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Antidepressants & Psychotropics > Remeron® (mirtazapine)
Remeron® (mirtazapine)
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Remeron & Cortisol:
-
Effects of mirtazapine on dehydroepiandrosterone-sulfate and cortisol plasma
concentrations in depressed patients - J Psychiatr Res. 2008 Aug 13 -
"Mirtazapine significantly reduced both COR and
DHEA-S concentrations, but had no impact on the COR/DHEA-S ratio"
-
Mirtazapine Attenuates Hypothalamic-pituitary-adrenocortical Axis Hyperactivity in Depressed Patients - Doctor's Guide, 4/17/03 -
"it has been shown to have an acute inhibiting effect on cortisol secretion in healthy subjects ... Apparently, mirtazapine rapidly attenuates HPA axis hyperactivity in depressed patients via direct
pharmaco-endocrinological effects. However, this amelioration of HPA system dysregulation is not necessarily related to clinical improvement" - Click here for a previous study.
- Mirtazapine Regulates Stress Hormones, Improves Sleep In Depressed Patients - Doctor's Guide, 8/8/01
- Effects of mirtazapine on growth hormone, prolactin, and cortisol secretion in healthy male subjects - Psychoneuroendocrinology 1999
Oct;24(7):769-84 - "The t-test for paired samples revealed a highly significant difference (P < 0.01) in COR-AUC-values between the mirtazapine group (mean COR-AUC: 1558.07 micrograms/100 ml x 240 min) and the placebo group (mean COR-AUC: 2698.86 micrograms/100 ml x 240 min)."
- Note: The way I read that, there was a 42% decrease in cortisol with 15 mg of mirtazapine over a four hour period. Click here for more info on the study.
News & Research:
- Remeron
(mirtazapine) - rxlist.com
-
How Does Mirtazapine
Induce Weight Gain? - Medscape, 3/6/09
-
Analysis Shows Sertraline, Escitalopram More Effective Than 10 Other
New-Generation Antidepressants - Doctor's Guide, 1/29/09 -
"Sertraline and escitalopram were found to be the
best antidepressants overall in terms of efficacy and acceptability.
Sertraline was more efficacious than duloxetine (by 30%); than both
duloxetine and fluvoxamine (by 27% for both); 25% fluoxetine (by 25%);
paroxetine (by 22%); and reboxetine (by 85%) ... Escitalopram was more
efficacious than duloxetine (by 33%); fluoxetine (by 32%); fluvoxamine (by
35%); paroxetine (by 30%); and reboxetine (by 95%). As with sertraline and
escitalopram, mirtazapine and venlafaxine were also more efficacious than
these other drugs ... However, escitalopram and sertraline showed the best
profile of acceptability, leading to significantly fewer discontinuations of
treatment than did duloxetine, fluvoxamine, paroxetine, reboxetine, and
venlafaxine"
-
Combining Mirtazapine (Remeron) with Other Antidepressants Improves
Remission Rates in Patients with Unipolar Depression - Doctor's Guide,
11/11/05
-
Antidepressant Combos Show Synergistic Benefit - Clinical Psychiatry
News, 9/05 - "combined mirtazapine
and paroxetine (Paxil) achieved superior remission of depression, compared
with either agent alone ... mirtazapine increases norepinephrine, and
long-term treatment with selective serotonin reuptake inhibitors such as
paroxetine can decrease levels of this neurotransmitter"
-
Mirtazapine Betters Major SSRIs for Treatment of Depression - Doctor's
Guide, 5/27/05 - "A meta-analysis of
clinical trials involving more than 2,500 subjects suggests that treatment
of depression with mirtazapine (Remeron) results in a more rapid onset of
clinical improvement compared to treatment with fluoxetine, paroxetine, and
sertraline (all SSRIs)" - See Remeron (mirtazapine) at OffshoreRX.com
 .
-
Mirtazapine Tied to Psychomotor Deficits - Clinical Psychiatry News, 12/04
- Mirtazapine Plus Clozapine Appears to Improve Negative Symptoms of Schizophrenia - Doctor's Guide, 4/21/04
- Patient with Delayed, Persistent Initial Response To Mirtazapine May Benefit the Most from Continued Therapy - Doctor's Guide, 4/5/04
- Mirtazapine More Effective Than Sertraline On Veterans' Post-Traumatic Stress Disorder - Doctor's Guide, 10/14/03
- Mirtazapine Effective For Anxiety and Depression in Alcohol Detoxification - Doctor's Guide, 10/6/03
- Mirtazapine Can Be Added To Clozapine, Risperidone Or Olanzapine Without Pharmacokinetic Interaction, In Treatment Of Schizophrenia - Doctor's Guide, 8/21/03
- Case Report: Mirtazapine Associated With Hypertriglyceridaemia, Acute Pancreatitis And Diabetic Ketoacidosis - Doctor's Guide, 8/13/03
-
Try Mirtazapine or Escitalopram for Speedy Onset - Clinical Psychiatry News, 8/03 -
"When you need
the quickest possible antidepressant effect, consider choosing mirtazapine or escitalopram for treatment or combining a selective serotonin reuptake inhibitor with
pindolol
or olanzapine"
- Mirtazapine Reduces Sleep Interruptions - Physician's Weekly, 7/7/03
- Antidepressant [Remeron] Is Promising for Sleep Apnea - WebMD, 6/5/03
-
Mirtazapine Lifts Mood of Older Depressed Patients - Clinical Psychiatry News, 6/03 -
"The drug's anxiolytic and sleep-improving properties, minimal gastrointestinal side effects, low risk of drug-drug interactions, and modest associated weight gain are significant advantages"
- Venlafaxine Beats Selective Serotonin-Reuptake Inhibitors in Remission of Depression - Doctor's Guide, 5/22/03 -
"The results of this
largest-of-all comparative study of venlafaxine and other agents supports the conclusions of other investigators that, compared to other SSRIs, venlafaxine helps patients achieve remission of symptoms at relatively higher rates" - Note:
Venlafaxine increases both serotonin and norepinephrine, as does mirtazapine and the investigational drug duloxetine.
- Mirtazapine-Amitriptyline Combination Warrants Caution - Doctor's Guide, 3/12/03
- Oral Mirtazapine Effective, Well-tolerated by Depressed Nursing-Home Patients - Doctor's Guide, 3/7/03
- Mirtazapine May Be Superior to Sertraline in Onset Time, Symptom Reduction among Patients with Major Depression - Doctor's Guide, 11/4/02
- Intravenous Mirtazapine Effective In Treating Depression - Doctor's Guide, 2/1/02
- Doctors Target Two Brain Chemicals to Treat Depression, Anxiety - WebMD, 9/17/01 -
"Prozac works by increasing the availability of the mood chemical serotonin, while Effexor
targets serotonin and norepinephrine, another brain chemical that plays a role in anxiety and depression ... there's a whole series of other studies in the area of anxiety disorders and new medications that are in development that target both brain chemicals ... One such drug, Remeron, is currently available"
- New Options for Severe Depression - WebMD, 7/23/01
- Remeron SolTab (Mirtazapine) Effective, Safe for Treatment of Depression in Senior Citizens - Doctor's Guide, 5/8/01 -
"But what we found here is that mirtazapine
was faster-acting and produced an overall better result in the first six weeks of treatment than paroxetine"
- Mirtazapine May Improve Parkinsonian Tremor And Essential Tremor - Doctor's Guide, 5/8/01
- FDA Approves Remeron SolTab (Mirtazapine) For Depression - Doctor's Guide, 1/12/01
- Mirtazapine Effective And Well-Tolerated Anti-Depressant - Doctor's Guide, 1/8/01
- New Antidepressant Also Helps You Sleep - WebMD, 7/25/00
- Mirtazapine as a Treatment for Major Depression - Doctor's Guide, 5/18/00 -
"Results show that mirtazapine seemed to have a faster onset of action than did citalopram"
- Paroxetine Safer than Mirtazapine for Car Driving Performance - Doctor's Guide, 5/18/00
- Remeron Relieves Depression Quicker Than Do Some SSRIs - Doctor's Guide, 12/15/99
- Depression Drug, Mirtazapine, Steadies Hand Tremor - Doctor's Guide, 9/22/99
- Remeron More Effective, Faster Working Than Cipramil or Paxil, Study Shows - Doctor's Guide, 11/3/98
- Remeron Found Superior To Fluoxetine In Early Depression Treatment - Doctor's Guide, 6/25/98
- Remeron Cleared by FDA for the Treatment of Depression - Doctor's Guide, 6/19/96
Abstracts:
-
Effect of mirtazapine treatment on body composition and metabolism - J
Clin Psychiatry. 2006 Mar;67(3):421-4 - "The antidepressant therapy with
mirtazapine was associated with a significant increase in body weight, body
fat mass, and leptin concentration"
-
Which antidepressants have demonstrated superior efficacy? A review of the
evidence - Int Clin Psychopharmacol. 2007 Nov;22(6):323-329 -
"Criteria were defined to judge the strength of
evidence. Two pivotal studies in moderate-to-severe major depressive
disorder that demonstrate superiority on the primary efficacy measure, or
alternatively one pivotal study supported by consistent results from
meta-analyses, was considered to constitute evidence for definite
superiority. Three antidepressants met these criteria: clomipramine,
venlafaxine, and escitalopram. Three antidepressants were found to have
probable superiority: milnacipran, duloxetine, and mirtazapine. Only
escitalopram was found to have definite superiority in the treatment of
severe depression; probable superiority was identified for venlafaxine and
possible superiority for milnacipran and clomipra"
-
Effect of mirtazapine treatment on body composition and metabolism - J
Clin Psychiatry. 2006 Mar;67(3):421-4 - "The antidepressant therapy with
mirtazapine was associated with a significant increase in body weight, body
fat mass, and leptin concentration"
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