
- Rosuvastatin Improves Apolipoprotein Levels - Doctor's Guide, 10/1/03
- Cholesterol Carriers May Offer Predict Second Heart Attack More Accurately - Doctor's Guide, 5/17/99 -
"ApoA-1 and apo B carry cholesterol in the bloodstream. Apo B is a cholesterol donor, while apoA-1
is a cholesterol scavenger"
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