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Home > Anti-aging Research
Gene Variant Interacts with Fish Oil Supplementation to Influence Serum
Adiponectin in Older Individuals - J Nutr. 2013 May 8 -
"Individuals homozygous for the +45 T-allele aged >58 y
had a 22% increase in serum adiponectin concentration compared with baseline
after the highest dose (P-treatment effect = 0.008). If substantiated in a
larger sample, a diet high in n3 PUFAs may be recommended for older individuals,
especially those of the +45 TT genotype who have reported increased risk of
hypoadiponectinemia, type 2 diabetes, and obesity"
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
research: Limiting carbs to dinner-time increases satiety, reduces risk for
diabetes and cardiovascular disease - Science Daily, 11/11/12 -
"randomly assigned 78 police officers to either the
experimental diet (carbohydrates at dinner) or a control weight loss diet
(carbohydrates throughout the day). 63 subjects finished the six-month program
... researchers examined the experimental diet's effect on the secretion of
three hormones: leptin, considered to be the satiety hormone, whose level in the
blood is usually low during the day and high during the night; ghrelin,
considered the hunger hormone, whose level in the blood is usually high during
the day and low during the night; and adiponectin, considered the link between
obesity, insulin resistance and the metabolic syndrome, whose curve is low and
flat in obese people ... the innovative dietary manipulation led to changes in
daylight hormonal profiles in favor of the dieters: the satiety hormone leptin's
secretion curve became convex during daylight hours with a nadir in the late
day; the hunger hormone ghrelin's secretion curve became concave, peaking only
in the evening hours; and the curve of adiponectin, considered the link between
obesity, insulin resistance and the metabolic syndrome, was elevated. At the
same time this dietary pattern led to lower hunger scores, and better
anthropometric (weight, abdominal circumference and body fat), biochemical
(blood sugar, blood lipids) and inflammatory outcomes compared to the control
at 80 mg/Day Increases High-Molecular-Weight Adiponectin Levels and Improves
Insulin Resistance in Diabetic Patients - Adv Ther. 2012 Jul 20 -
"patients with type 2 diabetes and hypertension with
poor control of blood pressure by 40 mg/day telmisartan were randomly assigned
into the telmisartan 80 mg/day (Tel80) group (dose increase from 40 to 80
mg/day) or the telmisartan 40 mg + amlodipine 5 mg (Tel40 + Aml5) group ...
Although the antihypertensive effects of the two doses of telmisartan were
similar, a significant increase in HMW adiponectin levels was noted only in the
Tel80 group" - See telmisartan at
curbs depressive-like symptoms in stressed mice - Science Daily, 7/9/12 -
"A hormone with anti-diabetic properties also reduces
depression-like symptoms in mice ... The hormone, called
adiponectin, is secreted by adipose tissue
and sensitizes the body to the action of insulin, a hormone that lowers blood
sugar ... So far, only about half of the patients suffering from
major depressive disorders are treated to the
point of remission with antidepressant drugs ... The prevalence of depression in
the diabetic population is two to three times higher than in the non-diabetic
population. Unfortunately, the use of current antidepressants can worsen the
control of diabetic patients. Adiponectin, with its anti-diabetic activity,
would serve as an innovative therapeutic target for depression treatments,
especially for those individuals with diabetes or prediabetes and perhaps those
who fail to respond to currently available antidepressants" - [Abstract]
of pioglitazone treatment on 15-epi-lipoxin A(4) levels in patients with type 2
diabetes - Atherosclerosis. 2012 May 7 - "Arachidonic
acid-derived eicosanoids (lipoxins and 15-epilipoxins) have a major role in
resolution of inflammation. 15-epi-lipoxin A(4) (15-epi-LXA(4)) is a lipid
mediator with strong anti-inflammatory and inflammation-resolving effects ...
PIO 15 increased plasma 15-epi-LXA(4) levels (0.63 ± 0.06-1.05 ± 0.08 ng/mL, p <
0.01) and adiponectin levels (6.4 ± 0.3-10.1 ± 0.7 μg/mL, p < 0.001) and
decreased fasting plasma glucose (125 ± 8-106 ± 9 mg/dL, p < 0.05), free fatty
acids (FFA) (414 ± 46-320 ± 38 μmol/l, p < 0.05) and HOMA-IR (5.3 ± 0.4 to 4.0 ±
0.4, p < 0.05). Body weight (Δ = 0.2 kg) and HbA1c (7.4 ± 0.2-7.1 ± 0.2%) did
not change significantly. PIO 30 treated patients had similar increase in plasma
15-epi-LXA(4) (0.64 ± 0.10-1.08 ± 0.09 ng/mL, p < 0.01), and decrease in plasma
FFA (423 ± 42-317 ± 40 μmol/l, p < 0.05) despite a greater increase in plasma
adiponectin (6.5 ± 0.4-15.5 ± 0.7 ug/mL, p < 0.001) and a greater reduction in
HbA1c (8.7 ± 0.5-7.4 ± 0.3%, p < 0.01), FPG (159 ± 16-120 ± 10 mg/dL, p < 0.01),
and HOMA-IR (6.6 ± 0.8-4.4 ± 0.4, p < 0.005). Furthermore, PIO 30 treated
patients had a significant increase in body weight (Δ = 1.7 kg, p < 0.02)"
- See pioglitazone at
rich in slowly digested carbs reduces markers of inflammation in overweight and
obese adults - Science Daily, 1/11/12 - "Among
overweight and obese adults, a diet rich in slowly digested carbohydrates, such
as whole grains, legumes and other high-fiber foods, significantly reduces
markers of inflammation associated with chronic disease ... a low-glycemic-load
diet reduced a biomarker of inflammation called C-reactive protein by about 22
percent ... C-reactive protein is associated with an increased risk for many
cancers as well as cardiovascular disease ... a low-glycemic-load diet modestly
increased -- by about 5 percent -- blood levels of a protein hormone called
adiponectin ... a low-glycemic-load diet modestly increased -- by about 5
percent -- blood levels of a protein hormone called adiponectin. This hormone
plays a key role in protecting against several cancers, including breast cancer,
as well as metabolic disorders such as type-2 diabetes, nonalcoholic fatty liver
disease and hardening of the arteries"
Dietary Resveratrol Has Differential Effects on Colorectal Tumorigenesis in
Adiponectin Knockout and Wild-Type Mice - Nutr Cancer. 2011 Sep 29 -
"Obesity is associated with a decrease in the antiinflammatory hormone,
adiponectin, and increases in the circulating concentrations of multiple
proinflammatory cytokines. These changes contribute to colon tumorigenesis.
Resveratrol increases adiponectin production in adipocytes and attenuates the
development of colon cancer. Thus, we hypothesized that adiponectin is an
integral component of the mechanism by which resveratrol antagonizes colorectal
tumorigenesis. To investigate this, we induced tumorigenesis in adiponectin
knockout (KO) and wild-type (Wt) C57BL/6 mice through combined azoxymethane and
dextran sodium sulfate treatment during which mice were fed a high-fat,
lard-based diet, or the same diet containing 20 mg/kg resveratrol. After 14 wk
on diet, Wt mice gained more weight and, on a percentage basis, had higher fat
mass and lower lean mass than KO mice. Resveratrol tended to attenuate this
response in male Wt mice. Resveratrol also tended to reduce aberrant crypt foci
development and decrease circulating interleukin 6 and insulin concentrations in
male but not female Wt mice. Taken together, resveratrol improved overall health
of obese Wt but not KO mice as hypothesized with a differential sex response" -
resveratrol products at iHerb.
Isomer-specific effects of conjugated linoleic acid on blood pressure, adipocyte
size and function - Br J Nutr. 2011 Sep 23:1-9 - "Consumption of conjugated linoleic acid (CLA) has been shown to modulate cytokine release from adipocytes
and positively influence blood pressure in younger rats, but its physiological
actions in older models with established hypertension and isomer-specific
effects on adipocyte size remain to be determined. Therefore, we investigated
the effects of CLA isomers on adipocyte size in relation to blood pressure and
adipokine production by hypertrophic adipocytes in older fa/fa Zucker rats with
established hypertension. fa/fa Zucker rats were fed with cis(c)9,
trans(t)11-CLA or t10, c12-CLA isomers for 8 weeks and compared with lean and
obese rats fed with the control diet. Blood pressure and adipocyte size were
subsequently measured. Collagenase-isolated adipocytes were size-separated and
angiotensinogen and adiponectin protein levels quantified by Western blotting.
The t10, c12-CLA group had reduced blood pressure, fewer large adipocytes and
increased serum adiponectin. Angiotensinogen was present at higher levels in the
large adipocytes, whereas the converse was observed for adiponectin. The
beneficial effects of the t10, c12-CLA isomer on blood pressure and adipocyte
size in vivo may be due to its ability to reduce the number of large adipocytes,
which alters the levels of vasoactive molecules secreted from adipose tissue" -
CLA products at iHerb.
Harvard study supports coffee’s anti-diabetes potential - Nutra USA, 9/21/11
- "Five cups of coffee per day for two months were associated with significant
metabolic benefits and live function ... the metabolic benefits were more
pronounced in caffeinated coffee, a result that supports the hypothesis that
caffeine is responsible for some of the apparent benefits ... Coffee is also a
rich source of polyphenols ... one cup of the stuff could provide 350 milligrams
of phenolics ... Of these, the most abundant compounds in coffee are chlorogenic
acids, making up to 12 per cent of the green coffee bean. The most abundant of
these compounds is caffeic acid ... recruited 45 healthy, overweight coffee
drinking 40 year olds ... volunteers were asked to drink five cups of coffee per
day of instant caffeinated coffee, decaffeinated coffee, or water for eight
weeks ... coffee consumption was associated with a 60% reduction in blood levels
of a compound called interleukin-6, which can promote inflammation, compared
with the water group ... In addition, levels of adiponectin – a hormone released
from fat cells that plays an important role in the regulation of insulin
sensitivity and energy – also decreased in the caffeinated, but not
decaffeinated group" - [Abstract]
exercise may improve non-alcoholic fatty liver disease - Science Daily,
4/13/11 - "A study of 15 obese people with nonalcoholic
fatty liver disease revealed that the daily walks not only increase insulin
sensitivity, but improve the liver's polyunsaturated lipid index (PUI), which is
thought to be a marker of liver health ... The improvements are linked to an
increase in the hormone adiponectin ... Adiponectin influences the body's
response to insulin and is associated with a reduced risk of heart attack
because of its anti-inflammatory properties"
INFLUENCE OF BODY-MASS INDEX AND RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM ACTIVITY
ON THE RELATIONSHIP BETWEEN 25-HYDROXYVITAMIN D AND ADIPONECTIN IN CAUCASIAN MEN
- Eur J Endocrinol. 2011 Mar 14 - "Higher 25(OH)D concentrations were
independently associated with higher adiponectin levels, particularly when BMI
was high" - See
vitamin D products at iHerb.
results in reduced monocyte adhesion in patients with type 2 diabetes mellitus
- Atherosclerosis. 2010 Dec 25 - "increased adiponectin
by 30.5%" - See
Twinlab niacin 1000mg at iHerb.
Resveratrol’s health benefits linked to fat hormone control - Nutra USA,
1/11/11 - "adiponectin has a wide range of beneficial effects on obesity-related
medical complications, and noted that both adiponectin and resveratrol display
anti-obesity, anti-insulin resistance and anti-aging properties" - [Abstract]
resveratrol products at iHerb.
Up-regulation of Adiponectin by Resveratrol: THE ESSENTIAL ROLES OF THE Akt/FOXO1
AND AMP-ACTIVATED PROTEIN KINASE SIGNALING PATHWAYS AND DsbA-L - J Biol
Chem. 2011 Jan 7 - "RSV promotes adiponectin
multimerization in 3T3-L1 adipocytes via a Sirt1-independent mechanism. In
addition, we show that the stimulatory effect of RSV is regulated by both the
Akt/FOXO1 and the AMPK signaling pathways. Last, we show that DsbA-L plays a
critical role in the promoting effect of RSV on adiponectin multimerization and
cellular levels" - See
resveratrol products at iHerb.
effects of ascorbic acid and thiazolidinedione on secretion of high molecular
weight adiponectin from human adipocytes - Diabetes Obes Metab. 2010
Dec;12(12):1084-9 - "AA supplementation significantly increased secretion of HMW
adiponectin (1.7-fold) without altering adiponectin expression or total
adiponectin secretion. TZD significantly increased expression (3-fold) and
secretion of total (1.4-fold) but not HMW adiponectin. Combined supplementation
resulted in a significant increase in expression (3-fold) and secretion of total
(1.8-fold) and HMW (5-fold) adiponectin. Similar results were seen in cells
co-treated with TNFα" - High adiponectin is a
good thing. Actos (pioglitazone) is a TZD and is something I've been
taking for anti-aging for some time. Not only does it increase adiponectin
but it increases insulin sensitivity. See my
Insulin and Aging page.
See pioglitazone at
consumption but not green tea consumption is associated with adiponectin levels
in Japanese males - Eur J Nutr. 2010 Oct 16 - "We
not only revealed that habitual coffee consumption is associated with higher
adiponectin levels in Japanese males but also found a dose-dependent association
between coffee consumption and adiponectin levels. Therefore, our study
suggested that coffee components might play an important role in the elevation
of adiponectin level" - See my adiponectin
page. High adiponectin is a good thing.
of Japanese dietary pattern with serum adiponectin concentration in Japanese
adult men - Nutr Metab Cardiovasc Dis. 2010 Sep 27 -
"Although previous studies suggest that the traditional Japanese dietary pattern
is independently associated with a low cardiovascular disease mortality risk,
the mechanisms mediating or linking this association are not well understood.
Adiponectin has emerged as a valuable biomarker for cardiovascular diseases ...
Greater adherence to the "Japanese" dietary pattern was independently associated
to a higher serum adiponectin concentration in Japanese adult men. This finding
supports the hypothesis that the traditional Japanese diet may have a
potentially beneficial effect on adiponectin concentrations"
Astaxanthin’s heart benefits get human data support - Nutra USA, 8/9/10 -
"Daily supplements of the carotenoid astaxanthin may improve HDL ‘good’
cholesterol levels in people with mildly abnormal blood lipid levels ...
participants receiving the two highest doses experienced significant reductions
in their triglyceride levels, of 25 and 24 percent, respectively, compared to
baseline. Furthermore, people receiving 6 or 12 mg per day experienced
significant increases in their HDL-cholesterol levels of 10 and 15 percent,
respectively ... Additionally, adiponectin levels increased in the two highest
dose groups, with increases over 20 percent in the 12 mg per day group, and
between 15 and 20 percent in the 18 percent group" - See
Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex, 60 Softgelsor
astaxanthin products at iHerb.
Administration of natural astaxanthin increases serum HDL-cholesterol and
adiponectin in subjects with mild hyperlipidemia - Atherosclerosis. 2010
Apr;209(2):520-3 - "Multiple comparison tests showed that 12 and 18 mg/day doses
significantly reduced triglyceride, and 6 and 12 mg doses significantly
increased HDL-cholesterol. Serum adiponectin was increased by astaxanthin (12
and 18 mg/day), and changes of adiponectin correlated positively with
HDL-cholesterol changes independent of age and BMI" - See
Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex, 60 Softgelsor
astaxanthin products at iHerb.
Cutting fat and calories can lower cancer risk in dogs and people
- Science Daily, 7/22/10 - "obesity in both
dogs and humans limits the production of adiponectin, a hormone that
has been shown to inhibit cancer cell growth. He recommended
reducing calories, particularly those from sugar, which has the
additional danger of not only causing obesity, but also feeding
cancer cells and encouraging their growth"
Effects of a 1-year dietary intervention with n-3 polyunsaturated
fatty acid-enriched olive oil on non-alcoholic fatty liver disease
patients: a preliminary study - Int J Food Sci Nutr. 2010 May 13
- "Consumption of olive oil enriched with
n-3 PUFA demonstrated a significant improvement of liver
echo-texture and of the Doppler Perfusion Index after 12 months
(after: 0.19 +/- 0.02 vs. pre: 0.15 +/- 0.03; P < 0.05), whereas no
significant changes were seen at the end of follow-up in controls.
Moreover, patients who consumed the olive oil enriched with n-3 PUFA
showed a significant amelioration of liver enzymes, and of
triglycerides (post: 132.8 +/- 63.7 vs. pre: 164.5 +/- 85.5 mg/dl; P
= 0.04) in a general linear model adjusted for age and gender.
Interestingly, patients reported to have a significant increase of
adiponectin levels (post: 1,487.9 +/- 96.7 vs. pre: 1,143 +/- 24.8
mug/ml; P = 0.04)"
Coffee’s anti-diabetes benefit strengthen - Nutra USA, 3/16/10 -
"adiponectin levels increased by 6 per cent.
Adiponectin is a protein hormone linked to various metabolic
processes, and levels are inversely related to body fat levels"
Dietary supplementation of n-3 PUFA reduces weight gain and improves
postprandial lipaemia and the associated inflammatory response in
the obese JCR:LA-cp rat - Diabetes Obes Metab. 2009 Nov 16 -
"n-3 PUFA treatment resulted in a
significant improvement (i.e. decrease) in the postprandial response
for triglyceride (45%) (p < 0.05), apoB48 (45%) (p < 0.03) and LBP
(33%) (p < 0.05) compared to controls (measured as area under the
clearance curve). In contrast, we observed a significant elevation
in postprandial haptoglobin (165%) (p < 0.001) in obese rats
supplemented with 10% n-3 PUFA. Treatment with 5% n-3 PUFA in the
JCR:LA-cp obese animals resulted in a complementary decrease in
total body weight gain (6%) (p < 0.001) and an increase (i.e.
improvement) in adiponectin (33%) (p < 0.05) compared to controls,
without a concomitant reduction in food intake" - See
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
Trans-10, cis-12-conjugated linoleic acid reduces the hepatic
triacylglycerol content and the leptin mRNA level in adipose tissue
in obese Zucker fa/fa rats - Br J Nutr. 2009 Mar 19:1-13 -
"Conjugated linoleic acid (CLA) isomers have
been reported to reduce body weight and beneficially affect glucose
metabolism in animals, but the results are inconsistent and seem to
depend on animal model and type of CLA isomer. In the present study,
feeding male Zucker fa/fa rats diets supplemented with 1 % trans-10,
cis-12-CLA for 10 d reduced the liver TAG content without improving
the overall adiposity, and enhanced hepatic mitochondrial and
peroxisomal beta-oxidation ... The present results suggest that
dietary supplementation with trans-10, cis-12-CLA may increase the
catabolism of lipids in liver and adipose tissue. Moreover, we
provide new data suggesting that trans-10, cis-12-CLA modulates the
expression of resistin and adiponectin inversely in adipose tissue.
Hence, the present results suggest that trans-10, cis-12-CLA may
have some beneficial effects on lipid metabolism and adiposity but
possibly reduces insulin sensitivity" - See
CLA products at iHerb.
Conjugated Linoleic Acid Supplementation Enhances Antihypertensive
Effect of Ramipril in Chinese Patients With Obesity-Related
Hypertension - Am J Hypertens. 2009 Mar 19 -
"Participants were randomized to a daily
dose of 4.5 g/day CLA (nine 0.5-g capsules; a 50:50 isomer blend of
c 9,t 11 and t 10,c 12 CLA) with 37.5 mg/day ramipril (group 1) or
placebo with 37.5 mg/day ramipril (group 2) for 8 weeks ...
Treatment with CLA significantly enhanced the reduction effect of
ramipril on systolic BP and diastolic BP (P < 0.05). It also
increased plasma adiponectin concentration (P < 0.05) and decreased
plasma concentrations of leptin and angiotensinogen (P < 0.05);
however, significant change was not observed in ACE activity"
CLA products at iHerb.
Grape polyphenols may protect against obesity: Study - Nutra USA, 3/18/09 -
"animals fed a high-fat diet but supplemented with the
grape seed extract had adiponectin levels 61 per cent higher than animals only
fed the high fat diet. Adiponectin is a protein hormone linked to various
metabolic processes, and levels are inversely related to body fat levels"
- [Abstract] - See
OPC + 95 products at iHerb.
Chardonnay grape seed procyanidin extract supplementation prevents high-fat
diet-induced obesity in hamsters by improving adipokine imbalance and oxidative
stress markers - Mol Nutr Food Res. 2008 Nov 26 -
"GSE prevented in part these effects, reducing insulinemia and leptinemia by
16.5 and 45%, respectively, whereas adiponectin level increased by 61% compared
with obese controls. GSE lowered glycemia and HOMA-IR and strongly prevented
cardiac production of superoxide by 74% and NAD(P)H oxidase expression by 30%.
This is the first time that chronic consumption of grape phenolics is shown to
reduce obesity development and related metabolic pathways including adipokine
secretion and oxidative stress" - See
OPC + 95 products at iHerb.
Red Wine's Resveratrol May Help Battle Obesity - Science Daily,
6/16/08 - "resveratrol inhibited the pre-fat
cells from increasing and prevented them from converting into mature
fat cells. Also, resveratrol hindered fat storage. Most interesting,
according to Fischer-Posovszky, was that resveratrol reduced
production of certain cytokines (interleukins 6 and 8), substances
that may be linked to the development of obesity-related disorders,
such as diabetes and clogged coronary arteries. Also, resveratrol
stimulated formation of a protein known to decrease the risk of
heart attack. Obesity decreases this substance, called adiponectin"
Jarrow Resveratrol 100 at iHerb.
News & Research:
Adiponectin definition - Medterms.com - "Low levels of adiponectin are found
in people who are obese (and who are at increased risk of a heart attack)"
Plasma Adiponectin and
Pancreatic Cancer Risk in 5 US Cohorts - Medscape, 2/20/13 -
"In this pooled analysis, low prediagnostic levels of
circulating adiponectin were associated with an elevated risk of pancreatic
Thin Asians at Risk
for Diabetes Due to Hidden Body Fat - Medscape, 2/11/13 -
"Japanese American women are twice as likely to be
diagnosed with diabetes as whites, despite having lower body-mass indexes (BMIs)
... Indians are often diagnosed with diabetes 10 years earlier and 5- to
10-units BMI thinner than whites ... Both believe the explanation lies in
"hidden" visceral fat found inside the body, between organs, in Asians and
probably other ethnic groups too, but not in whites. This in turn affects the
levels of adipokines secreted, such as leptin and adiponectin, which can have
adverse metabolic effects ... Overall, Japanese women had significantly lower
BMIs (23.7 vs 25.3 kg/m2), leptin (15.0 vs 25.9 ng/mL), and adiponectin (11.7 vs
16.0 µg/mL) than whites ... one factor he believes may be playing an important
role in India is vegetarianism. People there consume high amounts of folate but
are deficient in vitamin B12, creating a low-B12/high-folate intrauterine
environment that "produces babies who are mostly insulin resistant.""
Adiponectin Levels at First Trimester of Pregnancy Are Associated With Increased
Insulin Resistance and Higher Risk of Developing Gestational Diabetes Mellitus
- Diabetes Care. 2013 Jan 8 - "Pregnant women with lower
adiponectin levels at 1st trimester have higher levels of insulin resistance and
are more likely to develop GDM independently of adiposity or glycemic
Prospective Study of Plasma Adiponectin and Pancreatic Cancer Risk in Five US
Cohorts - J Natl Cancer Inst. 2012 Dec 14 - "The
adipocyte-secreted hormone adiponectin has insulin-sensitizing and
anti-inflammatory properties. Although development of pancreatic cancer is
associated with states of insulin resistance and chronic inflammation, the
mechanistic basis of the associations is poorly understood ... conducted a
nested case-control study of 468 pancreatic cancer case subjects and 1080
matched control subjects from five prospective US cohorts: Health Professionals
Follow-up Study, Nurses' Health Study, Physicians' Health Study, Women's Health
Initiative, and Women's Health Study ... Plasma adiponectin was inversely
associated with pancreatic cancer risk, which was consistent across the five
prospective cohorts (P (heterogeneity) = .49) and independent of other markers
of insulin resistance (eg, diabetes, body mass index, physical activity, plasma
C-peptide). Compared with the lowest quintile of adiponectin, individuals in
quintiles 2 to 5 had multivariable odds ratios ([ORs] 95% confidence intervals
[CIs]) of OR = 0.61 (95% CI = 0.43 to 0.86), OR = 0.58 (95% CI = 0.41 to 0.84),
OR = 0.59 (95% CI = 0.40 to 0.87), and OR = 0.66 (95% CI = 0.44 to 0.97),
respectively (P (trend) = .04)"
adiponcetin associated with increased pancreatic cancer risk - Science
Daily, 12/14/12 - "Low adiponectin plasma levels are
associated with the insulin resistance that manifests in obesity and diabetes
mellitus, both of which are risk factors for pancreatic cancer ... The
researchers found a statistically significant inverse association between
prediagnostic plasma adiponectin levels and the risk of pancreatic cancer in the
five prospective cohorts"
potential risk factor for developing dementia and Alzheimer's disease in women
- Science Daily, 1/2/12 - "One of the main features of
adiponectin is that it has been shown to play a role in the sensitization of
insulin and therefore may become a therapeutic target for the treatment of T2D
(type 2 diabetes). Surprisingly, a higher adiponectin level was found to be a
predictor of all-cause and vascular mortality. In concurrence with the mortality
findings, the current investigation shows that an elevated adiponectin level is
also an independent predictor for all-cause dementia and AD in women"
Hormone in Women Linked to Dementia, Study Finds - ABC News, 1/2/12 -
"Adiponectin is supposed to be beneficial. It’s supposed
to decrease your risk of diabetes, supposed to decrease the risk of heart
disease. But in this particular study, to our surprise, it increased the risk of
dementia ... The researchers also found high levels of the hormone in the men
with dementia, but Schaefer said there were not enough men in the study to
establish a link as strong as the one in women"
and Carotid Intima-Media Thickness in the Northern Manhattan Study - Stroke.
2011 Dec 22 - "Our findings suggest that low adiponectin is associated with
increased IMT in a multiethnic cohort and support a protective role for
adiponectin in atherosclerosis"
therapy decreased subcutaneous fat and adiponectin in ageing men - Eur J
Endocrinol. 2011 Dec 21 - "Our data showed that
testosterone therapy decreased subcutaneous fat on the abdomen and lower
extremities, but had no significant effect on visceral fat. Moreover,
adiponectin levels were significantly decreased during testosterone therapy"
elevation by telmisartan ameliorates ISCHEMIC MYOCARDIUM IN Zucker Diabetic
Fatty rats with metabolic syndrome - Diabetes Obes Metab. 2011 Nov 3 -
"myocardial ischemia/reperfusion (I/R) injury ...
Telmisartan reduced the extension of the infarct size in a dose-dependent
fashion and decreased the levels of plasma troponin I, a specific marker of
myocardial damage. Telmisartan also caused a dose-dependent increase in
adiponectin both in plasma and cardiac tissue of infarcted ZDF rats. These
levels were minimally increased (p<0.05 vs vehicle) by telmisartan 7 mg/kg/day
and reached the maximum values with the highest dose of 12 mg/kg/day (p<0.01 vs
vehicle). In contrast, within the infarcted tissue telmisartan decreased the
expression of markers of inflammation such as the transcription factor NF-κB,
the toll-like receptors TLR2 and TLR4 as well as TNF-α cytokine. Nitrosative
stress was maximal in vehicle-treated infarcted hearts as evidenced by increased
expression of iNOS, which was almost abolished after treatement with
telmisartan. Conclusions: Treatment of ZDF rats for three weeks with
telmisartan, a dual angiotensin II receptor antagonist and partial PPAR-γ
receptor agonist, resulted in a significant reduction of myocardial damage
induced by I/R and was assocciated with increased adiponectin and a decrease in
induces regression and stabilization of coronary atherosclerotic plaques in
patients with impaired glucose tolerance - Diabet Med. 2011 Sep 26 -
"Compared with the control group, 6 months' treatment
with pioglitazone significantly decreased coronary plaque burden (50.7 ± 11.1
vs. 64.1 ± 10.3%, P < 0.05), plaque area (6.22 ± 2.03 vs. 8.31 ± 4.29, P <
0.05), thin-cap fibroatheroma prevalence (11 vs. 22%, P < 0.05) and percentage
of necrotic core area (16 ± 8 vs. 31 ± 7%, P < 0.05). Compared with the control
group, serum high-sensitivity C-reactive protein and plasma endothelin-1 levels
were significantly lower and adiponectin level significantly higher in patients
in the pioglitazone group. Serum adiponectin level was negatively correlated
with plasma endothelin-1 level and coronary plaque area (r = 0.739 and -0.431,
respectively, both P < 0.05). Conclusions: Pioglitazone may induce regression
and stabilization of coronary atherosclerotic plaques. The mechanisms might
involve inhibition of inflammation, increase in adiponectin level and
improvement in endothelial function"
and the Incidence of Type 2 Diabetes in Hispanics and African Americans: The
IRAS Family Study - Diabetes Care. 2011 Aug 4 -
"After adjustment for age, sex, ethnicity, and smoking, adiponectin was
significantly inversely associated with diabetes (odds ratio [OR] 0.54 per 1 SD
difference [95% CI 0.38-0.76])"
adiponectin-an independent indicator of liver fat accumulation - Metabolism.
2011 May 10 - "Adiponectin is a very strong predictor
for liver brightness, even after adjustment for the numerous other metabolic
risk factors, markers of inflammation, and novel obesity-related peptide
hormones. Whether low adiponectin levels predict to liver fat accumulation
remains to be explored in a future prospective follow-up of this cohort"
of plasma adiponectin levels with hearing thresholds in adults - Clin
Endocrinol (Oxf). 2011 Apr 30 - "Plasma adiponectin may
protect peripheral hearing function, particularly that related to high
frequencies. Adiponectin may be a mediator of obesity-associated, age-related
of adiponectin to the cardiometabolic risk of postmenopausal women with
loss-of-function lipoprotein lipase gene mutations - Menopause. 2011 Jan 19
- "these results suggest that a low plasma adiponectin
level significantly contributes to the cardiometabolic risk profile of
postmenopausal women with LPLD, independently of anthropometrics, lipids, and
clues uncover how 'starvation hormone' works - Science Daily, 12/26/10 -
"how the hormone adiponectin functions and eventually
could lead to new treatments for conditions ranging from diabetes and weight
loss to heart disease and cancer ... the researchers used models of inducible
cell suicide in both pancreatic beta cells, which produce insulin, and
cardiomyocytes, which are specific muscle cells located in a part of the heart
known as the myocardium, to determine how the single hormone could exert such
different influences ... When the researchers introduced adiponectin into cells,
they found that the hormone triggers the conversion of ceramides from a
destructive force into one that helps cells survive and inhibits cell death ...
the new findings have implications for the treatment of numerous diseases
including diabetes and cancer ... we can protect those cells from cell death
with adiponectin ... Adiponectin, which Dr. Scherer discovered in 1994, not only
controls sensitivity to insulin but also is known to play an integral role in
metabolism and obesity ... As a person accumulates more fat, however,
adiponectin levels decline. Once adiponectin levels start dropping, the body
begins storing fat in dangerous places such as the heart, liver and muscle
tissues -- where it can cause inflammation and pave the way for heart disease
... adiponectin is very important and is probably a key manipulator of lipid
Adiponectin shows potential in blocking obesity-related carcinogenesis -
Science Daily, 10/19/10 - "our results suggest an
attractive molecular strategy employing adiponectin analogues for potential
therapy of metastatic HCC ... With the prevalence of obesity in the U.S., our
study could significantly improve overall survival for a vast number of obese
liver cancer patients by using adiponectin to inhibit growth, invasion, and
migration of HCC cells"
High-Molecular-Weight Adiponectin and the Risk of Type 2 Diabetes in the ARIC
Study - J Clin Endocrinol Metab. 2010 Aug 18 -
"Adiponectin, synthesized by adipocytes, has been shown to be a predictor of
type 2 diabetes ... High-molecular-weight (HMW) adiponectin is thought to be the
most biologically active form of adiponectin in terms of glucose homeostasis ...
Overall hazard ratios (95% confidence intervals) for developing diabetes for
those in the fourth (vs. the first) quartile of total adiponectin, HMW
adiponectin, and the ratio of HMW to total were 0.40 (0.25-0.64), 0.38
(0.23-0.63), and 0.65 (0.42-0.99), respectively ... Conclusions: In this
community-based sample of U.S. adults, higher total and HMW adiponectin
concentrations were similarly associated with a lower incidence of diabetes over
9 yr of follow-up"
Adiponectin Is Associated with Obesity and Serum Lipids in West Africans - J
Clin Endocrinol Metab. 2010 Apr 9 - "Significant
negative associations were observed between log-adiponectin levels and measures
of obesity after adjusting for age and gender. Similarly, log-adiponectin levels
were significantly negatively associated with serum triglycerides and insulin
resistance but positively associated with high-density lipoprotein-cholesterol
and total cholesterol after adjusting for age, gender, and body mass index"
ameliorates hyperglycemia and metabolic profile in nonobese Cohen-Rosenthal
diabetic hypertensive rats via peroxisome proliferator activator receptor-gamma
activation - Metabolism. 2010 Jan 12 - "adiponectin
was significantly (60%, P < .01) increased by telmisartan ... The
telmisartan-induced increase in adiponectin was most probably associated with a
decrease in glucose and tumor necrosis factor alpha levels. Therefore, in
addition to its hypotensive effect, telmisartan demonstrated beneficial
thiazolidinedione-like effects" - See telmisartan at OffshoreRx.com.
Pioglitazone Reduces ER Stress in the Liver: Direct Monitoring of in vivo ER
Stress Using ER Stress-activated Indicator Transgenic Mice - Endocr J. 2009
Sep 29 - "8 weeks of
reduced the accumulation of fat droplets in the liver and attenuated the
development of insulin resistance. In the liver of the ERAI transgenic mice,
ERAI fluorescence activity was clearly reduced as early as after 4 weeks of
pioglitazone treatment, preceding the improvement of insulin resistance. In
addition, after the pioglitazone treatment, serum free fatty acid and
triglyceride levels were decreased, and serum adiponectin levels were increased.
These data indicate that pioglitazone treatment suppresses ER stress in the
liver which may explain, at least in part, the pharmacological effects of
pioglitazone to reduce insulin resistance"
Levels Of A Certain Protein Associated With Lower Risk Of Type 2 Diabetes -
Science Daily, 7/15/09 - "Persons with higher levels of
adiponectin, a protein that is produced by fat cells and that has
anti-inflammatory and insulin-sensitizing properties, have an associated lower
risk of type 2 diabetes"
Study Links a Protein With Diabetes Risk - WebMD, 7/7/09
Higher Levels of Adiponectin Associated With Lower Risk of Type 2 Diabetes -
Doctor's Guide, 7/7/09 - "Although these epidemiologic
studies cannot establish causality, the consistency of the association across
diverse populations, the dose-response relationship, and the supportive findings
in mechanistic studies indicate that adiponectin is a promising target for the
reduction of risk of type 2 diabetes"
pioglitazone increases serum high molecular weight adiponectin and improves
glycemic control in Japanese patients with poorly controlled type 2 diabetes
- Diabetes Res Clin Pract. 2009 Jun 20 - "7.5mg/day of
pioglitazone ... adiponectin increased markedly from 5.2 (2.4, 8.6)mug/ml at
baseline to 9.8 (4.1, 12.6)mug/ml" - See pioglitazone at OffshoreRX.com.
Improves Endothelial Function with Increased Adiponectin and High-density
Lipoprotein Cholesterol Levels in Type 2 Diabetes - Endocr J. 2009 Jun 9 -
"After treatment, HbA1c levels equally decreased in both groups, but PIO-treated
group had significantly increased high-density lipoprotein cholesterol (HDL-C)
levels, and decreased triglyceride, fasting insulin levels and HOMA-R. After
treatment, increases in %FMD, plasma HDL-C and adiponectin (APN) levels were
significantly greater in PIO-treated group than those in control group. Changes
of %FMD showed significant positive correlations with those of plasma APN and
HDL-C levels. In conclusion, the present study showed that treatment of T2DM
improved endothelial function with greater increases in %FMD, APN and HDL-C
levels in PIO-treated group than those in control group, suggesting the
beneficial effect of PIO on endothelial function in T2DM" - See pioglitazone at
safety of therapy with metformin plus pioglitazone in the treatment of patients
with type 2 diabetes: a double-blind, placebo-controlled, clinical trial -
Curr Med Res Opin. 2009 Mar 23 - "Mean HbA(1c) was
reduced by 0.67% in patients receiving pioglitazone plus metformin versus an
increase of 0.25% in those receiving metformin alone (p < 0.0001). After 8
weeks' treatment and until the end of the study, HbA(1c) was significantly lower
with pioglitazone plus metformin and more patients in this group achieved an
HbA(1c) < 6.5% (38.6% vs. 8.1%; p < 0.0001). FBG was also reduced by a
significantly greater amount in patients receiving pioglitazone plus metformin
compared with metformin monotherapy (-20.5 vs. 1.9 mg/dl; p < 0.0001).
Combination therapy was associated with significantly increased HDL-cholesterol,
total cholesterol, and adiponectin, and significantly decreased levels of
fasting insulin, free fatty acids, and homeostasis model assessment insulin
resistance (HOMA-R) compared with metformin monotherapy" - See
pioglitazone at OffshoreRX.com.
Adiponectin Is A Metabolic Link Between Obesity And Bone Mineral Density -
Science Daily, 11/25/08 - "adiponectin, a protein
secreted from adipocytes, is a metabolic link that can explain, in part, the
known positive relationship between obesity and both bone mineral density and
reduced susceptibility to fractures ... In summary, elevated circulating
adiponectin was associated with lower bone mass and weaker bones in growing mice
compared to control animals"
Of Key Hormone During First Trimester Of Pregnancy Could Lead To Earlier
Diagnosis Of Gestational Diabetes - Science Daily, 10/7/08 -
"New research shows women who develop diabetes during
pregnancy (gestational diabetes mellitus) have reduced levels of an
insulin-sensitive hormone, adiponectin, as early as nine weeks into the
Adiponectin May Be a Marker for Type 2 Diabetes - Medscape, 9/3/08 -
"Adiponectin levels were associated with a significantly
lower risk for type 2 diabetes in multivariate models that adjusted for body
mass index (BMI). For the highest quintiles vs the lowest quintiles, odds ratio
(OR) was 0.17 (95% confidence interval [CI], 0.12 - 0.25) for total adiponectin
and 0.10 (95% CI, 0.06 - 0.15) for high-molecular-weight adiponectin. Even after
adjustment for total adiponectin, a higher ratio of high-molecular-weight
adiponectin to total adiponectin was associated with a statistically
significantly lower risk for type 2 diabetes (OR, 0.45; 95% CI, 0.31 - 0.65) "
Adiponectin Levels Indicative of Diabetes Risk - Medscape, 4/29/08 -
"Baseline levels of adiponectin are inversely related to
diabetes risk in subjects at high risk for developing the condition"
Hormone May Contribute To Longevity - Science Daily, 11/21/07 -
"long-lived Snell dwarf mice burn less glucose and more
fatty acids during periods of fasting, and as a result produce fewer free
radicals ... The key to this switch may be adiponectin, a hormone produced by
fat cells that helps lower glucose production and stimulates cells to use fat
for energy instead. The researchers found that Snell mice had three times as
much adiponectin in their blood as control mice" - Something that was
also in today's abstracts (see below) was
increased adiponectin 156%.
Hormone Protects Obese Mice From Diabetes - WebMD, 8/23/07 -
"The high levels of adiponectin, however, made the mice
physiologically skinny ... This discovery also suggests that in people who have
low adiponectin levels fat cells don't send the signal that they're ready to
accept fat, Dr. Scherer said. Instead, the fat is stored in dangerous places --
liver, heart and muscle tissues -- where it can cause inflammation and pave the
way for disease"
Pioglitazone Treatment Increases Concentrations of Adiponectin in Plasma -
Doctor's Guide, 11/16/06 - "Results
showed there was a 6.9 mcg/mL mean increase in
adiponectin levels in the pioglitazone group while in non-pioglitazone
patients it decreased by 0.42 mcg/mL"
Adiponectin Level Found to be Independent Risk Factor for Endometrial Cancer
- Doctor's Guide, 3/34/05 - "The
investigators found that mean serum adiponectin levels were significantly
lower among patients with endometrial cancer than among controls"
Levels and Risk of Coronary Heart Disease: A Meta-analysis of Prospective
Studies - Am J Med Sci. 2012 Nov 1 - "Twelve
prospective studies comprising 8 nested case-control studies and 4 cohort
studies were included in the meta-analysis ... The pooled RR for CHD was 0.83
(95% CI, 0.69-0.98, P = 0.031). Subgroup analyses showed that the pooled RRs
(95% CIs) for CHD risk were 0.78 (0.66-0.92) and 0.75 (0.59-0.94) for men and
women, respectively. For studies with mean age less than 65 years, the pooled RR
(95% CI) for CHD risk was 0.72 (0.59-0.87). For studies with 100 or more CHD
cases, the pooled RR was marginally significant (RR = 0.83, 95% CI, 0.69-1.00; P
Stiffness Is Inversely Related to Plasma Adiponectin Levels in Young
Normotensive Patients With Type 1 Diabetes - Diabetes Care. 2012 Sep 21 -
"Data from 80 patients (age 27.1 ± 6.1 years, BMI 24.2 ±
3.1 kg/m(2), HbA(1c) 7.5 ± 1.6%, 39 men, adiponectin 13.9 ± 6.7 μg/mL, and PWV
5.6 ± 0.9 m/s) were analyzed. Log adiponectin inversely correlated with
age-adjusted PWV (r = -0.291, P = 0.009) and waist circumference (r = -0.427, P
< 0.001). In a fully adjusted model, age, expiration/inspiration index, and log
adiponectin were independently associated with PWV, explaining 39.6% of its
variance ... Arterial stiffness is inversely related to adiponectin concentration
in young patients with type 1 diabetes without major complications"
adiponectin levels in relation to prognosis in patients with angiographic
coronary artery disease - Metabolism. 2012 Jul 10 -
"major adverse cardiovascular events (MACE) ... The incidence of MACE was
significantly higher in the low adiponectin group (P=.037). In a multivariate
Cox regression analysis for adiponectin levels, previously documented risk
factors, coronary artery stenosis scores, and low adiponectin levels were
indicated as independent predictors of MACE in patients with CAD (RR 1.75; 95%
CI, 1.066-2.865; P=.027). Further adjustment for hsCRP, Ccr, LVEF, fasting
glucose and lipid profile did not attenuate this association (RR=2.36; 95% CI
1.338-4.167; P=.003). The relative risk for low adiponectin levels after
additional adjustment for the coronary score was 2.42 (95% CI 1.367-4.279;
P=.002). The Kaplan-Meier survival analysis curve suggested that patients with
lower adiponectin concentrations had a decreased event-free survival ratio
(log-rank χ(2) =4.592, P=.032)"
curbs depressive-like symptoms in stressed mice - Science Daily, 7/9/12 -
"A hormone with anti-diabetic properties also reduces
depression-like symptoms in mice ... The hormone, called adiponectin, is
secreted by adipose tissue and sensitizes the body to the action of insulin, a
hormone that lowers blood sugar ... So far, only about half of the patients
suffering from major depressive disorders are treated to the point of remission
with antidepressant drugs ... The prevalence of depression in the diabetic
population is two to three times higher than in the non-diabetic population.
Unfortunately, the use of current antidepressants can worsen the control of
diabetic patients. Adiponectin, with its anti-diabetic activity, would serve as
an innovative therapeutic target for depression treatments, especially for those
individuals with diabetes or prediabetes and perhaps those who fail to respond
to currently available antidepressants"
relationship of serum adiponectin concentration with type 2 diabetes mellitus
incidence in middle-aged Japanese workers: 6-year follow-up - Diabetes Metab
Res Rev. 2012 Jan 6 - "Age- and sex-adjusted homeostasis model assessment
insulin resistance (HOMA-IR) was inversely associated with adiponectin quintiles
at baseline. During six years of follow-up, 164 individuals developed T2DM. In a
fully-adjusted model, hazard ratios (95% confidence intervals) of T2DM in Q2 to
Q5 compared to Q1 were 0.62 (0.41-0.94), 0.44 (0.25-0.77), 0.40 (0.20-0.78) and
0.85 (0.48-1.49), respectively"
and high molecular weight adiponectin levels and risk of coronary heart disease
in women - Atherosclerosis. 2011 Jul 20 - "Adjusted
for matching factors, parental history of myocardial infarction, hormone
replacement therapy, alcohol consumption, physical activity, body mass index,
hypertension, and low-density lipoprotein cholesterol levels, the relative risk
in the highest versus lowest quintile was 0.50 (95%-CI 0.33-0.75; p trend=0.001)
for total adiponectin, 0.53 (95%-CI 0.35-0.80; p trend=0.004) for HMW
adiponectin, and 0.63 (95%-CI 0.43-0.93; p trend=0.03) for HMW/total adiponectin
ratio. After adjustment for diabetes, HDL-cholesterol, HbA1c, and CRP these
associations were attenuated and no longer significant (RRs, 0.84; 95%-CI
0.53-1.33; p trend=0.62; 0.95; 95%-CI 0.60-1.52; p trend=0.98; 0.97; 95%-CI
0.64-1.47; p trend=0.80) ... High levels of total and HMW adiponectin, and
HMW/total adiponectin ratio are associated with a lower risk of CHD among women.
HMW adiponectin and HMW/total adiponectin ratio are not more closely related to
risk than total adiponectin. These associations are largely mediated by
parameters related to glucose and lipid metabolism and inflammation, especially
association of circulating adiponectin levels with pancreatic cancer risk; a
study within the prospective EPIC cohort - Int J Cancer. 2011 Jun 16 -
"Overall, adiponectin showed no association with
pancreas cancer risk; however, among never smokers, higher circulating levels of
adiponectin were associated with a reduction in pancreatic cancer risk (OR =
0.44 [95% CI 0.23-0.82] for highest vs. lowest quartile), whereas among current
smokers there was no significant association (OR = 1.59 [95% CI 0.67-3.76] for
highest vs. lowest quartile; p-trend = 0.530; p-interaction = 0.309). In our
study, lower adiponectin concentrations may be associated with the development
of pancreatic cancer among never smokers, whereas the only other prospective
study being conducted so far showed a decrease in risk among male smokers"
longitudinal analysis on associations of adiponectin levels with metabolic
syndrome and carotid artery intima-media thickness. The Cardiovascular Risk in
Young Finns Study - Atherosclerosis. 2011 Apr 8 -
"In a multivariable model adjusted for age, sex, MetS components,
LDL-cholesterol, CRP, insulin, leptin, smoking and family history of coronary
disease, 1-unit increase in baseline adiponectin levels was associated with
reduced odds (odds ratio [OR]=0.94, 95% CI 0.89-0.99, P=0.04) of incident MetS.
Of the MetS components, adiponectin levels were inversely associated with the
incidence of hyperglycemia in multivariable analyses (OR=0.94 (0.90-0.99),
P=0.04). When studying the adiponectin×MetS interaction on IMT, we observed a
significant interaction when examining IMT in 2001 (r=-0.11 (MetS(-)) vs.
r=-0.17 (MetS(+)), P for interaction 0.047) and IMT in 2007 (r=-0.12 (MetS(-))
vs. r=-0.21 (MetS(+)), P for interaction 0.005), suggesting the inverse
association between adiponectin and IMT is stronger among those with MetS"
and adiponectin receptor in relation to colorectal cancer progression - Int
J Cancer. 2010 Dec 15;127(12):2758-67 - "Although
obesity is a risk factor for colorectal cancer, the underlying mechanism is not
clear. Adiponectin is an adipokine that binds to 2 types of receptors, AdipoR1
and AdipoR2. The plasma concentrations of adiponectin are reduced in obese
individuals and adiponectin has been reported to have anticarcinogenic
properties. Furthermore, AdipoR1 and AdipoR2 have been reported to be expressed
in several malignancies ... AdipoR1 and AdipoR2 immunostaining was detected in
72 and 68% of human colorectal cancer tissue, respectively. AdipoR1 and AdipoR2
expression levels were inversely related to T stage. The lowest AdipoR1 and
AdipoR2 expression were detected in poorly differentiated adenocarcinoma. RT-PCR
also showed the expression of AdipoR1 and AdipoR2 in HCT116 and SW620. MTT assay
and TUNEL assay demonstrated the tendency of growth inhibition and apoptosis
induction in both cell lines after full-length adiponectin treatment although
statistically insignificant. Microarray analysis revealed several gene responses
to full-length adiponectin, including upregulation of ENDOGL1 and MT1G. In
conclusion, AdipoR1 and AdipoR2 may be intimately related to the progression of
inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression
of AKT1 - J Biol Chem. 2011 Feb 7 - "adiponectin is
important in maintaining the balance of energy metabolism, inflammatory
responses and bone formation"
Hypoadiponectinemia is strongly associated with metabolic syndrome in korean
type 2 diabetes patients - J Am Coll Nutr. 2010 Jun;29(3):171-8 -
"Our findings show that hypoadiponectinemia is strongly
associated with MetS in type 2 DM patients. Dietary intake may be indirectly
associated with adiponectin levels through factors such as BMI, waist
circumference, insulin, homeostasis model assessment of insulin resistance
(HOMA-IR), triglyceride, HDL-cholesterol, and blood pressure. Therefore, our
results suggest that manipulation of the level of adiponectin may prevent MetS
and reduce the risk of cardiovascular disease in type 2 DM patients"
and Insulin Resistance Correlate with Telomere Length in Middle-aged Arabs: The
Influence of Circulating Adiponectin - Eur J Endocrinol. 2010 Aug -
"Studies in obesity have implicated adipocytokines in
the development of insulin resistance, which in turn may lead to accelerated
aging ... HOMA-IR was the most significant predictor for TL in males, explaining
35% of the variance (p = 0.01). In females, adiponectin, accounted for 28% of
the variance in TL (p = 0.01). Conclusion: Obesity and insulin resistance are
associated with chromosomal TL among adult Arabs. Evidence of causal relations
needs further investigation. The positive association of adiponectin to TL has
clinical implications as to the possible protective effects of this hormone from
accelerated aging" - Note: HOMA-IR = (glucose x insulin)/405 for
glucose in mass units (US units) mg/dL.
Pioglitazone, but not metformin, reduces liver fat in Type-2 diabetes mellitus
independent of weight changes - J Diabetes Complications. 2009 Jul 3 -
"metformin (Met) ... Pio plus the American Diabetes
Association diet (Pio+ADA) ... Pio plus a portion control weight loss diet (Pio+PC)
... The Pio+ADA group gained (mean+/-S.E.M.) 2.15+/-1.09 kg, while Pio+PC and
Met+ADA group lost -2.59+/-1.25 and -3.21+/-0.7 kg, respectively. Pio-treated
groups (Pio+ADA and Pio+PC) significantly decreased hepatic fat as indicated by
increased liver density on CT scan [10.1+/-2.4: 11.4+/-1.0 Hounsfield units
(HU)], compared with Met+ADA group (-2.4+/-3.1 HU). The Pio groups demonstrated
significantly increased serum adiponectin, (8.6+/-1.5; 7.4+/-1.6 mug/ml)
independent of weight change, compared to Met+ADA (-0.14+/-0.6 mugm/ml) group
which lost weight. Serum hs-CRP decreased in groups showing weight loss (Pio+PC,
-3.1+/-1.7 mg/l; Met+ADA, -1.5+/-1.2 mg/l) compared to Pio+ADA (1.8+/-3.0 mg/l)
group that gained weight" - Note: This is just one of the many
reasons I take pioglitazone even though I don't have diabetes. See
pioglitazone at pioglitazone at
Regulates Arterial Calcification - J Bone Miner Res. 2009 Mar 3 -
"adiponectin inhibited osteoblastic differentiation of
CVSMCs via AdipoR1/p38 signaling pathway ... Our findings firstly demonstrated
that Adiponectin(-/-) mice developed arterial calcification, and this could be
attributed to the loss of inhibitory action of adiponectin on osteoblastic
differentiation of CVSMCs. It suggested that adiponectin play a protective role
against arterial calcification"
drinking on adiponectin in healthy men and women: A randomised intervention
study of water, ethanol, red wine and beer with or without alcohol -
Diabetes Care. 2009 Feb 24 - "Among females adiponectin
significantly increased after with red wine (29,8% p<0.05), among men after
ethanol solution (17.4%, p<0.05) and beer (16.1%, p<0.05)"
Adiponectin Concentrations Are Associated with Body Composition and Plant-Based
Dietary Factors in Female Twins - J Nutr. 2008 Dec 23 -
"A significant relationship between adiponectin and 3
derived dietary patterns (F&V, dieting, traditional English), carbohydrate,
protein, trans fat, and alcohol intake was also observed. Strong inverse
associations with adiponectin were observed for BMI (-10.72%; 95% CI: -13.78,
-7.55), total (-6.89%: 95% CI: -10.34, -3.30; P < 0.05), and central fat mass
(-12.50%; 95% CI: -15.82, -9.05; P < 0.05); these relationships were significant
both when twins were analyzed as individuals and when characteristics were
contrasted within-twin pairs, suggesting a direct effect. We observed modest
associations between dietary factors and adiponectin in female twins,
independent of adiposity, and report strong inverse associations with body
composition. These data reinforce the importance of weight maintenance and
increasing consumption of diets rich in plant-based foods to prevent CVD and
type 2 diabetes"
Telmisartan and Ramipril on Adiponectin and Blood Pressure in Patients with Type
2 Diabetes - Am J Hypertens. 2008 Oct 30 - "There
was a significant increase in adiponectin levels in the telmisartan (0.68 (95%
confidence interval (CI), 0.27 to 1.10) microg/ml, P < 0.01) but not in the
Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty
acids and plant sterols in hyperlipidemic individuals - Atherosclerosis.
2008 Sep 27 - "The combination of n-3 PUFA and plant
sterols reduced several inflammatory markers. High sensitivity C-reactive
protein (hs-CRP) was reduced by 39% (P=0.009), tumor necrosis factor-alpha
(TNF-alpha) by 10% (P=0.02), interleukin-6 (IL-6) by 10.7% (P=0.009),
leukotriene B(4) (LTB(4)) by 29.5% (P=0.01) and adiponectin was increased by
29.5% (P=0.05). Overall cardiovascular risk was reduced by 22.6% (P=0.006) in
the combination group. CONCLUSION: We have demonstrated, for the first time that
dietary intervention with n-3 PUFA and plant sterols reduces systemic
inflammation in hyperlipidemic individuals. Furthermore, our results suggest
that reducing inflammation provides a potential mechanism by which the
combination of n-3 PUFA and plant sterols are cardioprotective"
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
atherosclerosis by increasing cholesterol efflux from macrophages - Biochem
Biophys Res Commun. 2008 Aug 11
Relation of dietary and other lifestyle traits to difference in serum
adiponectin concentration of Japanese in Japan and Hawaii: the INTERLIPID Study
- Am J Clin Nutr. 2008 Aug;88(2):424-30 - "The
significantly higher mean serum adiponectin concentration in Japan than in
Hawaii may be attributable largely to differences in BMI"
adiponectin concentrations are associated with the metabolically healthy obese
phenotype - J Clin Endocrinol Metab. 2008 Aug 5 -
"Certain obese individuals have adiponectin levels similar to those found in
normal BMI subjects; this is associated with the metabolically healthy obese
Adiponectin, but not leptin or high-sensitivity C-reactive protein, is
associated with blood pressure independently of general and abdominal adiposity
- Hypertens Res. 2008 Apr;31(4):633-40 - "all three
markers were significantly correlated with systolic blood pressure (negative
correlation for adiponectin and positive correlations for leptin and hs-CRP)"
Telmisartan but not candesartan affects adiponectin expression in vivo and in
vitro - Hypertens Res. 2008 Apr;31(4):601-6 - "the
changes in serum adiponectin and plasma glucose over 3 months were significantly
greater in the telmisartan group than in the candesartan group. In vitro,
although the protein level of adiponectin was not significantly elevated, the
mRNA expression of adiponectin was elevated 1.5-fold by telmisartan in 3T3-L1
adipocytes. Our findings suggest that telmisartan may have beneficial effects in
type 2 diabetes beyond its antihypertensive effect" - I've been saying
that telmisartan should be the
first line treatment for
hypertension for some time now if natural methods such as coenzyme Q10 don't
Acarbose Treatment Increases Serum Total Adiponectin Levels in Patients with
Type 2 Diabetes - Endocr J. 2008 May 15 - "Treatment
with acarbose and pioglitazone decreased HbA1c values by 0.49 % and 0.63 %,
respectively. Pioglitazone, as expected, increased serum levels of total
adiponectin by 2.1 fold and its high molecular weight isoform by 3.6 fold. We
found that acarbose also caused a small but significant increase in serum
concentrations of total adiponectin. However, in contrast to pioglitazone, no
appreciable changes were observed in the levels of high molecular weight
Telmisartan treatment decreases visceral fat accumulation and improves serum
levels of adiponectin and vascular inflammation markers in Japanese hypertensive
patients - Hypertens Res. 2007 Dec;30(12):1205-10 -
"telmisartan treatment was associated with an improvement of vascular
inflammation, reductions in visceral fat and increases in serum adiponectin"
Peroxisome Proliferator-Activated Receptor gamma agonism modifies the effects of
growth hormone on lipolysis and insulin sensitivity - Clin Endocrinol (Oxf).
2008 Mar 10 - "Adiponectin levels almost doubled during
pioglitazone treatment " - See pioglitazone at
Adiponectin Levels are Associated with Atherogenic Dyslipidemia and Lipid-Rich
Plaque in Non-Diabetic Coronary Arteries - Br J Nutr. 2008 Feb 6;:1-8 -
"Low adiponectin levels are associated with atherogenic
lipoproteins (elevated triglycerides, small dense LDL cholesterol, low HDL
cholesterol), increased plaque volume, lipid-rich plaque, and ID-pathological
intimal thickening in the total cohort which was driven by the non-diabetic
population, suggesting an anti-atherogenic role in the early stages of lesion
of green tea on kidney tubules of diabetic rats - Br J Nutr. 2008 Feb 6;:1-8
- "It has been documented that
green tea (GT) and its catechin components improve renal failure and inhibit
the growth of mesangial cells ... GT treatment significantly (P < 0.01) reduced
the serum glucose, glycosylated protein, serum creatinine and blood urea N
levels by 29.6 (sem 3.7), 22.7 (sem 5.2), 38.9 (sem 10) and 41.7 (sem 1.9) %,
respectively ... the GT-treated group showed a significant 44 (sem 10.8) %
higher creatinine clearance (Ccr) ... GT reduced the urea N, creatinine, glucose
and protein excretion rates by 30 (sem 7.6), 35.4 (sem 5.3), 34.0 (sem 5.3) and
46.0 (sem 13.0) % compared with the 12 weeks diabetic group. Administration of
GT to 12 weeks diabetic rats significantly (P < 0.001) prevented (99.98 (sem
0.27) % less) the accumulation of glycogen in the kidney tubules. These results
indicate that in STZ diabetes, kidney function
appears to be improved with GT consumption which also prevents glycogen
accumulation in the renal tubules, probably by lowering blood levels of glucose.
Therefore, GT could be beneficial additional therapy in the management of
diabetic nephropathy" - See
Jarrow green tea at iHerb.
Increased total and high-molecular weight adiponectin after extended-release
niacin - Metabolism. 2008 Mar;57(3):404-9 - "at
least part of the cardioprotective benefits of niacin may be attributed to a
shift in the HMW/LMW adiponectin ratio in obese men with the metabolic syndrome"
Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes
Prevention Program - Diabetes. 2008 Jan 11 -
"Adiponectin is a powerful marker of diabetes risk in subjects at high risk of
diabetes, even after adjustment for weight. An increase in adiponectin in
lifestyle and placebo was associated with a reduction in diabetes risk. However,
these changes in adiponectin were comparatively small and less strongly related
to diabetes outcome than baseline adiponectin levels"
Coffee consumption is associated with higher plasma adiponectin concentrations
in women with and without type 2 diabetes: a prospective cohort study -
Diabetes Care. 2007 Dec 10 - "High consumption of
caffeine-containing coffee is associated with higher adiponectin and lower
inflammatory marker concentrations"
Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic
lipogenic enzymes in rats - Br J Nutr. 2007 Dec 7;:1-9 -
"Lipoic acid profoundly decreased serum and liver
concentrations of TAG, and also lowered serum concentrations of phospholipid and
NEFA, and the concentration of cholesterol in the liver. A hypoglycaemic effect
of this compound was also observed. Lipoic acid dose-dependently decreased the
activity and mRNA levels of fatty acid synthase, ATP-citrate lyase, glucose
6-phosphate dehydrogenase, malic enzyme and pyruvate kinase in the liver despite
that reductions were considerably attenuated in the NADPH-producing enzymes.
This compound also dose-dependently lowered the mRNA levels of spot 14,
adiponutrin, stearoyl-CoA desaturase 1, and Delta5- and Delta6-desaturases. In
addition, lipoic acid dose-dependently lowered serum concentrations of insulin
and leptin, but increased those of adiponectin. Lipoic acid appeared to reduce
hepatic lipogenesis and hence decreases serum and liver lipid levels.
Alterations in serum concentrations of insulin and (or) adiponectin may trigger
this consequence" - See
Doctor's Best, Best Stabilized R-Lipoic Acid Na-RALA
Adiponectin, the controversial hormone - Public Health Nutr. 2007
Oct;10(10A):1145-50 - "Considering the anti-inflammatory
properties of adiponectin and the fact that it is negatively associated with
adiposity, this cytokine could be one of the links between obesity and
inflammation. The main mechanisms of action of adiponectin are directed to a
protective role against atherogenic and insulin resistance processes. Research
has revealed interesting new functions far beyond metabolism, such as immunity,
cancer and bone formation. Contrary to all adipose-related proteins, adiponectin
decreases with obesity. Most of the contradictory data surrounding adiponectin
are related to plasma values and their relationship with body fat, gender
differences and insulin resistance"
High-molecular weight adiponectin is independently associated with the extent of
coronary artery disease in men - Atherosclerosis. 2007 Nov 14 -
"HMW adiponectin and the HMW/total-adiponectin ratio
inversely correlate with the extent of CAD. HMW adiponectin in particular seems
to be a better marker for CAD extent than total adiponectin"
Pioglitazone improves myocardial blood flow and glucose utilization in
nondiabetic patients with combined hyperlipidemia a randomized, double-blind,
placebo-controlled study - J Am Coll Cardiol. 2007 Nov 20;50(21):2051-8 -
"myocardial glucose utilization (MGU) and blood flow
(MBF) in nondiabetic patients with familial combined hyperlipidemia (FCHL) ...
in the pioglitazone group HDL cholesterol (+28%; p = 0.003) and adiponectin
(+156.2%; p = 0.0001) were increased and plasma insulin (-35%; p = 0.017) was
reduced ... In patients with FCHL treated with conventional lipid-lowering
therapy, the addition of pioglitazone led to significant improvements in MGU and
MBF, with a favorable effect on blood lipid and metabolic parameters"
Nutritional intervention to reduce the n-6/n-3 fatty acid ratio increases
adiponectin concentration and fatty acid oxidation in healthy subjects -
Eur J Clin Nutr. 2007 Aug 15 - "Dietary intervention
was associated with significant reductions in TNF-alpha (baseline: 2.2 (s.d.
0.3), post-intervention: 1.5 (s.d. 0.3) pg/ml, P=0.01) and low-density
lipoprotein-cholesterol (baseline: 2.5 (s.d. 0.2), post-intervention: 2.3 (s.d.
0.1) mmol/l, P=0.03) and increased adiponectin (baseline: 6.5 (s.d. 0.7),
post-intervention: 7.6 (s.d. 0.6) mug/ml, P=0.02). Fasting lipid oxidation
was increased (baseline: 0.7 (s.d. 0.1), post-intervention: 0.9 (s.d. 0.1)
mg/kg.min, P=0.01), whereas glucose oxidation decreased in both fasting
(baseline: 1.6 (s.d. 0.1), post-intervention: 1.3 (s.d. 0.1) mg/kg.min,
P=0.02) and hyperinsulinaemic conditions (baseline: 3.6 (s.d. 0.1),
post-intervention: 3.3 (s.d. 0.1) mg/kg.min, P=0.04). Insulin sensitivity
was not affected by the intervention. Conclusion: A decreased
n-6/n-3 PUFA ratio can be achieved with simple dietary counselling,
resulting in multiple, potentially favourable effects on the metabolic and
The effect of thiazolidinediones on adiponectin serum level: a meta-analysis
- Diabetes Obes Metab. 2007 Jul 21 - "The results
clearly reveal an increase of endogenous serum adiponectin levels by intake
of TZDs and may point to a potential new option to manage obesity-related
Low serum adiponectin is associated with high circulating oxidized
low-density lipoprotein in patients with type 2 diabetes mellitus and
coronary artery disease - Metabolism. 2007 Jul;56(7):881-886 -
"low adiponectin concentration indicates increased
oxidative state in the arterial wall, which further supports previous data
on the role of adipose tissue in atherogenesis"
The Differential Effects of Angiotensin II Type 1 Receptor Blockers on
Microalbuminuria in Relation to Low-Grade Inflammation in Metabolic
Hypertensive Patients - Am J Hypertens. 2007 May;20(5):565-72 -
"There was a significant increase in
high molecular weight adiponectin in the telmisartan group ... The
reductions of microalbuminuria and high-sensitivity C-reactive protein (hs-CRP)
were significant in the telmisartan group"
Adiponectin in health and disease - Diabetes Obes Metab. 2007
May;9(3):282-9 - "Adiponectin is an
important adipokine because of its beneficial effects on glucose and lipid
metabolism. Low levels of adiponectin are associated with disease states
such as diabetes and cardiovascular disease ... Adiponectin levels in humans
can be increased through indirect methods such as weight loss or treatment
Adiponectin accelerates reverse cholesterol transport by increasing high
density lipoprotein assembly in the liver - Biochem Biophys Res Commun.
2007 May 15 - "APN might protect
against atherosclerosis by increasing HDL assembly through enhancing ABCA1
pathway and apoA-1 synthesis in the liver"
Do low levels of circulating adiponectin represent a biomarker or just
another risk factor for the metabolic syndrome? - Diabetes Obes Metab.
2007 May;9(3):246-58 - "The
metabolic syndrome is currently defined by various combinations of insulin
resistance, obesity, dyslipidaemia and hypertension. The tendency for these
risk factors to appear simultaneously suggests a single aetiologic basis. A
low level of circulating adiponectin is associated with the appearance of
each metabolic syndrome risk factor ... An association between the metabolic
syndrome and low adiponectin supports the view that the development of the
metabolic syndrome may be triggered by a single underlying mechanism.
Clinical studies in the future may show that a low level of circulating
adiponectin is a primary biomarker for a specific cluster of metabolic
syndrome risk factors rather than all the possible combinations of risk
factors currently used to identify the metabolic syndrome"
Decreased Plasma Adiponectin is Associated with Insulin Resistance and HDL
Cholesterol in Overweight Subjects - Endocr J. 2007 May;54(2):221-6 -
"In overweight subjects, adiponectin
levels negatively correlated with body weight (r = -0.35, P<0.001), body
mass index (BMI) (r = -0.28, P<0.006), systolic blood pressure (r = -0.21,
P<0.04), fasting insulin (r = -0.19, P<0.01) and HOMA-IR (r = -0.20, P<0.01)
and positively with high-density lipoprotein cholesterol (HDL-C) (r = 0.27,
P<0.009). Overweight subjects with low HDL-C levels had significantly
decreased plasma adiponectin levels compared to those with high HDL-C levels
... findings may suggest that circulating adiponectin is associated with
insulin resistance and HDL-C levels independent from BMI in overweight
Raised alanine transaminase and decreased adiponectin are features of the
metabolic syndrome in patients with type 2 diabetes - Diabetes Obes
Metab. 2007 May;9(3):438-40 - "Mean
ALT was significantly higher in patients with the MS and higher ALT was
associated with lower adiponectin levels. As the number of features of MS
increased, ALT increased and adiponectin decreased independent of glycaemic
The effect of testosterone replacement therapy on adipocytokines and C-reactive
protein in hypogonadal men with type 2 diabetes - Eur J Endocrinol. 2007
May;156(5):595-602 - "Testosterone
treatment reduced leptin (-7141.9 +/- 1461.8 pg/ml;
P=0.0001) and adiponectin levels"
Lower plasma adiponectin is a marker of increased intima-media thickness
associated with type 2 diabetes mellitus and with male gender - Eur J
Endocrinol. 2007 Mar;156(3):387-94 - "Increased IMT in type 2 diabetes may in part be explained by lower plasma
adiponectin and higher triglycerides, but not by leptin, resistin, and
Effect of antihypertensive agents on plasma adiponectin levels in
hypertensive patients with metabolic syndrome - Nephrology (Carlton).
2007 Apr;12(2):147-53 - "Ramipril
and valsartan increased the plasma adiponectin levels significantly higher
than the other regimens"
treatment increases plasma levels of adiponectin and decreases levels of
resistin in overweight women with PCOS: a randomized placebo-controlled study - European
Journal of Endocrinology, Vol 156, Issue 2, 263-269 - "Rosiglitazone had beneficial effects on
serum levels of
adiponectin and resistin, suggesting that these adipocytokines may
contribute to the improvement in insulin sensitivity observed during the
Comparison of the effects of pioglitazone and metformin on insulin resistance
and hormonal markers in patients with impaired glucose tolerance and early
diabetes - Hypertens Res. 2007 Jan;30(1):23-30 - "pioglitazone was superior to metformin
for the improvement of insulin resistance and adiponectin "
Telmisartan improves lipid metabolism and adiponectin production but does
not affect glycemic control in hypertensive patients with type 2 diabetes
- Adv Ther. 2007 Jan-Feb;24(1):146-53 - "Triglyceride
levels were significantly decreased, however, and adiponectin levels
were significantly increased"
Effect of PPAR-gamma agonist on adiponectin levels in the metabolic
syndrome: lessons from the high fructose fed rat model - Am J Hypertens.
2007 Feb;20(2):206-10 - "rosiglitazone increased plasma levels of adiponectin fourfold from 4.3 +/-
0.1 to 18.4"
The effects of irbesartan and telmisartan on metabolic parameters and blood
pressure in obese, insulin resistant, hypertensive patients - J Endocrinol
Invest. 2006 Dec;29(11):957-61 - "Group
A (23) was submitted to irbesartan 150 mg/day, Group B (23) to telmisartan 80
mg/day for 6 months ... Both irbesartan or telmisartan reduced blood pressure
and ameliorated the insulin sensitivity, with increased adiponectin values; in
Group B, the amelioration of metabolic parameters was greater than in Group A"