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Home > Anti-aging Research > Adiponectin.

Adiponectin

Specific Recommendations:

• Thiazolidinediones
• Micardis (telmisartan)

News & Research:

• Adiponectin definition - Medterms.com - "Low levels of adiponectin are found in people who are obese (and who are at increased risk of a heart attack)"
• Adiponectin Levels Indicative of Diabetes Risk - Medscape, 4/29/08 - "Baseline levels of adiponectin are inversely related to diabetes risk in subjects at high risk for developing the condition"
• Fat Hormone May Contribute To Longevity - Science Daily, 11/21/07 - "long-lived Snell dwarf mice burn less glucose and more fatty acids during periods of fasting, and as a result produce fewer free radicals ... The key to this switch may be adiponectin, a hormone produced by fat cells that helps lower glucose production and stimulates cells to use fat for energy instead. The researchers found that Snell mice had three times as much adiponectin in their blood as control mice" - Something that was also in today's abstracts (see below) was pioglitazone, which increased adiponectin 156%.
• Key Hormone Protects Obese Mice From Diabetes - WebMD, 8/23/07 - "The high levels of adiponectin, however, made the mice physiologically skinny ... This discovery also suggests that in people who have low adiponectin levels fat cells don't send the signal that they're ready to accept fat, Dr. Scherer said. Instead, the fat is stored in dangerous places -- liver, heart and muscle tissues -- where it can cause inflammation and pave the way for disease"
• Pioglitazone Treatment Increases Concentrations of Adiponectin in Plasma - Doctor's Guide, 11/16/06 - "Results showed there was a 6.9 mcg/mL mean increase in adiponectin levels in the pioglitazone group while in non-pioglitazone patients it decreased by 0.42 mcg/mL"
• Adiponectin Level Found to be Independent Risk Factor for Endometrial Cancer - Doctor's Guide, 3/34/05 - "The investigators found that mean serum adiponectin levels were significantly lower among patients with endometrial cancer than among controls"

Abstracts:

• Telmisartan treatment decreases visceral fat accumulation and improves serum levels of adiponectin and vascular inflammation markers in Japanese hypertensive patients - Hypertens Res. 2007 Dec;30(12):1205-10 - "telmisartan treatment was associated with an improvement of vascular inflammation, reductions in visceral fat and increases in serum adiponectin"
• Peroxisome Proliferator-Activated Receptor gamma agonism modifies the effects of growth hormone on lipolysis and insulin sensitivity - Clin Endocrinol (Oxf). 2008 Mar 10 - "Adiponectin levels almost doubled during pioglitazone treatment " - See pioglitazone at OffshoreRX.com.
• Low Adiponectin Levels are Associated with Atherogenic Dyslipidemia and Lipid-Rich Plaque in Non-Diabetic Coronary Arteries - Br J Nutr. 2008 Feb 6;:1-8 - "Low adiponectin levels are associated with atherogenic lipoproteins (elevated triglycerides, small dense LDL cholesterol, low HDL cholesterol), increased plaque volume, lipid-rich plaque, and ID-pathological intimal thickening in the total cohort which was driven by the non-diabetic population, suggesting an anti-atherogenic role in the early stages of lesion development"
• Effect of green tea on kidney tubules of diabetic rats - Br J Nutr. 2008 Feb 6;:1-8 - "It has been documented that green tea (GT) and its catechin components improve renal failure and inhibit the growth of mesangial cells ... GT treatment significantly (P < 0.01) reduced the serum glucose, glycosylated protein, serum creatinine and blood urea N levels by 29.6 (sem 3.7), 22.7 (sem 5.2), 38.9 (sem 10) and 41.7 (sem 1.9) %, respectively ... the GT-treated group showed a significant 44 (sem 10.8) % higher creatinine clearance (Ccr) ... GT reduced the urea N, creatinine, glucose and protein excretion rates by 30 (sem 7.6), 35.4 (sem 5.3), 34.0 (sem 5.3) and 46.0 (sem 13.0) % compared with the 12 weeks diabetic group. Administration of GT to 12 weeks diabetic rats significantly (P < 0.001) prevented (99.98 (sem 0.27) % less) the accumulation of glycogen in the kidney tubules. These results indicate that in STZ diabetes, kidney function appears to be improved with GT consumption which also prevents glycogen accumulation in the renal tubules, probably by lowering blood levels of glucose. Therefore, GT could be beneficial additional therapy in the management of diabetic nephropathy" - See Jarrow green tea at iHerb.
• Increased total and high-molecular weight adiponectin after extended-release niacin - Metabolism. 2008 Mar;57(3):404-9 - "at least part of the cardioprotective benefits of niacin may be attributed to a shift in the HMW/LMW adiponectin ratio in obese men with the metabolic syndrome"
• Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes Prevention Program - Diabetes. 2008 Jan 11 - "Adiponectin is a powerful marker of diabetes risk in subjects at high risk of diabetes, even after adjustment for weight. An increase in adiponectin in lifestyle and placebo was associated with a reduction in diabetes risk. However, these changes in adiponectin were comparatively small and less strongly related to diabetes outcome than baseline adiponectin levels"
• Coffee consumption is associated with higher plasma adiponectin concentrations in women with and without type 2 diabetes: a prospective cohort study - Diabetes Care. 2007 Dec 10 - "High consumption of caffeine-containing coffee is associated with higher adiponectin and lower inflammatory marker concentrations"
• Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats - Br J Nutr. 2007 Dec 7;:1-9 - "Lipoic acid profoundly decreased serum and liver concentrations of TAG, and also lowered serum concentrations of phospholipid and NEFA, and the concentration of cholesterol in the liver. A hypoglycaemic effect of this compound was also observed. Lipoic acid dose-dependently decreased the activity and mRNA levels of fatty acid synthase, ATP-citrate lyase, glucose 6-phosphate dehydrogenase, malic enzyme and pyruvate kinase in the liver despite that reductions were considerably attenuated in the NADPH-producing enzymes. This compound also dose-dependently lowered the mRNA levels of spot 14, adiponutrin, stearoyl-CoA desaturase 1, and Delta5- and Delta6-desaturases. In addition, lipoic acid dose-dependently lowered serum concentrations of insulin and leptin, but increased those of adiponectin. Lipoic acid appeared to reduce hepatic lipogenesis and hence decreases serum and liver lipid levels. Alterations in serum concentrations of insulin and (or) adiponectin may trigger this consequence" - See Doctor's Best, Best Stabilized R-Lipoic Acid Na-RALA at iHerb.
• Adiponectin, the controversial hormone - Public Health Nutr. 2007 Oct;10(10A):1145-50 - "Considering the anti-inflammatory properties of adiponectin and the fact that it is negatively associated with adiposity, this cytokine could be one of the links between obesity and inflammation. The main mechanisms of action of adiponectin are directed to a protective role against atherogenic and insulin resistance processes. Research has revealed interesting new functions far beyond metabolism, such as immunity, cancer and bone formation. Contrary to all adipose-related proteins, adiponectin decreases with obesity. Most of the contradictory data surrounding adiponectin are related to plasma values and their relationship with body fat, gender differences and insulin resistance"
• High-molecular weight adiponectin is independently associated with the extent of coronary artery disease in men - Atherosclerosis. 2007 Nov 14 - "HMW adiponectin and the HMW/total-adiponectin ratio inversely correlate with the extent of CAD. HMW adiponectin in particular seems to be a better marker for CAD extent than total adiponectin"
• Pioglitazone improves myocardial blood flow and glucose utilization in nondiabetic patients with combined hyperlipidemia a randomized, double-blind, placebo-controlled study - J Am Coll Cardiol. 2007 Nov 20;50(21):2051-8 - "myocardial glucose utilization (MGU) and blood flow (MBF) in nondiabetic patients with familial combined hyperlipidemia (FCHL) ... in the pioglitazone group HDL cholesterol (+28%; p = 0.003) and adiponectin (+156.2%; p = 0.0001) were increased and plasma insulin (-35%; p = 0.017) was reduced ... In patients with FCHL treated with conventional lipid-lowering therapy, the addition of pioglitazone led to significant improvements in MGU and MBF, with a favorable effect on blood lipid and metabolic parameters"
• Nutritional intervention to reduce the n-6/n-3 fatty acid ratio increases adiponectin concentration and fatty acid oxidation in healthy subjects - Eur J Clin Nutr. 2007 Aug 15 - "Dietary intervention was associated with significant reductions in TNF-alpha (baseline: 2.2 (s.d. 0.3), post-intervention: 1.5 (s.d. 0.3) pg/ml, P=0.01) and low-density lipoprotein-cholesterol (baseline: 2.5 (s.d. 0.2), post-intervention: 2.3 (s.d. 0.1) mmol/l, P=0.03) and increased adiponectin (baseline: 6.5 (s.d. 0.7), post-intervention: 7.6 (s.d. 0.6) mug/ml, P=0.02). Fasting lipid oxidation was increased (baseline: 0.7 (s.d. 0.1), post-intervention: 0.9 (s.d. 0.1) mg/kg.min, P=0.01), whereas glucose oxidation decreased in both fasting (baseline: 1.6 (s.d. 0.1), post-intervention: 1.3 (s.d. 0.1) mg/kg.min, P=0.02) and hyperinsulinaemic conditions (baseline: 3.6 (s.d. 0.1), post-intervention: 3.3 (s.d. 0.1) mg/kg.min, P=0.04). Insulin sensitivity was not affected by the intervention.  Conclusion:  A decreased n-6/n-3 PUFA ratio can be achieved with simple dietary counselling, resulting in multiple, potentially favourable effects on the metabolic and inflammatory profiles"
• The effect of thiazolidinediones on adiponectin serum level: a meta-analysis - Diabetes Obes Metab. 2007 Jul 21 - "The results clearly reveal an increase of endogenous serum adiponectin levels by intake of TZDs and may point to a potential new option to manage obesity-related diseases"
• Low serum adiponectin is associated with high circulating oxidized low-density lipoprotein in patients with type 2 diabetes mellitus and coronary artery disease - Metabolism. 2007 Jul;56(7):881-886 - "low adiponectin concentration indicates increased oxidative state in the arterial wall, which further supports previous data on the role of adipose tissue in atherogenesis"
• The Differential Effects of Angiotensin II Type 1 Receptor Blockers on Microalbuminuria in Relation to Low-Grade Inflammation in Metabolic Hypertensive Patients - Am J Hypertens. 2007 May;20(5):565-72 - "There was a significant increase in high molecular weight adiponectin in the telmisartan group ... The reductions of microalbuminuria and high-sensitivity C-reactive protein (hs-CRP) were significant in the telmisartan group"
• Adiponectin in health and disease - Diabetes Obes Metab. 2007 May;9(3):282-9 - "Adiponectin is an important adipokine because of its beneficial effects on glucose and lipid metabolism. Low levels of adiponectin are associated with disease states such as diabetes and cardiovascular disease ... Adiponectin levels in humans can be increased through indirect methods such as weight loss or treatment with thiazolidinediones"
• Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver - Biochem Biophys Res Commun. 2007 May 15 - "APN might protect against atherosclerosis by increasing HDL assembly through enhancing ABCA1 pathway and apoA-1 synthesis in the liver"
• Do low levels of circulating adiponectin represent a biomarker or just another risk factor for the metabolic syndrome? - Diabetes Obes Metab. 2007 May;9(3):246-58 - "The metabolic syndrome is currently defined by various combinations of insulin resistance, obesity, dyslipidaemia and hypertension. The tendency for these risk factors to appear simultaneously suggests a single aetiologic basis. A low level of circulating adiponectin is associated with the appearance of each metabolic syndrome risk factor ... An association between the metabolic syndrome and low adiponectin supports the view that the development of the metabolic syndrome may be triggered by a single underlying mechanism. Clinical studies in the future may show that a low level of circulating adiponectin is a primary biomarker for a specific cluster of metabolic syndrome risk factors rather than all the possible combinations of risk factors currently used to identify the metabolic syndrome"
• Decreased Plasma Adiponectin is Associated with Insulin Resistance and HDL Cholesterol in Overweight Subjects - Endocr J. 2007 May;54(2):221-6 - "In overweight subjects, adiponectin levels negatively correlated with body weight (r = -0.35, P<0.001), body mass index (BMI) (r = -0.28, P<0.006), systolic blood pressure (r = -0.21, P<0.04), fasting insulin (r = -0.19, P<0.01) and HOMA-IR (r = -0.20, P<0.01) and positively with high-density lipoprotein cholesterol (HDL-C) (r = 0.27, P<0.009). Overweight subjects with low HDL-C levels had significantly decreased plasma adiponectin levels compared to those with high HDL-C levels ... findings may suggest that circulating adiponectin is associated with insulin resistance and HDL-C levels independent from BMI in overweight subjects"
• Raised alanine transaminase and decreased adiponectin are features of the metabolic syndrome in patients with type 2 diabetes - Diabetes Obes Metab. 2007 May;9(3):438-40 - "Mean ALT was significantly higher in patients with the MS and higher ALT was associated with lower adiponectin levels. As the number of features of MS increased, ALT increased and adiponectin decreased independent of glycaemic control"
• The effect of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes - Eur J Endocrinol. 2007 May;156(5):595-602 - "Testosterone treatment reduced leptin (-7141.9 +/- 1461.8 pg/ml; P=0.0001) and adiponectin levels"
• Lower plasma adiponectin is a marker of increased intima-media thickness associated with type 2 diabetes mellitus and with male gender - Eur J Endocrinol. 2007 Mar;156(3):387-94 - "Increased IMT in type 2 diabetes may in part be explained by lower plasma adiponectin and higher triglycerides, but not by leptin, resistin, and TNF-alpha"
• Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome - Nephrology (Carlton). 2007 Apr;12(2):147-53 - "Ramipril and valsartan increased the plasma adiponectin levels significantly higher than the other regimens"
• Rosiglitazone treatment increases plasma levels of adiponectin and decreases levels of resistin in overweight women with PCOS: a randomized placebo-controlled study - European Journal of Endocrinology, Vol 156, Issue 2, 263-269 - "Rosiglitazone had beneficial effects on serum levels of adiponectin and resistin, suggesting that these adipocytokines may contribute to the improvement in insulin sensitivity observed during the treatment"
• Comparison of the effects of pioglitazone and metformin on insulin resistance and hormonal markers in patients with impaired glucose tolerance and early diabetes - Hypertens Res. 2007 Jan;30(1):23-30 - "pioglitazone was superior to metformin for the improvement of insulin resistance and adiponectin "
• Telmisartan improves lipid metabolism and adiponectin production but does not affect glycemic control in hypertensive patients with type 2 diabetes - Adv Ther. 2007 Jan-Feb;24(1):146-53 - "Triglyceride levels were significantly decreased, however, and adiponectin levels were significantly increased"
• Effect of PPAR-gamma agonist on adiponectin levels in the metabolic syndrome: lessons from the high fructose fed rat model - Am J Hypertens. 2007 Feb;20(2):206-10 - "rosiglitazone increased plasma levels of adiponectin fourfold from 4.3 +/- 0.1 to 18.4"
• The effects of irbesartan and telmisartan on metabolic parameters and blood pressure in obese, insulin resistant, hypertensive patients - J Endocrinol Invest. 2006 Dec;29(11):957-61 - "Group A (23) was submitted to irbesartan 150 mg/day, Group B (23) to telmisartan 80 mg/day for 6 months ... Both irbesartan or telmisartan reduced blood pressure and ameliorated the insulin sensitivity, with increased adiponectin values; in Group B, the amelioration of metabolic parameters was greater than in Group A"

Related Searches:

• Doctor's Guide search of adiponectin
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