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QualityCounts.com Comprehensive
Anti-aging Research
Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.
Letrozole once a week normalizes serum testosterone in obesity-related male
hypogonadism - Eur J Endocrinol. 2008 May;158(5):741-7 -
"Isolated hypogonadotropic hypogonadism (IHH) is
frequently observed in severely obese men, probably as a result of increased
estradiol (E(2)) production and E(2)-mediated negative feedback on pituitary
LH secretion. Aromatase inhibitors can reverse this process ... treated with
2.5 mg letrozole once a week for 6 months ... Six weeks of treatment reduced
total E(2) from 123+/-11 to 58+/-7 pmol/l (P<0.001, mean+/-s.e.m.), and
increased serum LH from 4.4+/-0.6 to 11.1+/-1.5 U/l (P<0.001). Total
testosterone rose from 5.9+/-0.5 to 19.6+/-1.4 nmol/l (P<0.001), and free
testosterone from 163+/-13 to 604+/-50 pmol/l (P<0.001). Total testosterone
rose to within the normal range in all subjects, whereas free testosterone
rose to supraphysiological levels in 7 out of 12 men ... Letrozole 2.5 mg
once a week produced a sustained normalization of serum total testosterone
in obese men with IHH. However, free testosterone frequently rose to
supraphysiological levels. Therefore, a starting dose <2.5 mg once a week is
recommended" - See Femara (letrozole) at OffshoreRX.
I've been taking a quarter table a day but it sounds like that's way to much
an a quarter tablet every other day might be best which comes to 2.5 mg
every 8 days. People complain about the hassle to get doctors to
prescribe testosterone. It sounds like letrozole will give you the
same or better numbers without the hassle. Plus testosterone
replacement increases estrogen but letrozole has the advantage of decreasing
it. See my aromatization page.
Comparative assessment in young and elderly men of the gonadotropin response
to aromatase inhibition - J Clin Endocrinol Metab. 2005
Oct;90(10):5717-22 - "As assessed after 28 d of
treatment, letrozole lowered E2 by 46% in the young men (P = 0.002) and 62%
in the elderly men (P < 0.001). In both age groups, letrozole, but not
placebo, significantly increased LH levels (339 and 323% in the young and
the elderly, respectively) and T (146 and 99%, respectively) (P value of
young vs. elderly was not significant). Under letrozole, peak LH response to
GnRH was 152 and 52% increase from baseline in young and older men,
respectively"
Letrozole for Men -Google Groups - "The answer
is to reduce aromatase expression for both the middle aged and over age 65
elderly. For the last 7 years, I have used a tiny dose of letrozole, 10 mcg
daily. One tablet (2500 mcg = 2.5 mg) lasts for 250 days. Powder the tablet
and mix into a cup of powdered sugar - 1 cc scoop of the mix has 10 mcg
letrozole"
Letrozole-Femara - isteroids.com - "Letrozole is
probably the most powerful Aromatase Inhibitor used by athletes today"
Femara (Letrozole)
clinical pharmacology - RxList.com - "Letrozole's
terminal elimination half-life is about 2 days and steady-state plasma
concentration after daily 2.5 mg dosing is reached in 2-6 weeks"
Pain Makes Some End Breast Cancer Drug - WebMD, 9/6/07 -
"23% of the women in the new study given one of two
aromatase inhibitors -- Aromasin or Femara -- stopped taking their drugs due
to side effects, which also included hot flashes and nausea ... Forty-two
percent of the women reported serious bone and joint problems, such as
severe pain or difficulty opening a jar, and were referred for evaluation by
a rheumatologist"
Hormone Help for Ovarian Cancer? - WebMD, 6/15/07 -
"The patients took a drug called Femara, which is an
aromatase inhibitor, a type of drug that curbs estrogen production ...
monitored the women's blood level of a tumor marker called CA-125, a
substance found in higher concentrations in ovarian cancer than in other
cells ... Eleven of the 42 patients (26%) showed no tumor growth over six
months, based on their CA-125 levels"
Long-term Consequences of the Aromatase Inhibitors - Medscape, 11/16/05
- "The "short-term toxicities," such
as vasomotor symptoms, venothromboemboli, and gynecologic complications,
favor the use of AIs. However, long-term bone loss, altered lipid profiles,
and possible compromise in sexual functioning appear to be adversely
affected by the AIs"
