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Home > Anti-aging Research > HRT > Prempro
Prempro (estrogen and medroxyprogesterone acetate)
Related Topics:
- HRT in general / Female Sexuality / hot flashes / PMS / menopause /
contraception / osteoporosis
- Conjugated estrogens - Cenestin / Estrace / Ogen / Premarin
- Esterified estrogens - Menest
- Estrogen (estradiol) patches - Alora / Climara / Estraderm / Vivelle / Menostar
- Vaginal estrogen - Estring / Premarin
- Combination estrogen and methyltestosterone - Estratest
- Medroxyprogesterone - Cycrin / Provera
- Estrogen progestin tablets - Activella / Femhrt / Prempro
- Estrogen and progesterone patch - Combipatch
- Estrogen cream - Estrasorb
- Drospirenone and estradoil - Yasmin
/ Angeliq
- Transdermal - EstroGel® (estradiol gel)
/ Elestrin™/Bio-E-Gel® (estradiol gel)
Where to purchase:
General Information:
News & Research:
-
Lowest Effective Dose of Prempro (Conjugated Estrogens/Medroxyprogesterone) Now Available in the US - Doctor's Guide, 2/20/04
-
New Low Dose Hormone Therapy Prempro (Estrogen/ Medroxyprogesterone) Available in US - Doctor's Guide, 7/1/03
- Oestrogen Plus Progestin Therapy Ups Risk of Breast Cancer, Risk of Advanced Stage at Diagnosis - Doctor's Guide, 6/25/03 -
"randomly assigned
to receive daily equine oestrogens (0.625 mg) plus medroxyprogesterone acetate (2.5 mg) ... postmenopausal oestrogen plus progestin use significantly increases the incidence of breast cancer within a 5-year period"
- FDA Approves New Strength of Prempro, Low Dose Hormone Therapy - Doctor's Guide, 6/9/03 -
"Prempro 0.3 mg/1.5 mg is
approved for the treatment of moderate to severe symptoms associated with menopause, such as hot flashes, night sweats, and vaginal dryness; and for the prevention of postmenopausal osteoporosis."
- Combined Hormone Replacement Therapy May Increase Risk Of Dementia In Postmenopausal Women - Doctor's Guide,
5/29/03 - "participants received either 1 daily tablet of 0.625 mg conjugated equine oestrogen plus 2.5 mg medroxyprogesterone acetate ... the risk of probable dementia for women in the treatment group was twice that of women receiving placebo"
- HRT Now Linked to Alzheimer's, Dementia - WebMD, 5/27/03 - "Progestin has been shown to modify the beneficial effects of estrogen -- possibly increasing
the risk of heart disease and dementia ... A woman's age when she begins taking HRT, how long she takes it, and if she gets it from a patch or a pill -- all could have an effect on her risk"
- Oestrogen Plus Progestin Increases Risk of Stroke in Postmenopausal Women - Doctor's Guide, 5/25/03
-
Hormone Replacement Normalises Cholesterol in African-American Women - Doctor's Guide, 5/18/03 -
"randomised to daily combination HRT consisting
of 0.625 of conjugated oestrogen and 2.5 mg of medroxyprogesterone ... Overall, the women had an 8% increase in total HDL cholesterol ... They found an 8% reduction in the ratio of LDL to HDL ... LDL composition
measurements were not changed"
- Femhrt Increases Endothelial Dysfunction in Postmenopausal Non-Smokers - Doctor's Guide, 5/6/03 -
"Femhrt subjects
showed a statistically significant mean increase in vasodilation versus placebo in healthy women who never smoked ... Prempro and
Evista showed no such endothelial benefits for this subgroup or the smoker group"
- Renin Substrate Levels Decrease with Transdermal Hormone Therapy and Increase with Oral Hormone Therapy - Doctor's Guide, 5/6/03 -
"Oral Prempro
(conjugated equine estrogen/medroxyprogesterone) appears to increase plasma levels of renin substrate (angiotensinogen) to a significantly greater extent than CombiPatch (estradiol/norethindrone) ... The problem is that increases in the renin substrate (RS) can trigger activity in [renin-angiogenesis-aldosterone
system] that can lead, in turn, to higher blood pressure and, possibly, hypertension"
- Transdermal Hormones Better than Oral for Improving Women's Sexual Quality of Life - Doctor's Guide, 5/2/03 -
"At end point (20 weeks), 33% of
81 women on CombiPatch
eported improvement in Quality of Life scores compared to 17% of 84 on Prempro"
- FDA Approves Lower Dose Prempro (Conjugated Estrogens/ Medroxyprogesterone Acetate) - Doctor's Guide, 3/13/03
- Study Finds Breast Cancer Risk Due to Progestins in HRT - WebMD, 3/5/03 -
"Women who take combination hormone replacement therapy for more than four
years are at very high risk of breast cancer compared with women who have never used HRT. But estrogen-only HRT is virtually free of breast-cancer risk"
- Estradiol Alone Does Not Increase Breast Cancer Risk - Doctor's Guide, 12/16/02 -
"Hormone replacement therapy containing progestins
significantly elevates breast cancer risk, but preparations containing estradiol alone do not, a large Swedish observational study suggests"
- Increased Risks Lead To Halt In Large US Estrogen/Progestin Trial - Doctor's Guide, 7/9/02 -
"overall heath risks exceeded benefits from the use
of conjugated equine estrogens (0.625 milligrams per day) plus medroxyprogesterone acetate (2.5 mg/d), combined in one tablet"
- Stop Taking Prempro, Doctors Warn - WebMD, 7/9/02
- Hormone Therapy Linked to Ovarian Cancer - WebMD, 4/2/02 -
"ovarian cancer risk almost doubled in those taking either estrogen alone or an estrogen plus progestin regimen in
which progestin is not given every day (known as cyclic HRT). The researchers found no increased ovarian cancer risk in women taking continuous HRT, in which progestin is always given with estrogen"
- Hormone In Contraceptive Fights Cancer - Intelihealth, 1/2/02 -
"Progestin is the ingredient in oral contraceptive pills that provides the highest level of
protection against ovarian cancer ... the cancer risk was cut by about 50 percent in all women taking pills containing the hormones estrogen and progestin ... However, women who took pills containing high levels of progestin reduced their risk of ovarian cancer by an
additional 50 percent"
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