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Home > Health Conditions > Schizophrenia >
Antidepressants & Psychotropics > Zyprexa® (olanzapine)
Zyprexa® (olanzapine) (Eli Lilly and Co.)
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olanzapine at drugstore.com
- Zyprexa (olanzapine) - rxlist.com
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Newer Antipsychotic Drugs Increase the Risk of Sudden Cardiac Death
- WebMD, 1/14/09 - "because these older
agents cause movement disorders in some patients, they have largely
been replaced with newer medications such as Zyprexa, Risperdal, and
Seroquel ... Although the study's results reaffirmed that people who
use the older antipsychotic drugs are twice as likely as nonusers to
have sudden cardiac death, it also showed a similar increase in risk
for the newer medications. For these, the rate of sudden cardiac
death was more than twice that for nonusers"
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Treatment With An Anti-psychotic Drug Found To Cause Changes In
Metabolism Earlier Than Expected - Science Daily, 4/7/08
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Comparison Of Antipsychotic Treatments In Adolescents With
Schizophrenia - Science Daily, 2/28/08 -
"The researchers discovered that clozapine was approximately twice
as likely to produce a treatment response as olanzapine"
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Olanzapine May Be New Option for Post-Traumatic Stress Disorder
- Doctor's Guide, 10/19/07
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Lilly Adds Label Warnings for Mental Illness Drug - New York
Times, 10/5/07
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First Head-to-Head Study Suggests Significantly Greater Symptom Improvement
for Olanzapine and Fluoxetine Combination Capsules Compared to Lamotrigine
in Bipolar Depression - Doctor's Guide, 5/30/06
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Study Suggests Olanzapine and Fluoxetine Combination Capsules Improve
Symptoms of Treatment-Resistant Depression - Doctor's Guide, 5/30/06
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Lithium, Olanzapine Affect Different Domains in Bipolar - Clinical
Psychiatry News, 11/05
- CAFE
Study Shows Varying Benefits Among Atypical Antipsychotics - Medscape,
10/25/05
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Atypical Antipsychotics Offer Equivalent Benefit in First-Episode Psychosis
- Doctor's Guide, 10/25/05
- Antipsychotic Drugs: OK for Dementia Patients? - WebMD, 10/18/05
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Olanzapine vs. Risperidone in Schizophrenia - Clinical Psychiatry News,
9/05
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Aripiprazole Wins Out in Comparison With Olanzapine - Clinical
Psychiatry News, 9/05
- Schizophrenia Drug Face-Off: No Clear Winner - WebMD, 9/19/05
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Leading schizophrenia drug no better than older, cheaper kind -
USATODAY.com, 9/19/05
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Long-Term Study Shows Geodon (Ziprasidone HCl) Has Comparable Efficacy With
Fewer Adverse Metabolic Effects Than Zyprexa (Olanzapine) - Doctor's
Guide, 8/8/05
- Olanzapine May Be Better Than Lithium in Bipolar Disorder - Medscape,
7/8/05
- Second-Generation Antipsychotics Equally Effective in Schizophrenia -
Medscape, 6/30/05
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New Antipsychotic Drug Prevents Brain Loss In Schizophrenia - Doctor's
Guide, 4/5/05
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Olanzapine, Risperidone Outshine Others in Study - Clinical Psychiatry News, 1/05
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Novel Antipsychotics Found Effective in Bipolar Disorder - Clinical Psychiatry News, 1/05
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Two Atypical Anti-psychotic Drugs May Be Associated With An Increased Risk Of Diabetes For Patients With Schizophrenia - Science Daily, 1/5/05
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Clozapine, Olanzapine May be Associated with Increased Risk of Diabetes for Patients with Schizophrenia - Doctor's Guide, 1/3/05
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Long-Term Treatment With Zyprexa (Olanzapine) Appears to Reduce Violent Behavior in People With Schizophrenia Compared To Risperidone - Doctor's Guide, 12/14/04
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Comparative Study Shows Differences Between Atypical Antipsychotic Medications Geodon (Ziprasidone) and Zyprexa (Olanzapine) - Doctor's Guide, 10/12/04
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Some Anti-Psychotic Medications May Trigger Diabetes - Science Daily, 10/8/04 -
"The rate is five to 10 times higher than the estimated rate of 6.3 cases per
1,000 in the general U.S. population"
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Seizure Drug Combats Antipsychotic Side Effects - Psychiatric News, 6/18/04
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Olanzapine Appears More Effective Than Risperidone For Long-Term Negative Social Functioning Symptoms in Schizophrenia Patients - Doctor's Guide, 5/6/04
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Olanzapine Cuts Risk of Tardive Dyskinesia in Elderly Patients On Antipsychotics - Doctor's Guide, 4/30/04
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Olanzapine Gets Warning For Use in Elderly - Psychiatric News, 4/16/04
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Higher Mortality Seen in Olanzapine-Treated Elderly - Clinical Psychiatry News, 4/04
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FDA Approves Injectable Form of Zyprexa (Olanzapine) - Doctor's Guide, 3/29/04
- Olanzapine Labeling Change Indicates Risk of Hyperglycemia, Diabetes - Medscape, 3/22/04
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Olanzapine May Work as Adjunctive Therapy for Non-Responsive GAD Patients - Doctor's Guide, 3/16/04
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Glycine Reduces Negative And Cognitive Symptoms in Schizophrenic Patients Taking Olanzapine Or Risperidone - Doctor's Guide, 3/16/04 - See
Vitacost
glycine products.
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Electroencelphalogram Abnormalities Appear Less Frequent With Quetiapine Than With Haloperidol and Olanzapine - Doctor's Guide, 3/10/04
- Lilly Warns of Zyprexa Risks Among Elderly - WebMD, 2/20/04
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Zyprexa Appears to Delay Relapse in Patients with Schizophrenia Significantly Longer Than Other Atypical Antipsychotics - Doctor's Guide, 2/11/04
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Olanzapine Comparable to Haloperidol, Causes Fewer Extrapyramidal Symptoms - Doctor's Guide, 2/6/04
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Olanzapine Therapy May Cause Rapid Induction of Insulin Resistance - Doctor's Guide, 2/3/04
- New Drug for Long-Term Bipolar Treatment - WebMD, 1/15/04
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FDA Approves Zyprexa (Olanzapine) for Maintenance of Bipolar Disorder - Doctor's Guide, 1/15/04
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Olanzapine Helps Compliance in Schizophrenia - Clinical Psychiatry News Online, 1/04
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FDA Approves Symbyax (Olanzapine and Fluoxetine), First Medication for Bipolar Depression - Doctor's Guide, 12/30/03
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No Difference In Remission Of Manic Episodes In Bipolar Patients Taking Olanzapine Or Haloperidol - Doctor's Guide, 12/11/03
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Olanzapine Has Similar Efficacy, Costs More Than Haloperidol for Treatment of Schizophrenia - Doctor's Guide, 12/9/03
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Olanzapine Has Similar Efficacy, Costs More Than Haloperidol for Treatment of Schizophrenia - Doctor's Guide, 11/27/03
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Olanzapine Helps to Delay Bipolar Recurrence - Clinical Psychiatry News Online, 11/03
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Haloperidol, not Olanzapine, Linked With Brain Shrinkage in Schizophrenia - Doctor's Guide, 11/11/03
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Nutrition Counseling Effective in Controlling Weight Gain Associated With Olanzapine Use - Doctor's Guide, 11/3/03
- Olanzapine Reduces Violence Risk - Medscape, 10/31/03
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FDA to Require Diabetes Warning On Antipsychotics - Psychiatric News, 10/17/03
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Weight Gain is Potential Problem in Patients Switched from Risperidone to Olanzapine - Doctor's Guide, 10/16/03
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Olanzapine/Fluoxetine Combination Treats Bipolar Depression Without Triggering Mania - Doctor's Guide, 10/14/03
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Switch From Oral Olanzapine to Depot Risperidone Safe, May Improve Symptoms - Doctor's Guide, 10/3/03
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Olanzapine Treatment Associated with a Higher Incidence of Diabetes in Patients with Psychoses - Doctor's Guide, 9/17/03
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Antipsychotic-Induced Metabolic Syndrome Proves Costly - Clinical Psychiatry News, 9/03
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Oral Olanzapine May Effectively Treat Agitation in Schizophrenia Or Bipolar Disorder - Doctor's Guide, 8/29/03
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Olanzapine More Effective Against Manic Relapse - Clinical Psychiatry News, 8/03
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Try Mirtazapine or Escitalopram for Speedy Onset - Clinical Psychiatry News, 8/03 -
"When you need
the quickest possible antidepressant effect, consider choosing
mirtazapine or
escitalopram for treatment or combining a selective serotonin reuptake inhibitor with
pindolol or olanzapine"
- Olanzapine Relatively Safe During Breast-Feeding - Medscape, 8/8/03
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FDA Approves Zyprexa for Use in Combination with Lithium or Valproate to Treat Acute Manic Episodes of Bipolar I Disorder - Doctor's Guide, 7/16/03
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Therapeutic Dose Equivalency Calculation Method Proposed for Atypical Antipsychotic Medications - Doctor's Guide, 7/16/03 -
"The reported minimum effective doses identified were 4 mg/day for risperidone, 10 mg/day for olanzapine, 150 mg/day for quetiapine, 120 mg/day for ziprasidone, 15 mg/day for aripiprazole, and 4 mg/day for haloperidol"
- Olanzapine May Be Better Than Divalproex in Acute Mania - Medscape, 7/10/03
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Orally Disintegrating Zyprexa Zydis Reduces Acute or Breakthrough Symptoms of Schizophrenia - Doctor's Guide, 6/24/03
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Supratherapeutic Dosing of Olanzapine May Help Refractory Schizophrenia - Clinical Psychiatry News, 5/03
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Novel Antipsychotic's Side Effect Profile Offers Benefits - Clinical Psychiatry News, 5/03
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Antipsychotics Effective for Elderly Patients With Dementia - Psychiatric News, 4/18/03 -
"atypical antipsychotics have been
used to alleviate deteriorating behavioral symptoms in dementia patients, such as agitation and aggression. New research that she cited shows some atypical antipsychotics can actually improve cognition through activating
the release of acetylcholine in the cortex.
Clozapine, olanzapine, and
risperidone, she reported, robustly increased acetylcholine release in the cortex, while
ziprasidone only moderately increased
levels, compared with haloperidol and thioridazine, which did not elevate acetylcholine levels at all ... atypical antipsychotics
increase cortical dopamine and cholinesterase inhibitors at the very least increase cortical acetylcholine action, leading to an improvement in memory and thinking, as well as improvement in psychosis and behavior"
- 2 Schizophrenia Drugs Square Off - WebMD, 4/7/03
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Atypical Antipsychotics - Clinical Psychiatry News, 4/03
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Careful Monitoring of Children on Atypicals Is Critical - Clinical Psychiatry News, 4/03 -
"Olanzapine and
risperidone use in children and adolescents is associated with significantly more weight gain than
quetiapine"
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Olanzapine Broadly Effective In Acute Dysphoric Mania - Doctor's Guide, 3/31/03
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Antipsychotic Linked Weight Gain Not Counteracted By Serotonin Reuptake Inhibitors - Doctor's Guide, 3/24/03
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Health Canada Approves Zyprexa (Olanzapine), Treatment For Bipolar Disorder - Doctor's Guide, 3/18/03
- Antipsychotics and Glucose Dysregulation: Their Relationship to Treatment Decisions - Psychiatric Times, 3/03
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Olanzapine Improves Behaviour Disturbances in Nursing-Home Patients with Alzheimer's Disease - Doctor's Guide, 3/4/03
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Antipsychotics Raise Glucose, Cholesterol Levels In Schizophrenics - Doctor's Guide, 2/25/03 -
"Clozapine, olanzapine and
haloperidol are associated with increased plasma glucose level, and clozapine and olanzapine with raised cholesterol"
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Olanzapine Improves Psychotic Symptoms In Adolescents With Schizophrenia - Doctor's Guide, 1/31/03
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Olanzapine/Fluoxetine Combination Effective In Psychotic Depression - Doctor's Guide, 1/20/03
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Studies Support Calming Effect of Olanzapine - Clinical Psychiatry News, 1/03
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Some Antipsychotics May Be Tied To Increased Type 2 Diabetes Risk - Clinical Psychiatry News, 1/03 -
"the risk was increased by 3.1 among those on olanzapine (Zyprexa), 7.44 times among those on clozapine, 2.13 among those on high-potency conventional antipsychotics such as haloperidol and fluphenazine, and by 3.46 times among those on low-potency conventional antipsychotics such as chlorpromazine and thioridazine"
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Fewer Side Effects With Mood Stabilizer Depakote (Divalproex Sodium) Than With Antipsychotic Zyprexa (Olanzapine) - Doctor's Guide, 12/16/02
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Olanzapine For Schizophrenia Quintuples Hyperlipidaemia Risk - Doctor's Guide, 12/4/02
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Olanzapine Goes Head-to-Head With Flupenthixol - Clinical Psychiatry News, 12/02
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Try Higher Doses of Atypicals Before Giving Up - Clinical Psychiatry News, 12/02
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Olanzapine May Produce Rapid, Sustained Reduction in Prolactinemia in Patients with Schizophrenia - Doctor's Guide, 11/5/02
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Olanzapine May be Superior to Divalproex in Achieving Remission from Mania - Doctor's Guide, 11/4/02
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Zyprexa (Olanzapine) Reduces Recurrence in Combination Therapy for Bipolar Disorder - Doctor's Guide, 11/1/02
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Zyprexa (Olanzapine) Has Potential in Treating Adolescent Psychosis - Doctor's Guide, 10/28/02
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Olanzapine Safe and Effective for Adolescent Bipolar Disorder - Doctor's Guide, 10/25/02
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Olanzapine Benefits Older Patients - Clinical Psychiatry News, 10/02
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Studies Cite Links Between Olanzapine, Diabetes - Clinical Psychiatry News, 10/02
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Olanzapine Does Not Reduce Hallucinations In Parkinson's Disease - Doctor's Guide, 10/17/02
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Olanzapine Decreases Neuroleptic-induced Hyperprolactinemia in Schizophrenic Patients - Doctor's Guide, 10/16/02
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Olanzapine Shows Promise In Management of Tardive Dyskinesia In Schizophrenics - Doctor's Guide, 10/15/02
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Olanzapine Decreases Neuroleptic-Induced Hyperprolactinemia in Schizophrenic Patients - Doctor's Guide, 10/14/02
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Olanzapine Reduces Tardive Dyskinesia Symptoms - Doctor's Guide, 10/9/02
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Olanzapine/Fluoxetine Combination for Treatment-Resistant and Psychotic Depression Raises No New Safety Issues - Doctor's Guide, 10/9/02
- Schizophrenia Drugs [Zyprexa and Seroquel] Treat Bipolar - WebMD, 9/18/02
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New Data Suggest Zyprexa (Olanzapine) Superior To Standard Of Care (Lithium) For Preventing Mania Relapse In Bipolar Disorder - Doctor's Guide, 9/16/02
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Reduction of Psychotic Symptoms by Olanzapine in Patients with Probable Lewy Body Dementia - Doctor's Guide, 9/2/02
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Olanzapine-Fluoxetine for Treatment-Resistant Depression - Doctor's Guide, 9/2/02
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Olanzapine Versus Risperidone: A Comparison Of Hospital Length Of Stay In Adult Inpatients With Schizophrenia - Doctor's Guide, 9/2/02
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Olanzapine Effective For Chronic Headache But Should Be Used With Caution - Doctor's Guide, 8/30/02
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Olanzapine-Fluoxetine Better Than Olanzapine Alone For Psychotic Depression - Doctor's Guide, 8/29/02
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Olanzapine Appears More Effective Than Divalproex In Treatment Of Bipolar Mania - Doctor's Guide, 8/29/02
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Schizophrenics Taking Olanzapine Have Increased Diabetes Risk - Doctor's Guide, 8/5/02
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Rapid-Acting Olanzapine Effective in Acutely Agitated Patients with Dementia - Doctor's Guide, 7/22/02
- Warning About Antipsychotic Drug [Zyprexa] - Doctor's Guide, 7/1/02
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Olanzapine for Developmental Stuttering - Clinical Psychiatry News, 7/02
- Olanzapine Linked to Increased Risk of Diabetes - Doctor's Guide, 6/27/02
- Amisulpride Found Efficacious in Schizophrenia with Less Weight Gain than Olanzapine - Doctor's Guide, 6/26/02
- Olanzapine and Fluoxetine Improve Quality of Life in Bipolar Patients - Doctor's Guide, 6/25/02
- Olanzapine Reduces Need for Anticholinergics in Elderly Schizophrenics - Doctor's Guide, 6/24/02
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News - Possible Genetic Linkage Cited in Antipsychotic Drug Weight Gain - Doctor's Guide, 6/13/02
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Olanzapine Effective Treatment For Mania In Non-Responders To Earlier Mood Stabilisers - Doctor's Guide, 5/30/02
- Olanzapine Effective for the Treatment of Bipolar Depression - Doctor's Guide, 5/27/02
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Olanzapine May Improve Social Cognition in Patients with Schizophrenia - Doctor's Guide, 5/23/02
- Lamotrigine, Olanzapine Stabilize Mood in Bipolar Disorder - Medscape, 5/23/02
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Olanzapine-Fluoxetine Combination Shows Promise for Psychotic Major Depression - Doctor's Guide, 5/22/02
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Olanzapine Plus Lithium or Valproate Effective for Bipolar Relapse Prevention - Doctor's Guide, 5/22/02
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Olanzapine Proves Useful in Managing Psychocutaneous Disorders - Clinical Psychiatry News, 5/02
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Optimal Management of Psychosis & Agitation in the Elderly - Medscape, 3/20/02
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Olanzapine Curbs Tardive Dyskinesia - Clinical Psychiatry News, 3/02
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Divalproex Enhances Efficacy of Antipsychotics - Clinical Psychiatry News, 3/02
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Risperidone and Olanzapine May Reduce Risk of Extrapyramidal Symptoms - Doctor's Guide, 1/17/02
- Newer Antipsychotics Linked to Weight Gain - Doctor's Guide, 11/19/01
- Olanzapine May Reduce Symptoms Associated With Antipsychotic Therapies - Doctor's Guide, 11/19/01
- High Doses of Olanzapine do not Increase Prolactin Levels - Doctor's Guide, 11/18/01
- Zyprexa (Olanzapine) IntraMuscular Rapidly Controls Acute Agitation in Bipolar Mania - Doctor's Guide, 8/2/01
- Ziprasidone Has Less Effect Than Olanzapine on Weight, Lipids, Insulin Levels in Schizophrenia - Doctor's Guide, 7/23/01
- Olanzapine Reduces Alzheimer Agitation And Psychosis - Doctor's Guide, 6/18/01
- Olanzapine Has No Anticholinergic Effects in Elderly Patients With Dementia - Doctor's Guide, 5/11/01
- Geodon (Ziprasidone HCl) Better Tolerated Than Zyprexa (Olanzapine) In Schizophrenia and Schizoaffective Disorders - Doctor's Guide, 5/8/01
- Axid (Nizatidine) Cuts Weight Gain During Zyprexa (Olanzapine) Treatment For Schizophrenia - Doctor's Guide, 5/3/01
- Seroquel (Quetiapine): First-choice Treatment for Young People With Psychotic Illness - Doctor's Guide, 5/1/01
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Olanzapine's And Clozapine's Effect On Weight Gain Related To Insulin And Leptin - Doctor's Guide, 3/26/01 -
"the median insulin level was significantly higher in
olanzapine patients ... In the clozapine group, insulin levels were positively correlated to the drug serum concentration"
- Intramuscular Zyprexa (Olanzapine) Controls Agitation In Elderly With Dementia - Doctor's Guide, 2/27/01
- Fewer Side Effects With Depakote (Divalproex) Than With Olanzapine For Acute Mania - Doctor's Guide, 12/12/00 -
"The following adverse events showed a statistically significant difference: edema (0 percent
vs. 14 percent), somnolence (29 percent vs. 47 percent), speech disorder (0 percent vs. 7 percent), rhinitis (3 percent vs. 14 percent) and weight gain (10 percent vs. 25 percent), in the Depakote- and olanzapine-treated groups respectively ... Depakote patients had significantly less weight gain than olanzapine
patients ... Cases of life-threatening pancreatitis, some rapidly progressing to death, have been reported in both adults and children receiving valproate. The frequency of adverse effects, particularly elevated liver enzymes and thrombocytopenia may be dose-related. Valproate may produce teratogenic effects in the
offspring of women receiving the drug during pregnancy. Depakote (divalproex sodium) is a derivative of valproic acid"
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Fatal Reaction Linked To Olanzapine Use - Doctor's Guide, 11/16/00
- FDA Approves Zyprexa (Olanzapine) For Long-Term Treatment Of Schizophrenia - Doctor's Guide, 11/13/00
- Orally Disintegrating Formulation Of Antipsychotic Zyprexa (Olanzapine) Now Available - Doctor's Guide, 9/18/00
- Zyprexa (Olanzapine) Superior To Depakote (Valproate) For Acute Mania In Bipolar Disorder - Doctor's Guide, 9/11/00
- Intramuscular Zyprexa (Olanzapine) More Rapid, Effective Than Haloperidol - Doctor's Guide, 7/12/00
- Maximizing Functional Outcome in Psychotic Patients - Doctor's Guide, 5/23/00
- Olanzapine Effective for Juvenile Bipolar Disorder - Doctor's Guide, 5/18/00
- Olanzapine Reduces Behavioral and Psychotic Symptoms in Alzheimer's Patients - Doctor's Guide, 5/16/00
- Zyprexa (Olanzapine) Has Superior Benefits to Risperdal (Risperidone) in Treating Schizophrenia
- Doctor's Guide, 5/12/00
- Olanzapine Appears To Aggravate Parkinsonism - Doctor's Guide, 5/8/00
- Olanzapine may reduce psychotic symtoms in patients with dementia - Doctor's Guide, 5/3/00
- Risperdal (Risperidone) For Schizophrenia More Cost-effective Than Olanzapine - Doctor's Guide, 4/27/00
- FDA Approves Zyprexa (Olanzapine) For Manic Episodes In Bipolar Disorder - Doctor's Guide, 3/20/00
- Zyprexa Receives Approvable Letter For Treatment Of Acute Mania In Bipolar Disorder - Doctor's Guide, 10/28/99
- Risperidone More Cost Effective Than Olanzapine - Doctor's Guide, 9/24/99
- Olanzapine Highly Effective In Bipolar Disorder - Doctor's Guide, 9/22/99
- Zyprexa Reduces Hyperprolactinemia Prevalence In Schizophrenia Patients - Doctor's Guide, 8/2/99
- Zyprexa Reduces Symptoms Of Mania, Severe Depression In Bipolar Disorder - Doctor's Guide, 6/18/99
- Cognitive Improvement Associated With Olanzapine - Doctor's Guide, 5/28/99 -
"olanzapine produces more significant reduction in cognitive dysfunction in patients
with early stage schizophrenia over a one-year treatment period than do risperidone and haloperidol"
- Combination Treatment Often Necessary For Bipolar Disorder - Doctor's Guide, 5/27/99
- Zyprexa Reduces Behavioural, Psychiatric Symptoms Related To Alzheimer's - Doctor's Guide, 12/15/98
- Olanzapine More Tolerable, As Effective As Clozaril For Treatment-Resistant Patients - Doctor's Guide, 10/30/98
- Zyprexa Reduces Symptoms In Alzheimer’s Patients - Doctor's Guide, 9/22/98
- Antipsychotic Olanzapine Doesn’t Increase Prolactin Levels - Doctor's Guide, 6/3/98
- Atypical Antipsychotics May Be Used In First-Line Treatment Of Brain Disorders - Doctor's Guide, 12/1/97
- Study Shows New Schizophrenia Drug is Safer, More Effective - Doctor's Guide, 4/23/97
- Zyprexa Cleared by the FDA for Treatment of Psychotic Disorders - Doctor's Guide, 10/1/96
Abstracts:
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Metformin as an adjunctive treatment to control body weight and metabolic
dysfunction during olanzapine administration: A multicentric, double-blind,
placebo-controlled trial - Schizophr Res. 2007 Jul;93(1-3):99-108 -
"Metformin may safely assist olanzapine-treated
patients in body weight and carbohydrate metabolism control"
-
Life-threatening hyperglycemia and acidosis related to olanzapine: a case
report and review of the literature - J Intensive Care Med. 2007
Jan-Feb;22(1):52-5 - "The authors
postulate that treatment with olanzapine precipitated hyperglycemia, an
elevated creatine kinase level, and a high amylase level"
-
Risk of diabetes mellitus associated with atypical antipsychotic use among
medicaid patients with bipolar disorder: a nested case-control study -
Pharmacotherapy. 2007 Jan;27(1):27-35 -
"the risk of diabetes was greatest
among patients taking risperidone (hazard ratio [HR] 3.8, 95% confidence
interval [CI] 2.7-5.3), olanzapine (3.7, 95% CI 2.5-5.3), and quetiapine
(2.5, 95% CI 1.4-4.3). The risk for developing diabetes was also associated
with weight gain (HR 2.5, 95% CI 1.9-3.4), hypertension (HR 1.6, 95% CI
1.2-2.2), and substance abuse (HR 1.5"
-
Effect of Olanzapine on Body Composition and Energy Expenditure in Adults With First-Episode Psychosis - Am J Psychiatry 162:118-123, January 2005 -
"After
approximately 12 weeks of olanzapine therapy, the median increase in body weight was 4.7 kg, a significant increase of 7.3% from first observation ... Olanzapine appears to have induced an increase in central body fat deposition, insulin, and triglyceride levels, suggesting the possible development of insulin
resistance. The decrease in fat oxidation may be secondary or predispose patients to olanzapine-induced weight gain"
-
Attenuation of Olanzapine-Induced Weight Gain With Reboxetine in Patients With Schizophrenia: A Double-Blind, Placebo-Controlled Study
- Am J Psychiatry 160:297-302, 2/03
-
An Assessment of the Independent Effects of Olanzapine and Risperidone Exposure on the Risk of Hyperlipidemia in Schizophrenic Patients - Archives of General Psychiatry, 11/02 -
"Olanzapine use was associated with nearly a 5-fold increase in the odds of developing hyperlipidemia compared with no antipsychotic exposure"
-
A Double-blind, Placebo-Controlled Dose-Response Comparison of Intramuscular Olanzapine and Haloperidol in the Treatment of Acute Agitation in Schizophrenia - Archives of General
Psychiatry, 5/02
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