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Antidepressants & Psychotropics > ProzacŪ (fluoxetine hydrochloride)
ProzacŪ (fluoxetine hydrochloride) (Eli Lilly and Co.)
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News & Research:
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Prozac (fluoxetine) - rxlist.com
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St. John's Wort Equivalent to World's Best-selling Antidepressant - herbs.org
- Fluoxetine at drugstore.com

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Omega-3 EPA may benefit depressives, says study - Nutra USA, 4/7/08 - [Abstract]
- "were randomly assigned to receive a daily EPA
supplement (1000 mg, supplied by Minami Nutrition, Belgium), or 20 mg
fluoxetine daily, or a combination of the two for two months ... At the end
of the study, data from the 48 people who finished the study showed a 50 per
cent reduction in HDRS scores for people in the EPA group, a 56 per cent
reduction in people in the fluoxetin group, and a 81 per cent reduction in
people in the combined intervention group" - See
Mega Twin EPA at iHerb
.
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Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic
acid and fluoxetine, separately and in combination, in major depressive
disorder - Aust N Z J Psychiatry. 2008 Mar;42(3):192-8 -
"EPA + fluoxetine combination was significantly
better than fluoxetine or EPA alone from the fourth week of treatment.
Fluoxetine and EPA appear to be equally effective in controlling depressive
symptoms. Response rates (>/=50% decrease in baseline HDRS) were 50%, 56%
and 81% in the fluoxetine, EPA and combination groups, respectively"
- See Mega Twin EPA at
iHerb
.
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First Head-to-Head Study Suggests Significantly Greater Symptom Improvement
for Olanzapine and Fluoxetine Combination Capsules Compared to Lamotrigine
in Bipolar Depression - Doctor's Guide, 5/30/06
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Study Suggests Olanzapine and Fluoxetine Combination Capsules Improve
Symptoms of Treatment-Resistant Depression - Doctor's Guide, 5/30/06
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Popularity Doesn't Necessarily Make Prozac Best Antidepressant Choice -
Doctor's Guide, 12/6/05
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Eszopiclone (Lunesta) With Fluoxetine (Prozac) Improves Comorbid Insomnia in
Depression - Doctor's Guide, 5/30/05
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Mirtazapine Betters Major SSRIs for Treatment of Depression - Doctor's
Guide, 5/27/05 - "A meta-analysis of
clinical trials involving more than 2,500 subjects suggests that treatment
of depression with mirtazapine (Remeron) results in a more rapid onset of
clinical improvement compared to treatment with fluoxetine, paroxetine, and
sertraline (all SSRIs)" - See Remeron (mirtazapine) at OffshoreRX.com
.
- Prozac: A Weight-Loss Drug? - WebMD, 7/12/04
- Fluoxetine Appears Monotherapy Safe, Effective For Bipolar Type Major Depressive Episode - Doctor's Guide, 3/16/04
- Treatment Adequacy Appears More Likely With Venlafaxine Extended Release Than Fluoxetine In Depressed Patients - Doctor's Guide, 2/10/04
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FDA Approves Symbyax (Olanzapine and Fluoxetine), First Medication for Bipolar Depression - Doctor's Guide, 12/30/03
- Olanzapine/Fluoxetine Combination Treats Bipolar Depression Without Triggering Mania - Doctor's Guide, 10/14/03
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Fluoxetine Is Tx of Choice for Bulimia, but Most Continue to Binge - Clinical Psychiatry News, 9/03
- Citalopram Effective in Patients Who React Adversely to Fluoxetine - Doctor's Guide, 6/5/03
- Fluoxetine Treatment For Depression Should Continue For Set Period For Proper Assessment - Doctor's Guide, 4/9/03
- Fluoxetine Useful In Treating Childhood Anxiety Disorders - Doctor's Guide, 4/2/03
- Fluoxetine Mildly Effective in Elderly Patients with Dysthymic Disorder - Doctor's Guide, 3/7/03
- Olanzapine/Fluoxetine Combination Effective In Psychotic Depression - Doctor's Guide, 1/20/03
- SSRIs May Increase Risk of Gastrointestinal Bleeding - Medscape, 1/17/03 -
"Selective serotonin reuptake inhibitors (SSRIs) are associated with
an increased risk of gastrointestinal (GI) bleeding, especially when combined with nonsteroidal anti-inflammatory drugs (NSAIDs)" - Examples of SSRIs are Prozac,
Paxil and Zoloft.
- FDA Approves Prozac For Pediatric Use To Treat Depression, Obsessive Compulsive Disorder - Doctor's Guide, 1/6/03
- FDA approves Prozac for children - USA Today, 1/3/03
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Fluoxetine at 20 mg Safe in Children - Clinical Psychiatry News, 12/02
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Age May Affect Rate of Response To Fluoxetine - Clinical Psychiatry News, 10/02
- Olanzapine/Fluoxetine Combination for Treatment-Resistant and Psychotic Depression Raises No New Safety Issues - Doctor's Guide, 10/9/02
- SNRI Reboxetine Safe and Effective Adjunct for SSRI Fluoxetine Partial Responders in Major Depression - Doctor's Guide, 10/8/02
- Premenstrual Dysphoric Syndrome Cut By Daily Fluoxetine - Doctor's Guide, 9/24/02
- Fluoxetine Effective in Premenstrual Dysphoric Disorder - Medscape, 9/6/02
- Poor Response To Fluoxetine Antidepressant Therapy Appears Linked To High Serum Cholesterol - Doctor's Guide, 9/5/02 -
"patients with elevated
cholesterol levels were significantly more likely to be nonresponders to fluoxetine therapy than were patients with nonelevated
cholesterol levels"
- Olanzapine-Fluoxetine for Treatment-Resistant Depression - Doctor's Guide, 9/2/02
- Boosting Fluoxetine As Effective As Adding Lithium Or Desipramine For Unresponsive Depression - Doctor's Guide, 8/30/02
- Olanzapine-Fluoxetine Better Than Olanzapine Alone For Psychotic Depression - Doctor's Guide, 8/29/02
- Extended Use of Clonazepam with Fluoxetine Safe and Effective for Major Depression in Outpatients - Doctor's Guide, 8/23/02
- Increasing Drug Dose Appears Effective for Depressed Patients Who Relapse on Fluoxetine - Doctor's Guide, 8/20/02
- Venlafaxine Appears More Effective Than Fluoxetine In Treating Depression With Concomitant Anxiety - Doctor's Guide, 8/9/02 -
"An overall response was seen in 75 percent of patients receiving venlafaxine and 51 percent of patients receiving fluoxetine. At their final visit, 59 percent of patients taking venlafaxine and 40 percent taking fluoxetine were virtually asymptomatic"
- Olanzapine and Fluoxetine Improve Quality of Life in Bipolar Patients - Doctor's Guide, 6/25/02
- Sertraline Beats Fluoxetine for Severe Depression - Doctor's Guide, 5/22/02
- Olanzapine-Fluoxetine Combination Shows Promise for Psychotic Major Depression - Doctor's Guide, 5/22/02
- Response to Antidepressent Therapy Appears Age Dependent - Doctor's Guide, 5/15/02
- Characterising Fluvoxamine Metabolism - Doctor's Guide, 4/19/02 -
"the higher fluvoxamine doses inhibited CYP1A2 and
CYP2C19 by approximately 75 to 80 per cent. The inhibition with the lower doses was around 40 to 50 per cent"
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Generic Fluoxetine May Offer Lower Bioequivalence - Clinical Psychiatry News, 4/02
- False Alarm: Study Doesn't Link Prozac to Cancer - WebMD, 3/28/02
- Fluoxetine Effective In Women With Fibromyalgia - Doctor's Guide, 3/28/02
- Generic Prozac: Can You Trust It? - WebMD, 8/28/01
- Generic Version Of Prozac Opens - Intelihealth, 8/21/01
- Prozac Goes Generic - WebMD, 8/3/01
- Prozac Effective in Sustaining Remission of Eating Disorders - Doctor's Guide, 4/24/01 -
"followed for one year 35 anorexia outpatients who were discharged from the hospital after they recovered a
significant amount of their body weight. Fluoxetine was prescribed for 16 of the patients while the remainder took a placebo. Among the patients on fluoxetine, 10 of 16 did not relapse and maintained a healthy body weight, while only three out of 19 on placebo were successful"
- Depression Remission Better With Venlafaxine Than Selective Serotonin Uptake Inhibitors - Doctor's Guide, 3/1/01 -
"Remission rates among depressed patients treated
with venlafaxine are significantly higher than among patients treated with selective serotonin reuptake inhibitors."
- FDA approves once-a-week Prozac - USA Today, 2/27/01
- Attention Deficit Discovery - WebMD, 11/6/00 -
"When we gave these animals [Prozac], which affects the serotonin system, it had a dramatic effect on learning and memory, improving performance
fourfold."
- Bulimia: Prozac Can Help Where Talk Therapy Fails - WebMD, 8/3/00
- FDA Approves Prozac To Treat Severe Premenstrual Syndrome - Intelihealth, 7/7/00
- Questions Raised About Prozac's Link to Violent Behaviors - WebMD, 6/22/00
- A placebo-controlled study of fluoxetine versus imipramine in the acute treatment of atypical depression - Medline, 3/00
- Older Tricyclics More Effective Than Newer Antidepressants In Post-Stroke Depression - Doctor's Guide, 3/2/00
- Effexor More Effective Than Prozac In Achieving Remission In Depression - Doctor's Guide, 2/10/00
- FDA Advisory Panel Recommends Prozac For Premenstrual Dysphoric Disorder - Doctor's Guide, 11/4/99
- FDA Approves Prozac For Seniors With Depression - Doctor's Guide, 10/7/99
- Study: Prozac no better than older depression drugs - CNN, 3/19/99
- Remeron Found Superior To Fluoxetine In Early Depression Treatment - Doctor's Guide, 6/25/98
- Effexor XR Produces Significantly Higher Depression Remission Rates Than Prozac - Doctor's Guide, 6/2/98
Abstracts:
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An open-label pilot study of the combination therapy of metformin and
fluoxetine for weight reduction - Int J Obes (Lond). 2006 Sep 12 -
"In a 6.68-month period, a 7.89 kg
decrease in weight (9.32%) and a 3.43 U decrease in BMI (10.14%) were
observed in participants of the case group that was statistically
significant"
- Equivalence of St John's wort extract (Ze 117) and fluoxetine: a randomized, controlled study in mild-moderate depression - Int Clin Psychopharmacol 2000
Mar;15(2):61-8 - "We concluded that hypericum and fluoxetine are equipotent with respect to all main parameters used to investigate antidepressants in
this population. Although hypericum may be superior in improving the responder rate, the main difference between the two treatments is safety. Hypericum was superior to fluoxetine in overall incidence
of side-effects, number of patients with side-effects and the type of side-effect reported"
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