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Home > Anti-aging Research >
papaverine, phentolamine, and alprostadil
Trimix (alprostadil plus papaverine plus
phentolamine)
Related Topics:
News & Research:
- Erectile Dysfunction
- eMedicine - "Alprostadil, a synthetic PGE1, is the
most common single agent used for intracavernosal injections. When combined
with papaverine and Regitine, the mixture is called Trimix and it has
roughly twice the efficacy of alprostadil alone. In one study of 683 men,
94% reported having erections suitable for penetration after alprostadil
injections"
-
ABC of sexual health: Erectile dysfunction - bmj.com -
"Triple therapy (a combination of
papaverine, phentolamine, and alprostadil) is used for patients in whom
individual drugs have failed"
-
Papaverine plus phentolamine plus alprostadil (trimix) -
clinicalevidence.com - "a mix of
alprostadil plus papaverine plus phentolamine (trimix) was more effective
than intracavernosal alprostadil in producing erections in men who failed to
get erections with bimix"
-
Erectile Dysfunction in Diabetes: Pills for Penile Failure -
diabetes.org - "The commonly used
mixture is alprostadil, papaverine, and phentolamine, referred to as trimix.
Although urologists have used these drugs for a decade or more, the FDA only
approved alprostadil for this use in 1995. While pain may be more frequent
with alprostadil than with the mixture, the incidence of prolonged erection
(5%) and priapism (1%) are rare and make it the drug of choice"
-
Treatment Options for Erectile Dysfunction in Patients Failing Oral
DrugTherapy - corporate-ir.net
-
Doppler
Evaluation of Erectile Dysfunction – Part 1 - Medscape, 1/9/07 -
"Injection should always be made in the distal
two-third part of the penis on one side only because of the presence of a
septum in between the two corpora cavernosa in the proximal part of the
penis, which is deficient distally, thus allowing bilateral perfusion of the
injected vasoactive substance"
Abstracts:
-
Injection therapy for the treatment of erectile dysfunction: a comparison
between alprostadil and a combination of vasoactive intestinal polypeptide
and phentolamine mesilate - Curr Med Res Opin. 2007 Sep 14 -
"VIP/phentolamine and alprostadil were effective
treatments for ED, however the VIP/ phentolamine combination was preferred
by more patients, which may be because it was much less likely to cause
pain"
-
A prospective randomized study to optimize the dosage of trimix ingredients
and compare its efficacy and safety with prostaglandin E1 - Int J Impot
Res. 2005 Jul-Aug;17(4):346-53 - "even at the smallest dose of ingredients of Tx, there are no significant
differences in hemodynamic effects, rigidity, pain and self-satisfaction
between the two drugs. However, Tx produces a longer duration of erection
and more priapism than PgE1"
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